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CYTR - HTH-type transcriptional repressor CytR
UniProt: P0ACN7 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10200
Length: 341 (331)
Sequences: 13265
Seq/Len: 40.08
CYTR
Paralog alert: 0.91 [within 20: 0.49] - ratio of genomes with paralogs
Cluster includes: ALSB ARAF ASCG CRA CYTR DGAL EBGR GALR GALS GNTR IDNR LACI LSRB MALI PURR RBSB RBSR TORT TRER XYLF YCJW YPHF YTFQ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
169_L 208_Q 3.604 1.00
184_H 247_T 3.548 1.00
270_K 273_E 3.494 1.00
18_K 50_E 3.435 1.00
175_A 278_I 3.127 1.00
282_N 297_A 2.775 1.00
46_K 50_E 2.634 1.00
184_H 276_S 2.62 1.00
264_A 275_L 2.528 1.00
203_L 207_V 2.495 1.00
38_Q 42_N 2.489 1.00
42_N 46_K 2.446 1.00
173_F 212_R 2.412 1.00
126_G 311_L 2.382 1.00
88_G 304_G 2.38 1.00
177_N 181_E 2.279 1.00
162_P 314_Q 2.251 1.00
92_T 309_L 2.19 1.00
306_E 309_L 2.177 1.00
172_A 176_V 2.13 1.00
41_R 45_E 2.123 1.00
29_A 44_V 2.118 1.00
92_T 95_N 2.1 1.00
173_F 208_Q 2.064 1.00
233_S 266_R 2.06 1.00
241_D 267_Q 1.995 1.00
171_A 280_F 1.968 1.00
180_Y 213_C 1.939 1.00
93_A 308_M 1.905 1.00
30_L 48_A 1.898 1.00
236_M 249_V 1.892 1.00
170_T 174_D 1.885 1.00
270_K 274_D 1.881 1.00
172_A 250_F 1.878 1.00
182_Q 337_T 1.861 1.00
232_G 259_G 1.825 1.00
269_L 274_D 1.821 1.00
173_F 209_A 1.811 1.00
297_A 330_E 1.811 1.00
177_N 213_C 1.8 1.00
177_N 209_A 1.799 1.00
91_V 301_Y 1.785 1.00
173_F 177_N 1.772 1.00
13_K 23_T 1.772 1.00
237_Q 267_Q 1.766 1.00
15_V 47_A 1.747 1.00
176_V 206_Y 1.743 1.00
299_P 302_E 1.686 1.00
233_S 263_Q 1.676 1.00
176_V 180_Y 1.67 1.00
236_M 260_A 1.657 1.00
19_A 47_A 1.647 1.00
169_L 204_Q 1.641 1.00
92_T 305_R 1.638 1.00
292_P 335_G 1.627 1.00
237_Q 263_Q 1.612 1.00
70_I 93_A 1.611 1.00
45_E 49_R 1.61 1.00
178_Y 337_T 1.598 1.00
29_A 48_A 1.586 1.00
15_V 19_A 1.577 1.00
92_T 308_M 1.576 1.00
278_I 294_T 1.553 1.00
45_E 48_A 1.544 1.00
265_K 290_D 1.536 1.00
88_G 301_Y 1.531 1.00
167_D 170_T 1.529 1.00
282_N 334_R 1.521 1.00
205_G 209_A 1.517 1.00
313_D 318_Q 1.516 1.00
190_I 260_A 1.514 1.00
180_Y 209_A 1.507 1.00
204_Q 208_Q 1.493 1.00
179_L 248_A 1.491 1.00
302_E 305_R 1.488 1.00
177_N 212_R 1.485 1.00
251_C 260_A 1.475 1.00
174_D 329_C 1.465 1.00
178_Y 182_Q 1.435 1.00
189_C 252_H 1.432 1.00
18_K 47_A 1.417 1.00
184_H 248_A 1.416 1.00
302_E 306_E 1.416 1.00
264_A 269_L 1.413 1.00
309_L 313_D 1.411 1.00
188_G 246_P 1.407 0.99
263_Q 267_Q 1.406 0.99
89_I 128_L 1.403 0.99
218_D 221_Y 1.403 0.99
170_T 173_F 1.402 0.99
263_Q 266_R 1.398 0.99
71_L 124_I 1.396 0.99
72_V 89_I 1.393 0.99
172_A 205_G 1.389 0.99
176_V 205_G 1.376 0.99
261_L 277_I 1.374 0.99
176_V 209_A 1.373 0.99
47_A 51_V 1.365 0.99
96_H 312_L 1.355 0.99
56_Q 59_G 1.347 0.99
37_S 40_T 1.345 0.99
186_R 245_P 1.33 0.99
237_Q 266_R 1.33 0.99
254_D 295_T 1.318 0.99
68_R 98_Y 1.313 0.99
14_D 17_L 1.3 0.99
92_T 96_H 1.29 0.99
18_K 51_V 1.29 0.99
236_M 264_A 1.29 0.99
12_M 26_V 1.274 0.99
93_A 100_V 1.271 0.99
201_Y 204_Q 1.269 0.99
15_V 51_V 1.265 0.99
178_Y 333_I 1.264 0.99
171_A 329_C 1.256 0.99
180_Y 215_I 1.248 0.99
261_L 271_V 1.243 0.98
178_Y 181_E 1.239 0.98
188_G 239_L 1.23 0.98
56_Q 62_V 1.228 0.98
68_R 125_D 1.227 0.98
299_P 327_M 1.221 0.98
249_V 260_A 1.221 0.98
187_I 210_L 1.218 0.98
103_G 119_I 1.211 0.98
243_P 246_P 1.196 0.98
72_V 100_V 1.195 0.98
276_S 337_T 1.189 0.98
223_A 238_Q 1.185 0.98
13_K 17_L 1.183 0.98
254_D 279_G 1.18 0.98
206_Y 210_L 1.178 0.98
304_G 308_M 1.172 0.98
12_M 23_T 1.169 0.97
40_T 43_R 1.16 0.97
71_L 119_I 1.155 0.97
47_A 50_E 1.154 0.97
38_Q 41_R 1.152 0.97
207_V 211_R 1.149 0.97
182_Q 333_I 1.143 0.97
59_G 62_V 1.137 0.97
279_G 295_T 1.134 0.97
234_K 238_Q 1.132 0.97
149_M 152_A 1.131 0.97
46_K 49_R 1.125 0.97
230_E 234_K 1.118 0.96
259_G 263_Q 1.116 0.96
175_A 250_F 1.112 0.96
187_I 248_A 1.112 0.96
43_R 47_A 1.103 0.96
210_L 215_I 1.103 0.96
251_C 257_A 1.102 0.96
32_N 41_R 1.1 0.96
181_E 213_C 1.098 0.96
282_N 286_T 1.096 0.96
28_R 33_P 1.095 0.96
42_N 45_E 1.093 0.96
226_D 231_A 1.091 0.96
89_I 308_M 1.078 0.95
209_A 212_R 1.078 0.95
29_A 36_V 1.077 0.95
103_G 115_F 1.075 0.95
182_Q 276_S 1.069 0.95
169_L 201_Y 1.058 0.95
175_A 296_I 1.056 0.95
72_V 86_I 1.054 0.95
128_L 307_A 1.053 0.95
67_S 125_D 1.051 0.94
10_A 51_V 1.048 0.94
174_D 177_N 1.045 0.94
169_L 205_G 1.044 0.94
186_R 247_T 1.04 0.94
58_M 61_N 1.029 0.94
186_R 218_D 1.027 0.94
233_S 262_S 1.025 0.93
19_A 26_V 1.022 0.93
236_M 240_L 1.021 0.93
25_T 28_R 1.014 0.93
208_Q 212_R 1.01 0.93
91_V 305_R 1.01 0.93
306_E 325_R 1.01 0.93
254_D 257_A 1.01 0.93
189_C 203_L 1.009 0.93
185_K 247_T 1.008 0.93
261_L 289_C 1.003 0.93
96_H 309_L 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3dbiA30.97361000.078Contact Map0.758
1qpzA10.96771000.086Contact Map0.776
2o20A80.96771000.088Contact Map0.846
3bilA20.97951000.089Contact Map0.674
2hsgA10.96481000.092Contact Map0.774
3kjxA40.99411000.094Contact Map0.794
3e3mA40.99411000.097Contact Map0.824
3h5oA20.97361000.1Contact Map0.795
3ctpA20.95891000.105Contact Map0.746
3jvdA20.9561000.107Contact Map0.685
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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