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OPENSEQ.org
SERC - Phosphoserine aminotransferase
UniProt: P23721 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10946
Length: 362 (354)
Sequences: 10796
Seq/Len: 30.50
SERC
Paralog alert: 0.94 [within 20: 0.15] - ratio of genomes with paralogs
Cluster includes: AAT ALAA ALAC ARNB AVTA CSDA HIS8 ISCS MALY RFFA SERC SUFS TYRB YBDL YDCR YJIR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
275_L 348_K 3.96 1.00
150_P 178_T 3.663 1.00
279_V 351_T 3.387 1.00
160_D 163_P 3.248 1.00
56_D 254_K 3.164 1.00
175_F 192_I 3.08 1.00
162_T 188_R 3.064 1.00
93_T 117_N 3.056 1.00
275_L 344_L 3.041 1.00
251_L 254_K 2.997 1.00
59_D 257_K 2.75 1.00
185_D 188_R 2.686 1.00
242_P 245_A 2.67 1.00
271_Q 344_L 2.63 1.00
16_A 20_K 2.593 1.00
194_A 207_I 2.495 1.00
165_F 171_V 2.455 1.00
320_A 356_E 2.449 1.00
274_E 278_G 2.351 1.00
93_T 115_T 2.314 1.00
336_A 350_L 2.312 1.00
93_T 140_S 2.266 1.00
62_N 185_D 2.266 1.00
151_N 296_S 2.263 1.00
68_K 212_E 2.24 1.00
56_D 257_K 2.141 1.00
56_D 250_G 2.133 1.00
23_Q 27_R 2.123 1.00
289_D 303_Q 2.097 1.00
22_A 248_L 2.017 1.00
80_F 103_A 2.003 1.00
93_T 143_A 1.983 1.00
270_Q 274_E 1.951 1.00
196_A 249_S 1.937 1.00
52_E 254_K 1.935 1.00
21_Q 251_L 1.926 1.00
279_V 282_N 1.92 1.00
98_D 120_D 1.906 1.00
276_L 338_I 1.871 1.00
55_K 59_D 1.862 1.00
275_L 279_V 1.855 1.00
122_K 128_L 1.845 1.00
266_D 270_Q 1.809 1.00
92_T 144_A 1.774 1.00
189_Y 192_I 1.768 1.00
83_V 191_V 1.764 1.00
133_P 136_E 1.743 1.00
146_M 169_V 1.741 1.00
145_Y 172_A 1.716 1.00
80_F 172_A 1.711 1.00
287_R 303_Q 1.702 1.00
74_G 78_G 1.696 1.00
148_Y 164_D 1.659 1.00
76_G 176_S 1.632 1.00
16_A 27_R 1.626 1.00
183_P 263_A 1.603 1.00
17_E 258_A 1.596 1.00
73_H 79_Q 1.579 1.00
95_D 143_A 1.574 1.00
264_E 267_K 1.565 1.00
24_Q 28_D 1.555 1.00
92_T 142_N 1.554 1.00
267_K 271_Q 1.554 1.00
120_D 136_E 1.55 1.00
62_N 187_S 1.537 1.00
19_L 23_Q 1.512 1.00
52_E 56_D 1.505 1.00
199_N 249_S 1.502 1.00
173_A 189_Y 1.501 1.00
115_T 140_S 1.499 1.00
53_A 250_G 1.492 1.00
93_T 142_N 1.489 1.00
202_P 248_L 1.477 1.00
15_P 255_W 1.456 1.00
52_E 250_G 1.454 1.00
158_A 182_R 1.45 1.00
279_V 348_K 1.449 1.00
135_R 138_Q 1.449 1.00
64_P 187_S 1.441 1.00
324_A 334_M 1.439 1.00
161_E 173_A 1.435 1.00
17_E 255_W 1.422 1.00
96_Y 106_A 1.421 1.00
79_Q 193_Y 1.418 1.00
20_K 23_Q 1.416 1.00
186_V 209_I 1.414 1.00
20_K 24_Q 1.41 1.00
283_S 355_V 1.397 0.99
138_Q 167_A 1.392 0.99
196_A 201_G 1.392 0.99
200_I 339_Y 1.39 0.99
178_T 192_I 1.387 0.99
320_A 353_F 1.371 0.99
349_A 353_F 1.356 0.99
273_A 277_Y 1.341 0.99
277_Y 300_V 1.341 0.99
287_R 307_S 1.333 0.99
49_V 247_Y 1.325 0.99
17_E 251_L 1.324 0.99
98_D 118_V 1.322 0.99
99_A 159_I 1.32 0.99
263_A 267_K 1.304 0.99
279_V 355_V 1.287 0.99
122_K 131_V 1.287 0.99
9_S 299_N 1.287 0.99
6_N 350_L 1.278 0.99
345_E 348_K 1.272 0.99
179_I 184_I 1.264 0.99
128_L 291_A 1.263 0.99
162_T 166_G 1.256 0.99
19_L 27_R 1.25 0.99
48_Q 52_E 1.248 0.99
278_G 282_N 1.242 0.98
191_V 210_V 1.241 0.98
69_V 209_I 1.24 0.98
137_W 164_D 1.225 0.98
343_P 346_G 1.214 0.98
95_D 117_N 1.214 0.98
61_L 186_V 1.213 0.98
179_I 194_A 1.208 0.98
150_P 192_I 1.206 0.98
268_I 271_Q 1.204 0.98
94_A 106_A 1.197 0.98
250_G 254_K 1.196 0.98
349_A 352_D 1.194 0.98
276_L 336_A 1.191 0.98
117_N 140_S 1.19 0.98
282_N 355_V 1.188 0.98
355_V 359_R 1.186 0.98
302_F 336_A 1.186 0.98
163_P 166_G 1.184 0.98
97_V 148_Y 1.182 0.98
170_V 214_L 1.178 0.98
342_M 346_G 1.177 0.98
122_K 133_P 1.177 0.98
96_Y 118_V 1.176 0.98
50_A 246_W 1.171 0.98
147_H 172_A 1.168 0.97
338_I 347_V 1.167 0.97
151_N 178_T 1.161 0.97
196_A 205_L 1.16 0.97
183_P 266_D 1.159 0.97
184_I 192_I 1.15 0.97
64_P 212_E 1.14 0.97
289_D 301_P 1.132 0.97
172_A 193_Y 1.129 0.97
351_T 355_V 1.124 0.97
316_E 319_A 1.118 0.96
26_L 244_F 1.116 0.96
60_L 253_F 1.113 0.96
170_V 190_G 1.112 0.96
66_N 212_E 1.109 0.96
56_D 59_D 1.109 0.96
322_L 350_L 1.108 0.96
268_I 272_K 1.107 0.96
21_Q 24_Q 1.106 0.96
265_M 268_I 1.099 0.96
57_F 253_F 1.099 0.96
313_F 354_M 1.097 0.96
277_Y 295_R 1.097 0.96
87_I 170_V 1.092 0.96
84_P 106_A 1.085 0.96
267_K 270_Q 1.078 0.95
271_Q 275_L 1.058 0.95
148_Y 161_E 1.056 0.95
134_M 137_W 1.055 0.95
276_L 347_V 1.053 0.95
276_L 300_V 1.053 0.95
350_L 354_M 1.052 0.95
64_P 68_K 1.052 0.95
55_K 66_N 1.051 0.94
277_Y 288_N 1.047 0.94
8_S 342_M 1.046 0.94
18_V 252_V 1.04 0.94
315_E 319_A 1.034 0.94
8_S 12_A 1.029 0.94
285_F 307_S 1.026 0.94
344_L 348_K 1.018 0.93
352_D 356_E 1.017 0.93
117_N 143_A 1.015 0.93
53_A 246_W 1.014 0.93
139_L 146_M 1.007 0.93
205_L 245_A 1.005 0.93
55_K 58_R 1.005 0.93
76_G 193_Y 1.004 0.93
83_V 208_V 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3e77A30.97511000.407Contact Map0.68
3qm2A20.98071000.412Contact Map0.633
3e9kA10.95031000.413Contact Map0.666
3m5uA20.97511000.427Contact Map0.698
2c0rA20.98071000.429Contact Map0.683
1w23A20.98341000.434Contact Map0.739
3islA20.9421000.434Contact Map0.674
3ffrA10.9421000.441Contact Map0.679
3zrpA20.93371000.442Contact Map0.665
3nnkA160.9421000.448Contact Map0.704
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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