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OPENSEQ.org
GABP - GABA permease
UniProt: P25527 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11330
Length: 466 (445)
Sequences: 10827
Seq/Len: 24.33
GABP
Paralog alert: 0.82 [within 20: 0.38] - ratio of genomes with paralogs
Cluster includes: ADIC ANSP ARCD AROP CADB CYCA FRLA GABP GADC LYSP MMUP PHEP PLAP POTE PROY PUUP YBAT YCAM YGJI YIFK YJEH YJEM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
324_V 336_V 4.175 1.00
376_L 411_I 3.812 1.00
138_T 342_T 3.447 1.00
316_S 326_G 3.092 1.00
15_K 228_D 3.054 1.00
170_G 255_V 3.035 1.00
327_K 336_V 2.964 1.00
55_G 246_S 2.926 1.00
229_T 232_K 2.828 1.00
232_K 236_R 2.821 1.00
131_L 349_V 2.744 1.00
384_R 388_I 2.673 1.00
408_W 412_G 2.465 1.00
379_A 410_V 2.448 1.00
284_H 288_I 2.431 1.00
319_G 323_A 2.412 1.00
339_L 343_G 2.381 1.00
227_S 233_H 2.335 1.00
324_V 327_K 2.274 1.00
313_Y 317_R 2.233 1.00
20_T 240_S 2.222 1.00
95_G 315_L 2.219 1.00
329_N 335_Y 2.199 1.00
16_S 240_S 2.184 1.00
56_L 409_L 2.151 1.00
64_M 379_A 2.097 1.00
79_S 318_R 2.095 1.00
168_F 172_V 2.094 1.00
16_S 233_H 2.062 1.00
264_M 279_L 2.06 1.00
46_A 203_V 2.057 1.00
225_A 317_R 2.013 1.00
325_M 340_L 2.006 1.00
83_D 88_R 1.963 1.00
15_K 18_H 1.962 1.00
83_D 91_G 1.961 1.00
10_L 328_I 1.954 1.00
67_E 386_R 1.924 1.00
86_I 384_R 1.914 1.00
86_I 380_V 1.898 1.00
226_E 310_R 1.861 1.00
56_L 60_M 1.85 1.00
236_R 240_S 1.848 1.00
19_V 227_S 1.823 1.00
142_L 335_Y 1.804 1.00
142_L 339_L 1.799 1.00
405_W 409_L 1.785 1.00
146_K 150_E 1.78 1.00
138_T 338_V 1.771 1.00
139_G 143_L 1.744 1.00
157_L 161_I 1.73 1.00
16_S 20_T 1.73 1.00
94_I 377_V 1.723 1.00
380_V 411_I 1.722 1.00
50_A 206_A 1.712 1.00
189_L 192_S 1.708 1.00
64_M 407_T 1.698 1.00
412_G 416_F 1.696 1.00
442_I 446_P 1.695 1.00
261_P 264_M 1.693 1.00
99_W 341_S 1.689 1.00
89_W 444_T 1.682 1.00
384_R 387_K 1.677 1.00
229_T 233_H 1.676 1.00
82_A 94_I 1.665 1.00
160_V 164_L 1.656 1.00
131_L 346_F 1.625 1.00
39_A 47_V 1.622 1.00
229_T 236_R 1.61 1.00
243_W 247_I 1.61 1.00
117_L 129_F 1.598 1.00
239_N 243_W 1.592 1.00
20_T 244_R 1.589 1.00
52_L 250_L 1.577 1.00
402_L 406_L 1.57 1.00
60_M 409_L 1.563 1.00
230_P 235_V 1.559 1.00
18_H 153_F 1.558 1.00
134_T 345_A 1.556 1.00
434_T 438_A 1.548 1.00
336_V 340_L 1.529 1.00
441_I 445_V 1.528 1.00
57_L 413_F 1.514 1.00
312_L 337_A 1.512 1.00
329_N 333_T 1.51 1.00
14_L 18_H 1.51 1.00
70_V 397_R 1.507 1.00
383_L 408_W 1.497 1.00
382_Q 407_T 1.485 1.00
135_L 346_F 1.48 1.00
308_A 341_S 1.468 1.00
287_L 291_C 1.457 1.00
309_S 338_V 1.446 1.00
323_A 327_K 1.423 1.00
331_S 335_Y 1.422 1.00
343_G 347_L 1.406 0.99
323_A 326_G 1.406 0.99
82_A 377_V 1.403 0.99
411_I 415_T 1.399 0.99
171_A 175_S 1.395 0.99
110_A 134_T 1.384 0.99
275_S 278_E 1.377 0.99
27_V 245_I 1.374 0.99
135_L 342_T 1.365 0.99
438_A 442_I 1.365 0.99
131_L 135_L 1.358 0.99
435_G 438_A 1.356 0.99
46_A 196_M 1.354 0.99
87_G 90_A 1.353 0.99
16_S 236_R 1.352 0.99
106_I 345_A 1.349 0.99
223_A 306_Y 1.348 0.99
40_I 47_V 1.342 0.99
143_L 331_S 1.341 0.99
86_I 90_A 1.337 0.99
167_I 251_C 1.336 0.99
404_P 408_W 1.333 0.99
275_S 279_L 1.33 0.99
23_S 241_V 1.327 0.99
61_I 379_A 1.325 0.99
389_L 392_E 1.315 0.99
141_N 302_N 1.31 0.99
72_T 84_K 1.31 0.99
110_A 301_L 1.307 0.99
134_T 342_T 1.306 0.99
161_I 165_A 1.306 0.99
62_M 242_I 1.302 0.99
312_L 321_A 1.298 0.99
85_A 381_S 1.295 0.99
75_T 225_A 1.287 0.99
138_T 339_L 1.285 0.99
196_M 203_V 1.278 0.99
11_G 332_K 1.276 0.99
137_L 301_L 1.271 0.99
233_H 236_R 1.271 0.99
24_I 244_R 1.265 0.99
14_L 149_G 1.255 0.99
130_S 349_V 1.254 0.99
80_T 84_K 1.25 0.99
380_V 384_R 1.248 0.99
69_A 81_Y 1.247 0.99
446_P 449_A 1.245 0.98
92_Y 96_W 1.23 0.98
138_T 142_L 1.228 0.98
10_L 313_Y 1.226 0.98
49_L 203_V 1.222 0.98
278_E 283_P 1.221 0.98
172_V 177_F 1.218 0.98
62_M 238_T 1.215 0.98
113_A 294_L 1.211 0.98
162_A 292_V 1.204 0.98
376_L 380_V 1.203 0.98
419_V 423_F 1.197 0.98
54_A 210_T 1.19 0.98
317_R 326_G 1.189 0.98
328_I 332_K 1.189 0.98
52_L 56_L 1.183 0.98
278_E 286_K 1.182 0.98
48_L 254_F 1.18 0.98
145_V 306_Y 1.175 0.98
34_V 112_I 1.17 0.97
432_I 435_G 1.169 0.97
74_D 80_T 1.166 0.97
327_K 335_Y 1.164 0.97
215_M 371_A 1.164 0.97
188_R 192_S 1.162 0.97
175_S 183_V 1.161 0.97
171_A 255_V 1.158 0.97
87_G 445_V 1.152 0.97
193_G 196_M 1.145 0.97
247_I 251_C 1.144 0.97
376_L 415_T 1.14 0.97
224_A 234_I 1.139 0.97
14_L 19_V 1.139 0.97
231_E 397_R 1.134 0.97
313_Y 328_I 1.132 0.97
160_V 248_F 1.126 0.97
82_A 90_A 1.125 0.97
435_G 439_I 1.122 0.97
336_V 339_L 1.117 0.96
442_I 445_V 1.115 0.96
204_L 416_F 1.111 0.96
17_R 150_E 1.109 0.96
17_R 21_M 1.103 0.96
405_W 408_W 1.102 0.96
65_L 78_F 1.098 0.96
251_C 255_V 1.096 0.96
142_L 333_T 1.089 0.96
71_A 397_R 1.086 0.96
436_L 440_G 1.085 0.96
151_F 155_L 1.084 0.96
29_G 249_Y 1.084 0.96
19_V 237_A 1.082 0.96
49_L 52_L 1.08 0.95
142_L 329_N 1.078 0.95
39_A 43_A 1.071 0.95
139_G 142_L 1.068 0.95
18_H 150_E 1.067 0.95
170_G 259_L 1.064 0.95
55_G 214_F 1.052 0.95
218_E 222_I 1.048 0.94
228_D 233_H 1.047 0.94
96_W 321_A 1.044 0.94
13_G 146_K 1.043 0.94
383_L 404_P 1.043 0.94
383_L 407_T 1.041 0.94
136_A 298_T 1.038 0.94
60_M 406_L 1.037 0.94
150_E 153_F 1.029 0.94
79_S 314_S 1.028 0.94
444_T 448_M 1.021 0.93
128_L 132_V 1.017 0.93
305_L 309_S 1.017 0.93
416_F 420_V 1.017 0.93
152_E 302_N 1.013 0.93
89_W 441_I 1.004 0.93
124_I 128_L 1.004 0.93
402_L 405_W 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4djkA20.96571000.331Contact Map0.599
3l1lA10.93991000.358Contact Map0.685
3giaA10.92271000.373Contact Map0.598
2xq2A10.9798.10.895Contact Map0.49
3dh4A40.9421980.897Contact Map0.39
2jlnA10.89797.40.908Contact Map0.405
4m48A10.946494.60.93Contact Map0.368
2a65A10.918592.80.935Contact Map0.417
2wswA10.789749.60.957Contact Map0.321
1wazA10.09445.10.973Contact Map0.708
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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