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OPENSEQ.org
IDNR - HTH-type transcriptional regulator IdnR
UniProt: P39343 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12538
Length: 332 (325)
Sequences: 13777
Seq/Len: 42.39
IDNR
Paralog alert: 0.91 [within 20: 0.50] - ratio of genomes with paralogs
Cluster includes: ALSB ARAF ASCG CRA CYTR DGAL EBGR GALR GALS GNTR IDNR LACI LSRB MALI PURR RBSB RBSR TORT TRER XYLF YCJW YPHF YTFQ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
165_R 204_D 3.751 1.00
180_V 242_D 3.69 1.00
265_A 268_E 3.555 1.00
14_L 46_E 3.453 1.00
171_M 273_A 3.223 1.00
277_G 292_I 2.946 1.00
180_V 271_S 2.716 1.00
42_K 46_E 2.675 1.00
199_Y 203_C 2.637 1.00
34_K 38_E 2.572 1.00
259_C 270_I 2.556 1.00
38_E 42_K 2.508 1.00
122_G 306_L 2.486 1.00
169_F 208_L 2.458 1.00
84_G 299_G 2.438 1.00
173_C 177_E 2.323 1.00
88_V 304_Q 2.286 1.00
168_A 172_V 2.274 1.00
301_M 304_Q 2.268 1.00
169_F 204_D 2.166 1.00
88_V 91_E 2.162 1.00
25_Y 40_I 2.154 1.00
37_G 41_A 2.148 1.00
167_A 275_F 2.137 1.00
228_M 261_E 2.127 1.00
26_I 44_M 2.021 1.00
236_S 262_R 2.003 1.00
176_L 209_H 1.998 1.00
166_Q 170_D 1.992 1.00
89_T 303_A 1.969 1.00
231_M 244_V 1.929 1.00
173_C 205_A 1.92 1.00
168_A 245_F 1.915 1.00
169_F 205_A 1.887 1.00
265_A 269_Q 1.879 1.00
227_G 254_G 1.869 1.00
173_C 209_H 1.864 1.00
87_S 296_F 1.83 1.00
174_T 178_K 1.82 1.00
9_Q 19_K 1.817 1.00
169_F 173_C 1.814 1.00
264_L 269_Q 1.814 1.00
232_R 262_R 1.809 1.00
172_V 202_Y 1.784 1.00
11_I 43_I 1.757 1.00
165_R 200_Q 1.752 1.00
172_V 176_L 1.721 1.00
88_V 300_R 1.708 1.00
228_M 258_L 1.704 1.00
15_A 43_I 1.701 1.00
231_M 255_A 1.679 1.00
232_R 258_L 1.676 1.00
294_P 297_D 1.664 1.00
308_S 313_N 1.656 1.00
175_M 243_G 1.655 1.00
41_A 45_E 1.641 1.00
66_L 89_T 1.633 1.00
25_Y 44_M 1.629 1.00
41_A 44_M 1.628 1.00
163_D 166_Q 1.624 1.00
11_I 15_A 1.611 1.00
88_V 303_A 1.598 1.00
84_G 296_F 1.563 1.00
201_G 205_A 1.562 1.00
200_Q 204_D 1.562 1.00
176_L 205_A 1.549 1.00
297_D 300_R 1.544 1.00
187_L 255_A 1.541 1.00
273_A 289_A 1.526 1.00
246_C 255_A 1.516 1.00
186_Y 247_T 1.509 1.00
166_Q 169_F 1.508 1.00
185_L 241_L 1.49 1.00
68_I 85_I 1.483 1.00
14_L 43_I 1.479 1.00
180_V 243_G 1.473 1.00
258_L 262_R 1.47 1.00
297_D 301_M 1.469 1.00
260_R 285_I 1.467 1.00
168_A 201_G 1.46 1.00
304_Q 308_S 1.458 1.00
173_C 208_L 1.456 1.00
67_G 120_I 1.451 1.00
259_C 264_L 1.445 1.00
256_L 272_I 1.444 1.00
92_H 307_L 1.44 1.00
43_I 47_I 1.439 1.00
258_L 261_E 1.437 1.00
172_V 201_G 1.418 1.00
249_D 290_S 1.415 1.00
64_Y 94_Y 1.403 0.99
232_R 261_E 1.401 0.99
172_V 205_A 1.399 0.99
33_A 36_T 1.387 0.99
182_H 240_D 1.381 0.99
88_V 92_H 1.379 0.99
85_I 124_I 1.377 0.99
52_N 55_P 1.362 0.99
8_L 22_V 1.348 0.99
231_M 259_C 1.347 0.99
10_D 13_T 1.343 0.99
197_Q 200_Q 1.331 0.99
174_T 177_E 1.327 0.99
89_T 96_T 1.317 0.99
14_L 47_I 1.293 0.99
11_I 47_I 1.287 0.99
176_L 211_L 1.274 0.99
64_Y 121_D 1.268 0.99
274_G 290_S 1.262 0.99
254_G 258_L 1.258 0.99
52_N 58_L 1.256 0.99
36_T 39_R 1.252 0.99
68_I 96_T 1.238 0.98
55_P 58_L 1.236 0.98
9_Q 13_T 1.234 0.98
256_L 266_V 1.232 0.98
184_I 206_M 1.224 0.98
8_L 19_K 1.221 0.98
244_V 255_A 1.218 0.98
202_Y 206_M 1.216 0.98
225_H 229_Q 1.214 0.98
246_C 252_A 1.203 0.98
34_K 37_G 1.199 0.98
203_C 207_M 1.197 0.98
185_L 234_A 1.193 0.98
136_K 140_S 1.187 0.98
43_I 46_E 1.185 0.98
99_A 115_L 1.179 0.98
249_D 274_G 1.179 0.98
206_M 211_L 1.177 0.98
85_I 303_A 1.175 0.98
28_S 37_G 1.175 0.98
42_K 45_E 1.175 0.98
67_G 115_L 1.168 0.97
178_K 271_S 1.165 0.97
24_R 29_P 1.16 0.97
299_G 303_A 1.159 0.97
205_A 208_L 1.156 0.97
238_N 241_L 1.15 0.97
124_I 302_A 1.148 0.97
39_R 43_I 1.144 0.97
171_M 291_V 1.139 0.97
170_D 173_C 1.138 0.97
228_M 257_L 1.123 0.97
277_G 281_G 1.121 0.97
165_R 197_Q 1.118 0.96
229_Q 233_D 1.118 0.96
54_A 57_M 1.118 0.96
165_R 201_G 1.116 0.96
171_M 245_F 1.11 0.96
182_H 242_D 1.109 0.96
25_Y 32_V 1.107 0.96
38_E 41_A 1.101 0.96
21_T 24_R 1.093 0.96
174_T 289_A 1.088 0.96
86_E 90_S 1.087 0.96
177_E 209_H 1.085 0.96
6_I 47_I 1.078 0.95
44_M 47_I 1.069 0.95
165_R 169_F 1.069 0.95
184_I 243_G 1.068 0.95
99_A 111_S 1.067 0.95
15_A 22_V 1.066 0.95
162_F 293_T 1.06 0.95
231_M 235_L 1.059 0.95
249_D 252_A 1.052 0.95
68_I 82_L 1.052 0.95
162_F 294_P 1.052 0.95
92_H 304_Q 1.041 0.94
221_I 226_L 1.04 0.94
204_D 208_L 1.04 0.94
200_Q 203_C 1.038 0.94
301_M 305_M 1.036 0.94
87_S 300_R 1.031 0.94
256_L 284_M 1.03 0.94
63_S 121_D 1.028 0.94
246_C 251_I 1.024 0.93
148_L 302_A 1.021 0.93
186_Y 199_Y 1.013 0.93
228_M 232_R 1.01 0.93
259_C 272_I 1.006 0.93
296_F 300_R 1.004 0.93
306_L 310_I 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2o20A80.98491000.045Contact Map0.853
3dbiA30.98491000.056Contact Map0.765
3kjxA40.9971000.057Contact Map0.809
3h5oA20.9881000.06Contact Map0.785
2hsgA10.98191000.063Contact Map0.767
3bilA20.98491000.063Contact Map0.68
3e3mA40.9971000.065Contact Map0.818
1qpzA10.97891000.068Contact Map0.763
3jvdA20.96081000.075Contact Map0.693
3ctpA20.96691000.077Contact Map0.731
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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