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OPENSEQ.org
PHEP - Phenylalanine-specific permease
UniProt: P24207 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10708
Length: 458 (442)
Sequences: 10987
Seq/Len: 24.86
PHEP
Paralog alert: 0.82 [within 20: 0.39] - ratio of genomes with paralogs
Cluster includes: ADIC ANSP ARCD AROP CADB CYCA FRLA GABP GADC LYSP MMUP PHEP PLAP POTE PROY PUUP YBAT YCAM YGJI YIFK YJEH YJEM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
331_F 343_N 4.079 1.00
147_N 349_G 3.458 1.00
383_I 418_I 3.239 1.00
179_G 263_V 3.155 1.00
24_H 236_R 3.065 1.00
323_S 333_T 3.039 1.00
334_R 343_N 2.966 1.00
237_D 240_K 2.846 1.00
391_R 395_A 2.826 1.00
240_K 244_K 2.809 1.00
64_G 254_L 2.71 1.00
140_A 356_V 2.616 1.00
346_M 350_A 2.428 1.00
326_G 330_K 2.418 1.00
291_V 295_A 2.347 1.00
331_F 334_R 2.29 1.00
415_Y 419_A 2.287 1.00
386_C 417_C 2.276 1.00
439_I 443_V 2.269 1.00
235_A 241_S 2.267 1.00
336_S 342_I 2.247 1.00
320_F 324_V 2.244 1.00
104_G 322_L 2.242 1.00
272_E 286_N 2.231 1.00
177_G 181_W 2.183 1.00
65_I 416_L 2.138 1.00
25_N 241_S 2.137 1.00
29_Q 248_Q 2.103 1.00
88_A 325_Q 2.088 1.00
73_Q 386_C 2.083 1.00
25_N 248_Q 2.08 1.00
233_A 324_V 2.029 1.00
92_Y 97_P 1.993 1.00
24_H 27_H 1.959 1.00
332_L 347_L 1.953 1.00
92_Y 100_G 1.937 1.00
76_E 393_R 1.915 1.00
269_P 272_E 1.909 1.00
55_A 211_L 1.898 1.00
98_F 452_F 1.869 1.00
95_W 391_R 1.858 1.00
95_W 387_L 1.856 1.00
234_E 317_R 1.841 1.00
19_L 335_V 1.838 1.00
25_N 29_Q 1.827 1.00
412_F 416_L 1.824 1.00
244_K 248_Q 1.819 1.00
151_L 342_I 1.812 1.00
28_I 235_A 1.794 1.00
151_L 346_M 1.782 1.00
147_N 345_L 1.78 1.00
65_I 69_L 1.777 1.00
391_R 394_A 1.765 1.00
166_L 170_L 1.761 1.00
148_A 152_V 1.723 1.00
59_G 214_S 1.713 1.00
155_R 159_E 1.707 1.00
48_A 56_V 1.701 1.00
91_A 103_S 1.698 1.00
108_W 348_S 1.695 1.00
450_M 454_T 1.687 1.00
419_A 423_M 1.68 1.00
440_L 443_V 1.657 1.00
237_D 241_S 1.648 1.00
103_S 384_M 1.635 1.00
73_Q 414_N 1.628 1.00
27_H 162_F 1.628 1.00
409_L 413_G 1.62 1.00
237_D 244_K 1.589 1.00
169_V 173_I 1.573 1.00
387_L 418_I 1.561 1.00
23_L 27_H 1.552 1.00
238_P 243_P 1.546 1.00
29_Q 252_R 1.544 1.00
144_I 353_S 1.531 1.00
140_A 353_S 1.525 1.00
442_P 446_V 1.494 1.00
319_L 344_S 1.488 1.00
126_M 138_W 1.484 1.00
247_N 251_Y 1.479 1.00
446_V 450_M 1.475 1.00
439_I 442_P 1.47 1.00
204_F 211_L 1.464 1.00
315_N 348_S 1.453 1.00
61_G 258_I 1.45 1.00
316_S 345_L 1.44 1.00
96_G 99_A 1.43 1.00
144_I 349_G 1.426 1.00
143_F 352_T 1.425 1.00
343_N 347_L 1.421 1.00
251_Y 255_L 1.42 1.00
49_I 56_V 1.417 1.00
436_L 439_I 1.407 0.99
336_S 340_V 1.406 0.99
338_R 342_I 1.4 0.99
282_M 285_H 1.392 0.99
91_A 384_M 1.391 0.99
389_H 414_N 1.386 0.99
438_A 443_V 1.385 0.99
330_K 333_T 1.384 0.99
294_S 298_F 1.379 0.99
390_L 415_Y 1.373 0.99
282_M 286_N 1.368 0.99
231_T 313_Y 1.367 0.99
170_L 174_G 1.356 0.99
152_V 338_R 1.356 0.99
330_K 334_R 1.355 0.99
140_A 144_I 1.353 0.99
25_N 244_K 1.34 0.99
95_W 99_A 1.337 0.99
150_N 309_N 1.335 0.99
139_A 356_V 1.332 0.99
454_T 457_R 1.321 0.99
115_G 352_T 1.318 0.99
81_E 93_K 1.309 0.99
63_A 218_I 1.306 0.99
176_I 259_G 1.306 0.99
319_L 328_A 1.301 0.99
147_N 346_M 1.3 0.99
23_L 158_G 1.299 0.99
94_Y 388_A 1.297 0.99
438_A 442_P 1.296 0.99
146_I 308_Y 1.294 0.99
70_I 386_C 1.294 0.99
449_F 453_K 1.293 0.99
276_N 282_M 1.292 0.99
387_L 391_R 1.288 0.99
426_L 430_T 1.282 0.99
119_L 308_Y 1.272 0.99
119_L 143_F 1.268 0.99
122_A 301_L 1.257 0.99
418_I 422_G 1.252 0.99
101_F 105_W 1.252 0.99
32_A 249_V 1.25 0.99
84_S 233_A 1.241 0.98
33_L 252_R 1.241 0.98
411_P 415_Y 1.239 0.98
55_A 204_F 1.238 0.98
69_L 416_L 1.235 0.98
396_M 399_Q 1.234 0.98
285_H 290_N 1.233 0.98
20_H 339_G 1.232 0.98
36_A 253_I 1.224 0.98
23_L 28_I 1.222 0.98
180_L 263_V 1.217 0.98
71_M 246_V 1.217 0.98
89_H 93_K 1.214 0.98
78_V 90_F 1.213 0.98
285_H 293_A 1.212 0.98
171_A 299_V 1.212 0.98
452_F 456_R 1.209 0.98
143_F 349_G 1.209 0.98
335_V 339_G 1.207 0.98
96_G 453_K 1.205 0.98
71_M 250_V 1.201 0.98
409_L 412_F 1.201 0.98
43_L 121_A 1.2 0.98
147_N 151_L 1.198 0.98
241_S 244_K 1.195 0.98
324_V 333_T 1.192 0.98
154_V 313_Y 1.186 0.98
334_R 342_I 1.182 0.98
397_R 403_T 1.171 0.98
19_L 320_F 1.17 0.97
180_L 184_F 1.158 0.97
83_V 89_H 1.147 0.97
26_R 30_L 1.145 0.97
443_V 446_V 1.14 0.97
423_M 427_L 1.14 0.97
26_R 159_E 1.137 0.97
136_W 140_A 1.132 0.97
436_L 440_L 1.131 0.97
58_L 211_L 1.128 0.97
223_G 378_L 1.128 0.97
438_A 441_L 1.124 0.97
255_L 259_G 1.111 0.96
350_A 354_L 1.11 0.96
394_A 397_R 1.109 0.96
91_A 99_A 1.107 0.96
232_A 242_I 1.105 0.96
64_G 222_F 1.102 0.96
61_G 65_I 1.102 0.96
383_I 387_L 1.099 0.96
343_N 346_M 1.094 0.96
320_F 335_V 1.094 0.96
236_R 241_S 1.093 0.96
148_A 151_L 1.089 0.96
151_L 336_S 1.088 0.96
22_G 155_R 1.087 0.96
208_W 211_L 1.082 0.96
390_L 414_N 1.081 0.95
259_G 263_V 1.08 0.95
105_W 328_A 1.078 0.95
412_F 415_Y 1.078 0.95
422_G 426_L 1.077 0.95
435_R 439_I 1.077 0.95
179_G 267_L 1.074 0.95
126_M 301_L 1.067 0.95
69_L 413_G 1.066 0.95
160_T 164_F 1.06 0.95
184_F 191_K 1.059 0.95
226_E 230_I 1.057 0.95
32_A 228_I 1.054 0.95
57_L 262_V 1.054 0.95
289_S 292_V 1.051 0.94
437_S 441_L 1.05 0.94
85_G 88_A 1.047 0.94
74_L 87_F 1.044 0.94
27_H 159_E 1.044 0.94
383_I 422_G 1.043 0.94
450_M 453_K 1.043 0.94
108_W 319_L 1.042 0.94
190_E 195_D 1.042 0.94
27_H 158_G 1.038 0.94
88_A 321_G 1.031 0.94
151_L 340_V 1.03 0.94
149_V 160_T 1.026 0.94
390_L 394_A 1.025 0.93
437_S 442_P 1.018 0.93
24_H 155_R 1.017 0.93
389_H 393_R 1.017 0.93
145_I 305_L 1.011 0.93
28_I 245_A 1.009 0.93
31_I 231_T 1.008 0.93
146_I 309_N 1.008 0.93
30_L 162_F 1.006 0.93
48_A 52_A 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4djkA20.94541000.341Contact Map0.605
3l1lA10.92581000.357Contact Map0.683
3giaA10.90391000.372Contact Map0.598
2jlnA10.890898.40.882Contact Map0.443
3dh4A40.9389980.895Contact Map0.42
2xq2A10.938997.40.907Contact Map0.51
4m48A10.925891.50.936Contact Map0.372
2a65A10.91782.40.945Contact Map0.462
3j1zP20.25989.70.969Contact Map0.423
2oynA10.10043.70.975Contact Map0.195
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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