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OPENSEQ.org
RBSR - Ribose operon repressor
UniProt: P0ACQ0 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10819
Length: 330 (330)
Sequences: 13654
Seq/Len: 41.38
RBSR
Paralog alert: 0.91 [within 20: 0.49] - ratio of genomes with paralogs
Cluster includes: ALSB ARAF ASCG CRA CYTR DGAL EBGR GALR GALS GNTR IDNR LACI LSRB MALI PURR RBSB RBSR TORT TRER XYLF YCJW YPHF YTFQ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
177_H 240_Q 3.632 1.00
162_L 201_A 3.586 1.00
263_Q 266_Q 3.447 1.00
10_L 42_E 3.401 1.00
168_A 271_I 3.103 1.00
275_D 290_H 2.786 1.00
177_H 269_A 2.693 1.00
38_A 42_E 2.622 1.00
257_L 268_I 2.51 1.00
196_L 200_R 2.495 1.00
30_E 34_A 2.466 1.00
118_G 304_L 2.434 1.00
34_A 38_A 2.431 1.00
80_G 297_G 2.424 1.00
166_D 205_R 2.368 1.00
170_Q 174_D 2.246 1.00
155_D 307_R 2.202 1.00
299_L 302_D 2.185 1.00
84_S 302_D 2.18 1.00
165_G 169_T 2.177 1.00
21_V 36_V 2.109 1.00
33_T 37_E 2.097 1.00
84_S 87_E 2.085 1.00
226_F 259_Q 2.078 1.00
166_D 201_A 2.043 1.00
164_G 273_Y 2.02 1.00
22_I 40_I 1.954 1.00
85_C 301_I 1.931 1.00
234_S 260_A 1.924 1.00
173_I 206_A 1.922 1.00
163_L 167_L 1.906 1.00
165_G 243_F 1.877 1.00
166_D 202_A 1.873 1.00
229_M 242_V 1.863 1.00
263_Q 267_D 1.846 1.00
225_G 252_G 1.845 1.00
170_Q 202_A 1.837 1.00
262_L 267_D 1.805 1.00
166_D 170_Q 1.774 1.00
290_H 323_I 1.771 1.00
170_Q 206_A 1.76 1.00
230_R 260_A 1.75 1.00
83_R 294_D 1.748 1.00
5_K 15_T 1.729 1.00
7_V 39_A 1.726 1.00
169_T 199_Y 1.719 1.00
169_T 173_I 1.696 1.00
292_P 295_E 1.691 1.00
226_F 256_A 1.676 1.00
162_L 197_E 1.674 1.00
84_S 298_E 1.669 1.00
11_A 39_A 1.657 1.00
229_M 253_V 1.643 1.00
306_H 311_P 1.626 1.00
230_R 256_A 1.619 1.00
7_V 11_A 1.607 1.00
285_P 328_G 1.598 1.00
37_E 41_K 1.595 1.00
171_Y 175_K 1.582 1.00
62_I 85_C 1.581 1.00
21_V 40_I 1.576 1.00
145_M 300_A 1.573 1.00
183_I 253_V 1.552 1.00
84_S 301_I 1.547 1.00
37_E 40_I 1.543 1.00
160_N 163_L 1.534 1.00
271_I 287_T 1.527 1.00
275_D 327_R 1.525 1.00
295_E 298_E 1.524 1.00
172_L 241_A 1.522 1.00
198_G 202_A 1.502 1.00
80_G 294_D 1.501 1.00
197_E 201_A 1.495 1.00
244_T 253_V 1.477 1.00
173_I 202_A 1.461 1.00
182_C 245_G 1.451 1.00
258_Y 283_T 1.447 1.00
170_Q 205_R 1.443 1.00
63_G 116_V 1.443 1.00
177_H 241_A 1.441 1.00
167_L 322_P 1.427 1.00
165_G 198_G 1.425 1.00
254_Y 270_V 1.42 1.00
10_L 39_A 1.42 1.00
181_A 239_P 1.418 1.00
256_A 260_A 1.413 1.00
302_D 306_H 1.412 1.00
257_L 262_L 1.409 1.00
88_R 305_I 1.408 1.00
295_E 299_L 1.402 0.99
230_R 259_Q 1.398 0.99
256_A 259_Q 1.395 0.99
64_M 81_V 1.393 0.99
163_L 166_D 1.389 0.99
169_T 198_G 1.382 0.99
39_A 43_L 1.38 0.99
247_D 288_T 1.369 0.99
179_R 238_R 1.367 0.99
169_T 202_A 1.359 0.99
211_P 214_Y 1.358 0.99
48_S 51_A 1.356 0.99
81_V 120_L 1.349 0.99
175_K 330_A 1.344 0.99
60_H 90_Y 1.339 0.99
29_S 32_I 1.323 0.99
84_S 88_R 1.304 0.99
6_D 9_R 1.302 0.99
229_M 257_L 1.295 0.99
194_L 197_E 1.294 0.99
7_V 43_L 1.292 0.99
4_M 18_V 1.291 0.99
10_L 43_L 1.28 0.99
171_Y 174_D 1.27 0.99
164_G 322_P 1.268 0.99
181_A 232_L 1.256 0.99
173_I 208_L 1.247 0.99
171_Y 326_E 1.246 0.98
85_C 92_L 1.231 0.98
254_Y 264_V 1.228 0.98
292_P 320_L 1.227 0.98
48_S 54_L 1.227 0.98
60_H 117_D 1.218 0.98
95_C 111_L 1.205 0.98
175_K 326_E 1.204 0.98
5_K 9_R 1.195 0.98
242_V 253_V 1.188 0.98
63_G 111_L 1.186 0.98
64_M 92_L 1.177 0.98
199_Y 203_M 1.177 0.98
180_I 203_M 1.176 0.98
32_I 35_K 1.176 0.98
4_M 15_T 1.174 0.98
200_R 204_K 1.171 0.98
30_E 33_T 1.165 0.97
252_G 256_A 1.162 0.97
247_D 272_G 1.159 0.97
272_G 288_T 1.143 0.97
38_A 41_K 1.143 0.97
81_V 301_I 1.143 0.97
297_G 301_I 1.142 0.97
51_A 54_L 1.14 0.97
236_P 239_P 1.134 0.97
39_A 42_E 1.133 0.97
202_A 205_R 1.129 0.97
223_N 227_D 1.129 0.97
175_K 269_A 1.127 0.97
180_I 241_A 1.125 0.97
216_V 231_Q 1.123 0.97
219_D 224_G 1.115 0.96
35_K 39_A 1.115 0.96
203_M 208_L 1.113 0.96
244_T 250_A 1.11 0.96
95_C 107_N 1.105 0.96
162_L 194_L 1.1 0.96
120_L 300_A 1.099 0.96
168_A 243_F 1.095 0.96
167_L 170_Q 1.091 0.96
34_A 37_E 1.089 0.96
226_F 255_Q 1.078 0.95
179_R 240_Q 1.076 0.95
275_D 279_A 1.069 0.95
24_K 33_T 1.068 0.95
179_R 211_P 1.063 0.95
21_V 28_V 1.063 0.95
20_H 25_D 1.054 0.95
174_D 206_A 1.052 0.95
227_D 231_Q 1.049 0.94
2_A 43_L 1.048 0.94
162_L 198_G 1.047 0.94
64_M 78_V 1.042 0.94
132_E 136_R 1.042 0.94
17_T 20_H 1.042 0.94
168_A 289_I 1.036 0.94
201_A 205_R 1.034 0.94
50_L 53_S 1.033 0.94
247_D 250_A 1.03 0.94
171_Y 330_A 1.029 0.94
59_T 117_D 1.023 0.93
226_F 230_R 1.019 0.93
40_I 43_L 1.019 0.93
11_A 18_V 1.014 0.93
229_M 233_L 1.01 0.93
82_E 86_F 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2hsgA10.9971000.018Contact Map0.774
3dbiA30.99391000.02Contact Map0.76
2o20A80.99091000.022Contact Map0.857
1qpzA10.99391000.024Contact Map0.78
3kjxA40.9971000.035Contact Map0.791
3bilA20.98481000.038Contact Map0.675
3e3mA40.9971000.038Contact Map0.823
3h5oA20.99091000.044Contact Map0.795
3ctpA20.97581000.045Contact Map0.737
3jvdA20.96061000.052Contact Map0.683
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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