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YJEH - Inner membrane protein YjeH
UniProt: P39277 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12470
Length: 418 (391)
Sequences: 10804
Seq/Len: 27.63
YJEH
Paralog alert: 0.82 [within 20: 0.37] - ratio of genomes with paralogs
Cluster includes: ADIC ANSP ARCD AROP CADB CYCA FRLA GABP GADC LYSP MMUP PHEP PLAP POTE PROY PUUP YBAT YCAM YGJI YIFK YJEH YJEM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
305_Y 317_N 4.233 1.00
134_W 323_L 3.608 1.00
298_A 307_A 3.135 1.00
9_G 211_K 3.134 1.00
308_R 317_N 3.125 1.00
49_I 229_G 2.975 1.00
215_R 219_R 2.932 1.00
212_N 215_R 2.87 1.00
364_K 368_G 2.804 1.00
356_L 378_G 2.633 1.00
127_L 330_T 2.54 1.00
320_N 324_G 2.453 1.00
310_S 316_N 2.436 1.00
210_F 216_D 2.423 1.00
359_M 377_G 2.423 1.00
89_G 297_Q 2.377 1.00
266_G 270_I 2.336 1.00
246_G 249_M 2.331 1.00
14_I 223_I 2.278 1.00
305_Y 308_R 2.247 1.00
10_L 223_I 2.244 1.00
295_W 299_Q 2.213 1.00
375_V 379_L 2.203 1.00
301_N 304_H 2.161 1.00
10_L 216_D 2.136 1.00
58_V 359_M 2.11 1.00
160_V 238_V 2.093 1.00
61_I 366_L 2.066 1.00
50_I 376_V 2.048 1.00
73_A 300_H 2.042 1.00
80_F 364_K 2.029 1.00
4_L 309_L 2.002 1.00
77_G 85_E 2 1.00
9_G 12_Q 1.991 1.00
77_G 82_S 1.984 1.00
208_S 299_Q 1.983 1.00
127_L 327_V 1.944 1.00
10_L 14_I 1.939 1.00
306_L 321_A 1.933 1.00
219_R 223_I 1.926 1.00
138_T 316_N 1.913 1.00
209_E 292_R 1.899 1.00
50_I 54_P 1.895 1.00
80_F 360_L 1.86 1.00
134_W 319_L 1.845 1.00
142_S 146_N 1.829 1.00
135_Y 139_R 1.827 1.00
364_K 367_Q 1.816 1.00
13_G 210_F 1.815 1.00
155_I 160_V 1.784 1.00
93_L 322_V 1.781 1.00
138_T 320_N 1.77 1.00
131_A 327_V 1.742 1.00
46_P 233_W 1.723 1.00
44_A 189_A 1.708 1.00
212_N 216_D 1.689 1.00
88_T 357_L 1.664 1.00
76_V 88_T 1.649 1.00
8_L 12_Q 1.614 1.00
12_Q 149_T 1.604 1.00
372_L 376_V 1.598 1.00
226_L 230_L 1.594 1.00
157_A 160_V 1.591 1.00
212_N 219_R 1.59 1.00
213_P 218_P 1.585 1.00
14_I 227_L 1.581 1.00
269_W 273_V 1.575 1.00
126_E 330_T 1.566 1.00
291_A 319_L 1.537 1.00
222_M 226_L 1.537 1.00
206_L 288_Q 1.52 1.00
137_G 284_N 1.512 1.00
363_C 375_V 1.505 1.00
130_L 326_C 1.491 1.00
156_V 160_V 1.489 1.00
294_V 318_A 1.485 1.00
131_A 323_L 1.48 1.00
290_F 322_V 1.478 1.00
360_L 378_G 1.47 1.00
76_V 357_L 1.454 1.00
317_N 321_A 1.453 1.00
155_I 159_I 1.445 1.00
80_F 84_L 1.439 1.00
33_A 41_S 1.424 1.00
264_G 267_A 1.419 1.00
304_H 307_A 1.409 1.00
379_L 383_L 1.398 0.99
81_G 84_L 1.398 0.99
56_A 225_L 1.396 0.99
324_G 328_V 1.392 0.99
310_S 314_I 1.386 0.99
55_I 359_M 1.381 0.99
124_L 128_G 1.375 0.99
69_A 208_S 1.375 0.99
8_L 145_A 1.371 0.99
66_Y 78_M 1.37 0.99
48_L 193_M 1.366 0.99
134_W 320_N 1.365 0.99
304_H 308_R 1.357 0.99
123_L 127_L 1.354 0.99
360_L 364_K 1.35 0.99
10_L 219_R 1.35 0.99
371_R 374_A 1.341 0.99
18_S 227_L 1.336 0.99
127_L 131_A 1.331 0.99
21_L 228_A 1.323 0.99
371_R 375_V 1.318 0.99
86_R 90_W 1.317 0.99
378_G 382_V 1.306 0.99
17_L 224_G 1.291 0.99
63_G 75_F 1.29 0.99
141_A 288_Q 1.286 0.99
356_L 360_L 1.277 0.99
42_L 237_V 1.277 0.99
5_K 313_H 1.265 0.99
133_V 283_L 1.263 0.99
308_R 316_N 1.258 0.99
130_L 323_L 1.257 0.99
68_S 74_H 1.255 0.99
216_D 219_R 1.253 0.99
56_A 221_L 1.237 0.98
198_V 351_F 1.228 0.98
11_A 146_N 1.221 0.98
79_A 361_A 1.22 0.98
309_L 313_H 1.22 0.98
155_I 158_L 1.218 0.98
74_H 78_M 1.204 0.98
160_V 164_W 1.198 0.98
61_I 64_R 1.19 0.98
147_L 151_I 1.188 0.98
134_W 138_T 1.187 0.98
34_A 41_S 1.183 0.98
51_L 380_L 1.174 0.98
295_W 309_L 1.168 0.97
11_A 15_G 1.167 0.97
49_I 197_F 1.166 0.97
58_V 374_A 1.162 0.97
249_M 262_L 1.155 0.97
120_W 124_L 1.149 0.97
43_W 46_P 1.148 0.97
93_L 294_V 1.14 0.97
7_E 142_S 1.14 0.97
4_L 295_W 1.132 0.97
249_M 261_Q 1.131 0.97
162_I 167_D 1.13 0.97
8_L 13_G 1.123 0.97
43_W 186_L 1.119 0.96
230_L 234_G 1.117 0.96
155_I 163_W 1.115 0.96
379_L 382_V 1.115 0.96
76_V 84_L 1.112 0.96
90_W 302_P 1.11 0.96
332_V 335_A 1.108 0.96
356_L 382_V 1.107 0.96
201_E 205_H 1.104 0.96
211_K 216_D 1.099 0.96
135_Y 138_T 1.096 0.96
57_I 222_M 1.095 0.96
179_G 182_E 1.094 0.96
317_N 320_N 1.092 0.96
207_A 217_F 1.092 0.96
312_R 316_N 1.092 0.96
70_G 73_A 1.09 0.96
299_Q 307_A 1.09 0.96
182_E 185_G 1.088 0.96
138_T 314_I 1.083 0.96
112_Q 125_A 1.079 0.95
12_Q 146_N 1.076 0.95
13_G 220_A 1.074 0.95
158_L 162_I 1.072 0.95
362_G 374_A 1.071 0.95
73_A 296_S 1.071 0.95
54_P 373_L 1.063 0.95
171_A 174_P 1.063 0.95
260_V 265_V 1.062 0.95
26_V 235_C 1.06 0.95
161_A 165_A 1.057 0.95
104_L 283_L 1.055 0.95
96_I 101_P 1.045 0.94
146_N 150_V 1.034 0.94
59_F 72_V 1.032 0.94
234_G 238_V 1.026 0.94
95_V 99_G 1.022 0.93
46_P 50_I 1.021 0.93
148_Q 284_N 1.019 0.93
12_Q 145_A 1.018 0.93
14_I 17_L 1.017 0.93
229_G 233_W 1.017 0.93
9_G 142_S 1.016 0.93
133_V 284_N 1.014 0.93
138_T 310_S 1.013 0.93
372_L 375_V 1.012 0.93
310_S 313_H 1.011 0.93
151_I 281_A 1.008 0.93
62_L 362_G 1.003 0.93
363_C 378_G 1.003 0.93
17_L 203_F 1.001 0.92
331_L 334_H 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3giaA10.97851000.316Contact Map0.584
3l1lA10.99281000.319Contact Map0.698
4djkA20.98331000.361Contact Map0.617
2jlnA10.9187980.886Contact Map0.456
3dh4A40.971397.70.892Contact Map0.392
2xq2A10.971397.40.9Contact Map0.484
2a65A10.94591.70.93Contact Map0.385
4m48A10.964177.30.943Contact Map0.411
4ainA30.916344.60.954Contact Map0.409
4c7rA30.930641.30.955Contact Map0.399
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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