| UniProt: | P0AAE0 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG12504 | ||
| Length: | 470 (445) | ||
| Sequences: | 10789 | ||
| Seq/Len: | 24.24 |
| CYCA
Paralog alert: 0.82 [within 20: 0.39] - ratio of genomes with paralogs Cluster includes: ADIC ANSP ARCD AROP CADB CYCA FRLA GABP GADC LYSP MMUP PHEP PLAP POTE PROY PUUP YBAT YCAM YGJI YIFK YJEH YJEM |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 334_A | 346_K | 4.235 | 1.00 | |
| 388_T | 423_M | 3.432 | 1.00 | |
| 147_L | 352_C | 3.319 | 1.00 | |
| 179_G | 266_V | 3.284 | 1.00 | |
| 326_A | 336_A | 3.109 | 1.00 | |
| 24_T | 239_K | 3.106 | 1.00 | |
| 337_K | 346_K | 2.94 | 1.00 | |
| 243_K | 247_R | 2.905 | 1.00 | |
| 240_D | 243_K | 2.9 | 1.00 | |
| 64_G | 257_I | 2.782 | 1.00 | |
| 396_V | 400_Q | 2.777 | 1.00 | |
| 140_L | 359_V | 2.699 | 1.00 | |
| 294_A | 298_V | 2.427 | 1.00 | |
| 420_W | 424_A | 2.423 | 1.00 | |
| 329_G | 333_K | 2.386 | 1.00 | |
| 391_L | 422_C | 2.364 | 1.00 | |
| 334_A | 337_K | 2.296 | 1.00 | |
| 323_F | 327_Q | 2.292 | 1.00 | |
| 349_T | 353_I | 2.289 | 1.00 | |
| 238_T | 244_S | 2.285 | 1.00 | |
| 339_S | 345_A | 2.265 | 1.00 | |
| 275_S | 289_L | 2.259 | 1.00 | |
| 29_Q | 251_S | 2.226 | 1.00 | |
| 104_G | 325_L | 2.205 | 1.00 | |
| 25_N | 251_S | 2.197 | 1.00 | |
| 65_F | 421_V | 2.164 | 1.00 | |
| 73_A | 391_L | 2.13 | 1.00 | |
| 25_N | 244_S | 2.117 | 1.00 | |
| 88_S | 328_E | 2.115 | 1.00 | |
| 177_V | 181_V | 2.051 | 1.00 | |
| 92_S | 100_G | 2.047 | 1.00 | |
| 92_S | 97_P | 2.042 | 1.00 | |
| 55_S | 214_F | 2.036 | 1.00 | |
| 24_T | 27_H | 2.001 | 1.00 | |
| 335_F | 350_F | 2 | 1.00 | |
| 272_P | 275_S | 1.995 | 1.00 | |
| 236_A | 327_Q | 1.979 | 1.00 | |
| 19_L | 338_L | 1.957 | 1.00 | |
| 95_L | 396_V | 1.936 | 1.00 | |
| 95_L | 392_C | 1.922 | 1.00 | |
| 417_L | 421_V | 1.919 | 1.00 | |
| 396_V | 399_K | 1.896 | 1.00 | |
| 25_N | 29_Q | 1.891 | 1.00 | |
| 28_I | 238_T | 1.84 | 1.00 | |
| 151_L | 345_A | 1.834 | 1.00 | |
| 76_E | 398_R | 1.833 | 1.00 | |
| 247_R | 251_S | 1.825 | 1.00 | |
| 237_E | 320_R | 1.813 | 1.00 | |
| 65_F | 69_F | 1.81 | 1.00 | |
| 166_M | 170_V | 1.81 | 1.00 | |
| 147_L | 348_L | 1.806 | 1.00 | |
| 108_W | 351_S | 1.772 | 1.00 | |
| 151_L | 349_T | 1.738 | 1.00 | |
| 48_T | 56_I | 1.729 | 1.00 | |
| 59_V | 217_G | 1.726 | 1.00 | |
| 148_T | 152_A | 1.709 | 1.00 | |
| 447_P | 451_I | 1.708 | 1.00 | |
| 169_I | 173_V | 1.685 | 1.00 | |
| 155_K | 159_E | 1.657 | 1.00 | |
| 444_L | 448_L | 1.644 | 1.00 | |
| 414_L | 418_M | 1.641 | 1.00 | |
| 27_H | 162_F | 1.637 | 1.00 | |
| 240_D | 244_S | 1.636 | 1.00 | |
| 98_W | 457_W | 1.619 | 1.00 | |
| 91_A | 103_T | 1.611 | 1.00 | |
| 103_T | 389_I | 1.606 | 1.00 | |
| 73_A | 419_C | 1.594 | 1.00 | |
| 392_C | 423_M | 1.589 | 1.00 | |
| 240_D | 247_R | 1.586 | 1.00 | |
| 61_M | 261_V | 1.579 | 1.00 | |
| 23_L | 27_H | 1.576 | 1.00 | |
| 241_P | 246_P | 1.555 | 1.00 | |
| 29_Q | 255_R | 1.548 | 1.00 | |
| 140_L | 356_L | 1.547 | 1.00 | |
| 455_L | 459_F | 1.529 | 1.00 | |
| 126_A | 138_A | 1.529 | 1.00 | |
| 424_A | 428_F | 1.512 | 1.00 | |
| 250_N | 254_I | 1.512 | 1.00 | |
| 339_S | 343_V | 1.488 | 1.00 | |
| 322_L | 347_G | 1.484 | 1.00 | |
| 285_E | 289_L | 1.481 | 1.00 | |
| 395_L | 420_W | 1.479 | 1.00 | |
| 144_V | 356_L | 1.474 | 1.00 | |
| 333_K | 336_A | 1.465 | 1.00 | |
| 431_V | 435_L | 1.455 | 1.00 | |
| 346_K | 350_F | 1.454 | 1.00 | |
| 143_I | 355_L | 1.442 | 1.00 | |
| 285_E | 288_V | 1.441 | 1.00 | |
| 451_I | 455_L | 1.439 | 1.00 | |
| 318_T | 351_S | 1.437 | 1.00 | |
| 319_S | 348_L | 1.436 | 1.00 | |
| 254_I | 258_M | 1.432 | 1.00 | |
| 144_V | 352_C | 1.423 | 1.00 | |
| 49_I | 56_I | 1.418 | 1.00 | |
| 96_G | 99_A | 1.418 | 1.00 | |
| 25_N | 247_R | 1.413 | 1.00 | |
| 152_A | 341_R | 1.404 | 0.99 | |
| 79_L | 409_I | 1.389 | 0.99 | |
| 95_L | 99_A | 1.388 | 0.99 | |
| 341_R | 345_A | 1.378 | 0.99 | |
| 445_V | 448_L | 1.375 | 0.99 | |
| 91_A | 389_I | 1.374 | 0.99 | |
| 297_S | 301_F | 1.367 | 0.99 | |
| 81_N | 93_D | 1.36 | 0.99 | |
| 288_V | 293_P | 1.358 | 0.99 | |
| 333_K | 337_K | 1.357 | 0.99 | |
| 322_L | 331_A | 1.354 | 0.99 | |
| 55_S | 207_F | 1.336 | 0.99 | |
| 70_V | 391_L | 1.334 | 0.99 | |
| 207_F | 214_F | 1.332 | 0.99 | |
| 140_L | 144_V | 1.332 | 0.99 | |
| 94_L | 393_S | 1.329 | 0.99 | |
| 394_Y | 419_C | 1.321 | 0.99 | |
| 234_T | 316_F | 1.321 | 0.99 | |
| 353_I | 357_G | 1.316 | 0.99 | |
| 36_A | 256_I | 1.314 | 0.99 | |
| 23_L | 158_G | 1.312 | 0.99 | |
| 193_V | 198_A | 1.309 | 0.99 | |
| 150_N | 312_N | 1.305 | 0.99 | |
| 32_A | 252_I | 1.291 | 0.99 | |
| 279_E | 285_E | 1.291 | 0.99 | |
| 392_C | 396_V | 1.285 | 0.99 | |
| 84_Y | 236_A | 1.285 | 0.99 | |
| 454_G | 458_L | 1.277 | 0.99 | |
| 71_M | 253_P | 1.271 | 0.99 | |
| 119_V | 143_I | 1.271 | 0.99 | |
| 147_L | 349_T | 1.27 | 0.99 | |
| 139_S | 359_V | 1.265 | 0.99 | |
| 176_I | 262_F | 1.263 | 0.99 | |
| 146_L | 311_A | 1.262 | 0.99 | |
| 33_I | 255_R | 1.262 | 0.99 | |
| 170_V | 174_S | 1.26 | 0.99 | |
| 181_V | 187_F | 1.26 | 0.99 | |
| 20_R | 342_A | 1.257 | 0.99 | |
| 423_M | 427_V | 1.254 | 0.99 | |
| 244_S | 247_R | 1.253 | 0.99 | |
| 63_I | 221_A | 1.251 | 0.99 | |
| 71_M | 249_I | 1.248 | 0.99 | |
| 122_I | 304_L | 1.248 | 0.99 | |
| 416_K | 420_W | 1.247 | 0.99 | |
| 401_R | 404_L | 1.246 | 0.98 | |
| 115_G | 355_L | 1.245 | 0.98 | |
| 78_L | 90_F | 1.235 | 0.98 | |
| 147_L | 151_L | 1.232 | 0.98 | |
| 242_E | 409_I | 1.229 | 0.98 | |
| 327_Q | 336_A | 1.223 | 0.98 | |
| 19_L | 323_F | 1.218 | 0.98 | |
| 448_L | 451_I | 1.217 | 0.98 | |
| 57_I | 265_I | 1.215 | 0.98 | |
| 143_I | 352_C | 1.214 | 0.98 | |
| 101_Y | 105_W | 1.213 | 0.98 | |
| 119_V | 311_A | 1.209 | 0.98 | |
| 346_K | 349_T | 1.206 | 0.98 | |
| 96_G | 458_L | 1.198 | 0.98 | |
| 388_T | 392_C | 1.197 | 0.98 | |
| 69_F | 421_V | 1.191 | 0.98 | |
| 179_G | 270_V | 1.191 | 0.98 | |
| 337_K | 345_A | 1.187 | 0.98 | |
| 23_L | 28_I | 1.185 | 0.98 | |
| 26_R | 159_E | 1.181 | 0.98 | |
| 154_V | 316_F | 1.175 | 0.98 | |
| 338_L | 342_A | 1.175 | 0.98 | |
| 288_V | 296_A | 1.172 | 0.98 | |
| 26_R | 30_L | 1.169 | 0.97 | |
| 43_M | 121_A | 1.168 | 0.97 | |
| 414_L | 417_L | 1.167 | 0.97 | |
| 180_L | 266_V | 1.165 | 0.97 | |
| 455_L | 458_L | 1.163 | 0.97 | |
| 417_L | 420_W | 1.16 | 0.97 | |
| 171_A | 302_V | 1.158 | 0.97 | |
| 69_F | 418_M | 1.152 | 0.97 | |
| 61_M | 65_F | 1.143 | 0.97 | |
| 91_A | 99_A | 1.142 | 0.97 | |
| 58_F | 214_F | 1.142 | 0.97 | |
| 66_M | 425_F | 1.141 | 0.97 | |
| 388_T | 427_V | 1.14 | 0.97 | |
| 402_P | 408_S | 1.136 | 0.97 | |
| 148_T | 151_L | 1.132 | 0.97 | |
| 235_A | 245_L | 1.132 | 0.97 | |
| 258_M | 262_F | 1.129 | 0.97 | |
| 226_V | 383_F | 1.128 | 0.97 | |
| 83_E | 89_D | 1.126 | 0.97 | |
| 105_W | 331_A | 1.119 | 0.96 | |
| 89_D | 93_D | 1.104 | 0.96 | |
| 27_H | 159_E | 1.102 | 0.96 | |
| 440_R | 444_L | 1.101 | 0.96 | |
| 323_F | 338_L | 1.094 | 0.96 | |
| 22_N | 155_K | 1.093 | 0.96 | |
| 459_F | 462_K | 1.093 | 0.96 | |
| 211_L | 214_F | 1.083 | 0.96 | |
| 185_M | 194_E | 1.082 | 0.96 | |
| 262_F | 266_V | 1.081 | 0.95 | |
| 151_L | 339_S | 1.081 | 0.95 | |
| 169_I | 259_F | 1.076 | 0.95 | |
| 80_S | 404_L | 1.071 | 0.95 | |
| 126_A | 304_L | 1.069 | 0.95 | |
| 160_M | 164_F | 1.066 | 0.95 | |
| 151_L | 343_V | 1.065 | 0.95 | |
| 108_W | 322_L | 1.064 | 0.95 | |
| 292_L | 295_A | 1.063 | 0.95 | |
| 64_G | 225_F | 1.06 | 0.95 | |
| 229_E | 233_T | 1.051 | 0.94 | |
| 161_E | 312_N | 1.049 | 0.94 | |
| 74_M | 87_F | 1.047 | 0.94 | |
| 30_L | 162_F | 1.045 | 0.94 | |
| 85_K | 88_S | 1.042 | 0.94 | |
| 136_W | 140_L | 1.038 | 0.94 | |
| 24_T | 155_K | 1.036 | 0.94 | |
| 180_L | 185_M | 1.033 | 0.94 | |
| 28_I | 248_A | 1.032 | 0.94 | |
| 48_T | 52_A | 1.03 | 0.94 | |
| 88_S | 324_G | 1.028 | 0.94 | |
| 239_K | 244_S | 1.028 | 0.94 | |
| 32_A | 231_V | 1.028 | 0.94 | |
| 173_V | 177_V | 1.027 | 0.94 | |
| 441_Q | 445_V | 1.026 | 0.94 | |
| 448_L | 452_A | 1.025 | 0.93 | |
| 428_F | 432_L | 1.024 | 0.93 | |
| 457_W | 461_G | 1.018 | 0.93 | |
| 105_W | 453_L | 1.017 | 0.93 | |
| 399_K | 402_P | 1.015 | 0.93 | |
| 27_H | 158_G | 1.006 | 0.93 | |
| 452_A | 456_G | 1.002 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4djkA | 2 | 0.9362 | 100 | 0.356 | Contact Map | 0.592 |
| 3l1lA | 1 | 0.917 | 100 | 0.372 | Contact Map | 0.686 |
| 3giaA | 1 | 0.8957 | 100 | 0.386 | Contact Map | 0.604 |
| 2jlnA | 1 | 0.8894 | 98.5 | 0.883 | Contact Map | 0.422 |
| 3dh4A | 4 | 0.9298 | 98 | 0.897 | Contact Map | 0.41 |
| 2xq2A | 1 | 0.9277 | 97.6 | 0.907 | Contact Map | 0.5 |
| 2a65A | 1 | 0.9106 | 94.9 | 0.93 | Contact Map | 0.37 |
| 4m48A | 1 | 0.9213 | 93.2 | 0.935 | Contact Map | 0.319 |
| 1wazA | 1 | 0.0957 | 13.5 | 0.968 | Contact Map | 0.72 |
| 1m56C | 2 | 0.1426 | 6.4 | 0.973 | Contact Map | 0.506 |
Sequence Conservation (Image Generated using WebLogo v3)