| UniProt: | P39389 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG12579 | ||
| Length: | 470 (466) | ||
| Sequences: | 5345 | ||
| Seq/Len: | 11.47 |
| YJIR
Paralog alert: 0.67 [within 20: 0.09] - ratio of genomes with paralogs Cluster includes: AAT ALAA ALAC ARNB AVTA CSDA HIS8 ISCS MALY RFFA SERC SUFS TYRB YBDL YDCR YJIR |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 233_E | 272_R | 3.138 | 1.00 | |
| 422_M | 463_E | 3.022 | 1.00 | |
| 59_Q | 62_S | 2.963 | 1.00 | |
| 374_R | 451_S | 2.896 | 1.00 | |
| 220_P | 231_A | 2.841 | 1.00 | |
| 419_L | 461_I | 2.819 | 1.00 | |
| 274_D | 304_R | 2.809 | 1.00 | |
| 130_R | 354_T | 2.743 | 1.00 | |
| 222_D | 262_R | 2.74 | 1.00 | |
| 193_D | 242_K | 2.735 | 1.00 | |
| 456_E | 460_Q | 2.697 | 1.00 | |
| 21_R | 24_E | 2.66 | 1.00 | |
| 128_L | 351_A | 2.643 | 1.00 | |
| 189_C | 214_V | 2.602 | 1.00 | |
| 270_A | 277_I | 2.557 | 1.00 | |
| 182_S | 186_M | 2.509 | 1.00 | |
| 422_M | 460_Q | 2.503 | 1.00 | |
| 385_E | 455_R | 2.448 | 1.00 | |
| 194_I | 215_K | 2.421 | 1.00 | |
| 109_L | 457_A | 2.391 | 1.00 | |
| 373_Q | 377_A | 2.314 | 1.00 | |
| 392_C | 405_E | 2.269 | 1.00 | |
| 271_Q | 302_D | 2.258 | 1.00 | |
| 118_A | 371_I | 2.237 | 1.00 | |
| 246_L | 266_V | 2.224 | 1.00 | |
| 223_P | 262_R | 2.21 | 1.00 | |
| 311_F | 352_A | 2.203 | 1.00 | |
| 148_Q | 350_M | 2.194 | 1.00 | |
| 12_A | 53_M | 2.163 | 1.00 | |
| 227_I | 244_I | 2.096 | 1.00 | |
| 230_E | 265_A | 2.09 | 1.00 | |
| 260_D | 299_W | 2.069 | 1.00 | |
| 233_E | 237_E | 2.056 | 1.00 | |
| 156_A | 168_A | 2.049 | 1.00 | |
| 295_T | 298_S | 2.031 | 1.00 | |
| 456_E | 459_K | 2.028 | 1.00 | |
| 418_Q | 421_R | 1.987 | 1.00 | |
| 231_A | 234_L | 1.975 | 1.00 | |
| 225_T | 262_R | 1.973 | 1.00 | |
| 174_T | 180_S | 1.939 | 1.00 | |
| 228_S | 231_A | 1.931 | 1.00 | |
| 260_D | 264_R | 1.927 | 1.00 | |
| 450_L | 453_T | 1.913 | 1.00 | |
| 314_S | 361_Y | 1.913 | 1.00 | |
| 184_A | 278_F | 1.876 | 1.00 | |
| 378_L | 382_W | 1.853 | 1.00 | |
| 154_Q | 357_L | 1.837 | 1.00 | |
| 26_L | 56_I | 1.834 | 1.00 | |
| 147_G | 152_R | 1.83 | 1.00 | |
| 265_A | 268_S | 1.826 | 1.00 | |
| 225_T | 259_P | 1.824 | 1.00 | |
| 233_E | 273_H | 1.802 | 1.00 | |
| 233_E | 265_A | 1.8 | 1.00 | |
| 405_E | 441_C | 1.8 | 1.00 | |
| 180_S | 308_C | 1.79 | 1.00 | |
| 154_Q | 353_A | 1.782 | 1.00 | |
| 226_G | 262_R | 1.769 | 1.00 | |
| 179_N | 341_S | 1.765 | 1.00 | |
| 150_V | 357_L | 1.756 | 1.00 | |
| 205_S | 245_I | 1.753 | 1.00 | |
| 337_K | 341_S | 1.751 | 1.00 | |
| 155_I | 171_I | 1.709 | 1.00 | |
| 386_Y | 459_K | 1.699 | 1.00 | |
| 378_L | 455_R | 1.697 | 1.00 | |
| 199_S | 220_P | 1.697 | 1.00 | |
| 337_K | 344_N | 1.696 | 1.00 | |
| 267_L | 296_I | 1.69 | 1.00 | |
| 185_L | 209_L | 1.688 | 1.00 | |
| 300_D | 303_G | 1.684 | 1.00 | |
| 164_S | 297_H | 1.682 | 1.00 | |
| 155_I | 173_I | 1.652 | 1.00 | |
| 229_V | 262_R | 1.639 | 1.00 | |
| 177_C | 308_C | 1.635 | 1.00 | |
| 229_V | 269_L | 1.624 | 1.00 | |
| 152_R | 156_A | 1.619 | 1.00 | |
| 7_L | 38_V | 1.604 | 1.00 | |
| 269_L | 273_H | 1.603 | 1.00 | |
| 205_S | 209_L | 1.584 | 1.00 | |
| 195_V | 209_L | 1.577 | 1.00 | |
| 345_V | 348_T | 1.568 | 1.00 | |
| 418_Q | 422_M | 1.565 | 1.00 | |
| 187_A | 336_M | 1.56 | 1.00 | |
| 228_S | 262_R | 1.559 | 1.00 | |
| 270_A | 275_I | 1.558 | 1.00 | |
| 134_H | 354_T | 1.558 | 1.00 | |
| 287_A | 290_Y | 1.541 | 1.00 | |
| 268_S | 272_R | 1.54 | 1.00 | |
| 184_A | 306_L | 1.538 | 1.00 | |
| 153_E | 168_A | 1.537 | 1.00 | |
| 159_M | 325_A | 1.527 | 1.00 | |
| 127_E | 354_T | 1.522 | 1.00 | |
| 29_V | 40_I | 1.508 | 1.00 | |
| 62_S | 65_F | 1.505 | 1.00 | |
| 267_L | 299_W | 1.494 | 1.00 | |
| 236_L | 275_I | 1.493 | 1.00 | |
| 196_A | 241_I | 1.491 | 1.00 | |
| 172_I | 333_L | 1.477 | 1.00 | |
| 243_G | 278_F | 1.472 | 1.00 | |
| 154_Q | 356_V | 1.449 | 1.00 | |
| 382_W | 458_L | 1.449 | 1.00 | |
| 403_W | 429_G | 1.444 | 1.00 | |
| 324_V | 333_L | 1.441 | 1.00 | |
| 234_L | 238_Q | 1.441 | 1.00 | |
| 151_L | 173_I | 1.439 | 1.00 | |
| 377_A | 381_C | 1.437 | 1.00 | |
| 416_A | 426_V | 1.437 | 1.00 | |
| 321_V | 352_A | 1.435 | 1.00 | |
| 414_C | 418_Q | 1.429 | 1.00 | |
| 13_E | 17_Q | 1.429 | 1.00 | |
| 379_Y | 458_L | 1.427 | 1.00 | |
| 236_L | 269_L | 1.426 | 1.00 | |
| 264_R | 268_S | 1.418 | 1.00 | |
| 128_L | 132_V | 1.402 | 0.99 | |
| 411_D | 439_R | 1.392 | 0.99 | |
| 153_E | 157_R | 1.385 | 0.99 | |
| 281_D | 284_G | 1.383 | 0.99 | |
| 380_T | 402_L | 1.382 | 0.99 | |
| 459_K | 463_E | 1.377 | 0.99 | |
| 382_W | 455_R | 1.36 | 0.99 | |
| 378_L | 451_S | 1.358 | 0.99 | |
| 267_L | 305_V | 1.356 | 0.99 | |
| 166_V | 325_A | 1.356 | 0.99 | |
| 49_T | 53_M | 1.356 | 0.99 | |
| 170_D | 327_G | 1.351 | 0.99 | |
| 114_P | 372_Y | 1.35 | 0.99 | |
| 194_I | 217_I | 1.342 | 0.99 | |
| 196_A | 219_I | 1.341 | 0.99 | |
| 244_I | 275_I | 1.338 | 0.99 | |
| 155_I | 311_F | 1.336 | 0.99 | |
| 267_L | 277_I | 1.333 | 0.99 | |
| 15_I | 66_V | 1.332 | 0.99 | |
| 225_T | 261_A | 1.331 | 0.99 | |
| 198_E | 251_N | 1.331 | 0.99 | |
| 156_A | 171_I | 1.33 | 0.99 | |
| 419_L | 426_V | 1.326 | 0.99 | |
| 300_D | 304_R | 1.325 | 0.99 | |
| 376_L | 380_T | 1.309 | 0.99 | |
| 229_V | 266_V | 1.308 | 0.99 | |
| 131_V | 351_A | 1.307 | 0.99 | |
| 262_R | 265_A | 1.307 | 0.99 | |
| 3_R | 6_H | 1.302 | 0.99 | |
| 28_S | 60_P | 1.299 | 0.99 | |
| 260_D | 294_R | 1.299 | 0.99 | |
| 149_R | 153_E | 1.294 | 0.99 | |
| 171_I | 325_A | 1.291 | 0.99 | |
| 146_A | 334_M | 1.29 | 0.99 | |
| 354_T | 357_L | 1.286 | 0.99 | |
| 14_R | 19_L | 1.284 | 0.99 | |
| 386_Y | 455_R | 1.281 | 0.99 | |
| 109_L | 454_Y | 1.281 | 0.99 | |
| 294_R | 299_W | 1.281 | 0.99 | |
| 412_M | 430_S | 1.278 | 0.99 | |
| 287_A | 293_P | 1.275 | 0.99 | |
| 31_S | 35_E | 1.275 | 0.99 | |
| 56_I | 64_Y | 1.273 | 0.99 | |
| 259_P | 262_R | 1.272 | 0.99 | |
| 179_N | 337_K | 1.272 | 0.99 | |
| 196_A | 232_L | 1.271 | 0.99 | |
| 426_V | 442_L | 1.259 | 0.99 | |
| 158_L | 362_H | 1.257 | 0.99 | |
| 187_A | 333_L | 1.254 | 0.99 | |
| 288_T | 446_C | 1.253 | 0.99 | |
| 174_T | 322_G | 1.252 | 0.99 | |
| 411_D | 414_C | 1.247 | 0.99 | |
| 417_R | 421_R | 1.247 | 0.99 | |
| 25_K | 65_F | 1.246 | 0.98 | |
| 415_V | 464_A | 1.246 | 0.98 | |
| 197_V | 206_M | 1.245 | 0.98 | |
| 219_I | 227_I | 1.244 | 0.98 | |
| 127_E | 131_V | 1.244 | 0.98 | |
| 150_V | 353_A | 1.244 | 0.98 | |
| 278_F | 308_C | 1.242 | 0.98 | |
| 380_T | 395_R | 1.227 | 0.98 | |
| 43_V | 46_A | 1.214 | 0.98 | |
| 354_T | 358_E | 1.212 | 0.98 | |
| 32_L | 36_H | 1.211 | 0.98 | |
| 460_Q | 464_A | 1.21 | 0.98 | |
| 309_S | 323_W | 1.207 | 0.98 | |
| 462_G | 466_Y | 1.207 | 0.98 | |
| 49_T | 52_T | 1.203 | 0.98 | |
| 268_S | 271_Q | 1.2 | 0.98 | |
| 199_S | 218_E | 1.198 | 0.98 | |
| 419_L | 464_A | 1.197 | 0.98 | |
| 269_L | 275_I | 1.192 | 0.98 | |
| 9_T | 13_E | 1.192 | 0.98 | |
| 237_E | 273_H | 1.191 | 0.98 | |
| 196_A | 244_I | 1.189 | 0.98 | |
| 131_V | 354_T | 1.188 | 0.98 | |
| 57_T | 67_A | 1.179 | 0.98 | |
| 383_I | 387_F | 1.168 | 0.97 | |
| 422_M | 467_R | 1.161 | 0.97 | |
| 381_C | 455_R | 1.159 | 0.97 | |
| 379_Y | 402_L | 1.156 | 0.97 | |
| 308_C | 324_V | 1.156 | 0.97 | |
| 382_W | 386_Y | 1.155 | 0.97 | |
| 315_I | 352_A | 1.152 | 0.97 | |
| 125_W | 129_S | 1.151 | 0.97 | |
| 424_I | 460_Q | 1.15 | 0.97 | |
| 51_E | 56_I | 1.146 | 0.97 | |
| 8_A | 49_T | 1.143 | 0.97 | |
| 184_A | 333_L | 1.142 | 0.97 | |
| 250_C | 398_G | 1.14 | 0.97 | |
| 453_T | 456_E | 1.138 | 0.97 | |
| 178_H | 204_G | 1.135 | 0.97 | |
| 231_A | 235_A | 1.133 | 0.97 | |
| 384_R | 395_R | 1.133 | 0.97 | |
| 455_R | 459_K | 1.131 | 0.97 | |
| 422_M | 464_A | 1.13 | 0.97 | |
| 330_H | 334_M | 1.128 | 0.97 | |
| 154_Q | 157_R | 1.128 | 0.97 | |
| 380_T | 393_I | 1.122 | 0.97 | |
| 170_D | 330_H | 1.119 | 0.96 | |
| 186_M | 212_M | 1.116 | 0.96 | |
| 271_Q | 301_I | 1.112 | 0.96 | |
| 267_L | 300_D | 1.109 | 0.96 | |
| 261_A | 265_A | 1.107 | 0.96 | |
| 127_E | 360_H | 1.1 | 0.96 | |
| 190_K | 193_D | 1.097 | 0.96 | |
| 410_V | 415_V | 1.096 | 0.96 | |
| 221_T | 256_F | 1.091 | 0.96 | |
| 233_E | 269_L | 1.082 | 0.96 | |
| 371_I | 375_N | 1.079 | 0.95 | |
| 249_N | 281_D | 1.078 | 0.95 | |
| 276_V | 304_R | 1.076 | 0.95 | |
| 189_C | 193_D | 1.076 | 0.95 | |
| 161_D | 362_H | 1.076 | 0.95 | |
| 382_W | 454_Y | 1.072 | 0.95 | |
| 198_E | 221_T | 1.068 | 0.95 | |
| 195_V | 243_G | 1.06 | 0.95 | |
| 12_A | 55_L | 1.057 | 0.95 | |
| 415_V | 465_V | 1.052 | 0.95 | |
| 297_H | 300_D | 1.052 | 0.95 | |
| 31_S | 34_Q | 1.052 | 0.95 | |
| 189_C | 195_V | 1.052 | 0.95 | |
| 300_D | 305_V | 1.052 | 0.95 | |
| 6_H | 10_L | 1.052 | 0.95 | |
| 380_T | 384_R | 1.047 | 0.94 | |
| 311_F | 323_W | 1.046 | 0.94 | |
| 391_I | 404_I | 1.042 | 0.94 | |
| 424_I | 457_A | 1.036 | 0.94 | |
| 12_A | 16_E | 1.036 | 0.94 | |
| 20_Y | 66_V | 1.035 | 0.94 | |
| 313_K | 320_R | 1.03 | 0.94 | |
| 289_E | 397_K | 1.03 | 0.94 | |
| 261_A | 264_R | 1.027 | 0.94 | |
| 379_Y | 454_Y | 1.027 | 0.94 | |
| 202_Y | 245_I | 1.026 | 0.94 | |
| 236_L | 273_H | 1.025 | 0.93 | |
| 222_D | 228_S | 1.024 | 0.93 | |
| 205_S | 208_M | 1.023 | 0.93 | |
| 146_A | 152_R | 1.022 | 0.93 | |
| 183_L | 333_L | 1.02 | 0.93 | |
| 38_V | 43_V | 1.018 | 0.93 | |
| 115_D | 375_N | 1.015 | 0.93 | |
| 416_A | 428_A | 1.015 | 0.93 | |
| 267_L | 301_I | 1.011 | 0.93 | |
| 403_W | 443_R | 1.011 | 0.93 | |
| 424_I | 464_A | 1.011 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4mgrA | 4 | 0.9638 | 100 | 0.32 | Contact Map | 0.807 |
| 3pplA | 2 | 0.8319 | 100 | 0.421 | Contact Map | 0.582 |
| 3f6tA | 2 | 0.934 | 100 | 0.424 | Contact Map | 0.461 |
| 4je5A | 3 | 0.8574 | 100 | 0.443 | Contact Map | 0.773 |
| 3qguA | 2 | 0.8851 | 100 | 0.449 | Contact Map | 0.628 |
| 3ez1A | 2 | 0.8149 | 100 | 0.459 | Contact Map | 0.624 |
| 2x5fA | 2 | 0.8532 | 100 | 0.463 | Contact Map | 0.593 |
| 2r2nA | 4 | 0.8362 | 100 | 0.466 | Contact Map | 0.781 |
| 1vp4A | 2 | 0.8681 | 100 | 0.468 | Contact Map | 0.833 |
| 3aowA | 2 | 0.9255 | 100 | 0.473 | Contact Map | 0.883 |
Sequence Conservation (Image Generated using WebLogo v3)