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MALI - Maltose regulon regulatory protein MalI
UniProt: P18811 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10557
Length: 342 (329)
Sequences: 13015
Seq/Len: 39.56
MALI
Paralog alert: 0.90 [within 20: 0.46] - ratio of genomes with paralogs
Cluster includes: ALSB ARAF ASCG CRA CYTR DGAL EBGR GALR GALS GNTR IDNR LACI LSRB MALI PURR RBSB RBSR TORT TRER XYLF YCJW YPHF YTFQ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
182_H 245_S 3.632 1.00
167_M 206_A 3.571 1.00
15_A 47_E 3.434 1.00
173_L 285_A 3.14 1.00
268_Q 280_Q 3.087 1.00
289_D 304_S 2.871 1.00
182_H 283_S 2.82 1.00
43_A 47_E 2.662 1.00
35_T 39_E 2.512 1.00
270_G 279_E 2.511 1.00
171_Q 210_K 2.505 1.00
201_V 205_C 2.497 1.00
262_L 282_V 2.492 1.00
39_E 43_A 2.483 1.00
123_G 318_M 2.387 1.00
85_G 311_G 2.358 1.00
160_D 321_K 2.281 1.00
175_E 179_R 2.269 1.00
89_A 316_D 2.247 1.00
313_T 316_D 2.175 1.00
38_G 42_N 2.161 1.00
26_V 41_V 2.144 1.00
170_A 174_T 2.14 1.00
89_A 92_A 2.087 1.00
171_Q 206_A 2.033 1.00
169_A 287_F 1.986 1.00
231_A 264_K 1.972 1.00
27_L 45_I 1.97 1.00
178_I 211_F 1.966 1.00
168_Q 172_L 1.942 1.00
239_R 265_A 1.926 1.00
170_A 248_V 1.912 1.00
90_L 315_A 1.886 1.00
234_I 247_V 1.874 1.00
268_Q 281_Q 1.849 1.00
175_E 211_F 1.846 1.00
171_Q 207_T 1.834 1.00
175_E 207_T 1.822 1.00
171_Q 175_E 1.807 1.00
304_S 337_R 1.802 1.00
10_H 20_V 1.801 1.00
88_E 308_R 1.796 1.00
267_R 281_Q 1.789 1.00
12_V 44_A 1.772 1.00
235_T 265_A 1.761 1.00
174_T 204_Y 1.755 1.00
230_A 257_G 1.736 1.00
176_H 180_N 1.706 1.00
16_A 44_A 1.702 1.00
306_P 309_E 1.668 1.00
89_A 312_I 1.66 1.00
174_T 178_I 1.654 1.00
167_M 202_G 1.625 1.00
67_I 90_L 1.623 1.00
42_N 46_E 1.617 1.00
234_I 258_A 1.604 1.00
42_N 45_I 1.595 1.00
26_V 45_I 1.594 1.00
12_V 16_A 1.589 1.00
320_Q 325_E 1.581 1.00
235_T 261_G 1.579 1.00
231_A 261_G 1.576 1.00
89_A 315_A 1.569 1.00
263_L 297_D 1.566 1.00
289_D 341_A 1.561 1.00
188_L 258_A 1.549 1.00
85_G 308_R 1.535 1.00
285_A 301_T 1.534 1.00
165_D 168_Q 1.517 1.00
175_E 210_K 1.516 1.00
177_L 246_A 1.509 1.00
309_E 312_I 1.507 1.00
178_I 207_T 1.506 1.00
150_A 314_L 1.501 1.00
202_G 206_A 1.498 1.00
203_G 207_T 1.487 1.00
172_L 336_A 1.469 1.00
15_A 44_A 1.461 1.00
186_A 244_I 1.46 1.00
182_H 246_A 1.458 1.00
249_C 258_A 1.447 1.00
187_W 250_Y 1.445 1.00
309_E 313_T 1.443 1.00
68_G 121_V 1.432 1.00
170_A 203_G 1.43 1.00
216_H 219_W 1.425 1.00
168_Q 171_Q 1.423 1.00
44_A 48_L 1.417 1.00
69_L 86_L 1.407 0.99
86_L 125_V 1.402 0.99
316_D 320_Q 1.393 0.99
93_Q 319_M 1.391 0.99
262_L 267_R 1.385 0.99
261_G 264_K 1.382 0.99
53_N 56_A 1.378 0.99
65_G 95_R 1.373 0.99
34_S 37_T 1.37 0.99
259_W 284_L 1.351 0.99
174_T 207_T 1.346 0.99
261_G 265_A 1.342 0.99
176_H 340_A 1.34 0.99
174_T 203_G 1.336 0.99
11_D 14_L 1.329 0.99
184_R 243_T 1.326 0.99
234_I 262_L 1.322 0.99
15_A 48_L 1.321 0.99
89_A 93_Q 1.317 0.99
9_I 23_V 1.315 0.99
252_E 302_W 1.308 0.99
199_E 202_G 1.287 0.99
235_T 264_K 1.279 0.99
12_V 48_L 1.273 0.99
176_H 179_R 1.268 0.99
169_A 336_A 1.264 0.99
53_N 59_L 1.254 0.99
65_G 122_D 1.24 0.98
259_W 269_S 1.232 0.98
10_H 14_L 1.227 0.98
185_I 208_L 1.226 0.98
178_I 213_L 1.211 0.98
90_L 97_V 1.21 0.98
37_T 40_R 1.209 0.98
186_A 237_L 1.2 0.98
35_T 38_G 1.199 0.98
180_N 340_A 1.189 0.98
9_I 20_V 1.188 0.98
208_L 213_L 1.181 0.98
44_A 47_E 1.181 0.98
205_C 209_L 1.172 0.98
257_G 261_G 1.17 0.97
247_V 258_A 1.17 0.97
180_N 283_S 1.168 0.97
306_P 334_I 1.166 0.97
286_A 302_W 1.164 0.97
311_G 315_A 1.163 0.97
204_Y 208_L 1.154 0.97
40_R 44_A 1.152 0.97
100_L 116_L 1.15 0.97
252_E 286_A 1.149 0.97
43_A 46_E 1.148 0.97
56_A 59_L 1.142 0.97
221_L 236_A 1.142 0.97
69_L 97_V 1.142 0.97
289_D 293_T 1.136 0.97
241_N 244_I 1.132 0.97
25_L 30_K 1.129 0.97
185_I 246_A 1.128 0.97
173_L 248_V 1.123 0.97
249_C 255_A 1.118 0.96
39_E 42_N 1.117 0.96
29_G 38_G 1.117 0.96
228_K 232_E 1.099 0.96
259_W 296_D 1.078 0.95
167_M 203_G 1.076 0.95
86_L 315_A 1.074 0.95
172_L 175_E 1.069 0.95
179_R 211_F 1.069 0.95
68_G 116_L 1.067 0.95
69_L 83_T 1.064 0.95
26_V 33_I 1.06 0.95
167_M 199_E 1.06 0.95
207_T 210_K 1.059 0.95
173_L 303_A 1.056 0.95
234_I 238_L 1.056 0.95
64_S 122_D 1.053 0.95
184_R 245_S 1.052 0.95
7_I 48_L 1.05 0.94
232_E 236_A 1.049 0.94
22_T 25_L 1.048 0.94
252_E 255_A 1.047 0.94
206_A 210_K 1.044 0.94
55_Q 58_A 1.043 0.94
100_L 112_R 1.042 0.94
125_V 314_L 1.041 0.94
87_T 91_E 1.038 0.94
88_E 312_I 1.022 0.93
16_A 23_V 1.016 0.93
45_I 48_L 1.009 0.93
52_R 57_S 1.008 0.93
313_T 332_L 1.007 0.93
230_A 234_I 1.002 0.92
184_R 216_H 1.001 0.92
224_T 229_Q 1 0.92
167_M 171_Q 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3dbiA30.9621000.085Contact Map0.768
2o20A80.9621000.1Contact Map0.855
2hsgA10.95911000.1Contact Map0.781
3bilA20.95911000.102Contact Map0.655
1qpzA10.95321000.107Contact Map0.769
3kjxA40.97081000.109Contact Map0.789
3jvdA20.93571000.112Contact Map0.686
3e3mA40.97081000.114Contact Map0.829
3h5oA20.95911000.115Contact Map0.793
3ctpA20.93861000.124Contact Map0.738
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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