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OPENSEQ.org
GNTR - HTH-type transcriptional regulator GntR
UniProt: P0ACP5 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12630
Length: 331 (327)
Sequences: 13699
Seq/Len: 41.89
GNTR
Paralog alert: 0.91 [within 20: 0.50] - ratio of genomes with paralogs
Cluster includes: ALSB ARAF ASCG CRA CYTR DGAL EBGR GALR GALS GNTR IDNR LACI LSRB MALI PURR RBSB RBSR TORT TRER XYLF YCJW YPHF YTFQ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
180_H 241_D 3.754 1.00
165_F 203_Q 3.723 1.00
264_K 267_D 3.568 1.00
14_R 46_E 3.491 1.00
171_M 272_A 3.237 1.00
276_G 291_L 2.943 1.00
180_H 270_A 2.741 1.00
42_A 46_E 2.69 1.00
258_C 269_M 2.59 1.00
34_V 38_G 2.559 1.00
122_G 305_L 2.531 1.00
84_G 298_G 2.49 1.00
38_G 42_A 2.482 1.00
169_R 207_D 2.449 1.00
173_T 177_A 2.308 1.00
168_A 172_T 2.288 1.00
300_I 303_E 2.279 1.00
88_V 303_E 2.278 1.00
25_F 40_I 2.193 1.00
88_V 91_A 2.173 1.00
167_A 274_F 2.155 1.00
37_R 41_A 2.141 1.00
169_R 203_Q 2.136 1.00
227_I 260_R 2.12 1.00
26_L 44_L 2.005 1.00
235_R 261_L 1.991 1.00
176_I 208_A 1.968 1.00
89_T 302_A 1.966 1.00
230_I 243_V 1.959 1.00
166_E 170_Q 1.947 1.00
168_A 244_F 1.938 1.00
169_R 204_A 1.909 1.00
173_T 204_A 1.909 1.00
264_K 268_D 1.903 1.00
173_T 208_A 1.871 1.00
87_S 295_E 1.866 1.00
226_G 253_G 1.864 1.00
263_L 268_D 1.855 1.00
169_R 173_T 1.836 1.00
9_Q 19_K 1.81 1.00
172_T 201_Y 1.797 1.00
174_A 178_R 1.794 1.00
11_V 43_A 1.771 1.00
231_R 261_L 1.749 1.00
172_T 176_I 1.738 1.00
15_V 43_A 1.719 1.00
227_I 257_E 1.715 1.00
165_F 199_K 1.681 1.00
230_I 254_A 1.679 1.00
293_P 296_R 1.676 1.00
88_V 299_S 1.67 1.00
307_A 312_E 1.665 1.00
231_R 257_E 1.659 1.00
11_V 15_V 1.647 1.00
25_F 44_L 1.64 1.00
41_A 45_D 1.637 1.00
66_I 89_T 1.624 1.00
186_L 254_A 1.609 1.00
88_V 302_A 1.609 1.00
175_I 242_G 1.602 1.00
200_G 204_A 1.6 1.00
41_A 44_L 1.582 1.00
272_A 288_A 1.572 1.00
163_D 166_E 1.566 1.00
84_G 295_E 1.561 1.00
185_Y 246_T 1.558 1.00
296_R 299_S 1.552 1.00
199_K 203_Q 1.536 1.00
184_A 240_L 1.536 1.00
176_I 204_A 1.527 1.00
180_H 242_G 1.501 1.00
259_Q 284_E 1.485 1.00
173_T 207_D 1.484 1.00
168_A 200_G 1.479 1.00
303_E 307_A 1.479 1.00
245_C 254_A 1.476 1.00
67_G 120_I 1.476 1.00
148_L 301_G 1.476 1.00
166_E 169_R 1.467 1.00
68_V 85_I 1.465 1.00
172_T 200_G 1.464 1.00
14_R 43_A 1.464 1.00
296_R 300_I 1.455 1.00
158_I 308_R 1.453 1.00
257_E 261_L 1.438 1.00
52_N 55_P 1.438 1.00
258_C 263_L 1.437 1.00
43_A 47_L 1.435 1.00
248_D 289_S 1.435 1.00
231_R 260_R 1.427 1.00
92_H 306_L 1.424 1.00
182_H 239_Q 1.418 1.00
33_S 36_L 1.414 1.00
172_T 204_A 1.414 1.00
257_E 260_R 1.406 0.99
64_R 94_Y 1.392 0.99
255_A 271_I 1.388 0.99
85_I 124_I 1.387 0.99
88_V 92_H 1.364 0.99
89_T 96_T 1.363 0.99
8_L 22_V 1.359 0.99
230_I 258_C 1.351 0.99
11_V 47_L 1.35 0.99
10_D 13_D 1.345 0.99
174_A 177_A 1.342 0.99
176_I 210_L 1.311 0.99
14_R 47_L 1.297 0.99
253_G 257_E 1.27 0.99
183_I 205_M 1.269 0.99
273_G 289_S 1.259 0.99
52_N 58_L 1.257 0.99
184_A 233_A 1.25 0.99
36_L 39_K 1.25 0.99
205_M 210_L 1.245 0.98
34_V 37_R 1.244 0.98
255_A 265_V 1.231 0.98
68_V 96_T 1.23 0.98
201_Y 205_M 1.227 0.98
64_R 121_D 1.227 0.98
202_E 206_L 1.226 0.98
9_Q 13_D 1.223 0.98
243_V 254_A 1.219 0.98
99_A 115_M 1.218 0.98
43_A 46_E 1.209 0.98
8_L 19_K 1.205 0.98
224_S 228_E 1.203 0.98
67_G 115_M 1.194 0.98
248_D 273_G 1.193 0.98
178_R 270_A 1.192 0.98
298_G 302_A 1.188 0.98
245_C 251_A 1.188 0.98
237_Y 240_L 1.185 0.98
28_N 37_R 1.184 0.98
136_K 140_V 1.183 0.98
55_P 58_L 1.178 0.98
85_I 302_A 1.167 0.97
171_M 244_F 1.153 0.97
42_A 45_D 1.153 0.97
24_R 29_P 1.151 0.97
228_E 232_Q 1.146 0.97
39_K 43_A 1.143 0.97
276_G 280_G 1.141 0.97
204_A 207_D 1.139 0.97
182_H 241_D 1.137 0.97
220_S 225_S 1.134 0.97
170_Q 173_T 1.127 0.97
38_G 41_A 1.12 0.96
165_F 200_G 1.119 0.96
99_A 111_R 1.119 0.96
124_I 301_G 1.103 0.96
21_T 24_R 1.102 0.96
171_M 290_V 1.101 0.96
291_L 324_T 1.1 0.96
183_I 242_G 1.096 0.96
177_A 208_A 1.093 0.96
54_A 57_I 1.092 0.96
227_I 256_F 1.088 0.96
174_A 288_A 1.086 0.96
203_Q 207_D 1.086 0.96
68_V 82_L 1.08 0.95
25_F 32_V 1.079 0.95
162_F 293_P 1.077 0.95
248_D 251_A 1.076 0.95
86_E 90_D 1.065 0.95
162_F 292_T 1.062 0.95
165_F 169_R 1.058 0.95
44_L 47_L 1.057 0.95
293_P 321_L 1.05 0.94
87_S 299_S 1.046 0.94
230_I 234_R 1.043 0.94
63_S 121_D 1.036 0.94
92_H 303_E 1.029 0.94
15_V 22_V 1.028 0.94
300_I 304_R 1.025 0.93
170_Q 323_F 1.025 0.93
183_I 201_Y 1.019 0.93
255_A 283_M 1.018 0.93
226_G 230_I 1.014 0.93
199_K 202_E 1.013 0.93
245_C 250_L 1.008 0.93
51_P 56_D 1.007 0.93
305_L 309_I 1.005 0.93
181_R 241_D 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2o20A80.9941000.039Contact Map0.857
3dbiA30.99091000.049Contact Map0.755
2hsgA10.99091000.053Contact Map0.77
3bilA20.99091000.055Contact Map0.668
3e3mA411000.06Contact Map0.811
3kjxA411000.061Contact Map0.796
1qpzA10.98491000.061Contact Map0.767
3h5oA20.99091000.062Contact Map0.785
3jvdA20.96981000.068Contact Map0.687
3ctpA20.97281000.074Contact Map0.737
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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