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OPENSEQ.org
YTFQ - ABC transporter periplasmic-binding protein YtfQ
UniProt: P39325 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12517
Length: 318 (281)
Sequences: 15372
Seq/Len: 54.70
YTFQ
Paralog alert: 0.90 [within 20: 0.53] - ratio of genomes with paralogs
Cluster includes: ALSB ARAF ASCG CRA CYTR DGAL EBGR GALR GALS GNTR IDNR LACI LSRB MALI PURR RBSB RBSR TORT TRER XYLF YCJW YPHF YTFQ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
131_I 173_E 3.662 1.00
237_K 240_K 3.307 1.00
147_G 214_C 3.048 1.00
137_I 245_G 2.913 1.00
82_A 280_L 2.767 1.00
249_G 267_E 2.652 1.00
168_K 172_A 2.59 1.00
231_I 242_I 2.417 1.00
139_D 143_K 2.381 1.00
44_V 273_A 2.306 1.00
135_K 177_N 2.255 1.00
135_K 173_E 2.235 1.00
48_E 278_D 2.229 1.00
147_G 243_L 2.202 1.00
197_K 233_E 2.186 1.00
48_E 51_K 2.181 1.00
275_P 278_D 2.148 1.00
134_G 138_G 2.085 1.00
124_T 283_Y 2.066 1.00
133_E 247_I 2.053 1.00
135_K 174_A 2.053 1.00
142_V 178_A 2.048 1.00
49_A 277_F 1.959 1.00
139_D 174_A 1.938 1.00
132_L 136_L 1.935 1.00
201_E 234_A 1.89 1.00
48_E 274_G 1.88 1.00
205_K 234_A 1.879 1.00
141_L 215_M 1.875 1.00
282_K 287_G 1.869 1.00
200_M 216_V 1.859 1.00
207_E 211_K 1.85 1.00
236_L 241_D 1.821 1.00
131_I 169_K 1.821 1.00
47_S 271_N 1.82 1.00
135_K 139_D 1.798 1.00
201_E 230_A 1.784 1.00
196_G 226_G 1.767 1.00
134_G 217_Y 1.754 1.00
138_G 171_F 1.714 1.00
138_G 142_V 1.704 1.00
197_K 230_A 1.703 1.00
139_D 178_A 1.683 1.00
237_K 241_D 1.68 1.00
140_W 144_E 1.67 1.00
267_E 299_T 1.666 1.00
132_L 135_K 1.665 1.00
169_K 173_E 1.632 1.00
27_G 80_V 1.631 1.00
200_M 227_A 1.616 1.00
142_V 174_A 1.611 1.00
151_N 212_N 1.606 1.00
110_L 276_A 1.577 1.00
129_D 132_L 1.574 1.00
153_V 213_I 1.561 1.00
48_E 277_F 1.557 1.00
245_G 264_A 1.553 1.00
218_A 227_A 1.541 1.00
155_L 227_A 1.513 1.00
170_G 174_A 1.487 1.00
28_F 45_A 1.482 1.00
278_D 282_K 1.478 1.00
26_V 49_A 1.468 1.00
27_G 75_F 1.452 1.00
230_A 234_A 1.449 1.00
201_E 233_E 1.443 1.00
139_D 177_N 1.441 1.00
44_V 271_N 1.432 1.00
249_G 303_P 1.429 1.00
154_E 219_H 1.415 1.00
136_L 298_S 1.415 1.00
98_K 102_D 1.413 1.00
52_R 281_E 1.407 0.99
230_A 233_E 1.402 0.99
232_K 259_D 1.394 0.99
134_G 170_G 1.391 0.99
140_W 143_K 1.388 0.99
200_M 231_I 1.387 0.99
151_N 182_K 1.386 0.99
49_A 56_L 1.386 0.99
24_L 54_I 1.368 0.99
138_G 170_G 1.364 0.99
231_I 236_L 1.361 0.99
166_D 169_K 1.357 0.99
281_E 285_K 1.351 0.99
59_A 75_F 1.341 0.99
138_G 174_A 1.339 0.99
172_A 176_K 1.337 0.99
190_D 195_K 1.337 0.99
228_I 244_T 1.332 0.99
153_V 203_F 1.33 0.99
144_E 306_A 1.322 0.99
48_E 52_R 1.316 0.99
24_L 81_D 1.308 0.99
232_K 261_E 1.305 0.99
194_S 198_E 1.303 0.99
226_G 230_A 1.29 0.99
140_W 302_L 1.259 0.99
151_N 214_C 1.259 0.99
221_D 265_S 1.257 0.99
133_E 298_S 1.257 0.99
207_E 212_N 1.255 0.99
46_K 50_E 1.252 0.99
174_A 177_N 1.244 0.98
197_K 229_Q 1.235 0.98
171_F 175_I 1.231 0.98
131_I 135_K 1.229 0.98
45_A 84_F 1.226 0.98
28_F 56_L 1.217 0.98
73_R 99_E 1.2 0.98
25_T 55_T 1.199 0.98
84_F 276_A 1.191 0.98
197_K 201_E 1.191 0.98
45_A 277_F 1.188 0.98
207_E 213_I 1.183 0.98
142_V 181_I 1.181 0.98
136_L 139_D 1.176 0.98
246_S 265_S 1.174 0.98
228_I 238_P 1.172 0.98
59_A 71_A 1.166 0.97
131_I 170_G 1.162 0.97
216_V 227_A 1.161 0.97
144_E 243_L 1.161 0.97
147_G 215_M 1.158 0.97
198_E 202_S 1.141 0.97
144_E 302_L 1.138 0.97
152_V 175_I 1.126 0.97
269_T 296_T 1.124 0.97
131_I 166_D 1.122 0.97
187_Q 202_S 1.119 0.96
154_E 168_K 1.117 0.96
221_D 246_S 1.107 0.96
218_A 224_V 1.105 0.96
152_V 215_M 1.088 0.96
171_F 217_Y 1.073 0.95
200_M 204_I 1.073 0.95
140_W 306_A 1.072 0.95
231_I 244_T 1.063 0.95
67_N 70_K 1.054 0.95
273_A 277_F 1.042 0.94
275_P 279_A 1.041 0.94
195_K 198_E 1.034 0.94
137_I 266_V 1.032 0.94
137_I 217_Y 1.028 0.94
192_T 195_K 1.025 0.93
140_W 264_A 1.022 0.93
52_R 278_D 1.018 0.93
143_K 178_A 1.01 0.93
261_E 304_D 1.006 0.93
150_C 214_C 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2rgyA10.89311000.245Contact Map0.752
2iksA20.91191000.254Contact Map0.713
2hsgA10.91511000.255Contact Map0.756
3huuA40.9341000.258Contact Map0.807
3c3kA20.88681000.262Contact Map0.787
4irxA20.90881000.262Contact Map0.697
3h75A10.91511000.264Contact Map0.686
3dbiA30.92771000.265Contact Map0.731
2driA10.84911000.265Contact Map0.746
3k4hA20.89311000.265Contact Map0.778
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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