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GALR - HTH-type transcriptional regulator GalR
UniProt: P03024 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10364
Length: 343 (332)
Sequences: 13571
Seq/Len: 40.88
GALR
Paralog alert: 0.91 [within 20: 0.49] - ratio of genomes with paralogs
Cluster includes: ALSB ARAF ASCG CRA CYTR DGAL EBGR GALR GALS GNTR IDNR LACI LSRB MALI PURR RBSB RBSR TORT TRER XYLF YCJW YPHF YTFQ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
161_R 200_D 3.61 1.00
176_H 239_T 3.579 1.00
10_L 42_S 3.405 1.00
262_D 265_G 3.405 1.00
167_A 270_I 3.098 1.00
274_D 289_R 2.768 1.00
38_S 42_S 2.621 1.00
176_H 268_S 2.586 1.00
256_L 267_I 2.499 1.00
30_E 34_L 2.482 1.00
118_A 303_A 2.48 1.00
195_L 199_Y 2.468 1.00
34_L 38_S 2.444 1.00
80_A 296_A 2.416 1.00
165_W 204_E 2.352 1.00
169_R 173_Q 2.298 1.00
84_V 301_E 2.256 1.00
154_R 306_L 2.225 1.00
298_Q 301_E 2.19 1.00
164_A 168_T 2.148 1.00
21_V 36_V 2.114 1.00
84_V 87_H 2.108 1.00
165_W 200_D 2.102 1.00
33_R 37_H 2.073 1.00
225_E 258_D 2.062 1.00
163_G 272_F 2.027 1.00
233_G 259_N 2.021 1.00
172_I 205_S 1.969 1.00
22_I 40_M 1.92 1.00
85_A 300_A 1.91 1.00
228_M 241_V 1.896 1.00
162_Y 166_L 1.889 1.00
169_R 201_A 1.862 1.00
164_A 242_A 1.853 1.00
262_D 266_E 1.843 1.00
165_W 201_A 1.833 1.00
224_G 251_G 1.821 1.00
83_Q 293_V 1.811 1.00
289_R 322_T 1.789 1.00
165_W 169_R 1.787 1.00
174_Q 329_V 1.78 1.00
261_I 266_E 1.778 1.00
229_T 259_N 1.767 1.00
169_R 205_S 1.767 1.00
5_K 15_V 1.739 1.00
7_V 39_A 1.72 1.00
168_T 198_Y 1.72 1.00
225_E 255_V 1.695 1.00
161_R 196_Q 1.694 1.00
291_P 294_T 1.687 1.00
84_V 297_T 1.686 1.00
228_M 252_A 1.669 1.00
11_A 39_A 1.663 1.00
168_T 172_I 1.661 1.00
229_T 255_V 1.627 1.00
37_H 41_E 1.596 1.00
284_R 327_H 1.594 1.00
7_V 11_A 1.586 1.00
171_L 240_A 1.585 1.00
37_H 40_M 1.568 1.00
21_V 40_M 1.567 1.00
305_A 310_R 1.564 1.00
159_D 162_Y 1.557 1.00
170_H 329_V 1.552 1.00
80_A 293_V 1.547 1.00
62_V 85_A 1.541 1.00
274_D 326_R 1.539 1.00
84_V 300_A 1.535 1.00
170_H 174_Q 1.528 1.00
144_I 299_A 1.527 1.00
197_G 201_A 1.522 1.00
182_L 252_A 1.519 1.00
196_Q 200_D 1.515 1.00
270_I 286_T 1.508 1.00
172_I 201_A 1.497 1.00
243_C 252_A 1.488 1.00
169_R 204_E 1.476 1.00
294_T 297_T 1.466 1.00
162_Y 165_W 1.457 1.00
301_E 305_A 1.445 1.00
180_G 238_F 1.441 1.00
10_L 39_A 1.439 1.00
164_A 197_G 1.434 1.00
181_Y 244_Y 1.43 1.00
257_N 282_R 1.425 1.00
294_T 298_Q 1.42 1.00
256_L 261_I 1.419 1.00
176_H 240_A 1.415 1.00
63_G 116_C 1.412 1.00
255_V 258_D 1.405 0.99
81_V 120_V 1.404 0.99
253_M 269_L 1.395 0.99
168_T 197_G 1.392 0.99
64_L 81_V 1.389 0.99
255_V 259_N 1.388 0.99
178_R 237_N 1.382 0.99
229_T 258_D 1.378 0.99
88_T 304_L 1.375 0.99
168_T 201_A 1.37 0.99
39_A 43_L 1.359 0.99
210_N 213_L 1.358 0.99
48_N 51_A 1.357 0.99
29_S 32_S 1.353 0.99
166_L 321_P 1.35 0.99
246_D 287_T 1.335 0.99
228_M 256_L 1.316 0.99
60_E 90_N 1.312 0.99
193_D 196_Q 1.31 0.99
4_I 18_V 1.3 0.99
84_V 88_T 1.296 0.99
6_D 9_R 1.293 0.99
180_G 231_L 1.288 0.99
172_I 207_I 1.281 0.99
10_L 43_L 1.271 0.99
170_H 173_Q 1.266 0.99
85_A 92_L 1.264 0.99
7_V 43_L 1.249 0.99
63_G 111_L 1.232 0.98
48_N 54_L 1.228 0.98
170_H 325_R 1.226 0.98
163_G 321_P 1.222 0.98
60_E 117_A 1.211 0.98
179_I 202_L 1.206 0.98
253_M 263_V 1.204 0.98
199_Y 203_A 1.2 0.98
241_V 252_A 1.192 0.98
5_K 9_R 1.187 0.98
95_G 111_L 1.187 0.98
291_P 319_F 1.184 0.98
251_G 255_V 1.181 0.98
64_L 92_L 1.18 0.98
30_E 33_R 1.177 0.98
198_Y 202_L 1.176 0.98
32_S 35_A 1.173 0.98
4_I 15_V 1.162 0.97
39_A 42_S 1.159 0.97
226_Q 230_E 1.155 0.97
271_G 287_T 1.153 0.97
235_G 238_F 1.147 0.97
246_D 271_G 1.147 0.97
174_Q 325_R 1.147 0.97
95_G 107_A 1.14 0.97
215_T 230_E 1.138 0.97
268_S 329_V 1.136 0.97
81_V 300_A 1.132 0.97
51_A 54_L 1.117 0.96
38_S 41_E 1.11 0.96
202_L 207_I 1.11 0.96
296_A 300_A 1.108 0.96
20_R 25_S 1.106 0.96
35_A 39_A 1.103 0.96
222_S 226_Q 1.101 0.96
167_A 242_A 1.101 0.96
179_I 240_A 1.098 0.96
34_L 37_H 1.095 0.96
24_N 33_R 1.094 0.96
243_C 249_A 1.092 0.96
178_R 239_T 1.091 0.96
120_V 299_A 1.089 0.96
166_L 169_R 1.089 0.96
201_A 204_E 1.088 0.96
21_V 28_A 1.083 0.96
167_A 288_V 1.08 0.95
174_Q 268_S 1.071 0.95
161_R 193_D 1.064 0.95
225_E 254_G 1.062 0.95
178_R 210_N 1.059 0.95
218_E 223_G 1.055 0.95
17_T 20_R 1.044 0.94
161_R 197_G 1.043 0.94
200_D 204_E 1.038 0.94
173_Q 205_S 1.038 0.94
50_N 53_A 1.037 0.94
82_E 86_Y 1.031 0.94
274_D 278_S 1.03 0.94
132_A 136_K 1.03 0.94
59_T 117_A 1.029 0.94
246_D 249_A 1.026 0.94
64_L 78_V 1.023 0.93
2_A 43_L 1.018 0.93
83_Q 297_T 1.014 0.93
298_Q 317_N 1.013 0.93
181_Y 195_L 1.012 0.93
228_M 232_L 1.011 0.93
298_Q 302_L 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2hsgA10.96211000.109Contact Map0.775
3dbiA30.97081000.109Contact Map0.759
2o20A80.95631000.113Contact Map0.849
1qpzA10.98541000.113Contact Map0.781
3e3mA40.98831000.12Contact Map0.822
3bilA20.97671000.121Contact Map0.677
3kjxA40.97081000.126Contact Map0.792
3jvdA20.95341000.129Contact Map0.684
3ctpA20.95921000.13Contact Map0.741
3h5oA20.97671000.136Contact Map0.793
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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