| UniProt: | P77610 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG13776 | ||
| Length: | 499 (449) | ||
| Sequences: | 9689 | ||
| Seq/Len: | 21.58 |
| ANSP
Paralog alert: 0.80 [within 20: 0.33] - ratio of genomes with paralogs Cluster includes: ADIC ANSP ARCD AROP CADB CYCA FRLA GABP GADC LYSP MMUP PHEP PLAP POTE PROY PUUP YBAT YCAM YGJI YIFK YJEH YJEM |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 342_F | 354_A | 4.04 | 1.00 | |
| 394_A | 430_L | 3.821 | 1.00 | |
| 156_G | 360_L | 3.347 | 1.00 | |
| 334_A | 344_A | 3.274 | 1.00 | |
| 31_G | 247_K | 3.071 | 1.00 | |
| 188_G | 274_L | 3.048 | 1.00 | |
| 149_L | 367_V | 2.925 | 1.00 | |
| 402_R | 406_A | 2.862 | 1.00 | |
| 251_T | 255_K | 2.825 | 1.00 | |
| 71_G | 265_G | 2.734 | 1.00 | |
| 397_I | 429_T | 2.726 | 1.00 | |
| 345_K | 354_A | 2.712 | 1.00 | |
| 248_D | 251_T | 2.605 | 1.00 | |
| 427_W | 431_L | 2.546 | 1.00 | |
| 337_G | 341_S | 2.543 | 1.00 | |
| 357_L | 361_V | 2.423 | 1.00 | |
| 302_Y | 306_I | 2.421 | 1.00 | |
| 246_C | 252_M | 2.325 | 1.00 | |
| 342_F | 345_K | 2.3 | 1.00 | |
| 347_S | 353_Y | 2.258 | 1.00 | |
| 72_L | 428_L | 2.218 | 1.00 | |
| 331_R | 335_M | 2.213 | 1.00 | |
| 62_A | 222_A | 2.115 | 1.00 | |
| 80_A | 397_I | 2.104 | 1.00 | |
| 111_G | 333_M | 2.103 | 1.00 | |
| 343_M | 358_A | 2.097 | 1.00 | |
| 32_N | 252_M | 2.076 | 1.00 | |
| 36_Q | 259_S | 2.071 | 1.00 | |
| 186_V | 190_V | 2.068 | 1.00 | |
| 32_N | 259_S | 2.048 | 1.00 | |
| 452_A | 456_I | 2.047 | 1.00 | |
| 244_G | 335_M | 2.037 | 1.00 | |
| 283_A | 297_K | 2.007 | 1.00 | |
| 99_R | 107_A | 2.003 | 1.00 | |
| 31_G | 34_Q | 1.976 | 1.00 | |
| 102_L | 402_R | 1.952 | 1.00 | |
| 99_R | 104_E | 1.935 | 1.00 | |
| 95_V | 336_G | 1.933 | 1.00 | |
| 280_P | 283_A | 1.91 | 1.00 | |
| 105_K | 465_W | 1.908 | 1.00 | |
| 26_Y | 346_M | 1.894 | 1.00 | |
| 463_I | 467_G | 1.845 | 1.00 | |
| 398_V | 430_L | 1.839 | 1.00 | |
| 402_R | 405_K | 1.832 | 1.00 | |
| 431_L | 435_S | 1.821 | 1.00 | |
| 35_V | 246_C | 1.813 | 1.00 | |
| 160_M | 357_L | 1.808 | 1.00 | |
| 115_F | 359_T | 1.805 | 1.00 | |
| 424_F | 428_L | 1.804 | 1.00 | |
| 83_E | 404_R | 1.759 | 1.00 | |
| 80_A | 426_S | 1.749 | 1.00 | |
| 72_L | 76_F | 1.744 | 1.00 | |
| 156_G | 356_I | 1.736 | 1.00 | |
| 160_M | 353_Y | 1.723 | 1.00 | |
| 178_V | 182_V | 1.713 | 1.00 | |
| 245_E | 328_R | 1.707 | 1.00 | |
| 164_K | 168_E | 1.704 | 1.00 | |
| 157_T | 161_I | 1.703 | 1.00 | |
| 55_R | 63_L | 1.702 | 1.00 | |
| 66_V | 225_L | 1.697 | 1.00 | |
| 68_L | 269_V | 1.682 | 1.00 | |
| 102_L | 398_V | 1.68 | 1.00 | |
| 248_D | 255_K | 1.665 | 1.00 | |
| 421_G | 425_T | 1.66 | 1.00 | |
| 175_L | 179_L | 1.65 | 1.00 | |
| 255_K | 259_S | 1.643 | 1.00 | |
| 453_A | 456_I | 1.631 | 1.00 | |
| 455_P | 459_I | 1.627 | 1.00 | |
| 32_N | 36_Q | 1.596 | 1.00 | |
| 110_A | 395_F | 1.595 | 1.00 | |
| 400_Q | 426_S | 1.591 | 1.00 | |
| 401_M | 427_W | 1.573 | 1.00 | |
| 86_L | 416_S | 1.572 | 1.00 | |
| 189_T | 193_G | 1.564 | 1.00 | |
| 152_L | 363_Y | 1.557 | 1.00 | |
| 459_I | 463_I | 1.556 | 1.00 | |
| 327_G | 356_I | 1.54 | 1.00 | |
| 30_M | 34_Q | 1.539 | 1.00 | |
| 133_M | 147_F | 1.532 | 1.00 | |
| 76_F | 428_L | 1.507 | 1.00 | |
| 249_P | 254_P | 1.506 | 1.00 | |
| 262_W | 266_L | 1.502 | 1.00 | |
| 248_D | 252_M | 1.481 | 1.00 | |
| 293_T | 297_K | 1.474 | 1.00 | |
| 354_A | 358_A | 1.47 | 1.00 | |
| 149_L | 364_V | 1.467 | 1.00 | |
| 56_L | 63_L | 1.455 | 1.00 | |
| 36_Q | 263_R | 1.444 | 1.00 | |
| 34_Q | 171_F | 1.436 | 1.00 | |
| 98_A | 395_F | 1.434 | 1.00 | |
| 98_A | 110_A | 1.434 | 1.00 | |
| 293_T | 296_S | 1.409 | 1.00 | |
| 347_S | 351_V | 1.404 | 0.99 | |
| 305_S | 309_I | 1.397 | 0.99 | |
| 326_T | 359_T | 1.388 | 0.99 | |
| 73_F | 432_F | 1.387 | 0.99 | |
| 430_L | 434_L | 1.377 | 0.99 | |
| 185_L | 270_G | 1.376 | 0.99 | |
| 449_Y | 452_A | 1.37 | 0.99 | |
| 438_V | 442_F | 1.369 | 0.99 | |
| 423_P | 427_W | 1.366 | 0.99 | |
| 258_N | 262_W | 1.365 | 0.99 | |
| 330_L | 355_G | 1.364 | 0.99 | |
| 102_L | 106_A | 1.351 | 0.99 | |
| 341_S | 345_K | 1.338 | 0.99 | |
| 179_L | 183_T | 1.337 | 0.99 | |
| 101_F | 399_C | 1.336 | 0.99 | |
| 456_I | 459_I | 1.335 | 0.99 | |
| 153_T | 364_V | 1.323 | 0.99 | |
| 32_N | 255_K | 1.321 | 0.99 | |
| 103_G | 106_A | 1.312 | 0.99 | |
| 148_A | 367_V | 1.307 | 0.99 | |
| 250_Q | 416_S | 1.305 | 0.99 | |
| 88_R | 100_E | 1.298 | 0.99 | |
| 341_S | 344_A | 1.297 | 0.99 | |
| 447_G | 451_I | 1.29 | 0.99 | |
| 467_G | 470_K | 1.286 | 0.99 | |
| 77_I | 397_I | 1.283 | 0.99 | |
| 407_I | 410_G | 1.283 | 0.99 | |
| 27_H | 350_H | 1.282 | 0.99 | |
| 153_T | 360_L | 1.277 | 0.99 | |
| 108_Y | 112_W | 1.273 | 0.99 | |
| 201_N | 206_H | 1.273 | 0.99 | |
| 62_A | 215_F | 1.273 | 0.99 | |
| 408_K | 412_A | 1.271 | 0.99 | |
| 91_S | 244_G | 1.27 | 0.99 | |
| 30_M | 167_A | 1.269 | 0.99 | |
| 447_G | 452_A | 1.267 | 0.99 | |
| 462_V | 466_F | 1.267 | 0.99 | |
| 215_F | 222_A | 1.251 | 0.99 | |
| 452_A | 455_P | 1.249 | 0.99 | |
| 39_A | 260_V | 1.246 | 0.98 | |
| 394_A | 398_V | 1.246 | 0.98 | |
| 180_A | 310_V | 1.245 | 0.98 | |
| 103_G | 466_F | 1.242 | 0.98 | |
| 346_M | 350_H | 1.24 | 0.98 | |
| 40_I | 263_R | 1.233 | 0.98 | |
| 159_N | 320_N | 1.231 | 0.98 | |
| 122_G | 363_Y | 1.227 | 0.98 | |
| 33_R | 168_E | 1.221 | 0.98 | |
| 50_L | 128_A | 1.22 | 0.98 | |
| 252_M | 255_K | 1.212 | 0.98 | |
| 85_V | 97_Y | 1.21 | 0.98 | |
| 30_M | 35_V | 1.205 | 0.98 | |
| 242_A | 324_Y | 1.199 | 0.98 | |
| 112_W | 339_A | 1.198 | 0.98 | |
| 87_H | 416_S | 1.194 | 0.98 | |
| 155_V | 319_L | 1.193 | 0.98 | |
| 126_I | 152_L | 1.193 | 0.98 | |
| 129_V | 312_L | 1.19 | 0.98 | |
| 149_L | 153_T | 1.186 | 0.98 | |
| 394_A | 434_L | 1.184 | 0.98 | |
| 398_V | 402_R | 1.183 | 0.98 | |
| 142_V | 146_V | 1.182 | 0.98 | |
| 156_G | 160_M | 1.177 | 0.98 | |
| 361_V | 365_V | 1.174 | 0.98 | |
| 234_A | 389_I | 1.173 | 0.98 | |
| 64_A | 273_V | 1.169 | 0.97 | |
| 335_M | 344_A | 1.168 | 0.97 | |
| 76_F | 425_T | 1.167 | 0.97 | |
| 156_G | 357_L | 1.164 | 0.97 | |
| 65_L | 222_A | 1.164 | 0.97 | |
| 160_M | 351_V | 1.162 | 0.97 | |
| 126_I | 319_L | 1.16 | 0.97 | |
| 105_K | 462_V | 1.159 | 0.97 | |
| 449_Y | 453_A | 1.158 | 0.97 | |
| 345_K | 353_Y | 1.157 | 0.97 | |
| 451_I | 456_I | 1.153 | 0.97 | |
| 287_G | 293_T | 1.152 | 0.97 | |
| 451_I | 455_P | 1.15 | 0.97 | |
| 145_W | 149_L | 1.148 | 0.97 | |
| 43_A | 264_I | 1.144 | 0.97 | |
| 189_T | 274_L | 1.144 | 0.97 | |
| 157_T | 160_M | 1.142 | 0.97 | |
| 465_W | 469_R | 1.141 | 0.97 | |
| 163_V | 324_Y | 1.141 | 0.97 | |
| 223_L | 435_S | 1.138 | 0.97 | |
| 33_R | 37_M | 1.137 | 0.97 | |
| 354_A | 357_L | 1.137 | 0.97 | |
| 26_Y | 331_R | 1.135 | 0.97 | |
| 401_M | 423_P | 1.12 | 0.96 | |
| 160_M | 347_S | 1.119 | 0.96 | |
| 421_G | 424_F | 1.112 | 0.96 | |
| 55_R | 59_A | 1.11 | 0.96 | |
| 68_L | 72_L | 1.11 | 0.96 | |
| 161_I | 349_Q | 1.107 | 0.96 | |
| 31_G | 164_K | 1.107 | 0.96 | |
| 169_M | 173_F | 1.106 | 0.96 | |
| 78_L | 261_I | 1.106 | 0.96 | |
| 270_G | 274_L | 1.105 | 0.96 | |
| 397_I | 430_L | 1.104 | 0.96 | |
| 154_I | 316_L | 1.1 | 0.96 | |
| 412_A | 416_S | 1.099 | 0.96 | |
| 36_Q | 39_A | 1.098 | 0.96 | |
| 289_S | 293_T | 1.095 | 0.96 | |
| 349_Q | 353_Y | 1.093 | 0.96 | |
| 424_F | 427_W | 1.093 | 0.96 | |
| 243_A | 253_V | 1.092 | 0.96 | |
| 87_H | 412_A | 1.09 | 0.96 | |
| 87_H | 410_G | 1.086 | 0.96 | |
| 237_E | 241_T | 1.084 | 0.96 | |
| 296_S | 301_P | 1.081 | 0.95 | |
| 193_G | 202_T | 1.08 | 0.95 | |
| 112_W | 461_L | 1.08 | 0.95 | |
| 70_C | 229_V | 1.076 | 0.95 | |
| 405_K | 408_K | 1.074 | 0.95 | |
| 330_L | 339_A | 1.074 | 0.95 | |
| 78_L | 257_I | 1.072 | 0.95 | |
| 296_S | 304_G | 1.071 | 0.95 | |
| 401_M | 426_S | 1.07 | 0.95 | |
| 95_V | 332_S | 1.063 | 0.95 | |
| 152_L | 360_L | 1.062 | 0.95 | |
| 408_K | 411_K | 1.061 | 0.95 | |
| 384_F | 388_G | 1.058 | 0.95 | |
| 98_A | 399_C | 1.053 | 0.95 | |
| 451_I | 454_L | 1.053 | 0.95 | |
| 463_I | 466_F | 1.052 | 0.95 | |
| 182_V | 186_V | 1.044 | 0.94 | |
| 29_A | 164_K | 1.042 | 0.94 | |
| 34_Q | 168_E | 1.04 | 0.94 | |
| 79_R | 420_P | 1.04 | 0.94 | |
| 331_R | 346_M | 1.034 | 0.94 | |
| 117_N | 389_I | 1.028 | 0.94 | |
| 219_L | 222_A | 1.027 | 0.94 | |
| 38_I | 242_A | 1.025 | 0.93 | |
| 80_A | 419_L | 1.023 | 0.93 | |
| 435_S | 439_L | 1.02 | 0.93 | |
| 266_L | 270_G | 1.02 | 0.93 | |
| 444_Y | 447_G | 1.017 | 0.93 | |
| 98_A | 106_A | 1.015 | 0.93 | |
| 450_T | 455_P | 1.012 | 0.93 | |
| 133_M | 312_L | 1.011 | 0.93 | |
| 96_S | 100_E | 1.011 | 0.93 | |
| 90_S | 96_S | 1.009 | 0.93 | |
| 409_E | 412_A | 1.003 | 0.93 | |
| 441_A | 445_P | 1.001 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4djkA | 2 | 0.9299 | 100 | 0.432 | Contact Map | 0.595 |
| 3l1lA | 1 | 0.8798 | 100 | 0.451 | Contact Map | 0.683 |
| 3giaA | 1 | 0.8758 | 100 | 0.459 | Contact Map | 0.588 |
| 2jlnA | 1 | 0.8878 | 98.7 | 0.897 | Contact Map | 0.416 |
| 3dh4A | 4 | 0.9058 | 98.5 | 0.902 | Contact Map | 0.4 |
| 2xq2A | 1 | 0.9098 | 98.1 | 0.912 | Contact Map | 0.48 |
| 4m48A | 1 | 0.8958 | 96.3 | 0.935 | Contact Map | 0.309 |
| 2a65A | 1 | 0.8697 | 94.5 | 0.942 | Contact Map | 0.38 |
| 2m20A | 2 | 0.1042 | 25 | 0.97 | Contact Map | 0.414 |
| 1fftB | 2 | 0.1723 | 18.3 | 0.972 | Contact Map | 0.248 |
Sequence Conservation (Image Generated using WebLogo v3)