| UniProt: | P09053 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10107 | ||
| Length: | 417 (374) | ||
| Sequences: | 16909 | ||
| Seq/Len: | 45.21 |
| AVTA
Paralog alert: 0.94 [within 20: 0.22] - ratio of genomes with paralogs Cluster includes: AAT ALAA ALAC ARNB AVTA CSDA HIS8 ISCS MALY RFFA SERC SUFS TYRB YBDL YDCR YJIR |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 55_T | 59_E | 3.566 | 1.00 | |
| 312_Q | 395_P | 3.51 | 1.00 | |
| 311_Y | 315_Q | 3.19 | 1.00 | |
| 198_D | 202_L | 3.09 | 1.00 | |
| 88_R | 94_D | 3.052 | 1.00 | |
| 103_T | 109_A | 2.738 | 1.00 | |
| 48_D | 52_T | 2.676 | 1.00 | |
| 331_L | 344_W | 2.644 | 1.00 | |
| 316_E | 399_E | 2.584 | 1.00 | |
| 400_A | 404_I | 2.58 | 1.00 | |
| 362_R | 407_E | 2.573 | 1.00 | |
| 358_R | 361_A | 2.525 | 1.00 | |
| 82_L | 294_K | 2.46 | 1.00 | |
| 400_A | 403_K | 2.439 | 1.00 | |
| 262_A | 267_I | 2.393 | 1.00 | |
| 78_E | 290_C | 2.328 | 1.00 | |
| 202_L | 206_A | 2.205 | 1.00 | |
| 351_T | 354_Q | 2.182 | 1.00 | |
| 197_T | 200_E | 2.158 | 1.00 | |
| 52_T | 56_D | 2.126 | 1.00 | |
| 81_T | 85_G | 2.124 | 1.00 | |
| 208_A | 215_L | 2.116 | 1.00 | |
| 199_E | 202_L | 2.091 | 1.00 | |
| 320_I | 402_V | 2.084 | 1.00 | |
| 320_I | 403_K | 2.07 | 1.00 | |
| 319_A | 323_R | 2.069 | 1.00 | |
| 257_C | 289_M | 1.988 | 1.00 | |
| 111_F | 115_N | 1.983 | 1.00 | |
| 316_E | 395_P | 1.964 | 1.00 | |
| 85_G | 294_K | 1.949 | 1.00 | |
| 77_T | 81_T | 1.925 | 1.00 | |
| 212_G | 240_N | 1.925 | 1.00 | |
| 125_R | 181_G | 1.919 | 1.00 | |
| 315_Q | 319_A | 1.903 | 1.00 | |
| 81_T | 97_P | 1.885 | 1.00 | |
| 172_E | 203_K | 1.856 | 1.00 | |
| 182_M | 216_V | 1.832 | 1.00 | |
| 84_A | 97_P | 1.831 | 1.00 | |
| 220_A | 246_S | 1.829 | 1.00 | |
| 318_I | 322_R | 1.827 | 1.00 | |
| 216_V | 244_C | 1.823 | 1.00 | |
| 318_I | 334_K | 1.821 | 1.00 | |
| 35_L | 401_G | 1.813 | 1.00 | |
| 394_E | 397_K | 1.788 | 1.00 | |
| 113_L | 242_V | 1.786 | 1.00 | |
| 203_K | 206_A | 1.772 | 1.00 | |
| 366_M | 387_M | 1.759 | 1.00 | |
| 106_S | 244_C | 1.748 | 1.00 | |
| 358_R | 408_E | 1.729 | 1.00 | |
| 322_R | 332_I | 1.727 | 1.00 | |
| 320_I | 323_R | 1.717 | 1.00 | |
| 168_H | 200_E | 1.694 | 1.00 | |
| 260_I | 270_I | 1.68 | 1.00 | |
| 56_D | 291_E | 1.674 | 1.00 | |
| 82_L | 85_G | 1.67 | 1.00 | |
| 170_D | 173_H | 1.661 | 1.00 | |
| 317_T | 341_L | 1.656 | 1.00 | |
| 51_Q | 55_T | 1.645 | 1.00 | |
| 320_I | 406_A | 1.64 | 1.00 | |
| 359_L | 405_L | 1.638 | 1.00 | |
| 318_I | 341_L | 1.636 | 1.00 | |
| 128_K | 177_G | 1.632 | 1.00 | |
| 352_T | 370_H | 1.625 | 1.00 | |
| 160_L | 200_E | 1.618 | 1.00 | |
| 206_A | 210_Q | 1.612 | 1.00 | |
| 316_E | 320_I | 1.607 | 1.00 | |
| 76_K | 287_A | 1.607 | 1.00 | |
| 134_A | 152_S | 1.601 | 1.00 | |
| 171_F | 207_L | 1.588 | 1.00 | |
| 78_E | 294_K | 1.585 | 1.00 | |
| 362_R | 404_I | 1.581 | 1.00 | |
| 403_K | 407_E | 1.574 | 1.00 | |
| 87_L | 261_I | 1.566 | 1.00 | |
| 206_A | 209_N | 1.561 | 1.00 | |
| 208_A | 213_I | 1.56 | 1.00 | |
| 171_F | 203_K | 1.556 | 1.00 | |
| 98_Q | 264_E | 1.554 | 1.00 | |
| 113_L | 216_V | 1.553 | 1.00 | |
| 354_Q | 358_R | 1.535 | 1.00 | |
| 53_L | 291_E | 1.523 | 1.00 | |
| 320_I | 399_E | 1.518 | 1.00 | |
| 406_A | 410_E | 1.513 | 1.00 | |
| 56_D | 60_S | 1.509 | 1.00 | |
| 30_P | 363_G | 1.507 | 1.00 | |
| 282_G | 285_G | 1.504 | 1.00 | |
| 320_I | 324_Y | 1.494 | 1.00 | |
| 128_K | 180_T | 1.493 | 1.00 | |
| 95_I | 261_I | 1.492 | 1.00 | |
| 323_R | 406_A | 1.488 | 1.00 | |
| 308_P | 311_Y | 1.486 | 1.00 | |
| 83_L | 259_I | 1.486 | 1.00 | |
| 85_G | 89_E | 1.472 | 1.00 | |
| 342_W | 369_G | 1.462 | 1.00 | |
| 84_A | 100_I | 1.461 | 1.00 | |
| 207_L | 211_H | 1.458 | 1.00 | |
| 99_N | 264_E | 1.458 | 1.00 | |
| 83_L | 102_L | 1.455 | 1.00 | |
| 356_Y | 366_M | 1.449 | 1.00 | |
| 141_A | 145_L | 1.446 | 1.00 | |
| 309_F | 395_P | 1.423 | 1.00 | |
| 317_T | 402_V | 1.405 | 0.99 | |
| 82_L | 290_C | 1.403 | 0.99 | |
| 128_K | 179_E | 1.39 | 0.99 | |
| 52_T | 55_T | 1.385 | 0.99 | |
| 324_Y | 403_K | 1.384 | 0.99 | |
| 74_Q | 80_L | 1.366 | 0.99 | |
| 114_F | 184_C | 1.363 | 0.99 | |
| 48_D | 51_Q | 1.362 | 0.99 | |
| 395_P | 399_E | 1.349 | 0.99 | |
| 128_K | 151_V | 1.347 | 0.99 | |
| 154_R | 173_H | 1.34 | 0.99 | |
| 318_I | 332_I | 1.334 | 0.99 | |
| 247_L | 289_M | 1.333 | 0.99 | |
| 351_T | 384_H | 1.331 | 0.99 | |
| 296_N | 300_R | 1.331 | 0.99 | |
| 80_L | 84_A | 1.326 | 0.99 | |
| 207_L | 213_I | 1.324 | 0.99 | |
| 74_Q | 271_T | 1.316 | 0.99 | |
| 242_V | 260_I | 1.306 | 0.99 | |
| 200_E | 203_K | 1.305 | 0.99 | |
| 77_T | 97_P | 1.294 | 0.99 | |
| 242_V | 262_A | 1.292 | 0.99 | |
| 322_R | 334_K | 1.291 | 0.99 | |
| 176_I | 207_L | 1.29 | 0.99 | |
| 399_E | 403_K | 1.287 | 0.99 | |
| 51_Q | 59_E | 1.282 | 0.99 | |
| 354_Q | 357_Q | 1.281 | 0.99 | |
| 96_E | 264_E | 1.271 | 0.99 | |
| 309_F | 312_Q | 1.271 | 0.99 | |
| 314_V | 318_I | 1.267 | 0.99 | |
| 101_A | 267_I | 1.266 | 0.99 | |
| 117_F | 214_P | 1.266 | 0.99 | |
| 343_L | 389_M | 1.262 | 0.99 | |
| 344_W | 386_C | 1.261 | 0.99 | |
| 290_C | 294_K | 1.26 | 0.99 | |
| 108_S | 274_N | 1.254 | 0.99 | |
| 78_E | 287_A | 1.252 | 0.99 | |
| 199_E | 203_K | 1.245 | 0.98 | |
| 303_E | 308_P | 1.237 | 0.98 | |
| 245_M | 259_I | 1.233 | 0.98 | |
| 114_F | 144_G | 1.22 | 0.98 | |
| 397_K | 400_A | 1.217 | 0.98 | |
| 54_L | 58_L | 1.216 | 0.98 | |
| 134_A | 154_R | 1.216 | 0.98 | |
| 83_L | 100_I | 1.208 | 0.98 | |
| 274_N | 278_S | 1.204 | 0.98 | |
| 54_L | 288_M | 1.199 | 0.98 | |
| 116_L | 273_M | 1.195 | 0.98 | |
| 359_L | 366_M | 1.185 | 0.98 | |
| 304_T | 308_P | 1.184 | 0.98 | |
| 87_L | 259_I | 1.179 | 0.98 | |
| 101_A | 270_I | 1.176 | 0.98 | |
| 205_D | 215_L | 1.172 | 0.98 | |
| 100_I | 261_I | 1.171 | 0.98 | |
| 314_V | 391_Y | 1.169 | 0.97 | |
| 362_R | 411_R | 1.167 | 0.97 | |
| 364_V | 405_L | 1.167 | 0.97 | |
| 317_T | 398_I | 1.166 | 0.97 | |
| 114_F | 118_A | 1.161 | 0.97 | |
| 99_N | 238_N | 1.16 | 0.97 | |
| 319_A | 399_E | 1.159 | 0.97 | |
| 269_A | 272_N | 1.159 | 0.97 | |
| 291_E | 294_K | 1.156 | 0.97 | |
| 355_L | 387_M | 1.15 | 0.97 | |
| 177_G | 180_T | 1.15 | 0.97 | |
| 291_E | 295_R | 1.148 | 0.97 | |
| 303_E | 307_K | 1.142 | 0.97 | |
| 79_L | 102_L | 1.14 | 0.97 | |
| 315_Q | 334_K | 1.14 | 0.97 | |
| 104_N | 108_S | 1.139 | 0.97 | |
| 308_P | 312_Q | 1.137 | 0.97 | |
| 128_K | 149_L | 1.134 | 0.97 | |
| 209_N | 239_P | 1.126 | 0.97 | |
| 268_T | 272_N | 1.118 | 0.96 | |
| 52_T | 59_E | 1.112 | 0.96 | |
| 205_D | 241_I | 1.11 | 0.96 | |
| 53_L | 57_M | 1.106 | 0.96 | |
| 85_G | 88_R | 1.094 | 0.96 | |
| 53_L | 56_D | 1.094 | 0.96 | |
| 324_Y | 406_A | 1.085 | 0.96 | |
| 160_L | 170_D | 1.084 | 0.96 | |
| 109_A | 244_C | 1.079 | 0.95 | |
| 244_C | 260_I | 1.076 | 0.95 | |
| 118_A | 149_L | 1.076 | 0.95 | |
| 96_E | 99_N | 1.069 | 0.95 | |
| 317_T | 320_I | 1.059 | 0.95 | |
| 176_I | 213_I | 1.059 | 0.95 | |
| 319_A | 322_R | 1.049 | 0.94 | |
| 31_G | 397_K | 1.043 | 0.94 | |
| 396_E | 399_E | 1.042 | 0.94 | |
| 330_C | 343_L | 1.037 | 0.94 | |
| 51_Q | 58_L | 1.035 | 0.94 | |
| 84_A | 96_E | 1.032 | 0.94 | |
| 86_M | 90_K | 1.032 | 0.94 | |
| 35_L | 398_I | 1.027 | 0.94 | |
| 309_F | 313_R | 1.026 | 0.94 | |
| 160_L | 163_G | 1.024 | 0.93 | |
| 89_E | 299_L | 1.023 | 0.93 | |
| 314_V | 335_P | 1.018 | 0.93 | |
| 117_F | 182_M | 1.017 | 0.93 | |
| 257_C | 281_P | 1.016 | 0.93 | |
| 353_K | 370_H | 1.016 | 0.93 | |
| 358_R | 362_R | 1.011 | 0.93 | |
| 67_L | 287_A | 1.01 | 0.93 | |
| 106_S | 246_S | 1.007 | 0.93 | |
| 77_T | 80_L | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3if2A | 2 | 0.9808 | 100 | 0.321 | Contact Map | 0.65 |
| 3g7qA | 1 | 0.9784 | 100 | 0.323 | Contact Map | 0.658 |
| 4je5A | 3 | 0.9472 | 100 | 0.341 | Contact Map | 0.728 |
| 1vp4A | 2 | 0.9305 | 100 | 0.358 | Contact Map | 0.798 |
| 2r2nA | 4 | 0.9209 | 100 | 0.367 | Contact Map | 0.706 |
| 3pplA | 2 | 0.9185 | 100 | 0.368 | Contact Map | 0.595 |
| 3ez1A | 2 | 0.9065 | 100 | 0.376 | Contact Map | 0.638 |
| 2zc0A | 4 | 0.9185 | 100 | 0.377 | Contact Map | 0.782 |
| 3dydA | 2 | 0.9065 | 100 | 0.378 | Contact Map | 0.775 |
| 3fvsA | 2 | 0.9305 | 100 | 0.379 | Contact Map | 0.697 |
Sequence Conservation (Image Generated using WebLogo v3)