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OPENSEQ.org
GADC - Probable glutamate/gamma-aminobutyrate antiporter
UniProt: P63235 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12456
Length: 511 (456)
Sequences: 6815
Seq/Len: 14.95
GADC
Paralog alert: 0.79 [within 20: 0.27] - ratio of genomes with paralogs
Cluster includes: ADIC ANSP ARCD AROP CADB CYCA FRLA GABP GADC LYSP MMUP PHEP PLAP POTE PROY PUUP YBAT YCAM YGJI YIFK YJEH YJEM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
328_A 340_T 4.026 1.00
320_A 330_A 3.762 1.00
175_A 255_S 3.555 1.00
14_T 228_S 3.508 1.00
288_W 292_V 3.372 1.00
331_K 340_T 3.332 1.00
142_A 346_L 3.034 1.00
383_F 420_L 2.985 1.00
391_V 395_K 2.802 1.00
232_R 236_L 2.785 1.00
229_N 232_R 2.753 1.00
323_N 327_A 2.585 1.00
343_I 347_V 2.49 1.00
329_F 344_S 2.413 1.00
391_V 394_L 2.403 1.00
333_N 339_V 2.367 1.00
386_F 419_G 2.35 1.00
173_A 177_I 2.293 1.00
132_I 136_I 2.292 1.00
146_F 343_I 2.233 1.00
227_M 233_D 2.108 1.00
328_A 331_K 2.085 1.00
60_C 386_F 1.986 1.00
19_F 240_L 1.96 1.00
60_C 412_K 1.949 1.00
80_S 88_G 1.943 1.00
66_T 402_T 1.935 1.00
63_E 393_V 1.909 1.00
340_T 344_S 1.9 1.00
14_T 17_G 1.895 1.00
407_G 411_V 1.876 1.00
142_A 342_V 1.865 1.00
93_S 325_L 1.851 1.00
180_H 188_E 1.839 1.00
317_Y 321_Q 1.831 1.00
15_L 233_D 1.827 1.00
13_L 153_A 1.827 1.00
15_L 240_L 1.822 1.00
413_L 417_I 1.821 1.00
83_L 391_V 1.806 1.00
417_I 421_L 1.795 1.00
96_Y 345_Q 1.794 1.00
46_L 50_G 1.793 1.00
176_A 180_H 1.793 1.00
226_E 314_R 1.788 1.00
203_T 206_V 1.772 1.00
135_L 354_I 1.749 1.00
92_I 319_T 1.741 1.00
390_I 413_L 1.719 1.00
134_A 353_L 1.715 1.00
177_I 182_G 1.71 1.00
389_Y 412_K 1.706 1.00
225_N 321_Q 1.694 1.00
83_L 387_I 1.693 1.00
91_A 384_M 1.688 1.00
264_E 281_H 1.676 1.00
313_S 342_V 1.654 1.00
215_M 378_Y 1.641 1.00
89_F 93_S 1.64 1.00
15_L 19_F 1.64 1.00
83_L 87_W 1.623 1.00
65_A 78_W 1.61 1.00
18_F 227_M 1.599 1.00
421_L 425_M 1.596 1.00
133_A 137_I 1.585 1.00
236_L 240_L 1.577 1.00
41_S 194_F 1.573 1.00
79_V 91_A 1.572 1.00
80_S 85_P 1.564 1.00
76_F 322_K 1.555 1.00
354_I 357_T 1.537 1.00
47_L 51_I 1.537 1.00
394_L 397_P 1.535 1.00
327_A 330_A 1.529 1.00
309_I 313_S 1.503 1.00
10_A 336_G 1.499 1.00
14_T 150_K 1.498 1.00
420_L 424_I 1.495 1.00
229_N 233_D 1.494 1.00
231_G 402_T 1.493 1.00
335_N 339_V 1.493 1.00
347_V 351_I 1.486 1.00
150_K 154_R 1.478 1.00
390_I 416_A 1.473 1.00
131_T 135_L 1.469 1.00
321_Q 330_A 1.467 1.00
16_L 154_R 1.466 1.00
70_W 81_N 1.459 1.00
312_P 345_Q 1.457 1.00
261_P 264_E 1.448 1.00
169_F 173_A 1.447 1.00
340_T 343_I 1.441 1.00
139_W 350_S 1.434 1.00
316_M 325_L 1.431 1.00
229_N 236_L 1.428 1.00
50_G 414_V 1.425 1.00
17_G 157_K 1.414 1.00
161_F 165_L 1.413 1.00
327_A 331_K 1.41 1.00
13_L 17_G 1.401 0.99
146_F 339_V 1.373 0.99
414_V 418_V 1.367 0.99
414_V 417_I 1.355 0.99
243_V 247_C 1.348 0.99
176_A 255_S 1.339 0.99
230_P 235_P 1.338 0.99
143_L 147_G 1.337 0.99
438_Q 442_T 1.335 0.99
458_A 462_I 1.33 0.99
135_L 350_S 1.327 0.99
410_G 414_V 1.324 0.99
135_L 139_W 1.321 0.99
60_C 405_I 1.319 0.99
50_G 246_I 1.314 0.99
316_M 341_L 1.311 0.99
45_F 49_G 1.307 0.99
397_P 401_R 1.286 0.99
233_D 236_L 1.279 0.99
76_F 92_I 1.278 0.99
17_G 154_R 1.274 0.99
103_F 107_L 1.274 0.99
390_I 394_L 1.271 0.99
26_V 241_L 1.271 0.99
155_I 159_G 1.271 0.99
174_L 279_M 1.271 0.99
19_F 22_T 1.269 0.99
45_F 50_G 1.266 0.99
15_L 236_L 1.257 0.99
72_E 225_N 1.256 0.99
218_E 222_T 1.25 0.99
383_F 387_I 1.237 0.98
69_G 402_T 1.236 0.98
9_K 332_M 1.233 0.98
79_V 388_G 1.215 0.98
141_L 305_I 1.214 0.98
239_L 243_V 1.212 0.98
28_A 31_E 1.212 0.98
333_N 337_V 1.212 0.98
24_S 160_F 1.21 0.98
23_A 244_A 1.207 0.98
437_I 440_D 1.206 0.98
126_D 129_T 1.204 0.98
202_G 205_V 1.204 0.98
413_L 416_A 1.203 0.98
228_S 233_D 1.201 0.98
448_L 451_V 1.195 0.98
84_G 87_W 1.189 0.98
63_E 66_T 1.186 0.98
98_Q 102_G 1.183 0.98
459_L 463_L 1.181 0.98
58_G 242_M 1.179 0.98
332_M 336_G 1.178 0.98
291_R 295_A 1.178 0.98
331_K 339_V 1.177 0.98
344_S 348_I 1.176 0.98
143_L 146_F 1.175 0.98
412_K 416_A 1.175 0.98
224_V 234_Y 1.169 0.97
139_W 346_L 1.166 0.97
19_F 244_A 1.164 0.97
114_L 133_A 1.162 0.97
41_S 195_F 1.156 0.97
247_C 251_V 1.156 0.97
47_L 250_S 1.155 0.97
99_I 308_W 1.152 0.97
46_L 49_G 1.152 0.97
142_A 343_I 1.143 0.97
219_A 311_G 1.143 0.97
118_L 121_P 1.134 0.97
43_V 254_L 1.126 0.97
96_Y 100_A 1.122 0.97
138_L 349_T 1.117 0.96
200_K 203_T 1.114 0.96
154_R 157_K 1.113 0.96
244_A 248_L 1.111 0.96
393_V 397_P 1.109 0.96
16_L 20_A 1.105 0.96
133_A 136_I 1.104 0.96
373_L 377_I 1.104 0.96
194_F 197_D 1.1 0.96
98_Q 378_Y 1.1 0.96
387_I 391_V 1.098 0.96
73_G 76_F 1.089 0.96
172_I 251_V 1.082 0.96
408_G 411_V 1.081 0.95
28_A 249_S 1.081 0.95
142_A 146_F 1.08 0.95
83_L 388_G 1.075 0.95
76_F 318_V 1.073 0.95
229_N 235_P 1.071 0.95
22_T 220_S 1.064 0.95
12_Q 228_S 1.063 0.95
89_F 92_I 1.061 0.95
279_M 289_T 1.059 0.95
139_W 143_L 1.057 0.95
187_I 258_M 1.054 0.95
18_F 223_H 1.054 0.95
123_L 132_I 1.053 0.95
108_Y 356_L 1.051 0.94
175_A 259_V 1.042 0.94
251_V 255_S 1.036 0.94
415_V 419_G 1.035 0.94
204_L 425_M 1.035 0.94
202_G 206_V 1.034 0.94
82_T 388_G 1.033 0.94
104_I 107_L 1.033 0.94
407_G 410_G 1.033 0.94
203_T 207_F 1.033 0.94
172_I 175_A 1.031 0.94
49_G 210_F 1.027 0.94
132_I 135_L 1.027 0.94
390_I 412_K 1.019 0.93
355_I 358_N 1.018 0.93
396_H 399_L 1.018 0.93
455_V 459_L 1.017 0.93
273_Q 276_T 1.013 0.93
12_Q 150_K 1.012 0.93
77_A 81_N 1.011 0.93
58_G 238_M 1.009 0.93
177_I 181_S 1.005 0.93
380_C 427_F 1.004 0.93
38_S 206_V 1.002 0.92
94_F 381_A 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4djkA20.99221000.287Contact Map0.574
3l1lA10.85911000.495Contact Map0.682
3giaA10.85131000.511Contact Map0.537
2jlnA10.882698.30.905Contact Map0.446
2a65A10.861197.10.926Contact Map0.423
4m48A10.888596.60.931Contact Map0.423
3dh4A40.8943960.935Contact Map0.394
2xq2A10.882693.70.943Contact Map0.51
3j1zP20.33278.70.975Contact Map0.378
2l2tA20.08225.30.977Contact Map0.417
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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