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GALS - HTH-type transcriptional regulator GalS
UniProt: P25748 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10365
Length: 346 (332)
Sequences: 13626
Seq/Len: 41.04
GALS
Paralog alert: 0.91 [within 20: 0.47] - ratio of genomes with paralogs
Cluster includes: ALSB ARAF ASCG CRA CYTR DGAL EBGR GALR GALS GNTR IDNR LACI LSRB MALI PURR RBSB RBSR TORT TRER XYLF YCJW YPHF YTFQ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
176_H 239_T 3.595 1.00
161_L 200_S 3.588 1.00
262_A 265_L 3.417 1.00
10_Q 42_E 3.392 1.00
167_A 270_I 3.124 1.00
274_D 289_R 2.785 1.00
38_K 42_E 2.623 1.00
176_H 268_S 2.596 1.00
195_K 199_M 2.51 1.00
256_L 267_L 2.495 1.00
80_A 296_A 2.479 1.00
30_A 34_E 2.465 1.00
118_A 303_A 2.425 1.00
34_E 38_K 2.416 1.00
165_R 204_E 2.39 1.00
169_R 173_N 2.256 1.00
154_R 306_G 2.235 1.00
84_V 301_E 2.226 1.00
298_L 301_E 2.174 1.00
164_A 168_T 2.153 1.00
21_V 36_V 2.134 1.00
33_R 37_M 2.115 1.00
225_E 258_D 2.08 1.00
84_V 87_Q 2.069 1.00
165_R 200_S 2.054 1.00
163_G 272_F 2.023 1.00
22_L 40_V 1.961 1.00
233_G 259_N 1.958 1.00
172_L 205_Q 1.949 1.00
85_A 300_T 1.947 1.00
162_S 166_M 1.891 1.00
228_M 241_V 1.889 1.00
165_R 201_A 1.857 1.00
262_A 266_H 1.851 1.00
164_A 242_F 1.842 1.00
224_G 251_G 1.842 1.00
169_R 201_A 1.832 1.00
289_R 322_T 1.796 1.00
261_I 266_H 1.796 1.00
83_L 293_A 1.79 1.00
229_V 259_N 1.76 1.00
174_N 329_V 1.755 1.00
169_R 205_Q 1.745 1.00
5_R 15_V 1.743 1.00
165_R 169_R 1.742 1.00
7_V 39_A 1.729 1.00
161_L 196_A 1.708 1.00
84_V 297_K 1.7 1.00
168_T 172_L 1.699 1.00
168_T 198_W 1.685 1.00
225_E 255_A 1.677 1.00
228_M 252_A 1.669 1.00
229_V 255_A 1.653 1.00
291_P 294_S 1.645 1.00
11_A 39_A 1.64 1.00
62_I 85_A 1.635 1.00
7_V 11_A 1.607 1.00
21_V 40_V 1.597 1.00
37_M 41_S 1.596 1.00
305_Q 310_N 1.594 1.00
274_D 326_R 1.585 1.00
284_Q 327_H 1.584 1.00
170_M 329_V 1.578 1.00
171_L 240_A 1.569 1.00
37_M 40_V 1.556 1.00
159_D 162_S 1.556 1.00
84_V 300_T 1.536 1.00
80_A 293_A 1.534 1.00
182_L 252_A 1.528 1.00
144_I 299_A 1.516 1.00
196_A 200_S 1.516 1.00
243_A 252_A 1.505 1.00
172_L 201_A 1.502 1.00
294_S 297_K 1.499 1.00
197_G 201_A 1.495 1.00
170_M 174_N 1.489 1.00
270_I 286_T 1.484 1.00
301_E 305_Q 1.455 1.00
181_Y 244_Y 1.454 1.00
180_G 238_L 1.441 1.00
10_Q 39_A 1.431 1.00
169_R 204_E 1.431 1.00
162_S 165_R 1.426 1.00
257_K 282_D 1.421 1.00
294_S 298_L 1.42 1.00
63_G 116_C 1.412 1.00
229_V 258_D 1.411 1.00
253_L 269_I 1.41 1.00
255_A 258_D 1.41 1.00
164_A 197_G 1.403 0.99
176_H 240_A 1.399 0.99
256_L 261_I 1.395 0.99
81_V 120_I 1.392 0.99
39_A 43_L 1.388 0.99
255_A 259_N 1.383 0.99
88_H 304_L 1.378 0.99
64_V 81_V 1.367 0.99
48_N 51_A 1.362 0.99
210_P 213_W 1.361 0.99
168_T 197_G 1.361 0.99
29_S 32_T 1.36 0.99
168_T 201_A 1.341 0.99
246_D 287_T 1.335 0.99
60_D 90_K 1.334 0.99
178_R 237_Q 1.328 0.99
4_I 18_V 1.31 0.99
166_M 321_P 1.305 0.99
180_G 231_L 1.304 0.99
6_D 9_R 1.304 0.99
84_V 88_H 1.302 0.99
228_M 256_L 1.294 0.99
193_M 196_A 1.294 0.99
170_M 173_N 1.289 0.99
172_L 207_I 1.283 0.99
10_Q 43_L 1.27 0.99
85_A 92_V 1.263 0.99
7_V 43_L 1.248 0.99
251_G 255_A 1.245 0.98
170_M 325_R 1.238 0.98
48_N 54_L 1.226 0.98
64_V 92_V 1.218 0.98
60_D 117_N 1.216 0.98
63_G 111_L 1.209 0.98
95_G 111_L 1.203 0.98
5_R 9_R 1.196 0.98
163_G 321_P 1.19 0.98
179_I 202_L 1.187 0.98
253_L 263_I 1.185 0.98
199_M 203_K 1.181 0.98
241_V 252_A 1.178 0.98
246_D 271_G 1.175 0.98
30_A 33_R 1.174 0.98
4_I 15_V 1.167 0.97
198_W 202_L 1.161 0.97
32_T 35_A 1.155 0.97
271_G 287_T 1.148 0.97
296_A 300_T 1.141 0.97
39_A 42_E 1.137 0.97
268_S 329_V 1.134 0.97
51_A 54_L 1.131 0.97
291_P 319_F 1.125 0.97
81_V 300_T 1.125 0.97
222_P 226_A 1.124 0.97
132_A 136_D 1.121 0.97
174_N 325_R 1.12 0.96
202_L 207_I 1.12 0.96
24_N 33_R 1.119 0.96
95_G 107_A 1.117 0.96
38_K 41_S 1.115 0.96
35_A 39_A 1.113 0.96
235_N 238_L 1.107 0.96
21_V 28_V 1.103 0.96
174_N 268_S 1.101 0.96
167_A 242_F 1.095 0.96
226_A 230_E 1.095 0.96
120_I 299_A 1.094 0.96
20_R 25_S 1.089 0.96
166_M 169_R 1.089 0.96
34_E 37_M 1.086 0.96
161_L 193_M 1.082 0.96
225_E 254_T 1.082 0.96
243_A 249_A 1.079 0.95
179_I 240_A 1.076 0.95
17_T 20_R 1.066 0.95
215_G 230_E 1.063 0.95
201_A 204_E 1.062 0.95
82_D 86_Q 1.058 0.95
167_A 288_V 1.049 0.94
161_L 197_G 1.049 0.94
274_D 278_A 1.048 0.94
246_D 249_A 1.048 0.94
218_T 223_G 1.045 0.94
59_S 117_N 1.044 0.94
178_R 210_P 1.043 0.94
50_N 53_A 1.038 0.94
178_R 239_T 1.035 0.94
173_N 205_Q 1.035 0.94
228_M 232_L 1.024 0.93
11_A 18_V 1.017 0.93
200_S 204_E 1.016 0.93
225_E 229_V 1.014 0.93
88_H 301_E 1.011 0.93
81_V 296_A 1.011 0.93
177_Q 239_T 1.004 0.93
243_A 248_M 1.004 0.93
64_V 78_V 1.001 0.92
40_V 43_L 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3dbiA30.96241000.104Contact Map0.747
2hsgA10.95381000.108Contact Map0.77
1qpzA10.97691000.109Contact Map0.781
2o20A80.9481000.112Contact Map0.854
3kjxA40.96241000.121Contact Map0.791
3bilA20.98271000.122Contact Map0.677
3e3mA40.97981000.124Contact Map0.821
3ctpA20.95091000.124Contact Map0.745
3h5oA20.96821000.131Contact Map0.795
3jvdA20.94221000.137Contact Map0.686
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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