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YCJW - Uncharacterized HTH-type transcriptional regulator YcjW
UniProt: P77615 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13920
Length: 332 (326)
Sequences: 13844
Seq/Len: 42.47
YCJW
Paralog alert: 0.91 [within 20: 0.50] - ratio of genomes with paralogs
Cluster includes: ALSB ARAF ASCG CRA CYTR DGAL EBGR GALR GALS GNTR IDNR LACI LSRB MALI PURR RBSB RBSR TORT TRER XYLF YCJW YPHF YTFQ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
183_H 246_E 3.737 1.00
168_F 207_Q 3.674 1.00
269_A 272_Q 3.488 1.00
11_V 43_E 3.461 1.00
174_L 277_V 3.16 1.00
281_N 296_D 2.879 1.00
183_H 275_A 2.742 1.00
39_R 43_E 2.65 1.00
263_A 274_L 2.592 1.00
202_V 206_K 2.521 1.00
86_A 303_G 2.512 1.00
31_P 35_E 2.495 1.00
124_G 310_L 2.478 1.00
35_E 39_R 2.447 1.00
172_I 211_A 2.418 1.00
176_D 180_E 2.265 1.00
90_K 308_E 2.248 1.00
161_Y 313_L 2.218 1.00
305_Q 308_E 2.211 1.00
171_S 175_T 2.154 1.00
34_R 38_L 2.138 1.00
22_V 37_V 2.138 1.00
90_K 93_E 2.127 1.00
232_L 265_E 2.117 1.00
172_I 207_Q 2.099 1.00
170_D 279_Y 2.056 1.00
240_S 266_K 2.026 1.00
235_A 248_V 2.005 1.00
179_I 212_H 1.978 1.00
23_L 41_I 1.963 1.00
91_A 307_C 1.943 1.00
169_G 173_A 1.933 1.00
171_S 249_F 1.886 1.00
231_A 258_S 1.886 1.00
269_A 273_Q 1.88 1.00
172_I 208_S 1.876 1.00
177_A 181_S 1.858 1.00
176_D 208_S 1.85 1.00
89_A 300_Q 1.82 1.00
176_D 212_H 1.799 1.00
172_I 176_D 1.794 1.00
268_I 273_Q 1.789 1.00
6_Y 16_K 1.765 1.00
236_R 266_K 1.765 1.00
8_I 40_A 1.76 1.00
168_F 203_N 1.715 1.00
90_K 304_Q 1.709 1.00
12_A 40_A 1.708 1.00
175_T 179_I 1.703 1.00
312_R 317_K 1.691 1.00
175_T 205_Y 1.688 1.00
235_A 259_I 1.664 1.00
236_R 262_A 1.653 1.00
232_L 262_A 1.641 1.00
8_I 12_A 1.636 1.00
22_V 41_I 1.628 1.00
63_I 91_A 1.606 1.00
298_P 301_E 1.606 1.00
38_L 42_E 1.6 1.00
301_E 304_Q 1.59 1.00
150_I 306_S 1.59 1.00
189_L 259_I 1.574 1.00
38_L 41_I 1.573 1.00
86_A 300_Q 1.563 1.00
178_L 247_A 1.552 1.00
203_N 207_Q 1.543 1.00
179_I 208_S 1.542 1.00
90_K 307_C 1.538 1.00
204_G 208_S 1.533 1.00
166_D 169_G 1.523 1.00
277_V 293_G 1.474 1.00
308_E 312_R 1.467 1.00
176_D 211_A 1.463 1.00
301_E 305_Q 1.449 1.00
250_A 259_I 1.447 1.00
169_G 172_I 1.444 1.00
264_A 289_T 1.429 1.00
263_A 268_I 1.429 1.00
236_R 265_E 1.428 1.00
183_H 247_A 1.426 1.00
49_N 52_A 1.423 1.00
94_E 311_F 1.421 1.00
40_A 44_L 1.418 1.00
262_A 266_K 1.417 1.00
171_S 204_G 1.413 1.00
11_V 40_A 1.412 1.00
187_A 245_P 1.409 1.00
65_V 87_I 1.409 1.00
188_C 251_T 1.407 0.99
175_T 208_S 1.406 0.99
217_R 220_W 1.392 0.99
262_A 265_E 1.387 0.99
87_I 126_I 1.376 0.99
185_N 244_L 1.363 0.99
64_M 122_I 1.362 0.99
30_S 33_A 1.36 0.99
175_T 204_G 1.357 0.99
253_S 256_L 1.346 0.99
61_D 96_F 1.346 0.99
260_Y 276_V 1.343 0.99
177_A 180_E 1.341 0.99
7_D 10_R 1.333 0.99
235_A 263_A 1.331 0.99
91_A 98_V 1.328 0.99
5_I 19_V 1.326 0.99
90_K 94_E 1.319 0.99
200_D 203_N 1.316 0.99
253_S 294_G 1.29 0.99
8_I 44_L 1.277 0.99
11_V 44_L 1.273 0.99
179_I 214_I 1.257 0.99
49_N 55_L 1.256 0.99
187_A 238_L 1.255 0.99
260_Y 270_I 1.235 0.98
278_G 294_G 1.235 0.98
186_I 209_L 1.234 0.98
101_Q 117_I 1.232 0.98
61_D 123_K 1.217 0.98
6_Y 10_R 1.216 0.98
248_V 259_I 1.213 0.98
258_S 262_A 1.205 0.98
205_Y 209_L 1.202 0.98
206_K 210_A 1.192 0.98
5_I 16_K 1.192 0.98
242_S 245_P 1.186 0.98
31_P 34_R 1.183 0.98
138_A 142_K 1.183 0.98
52_A 55_L 1.181 0.98
65_V 98_V 1.178 0.98
33_A 36_K 1.168 0.97
281_N 285_S 1.164 0.97
87_I 307_C 1.16 0.97
303_G 307_C 1.158 0.97
40_A 43_E 1.155 0.97
64_M 117_I 1.15 0.97
39_R 42_E 1.148 0.97
174_L 249_F 1.146 0.97
181_S 275_A 1.145 0.97
229_E 233_K 1.133 0.97
209_L 214_I 1.133 0.97
232_L 261_R 1.122 0.97
186_I 247_A 1.122 0.97
225_G 230_T 1.121 0.97
174_L 295_I 1.119 0.96
208_S 211_A 1.116 0.96
253_S 278_G 1.11 0.96
21_R 26_Q 1.109 0.96
298_P 325_V 1.109 0.96
185_N 246_E 1.108 0.96
177_A 293_G 1.106 0.96
25_K 34_R 1.102 0.96
126_I 306_S 1.1 0.96
36_K 40_A 1.097 0.96
296_D 328_H 1.097 0.96
173_A 176_D 1.097 0.96
168_F 200_D 1.095 0.96
233_K 237_Q 1.089 0.96
168_F 204_G 1.087 0.96
88_T 92_E 1.087 0.96
185_N 217_R 1.087 0.96
101_Q 113_C 1.077 0.95
250_A 256_L 1.073 0.95
222_V 237_Q 1.072 0.95
22_V 29_I 1.067 0.95
235_A 239_L 1.064 0.95
207_Q 211_A 1.058 0.95
232_L 236_R 1.052 0.95
35_E 38_L 1.051 0.94
51_L 54_A 1.051 0.94
89_A 304_Q 1.05 0.94
18_T 21_R 1.049 0.94
41_I 44_L 1.042 0.94
188_C 202_V 1.041 0.94
168_F 172_I 1.041 0.94
180_E 212_H 1.037 0.94
231_A 235_A 1.027 0.94
173_A 327_T 1.026 0.94
94_E 308_E 1.023 0.93
165_T 297_V 1.022 0.93
311_F 315_S 1.022 0.93
3_P 44_L 1.016 0.93
12_A 19_V 1.015 0.93
305_Q 309_L 1.011 0.93
260_Y 288_L 1.007 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2hsgA10.98191000.031Contact Map0.777
3dbiA30.9881000.035Contact Map0.748
2o20A80.97591000.049Contact Map0.85
1qpzA10.97591000.05Contact Map0.769
3kjxA40.98191000.056Contact Map0.794
3bilA20.97291000.06Contact Map0.674
3e3mA40.98191000.061Contact Map0.804
3h5oA20.97591000.068Contact Map0.773
3h5tA10.98491000.072Contact Map0.735
3ctpA20.96081000.072Contact Map0.724
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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