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OPENSEQ.org
AROP - Aromatic amino acid transport protein AroP
UniProt: P15993 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10084
Length: 457 (442)
Sequences: 10997
Seq/Len: 24.88
AROP
Paralog alert: 0.82 [within 20: 0.39] - ratio of genomes with paralogs
Cluster includes: ADIC ANSP ARCD AROP CADB CYCA FRLA GABP GADC LYSP MMUP PHEP PLAP POTE PROY PUUP YBAT YCAM YGJI YIFK YJEH YJEM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
323_A 335_N 4.158 1.00
139_N 341_A 3.462 1.00
375_A 410_L 3.444 1.00
171_G 255_V 3.212 1.00
16_K 228_D 3.119 1.00
315_A 325_A 3.107 1.00
326_S 335_N 2.992 1.00
383_K 387_A 2.973 1.00
229_N 232_Q 2.904 1.00
232_Q 236_K 2.894 1.00
56_G 246_L 2.735 1.00
132_A 348_V 2.602 1.00
378_S 409_C 2.549 1.00
318_G 322_K 2.468 1.00
283_F 287_A 2.431 1.00
407_W 411_L 2.43 1.00
338_L 342_L 2.375 1.00
227_A 233_S 2.363 1.00
312_F 316_Q 2.279 1.00
323_A 326_S 2.279 1.00
96_G 314_L 2.239 1.00
328_D 334_V 2.234 1.00
80_S 317_Q 2.141 1.00
261_P 264_R 2.128 1.00
57_F 408_I 2.113 1.00
65_Q 378_S 2.112 1.00
17_N 233_S 2.105 1.00
47_G 203_L 2.095 1.00
264_R 278_E 2.087 1.00
324_L 339_V 2.063 1.00
169_I 173_W 2.015 1.00
225_A 316_Q 1.999 1.00
16_K 19_H 1.965 1.00
84_Y 92_G 1.96 1.00
17_N 240_Q 1.957 1.00
21_Q 240_Q 1.957 1.00
84_Y 89_S 1.956 1.00
431_Y 435_V 1.945 1.00
11_L 327_V 1.935 1.00
87_W 379_L 1.932 1.00
87_W 383_K 1.866 1.00
383_K 386_R 1.849 1.00
143_L 334_V 1.825 1.00
404_L 408_I 1.822 1.00
139_N 337_I 1.81 1.00
236_K 240_Q 1.808 1.00
68_E 385_R 1.805 1.00
57_F 61_L 1.798 1.00
226_E 309_R 1.783 1.00
17_N 21_Q 1.778 1.00
147_K 151_E 1.765 1.00
40_V 48_I 1.755 1.00
20_I 227_A 1.743 1.00
100_W 340_S 1.735 1.00
143_L 338_L 1.731 1.00
411_L 415_A 1.729 1.00
434_P 438_I 1.723 1.00
158_I 162_I 1.71 1.00
140_A 144_T 1.705 1.00
51_G 206_M 1.686 1.00
83_A 95_S 1.664 1.00
379_L 410_L 1.664 1.00
229_N 233_S 1.645 1.00
442_I 446_F 1.638 1.00
90_F 444_Y 1.629 1.00
65_Q 406_N 1.622 1.00
401_L 405_G 1.611 1.00
19_H 154_F 1.609 1.00
95_S 376_M 1.604 1.00
432_L 435_V 1.601 1.00
229_N 236_K 1.593 1.00
136_V 345_A 1.588 1.00
230_P 235_P 1.578 1.00
15_L 19_H 1.558 1.00
161_V 165_V 1.511 1.00
274_L 278_E 1.508 1.00
311_L 336_T 1.507 1.00
132_A 345_A 1.495 1.00
135_F 344_T 1.487 1.00
53_A 250_I 1.476 1.00
322_K 325_A 1.474 1.00
328_D 332_V 1.467 1.00
136_V 341_A 1.466 1.00
438_I 442_I 1.464 1.00
382_M 407_W 1.443 1.00
118_I 130_S 1.441 1.00
83_A 376_M 1.437 1.00
308_S 337_I 1.435 1.00
239_N 243_Y 1.435 1.00
381_H 406_N 1.432 1.00
307_N 340_S 1.43 1.00
21_Q 244_R 1.421 1.00
335_N 339_V 1.417 1.00
196_L 203_L 1.404 0.99
88_G 91_A 1.403 0.99
61_L 408_I 1.394 0.99
322_K 326_S 1.389 0.99
41_I 48_I 1.373 0.99
71_V 396_R 1.373 0.99
87_W 91_A 1.362 0.99
274_L 277_H 1.36 0.99
15_L 150_G 1.355 0.99
47_G 196_L 1.352 0.99
144_T 330_R 1.348 0.99
73_E 85_K 1.347 0.99
410_L 414_A 1.346 0.99
132_A 136_V 1.331 0.99
277_H 282_T 1.33 0.99
25_L 244_R 1.328 0.99
17_N 236_K 1.323 0.99
107_A 344_T 1.309 0.99
139_N 338_L 1.303 0.99
223_T 305_Y 1.302 0.99
243_Y 247_I 1.298 0.99
435_V 438_I 1.296 0.99
142_N 301_N 1.295 0.99
135_F 341_A 1.287 0.99
63_M 242_I 1.286 0.99
62_I 378_S 1.286 0.99
172_G 176_F 1.285 0.99
441_G 445_L 1.281 0.99
58_I 412_F 1.279 0.99
311_L 320_A 1.275 0.99
286_N 290_I 1.273 0.99
93_F 97_W 1.271 0.99
168_I 251_G 1.269 0.99
111_L 135_F 1.268 0.99
76_A 225_A 1.268 0.99
388_K 391_Q 1.268 0.99
330_R 334_V 1.267 0.99
114_V 293_L 1.262 0.99
233_S 236_K 1.257 0.99
12_K 331_G 1.257 0.99
63_M 238_T 1.255 0.99
70_V 82_F 1.253 0.99
379_L 383_K 1.251 0.99
111_L 300_Y 1.25 0.99
35_L 113_A 1.242 0.98
162_I 166_A 1.241 0.98
316_Q 325_A 1.238 0.98
231_E 396_R 1.236 0.98
86_Y 380_A 1.235 0.98
403_P 407_W 1.234 0.98
138_I 300_Y 1.223 0.98
163_A 291_V 1.223 0.98
11_L 312_F 1.219 0.98
431_Y 434_P 1.219 0.98
268_D 274_L 1.215 0.98
139_N 143_L 1.208 0.98
342_L 346_L 1.206 0.98
418_V 422_M 1.205 0.98
326_S 334_V 1.204 0.98
172_G 255_V 1.2 0.98
55_A 210_I 1.199 0.98
327_V 331_G 1.199 0.98
277_H 285_A 1.194 0.98
81_H 85_K 1.169 0.97
215_G 370_L 1.159 0.97
75_V 81_H 1.159 0.97
97_W 440_L 1.159 0.97
24_A 241_V 1.158 0.97
18_R 151_E 1.156 0.97
146_V 305_Y 1.15 0.97
375_A 379_L 1.148 0.97
404_L 407_W 1.146 0.97
131_A 348_V 1.144 0.97
15_L 20_I 1.138 0.97
56_G 214_F 1.136 0.97
375_A 414_A 1.136 0.97
88_G 445_L 1.131 0.97
83_A 91_A 1.126 0.97
312_F 327_V 1.125 0.97
18_R 22_L 1.124 0.97
281_D 284_V 1.123 0.97
140_A 143_L 1.121 0.97
143_L 328_D 1.119 0.96
72_E 391_Q 1.116 0.96
228_D 233_S 1.116 0.96
28_A 245_I 1.113 0.96
50_L 203_L 1.112 0.96
49_I 254_A 1.111 0.96
176_F 183_Q 1.11 0.96
128_W 132_A 1.105 0.96
389_Q 395_T 1.104 0.96
14_G 147_K 1.102 0.96
428_I 431_Y 1.101 0.96
335_N 338_L 1.099 0.96
401_L 404_L 1.098 0.96
218_E 222_I 1.096 0.96
442_I 445_L 1.094 0.96
53_A 57_F 1.091 0.96
182_P 187_S 1.089 0.96
152_M 156_F 1.076 0.95
143_L 332_V 1.075 0.95
161_V 248_F 1.07 0.95
77_G 80_S 1.069 0.95
100_W 311_L 1.069 0.95
40_V 44_A 1.063 0.95
251_G 255_V 1.062 0.95
444_Y 448_E 1.062 0.95
224_A 234_I 1.061 0.95
19_H 151_E 1.057 0.95
200_F 203_L 1.056 0.95
66_L 79_F 1.055 0.95
97_W 320_A 1.054 0.95
72_E 395_T 1.052 0.95
90_F 441_G 1.046 0.94
80_S 313_G 1.044 0.94
141_I 152_M 1.04 0.94
136_V 140_A 1.035 0.94
16_K 147_K 1.034 0.94
428_I 432_L 1.033 0.94
415_A 419_I 1.031 0.94
386_R 389_Q 1.027 0.94
175_L 258_S 1.026 0.94
61_L 405_G 1.021 0.93
204_V 415_A 1.019 0.93
72_E 396_R 1.013 0.93
23_I 223_T 1.013 0.93
304_V 308_S 1.01 0.93
19_H 150_G 1.009 0.93
125_I 129_V 1.009 0.93
64_R 239_N 1.008 0.93
382_M 386_R 1.004 0.93
247_I 251_G 1.003 0.93
20_I 237_A 1.003 0.93
83_A 380_A 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4djkA20.9651000.345Contact Map0.574
3l1lA10.94311000.369Contact Map0.679
3giaA10.92121000.394Contact Map0.59
3dh4A40.9431980.899Contact Map0.391
2xq2A10.943197.50.908Contact Map0.484
2jlnA10.888497.40.91Contact Map0.406
4m48A10.940996.10.924Contact Map0.328
2a65A10.945395.40.928Contact Map0.382
2wswA10.803151.80.957Contact Map0.275
3j1zP20.280110.20.97Contact Map0.377
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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