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HIS8 - Histidinol-phosphate aminotransferase
UniProt: P06986 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10446
Length: 356 (342)
Sequences: 19631
Seq/Len: 57.40
HIS8
Paralog alert: 0.93 [within 20: 0.27] - ratio of genomes with paralogs
Cluster includes: AAT ALAA ALAC ARNB AVTA CSDA HIS8 ISCS MALY RFFA SERC SUFS TYRB YBDL YDCR YJIR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
141_S 177_G 3.15 1.00
81_S 87_G 3.002 1.00
273_I 277_E 2.998 1.00
165_P 169_R 2.982 1.00
66_N 258_S 2.644 1.00
96_C 122_V 2.602 1.00
228_A 233_I 2.562 1.00
62_A 254_A 2.396 1.00
290_E 303_R 2.308 1.00
223_C 253_A 2.274 1.00
164_N 167_D 2.256 1.00
169_R 173_E 2.249 1.00
89_E 93_R 2.18 1.00
65_E 69_Q 2.092 1.00
100_K 148_K 2.062 1.00
317_Q 353_A 2.056 1.00
313_S 316_D 2.026 1.00
65_E 75_P 2.009 1.00
280_I 284_K 1.993 1.00
182_V 209_L 1.962 1.00
277_E 281_A 1.953 1.00
175_T 181_V 1.951 1.00
282_A 285_E 1.934 1.00
149_V 182_V 1.913 1.00
281_A 285_E 1.897 1.00
134_Q 167_D 1.896 1.00
117_A 122_V 1.891 1.00
166_Q 169_R 1.89 1.00
66_N 69_Q 1.881 1.00
91_L 182_V 1.866 1.00
136_D 139_G 1.843 1.00
107_P 126_T 1.831 1.00
278_Y 282_A 1.822 1.00
141_S 170_T 1.82 1.00
278_Y 345_Q 1.819 1.00
44_E 48_T 1.817 1.00
138_Q 170_T 1.814 1.00
84_A 209_L 1.813 1.00
69_Q 258_S 1.808 1.00
186_A 211_T 1.797 1.00
178_K 205_H 1.786 1.00
102_A 123_E 1.781 1.00
346_R 350_A 1.766 1.00
76_E 230_E 1.739 1.00
226_T 236_L 1.736 1.00
139_G 143_K 1.734 1.00
68_A 75_P 1.717 1.00
91_L 207_A 1.711 1.00
170_T 173_E 1.703 1.00
280_I 300_I 1.676 1.00
246_S 249_V 1.664 1.00
114_S 118_E 1.663 1.00
67_Y 225_F 1.658 1.00
280_I 293_F 1.647 1.00
279_L 300_I 1.631 1.00
321_L 334_L 1.631 1.00
139_G 142_D 1.624 1.00
130_L 167_D 1.611 1.00
66_N 254_A 1.578 1.00
144_L 174_L 1.564 1.00
101_D 123_E 1.553 1.00
62_A 258_S 1.538 1.00
175_T 179_A 1.511 1.00
137_L 174_L 1.507 1.00
77_Q 230_E 1.502 1.00
92_I 151_Y 1.496 1.00
301_L 324_Q 1.486 1.00
274_A 342_E 1.483 1.00
266_R 270_A 1.482 1.00
67_Y 80_V 1.461 1.00
346_R 349_D 1.451 1.00
266_R 269_V 1.436 1.00
173_E 176_R 1.434 1.00
207_A 226_T 1.427 1.00
173_E 177_G 1.425 1.00
284_K 291_Q 1.422 1.00
302_A 336_I 1.421 1.00
167_D 170_T 1.417 1.00
212_L 253_A 1.415 1.00
92_I 117_A 1.414 1.00
282_A 348_I 1.412 1.00
282_A 286_I 1.411 1.00
68_A 78_V 1.41 1.00
107_P 128_P 1.409 1.00
306_A 309_A 1.383 0.99
137_L 170_T 1.379 0.99
312_K 316_D 1.379 0.99
71_A 227_L 1.369 0.99
59_Q 237_M 1.353 0.99
114_S 126_T 1.341 0.99
309_A 313_S 1.34 0.99
79_L 233_I 1.34 0.99
86_E 240_I 1.335 0.99
64_I 68_A 1.333 0.99
276_R 280_I 1.333 0.99
61_K 251_D 1.321 0.99
174_L 179_A 1.296 0.99
74_K 230_E 1.295 0.99
307_S 325_N 1.294 0.99
207_A 228_A 1.292 0.99
150_V 179_A 1.291 0.99
141_S 174_L 1.288 0.99
92_I 96_C 1.288 0.99
59_Q 64_I 1.287 0.99
105_Y 124_C 1.283 0.99
67_Y 78_V 1.28 0.99
281_A 284_K 1.279 0.99
166_Q 170_T 1.276 0.99
128_P 139_G 1.274 0.99
278_Y 342_E 1.27 0.99
63_V 80_V 1.264 0.99
303_R 333_C 1.253 0.99
95_F 180_I 1.252 0.99
270_A 273_I 1.252 0.99
93_R 120_I 1.248 0.99
210_R 225_F 1.248 0.99
82_R 86_E 1.245 0.98
43_V 47_L 1.241 0.98
235_L 238_K 1.241 0.98
309_A 312_K 1.227 0.98
62_A 251_D 1.224 0.98
87_G 226_T 1.216 0.98
101_D 145_D 1.207 0.98
95_F 149_V 1.2 0.98
274_A 341_R 1.2 0.98
103_I 117_A 1.195 0.98
234_N 238_K 1.194 0.98
78_V 227_L 1.187 0.98
169_R 202_E 1.186 0.98
138_Q 142_D 1.175 0.98
310_V 313_S 1.174 0.98
255_Q 258_S 1.165 0.97
336_I 347_V 1.15 0.97
144_L 179_A 1.149 0.97
44_E 47_L 1.149 0.97
280_I 291_Q 1.149 0.97
94_A 236_L 1.143 0.97
254_A 258_S 1.143 0.97
94_A 239_V 1.142 0.97
165_P 198_G 1.138 0.97
130_L 136_D 1.137 0.97
82_R 246_S 1.136 0.97
141_S 145_D 1.133 0.97
347_V 350_A 1.129 0.97
102_A 125_R 1.128 0.97
71_A 225_F 1.125 0.97
180_I 207_A 1.123 0.97
62_A 65_E 1.122 0.97
303_R 332_G 1.116 0.96
313_S 317_Q 1.112 0.96
87_G 209_L 1.106 0.96
74_K 77_Q 1.101 0.96
98_P 121_G 1.098 0.96
104_L 147_V 1.096 0.96
270_A 274_A 1.095 0.96
204_P 229_N 1.09 0.96
271_Q 274_A 1.089 0.96
340_T 343_E 1.089 0.96
276_R 338_V 1.087 0.96
79_L 236_L 1.078 0.95
117_A 124_C 1.076 0.95
144_L 147_V 1.073 0.95
314_L 321_L 1.065 0.95
279_L 282_A 1.063 0.95
172_L 206_L 1.063 0.95
172_L 181_V 1.062 0.95
12_E 15_R 1.062 0.95
101_D 147_V 1.055 0.95
101_D 125_R 1.055 0.95
84_A 186_A 1.05 0.94
223_C 245_L 1.049 0.94
109_T 153_C 1.047 0.94
34_L 347_V 1.044 0.94
230_E 234_N 1.044 0.94
73_V 227_L 1.041 0.94
255_Q 259_P 1.036 0.94
275_E 278_Y 1.026 0.94
275_E 341_R 1.024 0.93
271_Q 275_E 1.023 0.93
77_Q 203_Y 1.014 0.93
138_Q 141_S 1.01 0.93
345_Q 349_D 1.008 0.93
311_F 321_L 1.008 0.93
68_A 74_K 1.008 0.93
104_L 127_V 1.003 0.93
70_Y 216_F 1.002 0.92
176_R 203_Y 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1fg7A10.99721000.211Contact Map0.675
4je5A30.99161000.307Contact Map0.738
3getA20.96071000.307Contact Map0.684
3e2yA20.96631000.312Contact Map0.765
3fvsA20.98311000.315Contact Map0.756
3dydA20.99441000.316Contact Map0.763
1vp4A20.99161000.316Contact Map0.793
3h14A10.96911000.316Contact Map0.624
2x5dA40.98881000.317Contact Map0.748
2r2nA40.98031000.318Contact Map0.778
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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