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OPENSEQ.org
ALAC - Glutamate-pyruvate aminotransferase AlaC
UniProt: P77434 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14198
Length: 412 (386)
Sequences: 19116
Seq/Len: 49.52
ALAC
Paralog alert: 0.94 [within 20: 0.25] - ratio of genomes with paralogs
Cluster includes: AAT ALAA ALAC ARNB AVTA CSDA HIS8 ISCS MALY RFFA SERC SUFS TYRB YBDL YDCR YJIR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
305_R 380_R 3.134 1.00
59_C 63_Q 3.118 1.00
104_T 110_G 2.925 1.00
190_L 194_E 2.855 1.00
304_K 308_D 2.847 1.00
124_T 145_Q 2.792 1.00
354_A 392_A 2.731 1.00
88_Q 94_E 2.689 1.00
82_A 290_E 2.588 1.00
320_M 333_K 2.554 1.00
52_P 56_E 2.55 1.00
309_V 384_R 2.533 1.00
165_I 202_R 2.509 1.00
349_K 353_E 2.464 1.00
385_Q 389_G 2.375 1.00
119_L 144_A 2.363 1.00
123_D 173_K 2.354 1.00
258_G 263_V 2.289 1.00
78_R 286_I 2.254 1.00
56_E 60_T 2.21 1.00
189_E 192_F 2.19 1.00
385_Q 388_R 2.182 1.00
194_E 198_A 2.167 1.00
253_I 285_A 2.105 1.00
81_R 85_R 2.081 1.00
312_K 316_E 1.989 1.00
112_A 116_L 1.985 1.00
313_G 387_I 1.942 1.00
81_R 97_P 1.927 1.00
308_D 312_K 1.916 1.00
313_G 316_E 1.908 1.00
311_V 315_H 1.893 1.00
200_A 207_V 1.881 1.00
124_T 147_R 1.859 1.00
191_E 194_E 1.851 1.00
311_V 323_M 1.846 1.00
313_G 388_R 1.828 1.00
160_E 163_R 1.827 1.00
208_V 239_F 1.81 1.00
77_P 81_R 1.807 1.00
41_F 386_A 1.806 1.00
139_A 144_A 1.783 1.00
354_A 389_G 1.777 1.00
85_R 290_E 1.775 1.00
162_E 195_K 1.772 1.00
129_N 148_S 1.771 1.00
204_D 235_V 1.77 1.00
309_V 380_R 1.739 1.00
379_N 382_R 1.738 1.00
82_A 85_R 1.731 1.00
152_V 192_F 1.72 1.00
174_M 208_V 1.71 1.00
158_F 192_F 1.691 1.00
107_S 239_F 1.671 1.00
84_S 97_P 1.663 1.00
342_G 345_E 1.662 1.00
212_A 241_T 1.658 1.00
195_K 198_A 1.654 1.00
315_H 321_V 1.63 1.00
348_K 352_N 1.619 1.00
309_V 313_G 1.602 1.00
278_F 281_L 1.591 1.00
256_M 266_L 1.588 1.00
297_R 301_E 1.586 1.00
358_V 372_V 1.581 1.00
114_L 237_V 1.579 1.00
349_K 393_M 1.573 1.00
136_I 140_V 1.564 1.00
313_G 384_R 1.562 1.00
78_R 290_E 1.558 1.00
114_L 208_V 1.556 1.00
125_V 139_A 1.548 1.00
124_T 169_Y 1.538 1.00
313_G 391_K 1.538 1.00
162_E 166_R 1.537 1.00
83_I 255_F 1.534 1.00
391_K 395_R 1.53 1.00
388_R 392_A 1.53 1.00
310_L 330_V 1.505 1.00
345_E 349_K 1.504 1.00
95_I 257_V 1.504 1.00
11_T 120_D 1.496 1.00
311_V 330_V 1.49 1.00
163_R 167_E 1.489 1.00
200_A 205_V 1.47 1.00
83_I 103_V 1.469 1.00
56_E 59_C 1.462 1.00
82_A 286_I 1.461 1.00
198_A 201_K 1.457 1.00
343_S 362_I 1.452 1.00
84_S 101_A 1.45 1.00
60_T 287_A 1.447 1.00
198_A 202_R 1.436 1.00
124_T 171_K 1.429 1.00
100_E 260_K 1.428 1.00
87_Y 257_V 1.427 1.00
124_T 172_P 1.419 1.00
190_L 224_P 1.416 1.00
76_I 283_V 1.414 1.00
316_E 391_K 1.409 1.00
380_R 384_R 1.407 0.99
55_V 59_C 1.392 0.99
85_R 89_D 1.377 0.99
36_E 355_K 1.376 0.99
57_K 287_A 1.371 0.99
350_L 390_I 1.368 0.99
313_G 317_A 1.363 0.99
237_V 256_M 1.362 0.99
310_L 387_I 1.355 0.99
129_N 150_P 1.355 0.99
311_V 321_V 1.342 0.99
297_R 300_A 1.337 0.99
345_E 348_K 1.332 0.99
98_E 260_K 1.322 0.99
83_I 101_A 1.317 0.99
301_E 304_K 1.311 0.99
315_H 323_M 1.307 0.99
384_R 388_R 1.302 0.99
192_F 195_K 1.298 0.99
190_L 229_V 1.297 0.99
347_A 358_V 1.293 0.99
60_T 64_R 1.29 0.99
332_A 374_F 1.286 0.99
74_R 80_R 1.285 0.99
302_Q 380_R 1.279 0.99
177_L 196_V 1.275 0.99
199_L 203_Y 1.275 0.99
115_M 139_A 1.269 0.99
115_M 176_I 1.254 0.99
242_L 285_A 1.25 0.99
109_E 270_K 1.244 0.98
237_V 258_G 1.244 0.98
74_R 267_A 1.241 0.98
96_D 260_K 1.24 0.98
80_R 84_S 1.239 0.98
127_V 146_V 1.233 0.98
191_E 195_K 1.231 0.98
331_W 361_G 1.226 0.98
136_I 148_S 1.22 0.98
102_I 263_V 1.217 0.98
312_K 315_H 1.216 0.98
382_R 385_Q 1.203 0.98
199_L 205_V 1.203 0.98
307_R 311_V 1.199 0.98
125_V 174_M 1.197 0.98
115_M 119_L 1.191 0.98
302_Q 305_R 1.19 0.98
194_E 229_V 1.185 0.98
89_D 293_Q 1.184 0.98
286_I 290_E 1.178 0.98
169_Y 172_P 1.177 0.98
240_F 255_F 1.172 0.98
87_Y 255_F 1.168 0.97
119_L 125_V 1.162 0.97
116_L 142_A 1.16 0.97
265_A 268_R 1.157 0.97
264_S 268_R 1.155 0.97
190_L 228_Q 1.155 0.97
52_P 55_V 1.153 0.97
287_A 290_E 1.142 0.97
101_A 257_V 1.142 0.97
78_R 283_V 1.141 0.97
301_E 305_R 1.141 0.97
333_K 371_H 1.139 0.97
350_L 358_V 1.138 0.97
105_I 109_E 1.137 0.97
117_A 269_I 1.128 0.97
163_R 166_R 1.126 0.97
165_I 203_Y 1.124 0.97
118_T 206_L 1.121 0.97
349_K 352_N 1.12 0.96
354_A 396_A 1.118 0.96
175_M 205_V 1.116 0.96
197_V 207_V 1.114 0.96
310_L 383_I 1.114 0.96
207_V 226_I 1.111 0.96
56_E 63_Q 1.108 0.96
165_I 195_K 1.105 0.96
308_D 323_M 1.096 0.96
339_A 345_E 1.086 0.96
346_F 372_V 1.085 0.96
219_D 325_K 1.083 0.96
270_K 274_D 1.079 0.95
84_S 96_D 1.072 0.95
78_R 81_R 1.072 0.95
110_G 256_M 1.063 0.95
79_L 103_V 1.061 0.95
100_E 233_R 1.06 0.95
201_K 234_D 1.059 0.95
161_L 199_L 1.057 0.95
121_H 143_G 1.055 0.95
307_R 376_L 1.049 0.94
160_E 164_A 1.046 0.94
317_A 388_R 1.04 0.94
11_T 14_D 1.04 0.94
139_A 146_V 1.039 0.94
126_L 149_V 1.038 0.94
206_L 237_V 1.033 0.94
110_G 239_F 1.032 0.94
306_R 309_V 1.032 0.94
201_K 231_G 1.025 0.93
312_K 384_R 1.024 0.93
126_L 172_P 1.021 0.93
117_A 266_L 1.019 0.93
310_L 313_G 1.019 0.93
30_A 34_R 1.011 0.93
381_D 384_R 1.007 0.93
227_M 238_E 1.004 0.93
41_F 383_I 1.002 0.92
96_D 100_E 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2x5dA40.99761000.304Contact Map0.779
3h14A10.94171000.336Contact Map0.651
1j32A20.93451000.337Contact Map0.805
3fvsA20.94171000.339Contact Map0.737
2o1bA10.94421000.339Contact Map0.724
3b46A20.95631000.343Contact Map0.801
3e2yA20.92231000.343Contact Map0.74
3dydA20.95391000.346Contact Map0.784
1o4sA20.9321000.347Contact Map0.823
2douA20.90781000.347Contact Map0.668
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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