| UniProt: | P0AAE2 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG13609 | ||
| Length: | 457 (445) | ||
| Sequences: | 10764 | ||
| Seq/Len: | 24.19 |
| PROY
Paralog alert: 0.82 [within 20: 0.39] - ratio of genomes with paralogs Cluster includes: ADIC ANSP ARCD AROP CADB CYCA FRLA GABP GADC LYSP MMUP PHEP PLAP POTE PROY PUUP YBAT YCAM YGJI YIFK YJEH YJEM |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 321_I | 333_V | 4.183 | 1.00 | |
| 373_I | 409_L | 3.527 | 1.00 | |
| 135_C | 339_T | 3.453 | 1.00 | |
| 167_G | 253_V | 3.173 | 1.00 | |
| 313_A | 323_S | 3.114 | 1.00 | |
| 12_S | 226_K | 3.093 | 1.00 | |
| 324_K | 333_V | 3 | 1.00 | |
| 230_K | 234_R | 2.878 | 1.00 | |
| 227_D | 230_K | 2.876 | 1.00 | |
| 381_A | 385_R | 2.861 | 1.00 | |
| 52_G | 244_L | 2.812 | 1.00 | |
| 128_L | 346_V | 2.645 | 1.00 | |
| 406_I | 410_I | 2.549 | 1.00 | |
| 376_L | 408_G | 2.449 | 1.00 | |
| 316_G | 320_K | 2.393 | 1.00 | |
| 281_F | 285_I | 2.354 | 1.00 | |
| 336_L | 340_T | 2.309 | 1.00 | |
| 92_G | 312_M | 2.304 | 1.00 | |
| 310_H | 314_E | 2.303 | 1.00 | |
| 321_I | 324_K | 2.287 | 1.00 | |
| 262_Q | 276_H | 2.263 | 1.00 | |
| 225_A | 231_S | 2.259 | 1.00 | |
| 326_S | 332_W | 2.238 | 1.00 | |
| 259_P | 262_Q | 2.22 | 1.00 | |
| 165_V | 169_G | 2.169 | 1.00 | |
| 53_I | 407_G | 2.163 | 1.00 | |
| 17_R | 238_S | 2.147 | 1.00 | |
| 61_A | 376_L | 2.135 | 1.00 | |
| 43_S | 201_M | 2.087 | 1.00 | |
| 13_T | 231_S | 2.076 | 1.00 | |
| 76_S | 315_Q | 2.06 | 1.00 | |
| 7_L | 325_T | 2.017 | 1.00 | |
| 322_F | 337_V | 2.016 | 1.00 | |
| 80_Q | 88_G | 1.984 | 1.00 | |
| 13_T | 238_S | 1.967 | 1.00 | |
| 80_Q | 85_P | 1.966 | 1.00 | |
| 223_G | 314_E | 1.952 | 1.00 | |
| 83_L | 377_L | 1.943 | 1.00 | |
| 83_L | 381_A | 1.925 | 1.00 | |
| 430_Y | 434_A | 1.916 | 1.00 | |
| 139_L | 332_W | 1.909 | 1.00 | |
| 12_S | 15_H | 1.889 | 1.00 | |
| 403_A | 407_G | 1.876 | 1.00 | |
| 53_I | 57_I | 1.869 | 1.00 | |
| 13_T | 17_R | 1.861 | 1.00 | |
| 64_E | 383_R | 1.823 | 1.00 | |
| 234_R | 238_S | 1.81 | 1.00 | |
| 135_C | 335_V | 1.804 | 1.00 | |
| 16_I | 225_A | 1.795 | 1.00 | |
| 224_E | 307_R | 1.795 | 1.00 | |
| 381_A | 384_R | 1.774 | 1.00 | |
| 136_A | 140_M | 1.749 | 1.00 | |
| 47_A | 204_S | 1.739 | 1.00 | |
| 433_F | 437_V | 1.735 | 1.00 | |
| 96_C | 338_M | 1.718 | 1.00 | |
| 154_F | 158_A | 1.709 | 1.00 | |
| 86_L | 443_W | 1.703 | 1.00 | |
| 139_L | 336_L | 1.697 | 1.00 | |
| 400_G | 404_T | 1.697 | 1.00 | |
| 143_K | 147_E | 1.693 | 1.00 | |
| 377_L | 409_L | 1.683 | 1.00 | |
| 91_T | 374_M | 1.683 | 1.00 | |
| 79_A | 91_T | 1.673 | 1.00 | |
| 157_V | 161_I | 1.665 | 1.00 | |
| 36_A | 44_V | 1.664 | 1.00 | |
| 227_D | 231_S | 1.659 | 1.00 | |
| 61_A | 405_T | 1.638 | 1.00 | |
| 441_I | 445_F | 1.633 | 1.00 | |
| 132_L | 343_L | 1.627 | 1.00 | |
| 410_I | 414_F | 1.617 | 1.00 | |
| 227_D | 234_R | 1.612 | 1.00 | |
| 228_P | 233_P | 1.595 | 1.00 | |
| 128_L | 343_L | 1.564 | 1.00 | |
| 431_V | 434_A | 1.533 | 1.00 | |
| 11_L | 15_H | 1.531 | 1.00 | |
| 309_L | 334_T | 1.531 | 1.00 | |
| 15_H | 150_F | 1.526 | 1.00 | |
| 380_I | 406_I | 1.517 | 1.00 | |
| 194_F | 201_M | 1.516 | 1.00 | |
| 241_M | 245_V | 1.49 | 1.00 | |
| 305_V | 338_M | 1.488 | 1.00 | |
| 333_V | 337_V | 1.484 | 1.00 | |
| 326_S | 330_I | 1.483 | 1.00 | |
| 17_R | 242_R | 1.478 | 1.00 | |
| 284_S | 288_F | 1.447 | 1.00 | |
| 306_G | 335_V | 1.445 | 1.00 | |
| 168_F | 172_I | 1.429 | 1.00 | |
| 320_K | 323_S | 1.425 | 1.00 | |
| 437_V | 441_I | 1.422 | 1.00 | |
| 49_I | 248_V | 1.421 | 1.00 | |
| 237_N | 241_M | 1.416 | 1.00 | |
| 84_G | 87_A | 1.412 | 1.00 | |
| 272_L | 275_Q | 1.408 | 1.00 | |
| 272_L | 276_H | 1.402 | 0.99 | |
| 82_N | 378_S | 1.399 | 0.99 | |
| 37_I | 44_V | 1.396 | 0.99 | |
| 379_Q | 405_T | 1.395 | 0.99 | |
| 131_V | 342_L | 1.392 | 0.99 | |
| 79_A | 374_M | 1.391 | 0.99 | |
| 114_M | 126_W | 1.386 | 0.99 | |
| 21_L | 242_R | 1.379 | 0.99 | |
| 440_L | 444_M | 1.372 | 0.99 | |
| 83_L | 87_A | 1.368 | 0.99 | |
| 409_L | 413_L | 1.362 | 0.99 | |
| 320_K | 324_K | 1.356 | 0.99 | |
| 13_T | 234_R | 1.344 | 0.99 | |
| 67_V | 395_K | 1.34 | 0.99 | |
| 221_T | 303_F | 1.34 | 0.99 | |
| 128_L | 132_L | 1.339 | 0.99 | |
| 132_L | 339_T | 1.336 | 0.99 | |
| 58_I | 376_L | 1.336 | 0.99 | |
| 69_N | 81_E | 1.327 | 0.99 | |
| 434_A | 437_V | 1.321 | 0.99 | |
| 131_V | 339_T | 1.317 | 0.99 | |
| 158_A | 162_I | 1.316 | 0.99 | |
| 43_S | 194_F | 1.31 | 0.99 | |
| 51_G | 208_V | 1.305 | 0.99 | |
| 107_V | 131_V | 1.295 | 0.99 | |
| 127_V | 346_V | 1.291 | 0.99 | |
| 275_Q | 280_T | 1.29 | 0.99 | |
| 110_F | 291_L | 1.288 | 0.99 | |
| 138_N | 299_N | 1.285 | 0.99 | |
| 89_Y | 93_W | 1.284 | 0.99 | |
| 402_V | 406_I | 1.284 | 0.99 | |
| 386_L | 389_E | 1.28 | 0.99 | |
| 314_E | 323_S | 1.279 | 0.99 | |
| 72_A | 223_G | 1.276 | 0.99 | |
| 135_C | 336_L | 1.275 | 0.99 | |
| 103_A | 342_L | 1.274 | 0.99 | |
| 231_S | 234_R | 1.27 | 0.99 | |
| 309_L | 318_A | 1.27 | 0.99 | |
| 275_Q | 283_A | 1.268 | 0.99 | |
| 107_V | 298_I | 1.267 | 0.99 | |
| 57_I | 407_G | 1.267 | 0.99 | |
| 377_L | 381_A | 1.257 | 0.99 | |
| 11_L | 146_G | 1.256 | 0.99 | |
| 59_M | 240_P | 1.252 | 0.99 | |
| 387_P | 391_V | 1.246 | 0.98 | |
| 66_S | 78_Y | 1.245 | 0.98 | |
| 14_R | 18_F | 1.244 | 0.98 | |
| 54_A | 411_F | 1.241 | 0.98 | |
| 24_A | 243_I | 1.238 | 0.98 | |
| 324_K | 332_W | 1.236 | 0.98 | |
| 134_I | 298_I | 1.235 | 0.98 | |
| 430_Y | 433_F | 1.232 | 0.98 | |
| 168_F | 253_V | 1.23 | 0.98 | |
| 229_E | 395_K | 1.228 | 0.98 | |
| 31_Y | 109_A | 1.227 | 0.98 | |
| 167_G | 257_I | 1.226 | 0.98 | |
| 340_T | 344_F | 1.225 | 0.98 | |
| 266_A | 272_L | 1.223 | 0.98 | |
| 59_M | 236_I | 1.222 | 0.98 | |
| 159_T | 289_V | 1.222 | 0.98 | |
| 11_L | 16_I | 1.207 | 0.98 | |
| 325_T | 329_G | 1.207 | 0.98 | |
| 20_A | 239_V | 1.206 | 0.98 | |
| 135_C | 139_L | 1.195 | 0.98 | |
| 124_W | 128_L | 1.194 | 0.98 | |
| 164_I | 249_G | 1.192 | 0.98 | |
| 8_K | 329_G | 1.19 | 0.98 | |
| 180_Q | 185_H | 1.181 | 0.98 | |
| 77_R | 81_E | 1.179 | 0.98 | |
| 7_L | 310_H | 1.175 | 0.98 | |
| 71_A | 77_R | 1.165 | 0.97 | |
| 142_V | 303_F | 1.164 | 0.97 | |
| 333_V | 336_L | 1.162 | 0.97 | |
| 93_W | 439_L | 1.159 | 0.97 | |
| 36_A | 40_A | 1.157 | 0.97 | |
| 84_G | 444_M | 1.154 | 0.97 | |
| 46_L | 201_M | 1.149 | 0.97 | |
| 45_L | 252_F | 1.149 | 0.97 | |
| 373_I | 413_L | 1.148 | 0.97 | |
| 222_A | 232_I | 1.139 | 0.97 | |
| 213_G | 368_T | 1.137 | 0.97 | |
| 417_G | 421_Y | 1.135 | 0.97 | |
| 49_I | 53_I | 1.134 | 0.97 | |
| 403_A | 406_I | 1.134 | 0.97 | |
| 387_P | 390_E | 1.128 | 0.97 | |
| 79_A | 87_A | 1.127 | 0.97 | |
| 136_A | 139_L | 1.121 | 0.97 | |
| 14_R | 147_E | 1.117 | 0.96 | |
| 93_W | 318_A | 1.112 | 0.96 | |
| 302_V | 306_G | 1.108 | 0.96 | |
| 445_F | 448_R | 1.105 | 0.96 | |
| 172_I | 181_P | 1.103 | 0.96 | |
| 139_L | 326_S | 1.1 | 0.96 | |
| 373_I | 377_L | 1.093 | 0.96 | |
| 68_H | 395_K | 1.093 | 0.96 | |
| 140_M | 328_R | 1.091 | 0.96 | |
| 400_G | 403_A | 1.086 | 0.96 | |
| 414_F | 418_L | 1.085 | 0.96 | |
| 139_L | 330_I | 1.078 | 0.95 | |
| 376_L | 409_L | 1.075 | 0.95 | |
| 149_E | 299_N | 1.07 | 0.95 | |
| 310_H | 325_T | 1.067 | 0.95 | |
| 198_W | 201_M | 1.066 | 0.95 | |
| 62_L | 75_F | 1.066 | 0.95 | |
| 46_L | 49_I | 1.065 | 0.95 | |
| 427_I | 430_Y | 1.064 | 0.95 | |
| 226_K | 231_S | 1.063 | 0.95 | |
| 216_E | 220_I | 1.062 | 0.95 | |
| 249_G | 253_V | 1.059 | 0.95 | |
| 20_A | 218_I | 1.058 | 0.95 | |
| 148_L | 152_F | 1.056 | 0.95 | |
| 10_G | 143_K | 1.053 | 0.95 | |
| 57_I | 404_T | 1.052 | 0.95 | |
| 52_G | 212_Y | 1.051 | 0.94 | |
| 16_I | 235_A | 1.048 | 0.94 | |
| 245_V | 249_G | 1.045 | 0.94 | |
| 73_S | 76_S | 1.043 | 0.94 | |
| 328_R | 332_W | 1.041 | 0.94 | |
| 68_H | 389_E | 1.041 | 0.94 | |
| 427_I | 431_V | 1.035 | 0.94 | |
| 60_R | 237_N | 1.035 | 0.94 | |
| 15_H | 147_E | 1.033 | 0.94 | |
| 114_M | 291_L | 1.029 | 0.94 | |
| 133_I | 295_L | 1.028 | 0.94 | |
| 76_S | 311_G | 1.02 | 0.93 | |
| 441_I | 444_M | 1.019 | 0.93 | |
| 132_L | 136_A | 1.018 | 0.93 | |
| 68_H | 391_V | 1.018 | 0.93 | |
| 161_I | 165_V | 1.016 | 0.93 | |
| 434_A | 438_V | 1.01 | 0.93 | |
| 443_W | 447_R | 1.009 | 0.93 | |
| 402_V | 405_T | 1.007 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4djkA | 2 | 0.9606 | 100 | 0.323 | Contact Map | 0.597 |
| 3l1lA | 1 | 0.9453 | 100 | 0.329 | Contact Map | 0.684 |
| 3giaA | 1 | 0.9234 | 100 | 0.355 | Contact Map | 0.605 |
| 3dh4A | 4 | 0.9344 | 98.1 | 0.891 | Contact Map | 0.393 |
| 2xq2A | 1 | 0.9344 | 97.7 | 0.9 | Contact Map | 0.474 |
| 2jlnA | 1 | 0.8906 | 97.5 | 0.903 | Contact Map | 0.417 |
| 2a65A | 1 | 0.9322 | 94.2 | 0.929 | Contact Map | 0.434 |
| 4m48A | 1 | 0.954 | 92.8 | 0.933 | Contact Map | 0.39 |
| 2wswA | 1 | 0.1575 | 6.4 | 0.971 | Contact Map | 0.376 |
| 3j1zP | 2 | 0.2823 | 6.1 | 0.971 | Contact Map | 0.301 |
Sequence Conservation (Image Generated using WebLogo v3)