May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
TRER - HTH-type transcriptional regulator TreR
UniProt: P36673 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12202
Length: 315 (311)
Sequences: 13660
Seq/Len: 43.92
TRER
Paralog alert: 0.91 [within 20: 0.50] - ratio of genomes with paralogs
Cluster includes: ALSB ARAF ASCG CRA CYTR DGAL EBGR GALR GALS GNTR IDNR LACI LSRB MALI PURR RBSB RBSR TORT TRER XYLF YCJW YPHF YTFQ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
160_E 200_A 3.672 1.00
175_H 234_T 3.595 1.00
13_L 45_Q 3.472 1.00
166_L 262_A 3.154 1.00
266_N 281_D 2.882 1.00
175_H 260_Q 2.684 1.00
41_A 45_Q 2.683 1.00
251_L 259_L 2.588 1.00
195_H 199_L 2.584 1.00
37_E 41_A 2.522 1.00
33_Q 37_E 2.496 1.00
164_K 204_A 2.462 1.00
121_G 295_L 2.452 1.00
83_T 288_G 2.394 1.00
290_Q 293_C 2.31 1.00
168_Q 172_D 2.288 1.00
87_A 293_C 2.269 1.00
153_A 298_Q 2.213 1.00
163_I 167_M 2.191 1.00
87_A 90_E 2.167 1.00
36_R 40_E 2.158 1.00
164_K 200_A 2.153 1.00
24_V 39_V 2.136 1.00
222_Y 253_E 2.107 1.00
162_A 264_V 2.044 1.00
161_G 165_I 1.977 1.00
171_Y 205_H 1.964 1.00
25_L 43_M 1.959 1.00
168_Q 201_F 1.922 1.00
88_F 292_A 1.912 1.00
225_V 236_L 1.904 1.00
164_K 201_F 1.879 1.00
163_I 237_L 1.863 1.00
221_G 246_G 1.859 1.00
86_P 285_A 1.852 1.00
169_R 173_Q 1.836 1.00
226_A 254_Q 1.831 1.00
164_K 168_Q 1.83 1.00
168_Q 205_H 1.799 1.00
167_M 198_Y 1.795 1.00
8_K 18_K 1.785 1.00
10_I 42_V 1.771 1.00
160_E 196_E 1.757 1.00
167_M 171_Y 1.733 1.00
230_T 254_Q 1.725 1.00
14_S 42_V 1.721 1.00
87_A 289_R 1.713 1.00
225_V 247_A 1.712 1.00
226_A 250_Y 1.668 1.00
222_Y 250_Y 1.662 1.00
40_E 44_N 1.645 1.00
297_A 302_R 1.64 1.00
283_G 286_E 1.63 1.00
65_V 88_F 1.615 1.00
286_E 289_R 1.606 1.00
170_L 235_A 1.605 1.00
24_V 43_M 1.605 1.00
10_I 14_S 1.578 1.00
40_E 43_M 1.568 1.00
158_D 161_G 1.565 1.00
181_L 247_A 1.562 1.00
87_A 292_A 1.553 1.00
83_T 285_A 1.537 1.00
145_L 291_A 1.537 1.00
196_E 200_A 1.534 1.00
238_C 247_A 1.534 1.00
262_A 278_V 1.526 1.00
197_A 201_F 1.495 1.00
171_Y 201_F 1.493 1.00
252_Q 274_H 1.485 1.00
180_Y 239_A 1.485 1.00
67_I 84_M 1.476 1.00
293_C 297_A 1.472 1.00
250_Y 254_Q 1.47 1.00
168_Q 204_A 1.464 1.00
161_G 164_K 1.459 1.00
91_Q 296_I 1.448 1.00
286_E 290_Q 1.447 1.00
250_Y 253_E 1.446 1.00
66_A 119_I 1.441 1.00
13_L 42_V 1.437 1.00
179_S 233_T 1.431 1.00
226_A 253_E 1.425 1.00
248_S 261_L 1.421 1.00
251_L 256_I 1.415 1.00
84_M 123_V 1.401 0.99
42_V 46_H 1.399 0.99
51_S 54_A 1.391 0.99
175_H 235_A 1.388 0.99
167_M 197_A 1.385 0.99
169_R 172_D 1.38 0.99
167_M 201_F 1.373 0.99
63_K 93_Y 1.372 0.99
32_S 35_T 1.368 0.99
163_I 197_A 1.357 0.99
193_R 196_E 1.353 0.99
241_D 279_T 1.352 0.99
225_V 251_L 1.348 0.99
87_A 91_Q 1.346 0.99
7_I 21_V 1.33 0.99
9_D 12_R 1.328 0.99
13_L 46_H 1.325 0.99
88_F 95_P 1.319 0.99
10_I 46_H 1.292 0.99
177_N 232_E 1.285 0.99
63_K 120_D 1.281 0.99
51_S 57_M 1.28 0.99
178_I 202_C 1.267 0.99
171_Y 207_L 1.245 0.98
8_K 12_R 1.242 0.98
219_K 223_E 1.24 0.98
66_A 114_L 1.234 0.98
179_S 228_V 1.224 0.98
35_T 38_R 1.218 0.98
33_Q 36_R 1.198 0.98
246_G 250_Y 1.193 0.98
236_L 247_A 1.19 0.98
199_L 203_K 1.19 0.98
198_Y 202_C 1.188 0.98
7_I 18_K 1.186 0.98
41_A 44_N 1.178 0.98
98_M 114_L 1.17 0.97
67_I 95_P 1.163 0.97
266_N 270_M 1.161 0.97
27_N 36_R 1.161 0.97
241_D 263_S 1.161 0.97
281_D 313_T 1.15 0.97
263_S 279_T 1.149 0.97
42_V 45_Q 1.147 0.97
215_G 220_Q 1.143 0.97
173_Q 260_Q 1.143 0.97
84_M 292_A 1.142 0.97
23_R 28_E 1.14 0.97
38_R 42_V 1.14 0.97
169_R 278_V 1.139 0.97
165_I 168_Q 1.137 0.97
54_A 57_M 1.136 0.97
202_C 207_L 1.131 0.97
288_G 292_A 1.13 0.97
283_G 310_I 1.129 0.97
98_M 110_H 1.123 0.97
123_V 291_A 1.118 0.96
177_N 234_T 1.115 0.96
201_F 204_A 1.114 0.96
248_S 273_L 1.112 0.96
238_C 244_A 1.109 0.96
166_L 280_V 1.107 0.96
37_E 40_E 1.106 0.96
160_E 193_R 1.106 0.96
222_Y 249_K 1.106 0.96
225_V 229_I 1.104 0.96
166_L 237_L 1.104 0.96
160_E 197_A 1.097 0.96
178_I 235_A 1.088 0.96
223_E 227_K 1.082 0.96
24_V 31_V 1.08 0.95
53_S 56_A 1.064 0.95
5_L 46_H 1.06 0.95
172_D 205_H 1.059 0.95
290_Q 294_Q 1.054 0.95
180_Y 195_H 1.05 0.94
165_I 312_A 1.05 0.94
200_A 204_A 1.049 0.94
241_D 244_A 1.046 0.94
85_L 89_Y 1.04 0.94
296_I 300_T 1.038 0.94
162_A 312_A 1.036 0.94
20_T 23_R 1.032 0.94
62_D 120_D 1.032 0.94
14_S 21_V 1.032 0.94
176_R 234_T 1.031 0.94
43_M 46_H 1.027 0.94
222_Y 226_A 1.022 0.93
91_Q 293_C 1.022 0.93
160_E 164_K 1.018 0.93
289_R 293_C 1.011 0.93
157_Y 282_P 1.004 0.93
221_G 225_V 1.003 0.93
157_Y 283_G 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3dbiA30.99371000.044Contact Map0.748
2o20A80.99681000.048Contact Map0.847
3bilA20.99681000.049Contact Map0.656
2hsgA10.99371000.064Contact Map0.775
3h5oA20.99371000.065Contact Map0.776
1jyeA10.99371000.065Contact Map0.769
3kjxA411000.067Contact Map0.793
3e3mA40.99681000.067Contact Map0.801
1qpzA10.98411000.069Contact Map0.767
3ctpA20.98411000.071Contact Map0.728
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0248 seconds.