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OPENSEQ.org

HIS2 - HIS8
UniProt: P06989 - P06986
Length: 559
Sequences: 359
Seq/Len: 0.66
I_Prob: 0.00

HIS2 - Histidine biosynthesis bifunctional protein HisIE
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: HIS2
HIS8 - Histidinol-phosphate aminotransferase
Paralog alert: 0.93 [within 20: 0.27] - ratio of genomes with paralogs
Cluster includes: AAT ALAA ALAC ARNB AVTA CSDA HIS8 ISCS MALY RFFA SERC SUFS TYRB YBDL YDCR YJIR
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution.

Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
40_E 337_T 1.41 0.00
70_N 131_D 1.33 0.00
74_V 220_G 1.26 0.00
139_Y 168_F 1.22 0.00
38_N 208_I 1.18 0.00
90_A 128_P 1.17 0.00
191_L 269_V 1.15 0.00
23_V 162_L 1.15 0.00
78_A 297_T 1.12 0.00
90_A 166_Q 1.12 0.00
115_L 32_V 1.11 0.00
17_G 182_V 1.10 0.00
59_Q 270_A 1.10 0.00
57_T 57_E 1.09 0.00
167_F 168_F 1.09 0.00
10_L 351_L 1.07 0.00
25_H 330_L 1.06 0.00
96_T 22_S 1.06 0.00
123_A 274_A 1.03 0.00
178_Y 217_A 1.03 0.00
10_L 77_Q 1.03 0.00
46_L 136_D 1.01 0.00
49_G 122_V 1.01 0.00
103_S 310_V 1.01 0.00
88_V 302_A 1.00 0.00
127_S 32_V 1.00 0.00
21_V 292_V 0.99 0.00
131_E 138_Q 0.99 0.00
58_K 22_S 0.99 0.00
115_L 182_V 0.99 0.00
75_V 132_N 0.97 0.00
121_L 94_A 0.96 0.00
44_K 182_V 0.96 0.00
203_Q 342_E 0.96 0.00
157_T 193_Q 0.94 0.00
185_Q 40_P 0.93 0.00
108_T 334_L 0.92 0.00
34_L 272_I 0.92 0.00
193_T 63_V 0.91 0.00
161_A 17_L 0.91 0.00
53_F 172_L 0.91 0.00
167_F 235_L 0.90 0.00
188_G 52_L 0.90 0.00
124_E 231_E 0.90 0.00
77_I 180_I 0.90 0.00
46_L 150_V 0.89 0.00
96_T 23_A 0.89 0.00
145_R 352_R 0.89 0.00
173_A 221_L 0.89 0.00
131_E 281_A 0.89 0.00
34_L 273_I 0.89 0.00
53_F 188_I 0.89 0.00
90_A 284_K 0.89 0.00
129_D 150_V 0.89 0.00
131_E 284_K 0.88 0.00
13_E 336_I 0.88 0.00
43_D 171_L 0.88 0.00
140_A 328_P 0.88 0.00
145_R 82_R 0.88 0.00
25_H 245_L 0.88 0.00
10_L 99_G 0.87 0.00
71_F 312_K 0.87 0.00
28_S 147_V 0.87 0.00
131_E 294_D 0.86 0.00
180_L 88_I 0.86 0.00
157_T 135_L 0.86 0.00
35_G 225_F 0.86 0.00
43_D 131_D 0.85 0.00
160_A 94_A 0.85 0.00
17_G 338_V 0.85 0.00
145_R 210_R 0.85 0.00
115_L 133_W 0.85 0.00
121_L 183_A 0.85 0.00
34_L 337_T 0.85 0.00
192_T 164_N 0.85 0.00
54_F 300_I 0.84 0.00
72_L 23_A 0.84 0.00
54_F 105_Y 0.84 0.00
103_S 330_L 0.84 0.00
53_F 58_C 0.83 0.00
71_F 336_I 0.83 0.00
47_E 258_S 0.83 0.00
150_V 343_E 0.83 0.00
44_K 170_T 0.82 0.00
103_S 173_E 0.82 0.00
145_R 197_A 0.82 0.00
33_M 153_C 0.82 0.00
159_L 250_A 0.82 0.00
103_S 327_Q 0.82 0.00
93_I 15_R 0.82 0.00
158_A 179_A 0.82 0.00
59_Q 309_A 0.82 0.00
25_H 41_T 0.81 0.00
74_V 205_H 0.81 0.00
10_L 303_R 0.81 0.00
107_D 151_Y 0.81 0.00
76_S 205_H 0.81 0.00
103_S 239_V 0.81 0.00
59_Q 230_E 0.80 0.00
69_G 73_V 0.80 0.00
99_K 114_S 0.80 0.00
105_F 80_V 0.80 0.00
61_L 152_V 0.80 0.00
140_A 131_D 0.80 0.00
49_G 14_V 0.80 0.00
194_V 152_V 0.79 0.00
63_T 22_S 0.79 0.00
51_V 22_S 0.79 0.00
67_T 344_S 0.79 0.00
196_E 230_E 0.79 0.00
174_S 141_S 0.79 0.00
194_V 331_S 0.79 0.00
10_L 332_G 0.79 0.00
139_Y 315_W 0.79 0.00
57_T 171_L 0.79 0.00
203_Q 180_I 0.79 0.00
75_V 302_A 0.79 0.00
106_G 73_V 0.79 0.00
174_S 348_I 0.78 0.00
72_L 24_R 0.78 0.00
117_Q 142_D 0.78 0.00
67_T 342_E 0.78 0.00
41_A 27_G 0.78 0.00
21_V 99_G 0.78 0.00
59_Q 16_N 0.78 0.00
112_W 162_L 0.78 0.00
135_T 196_L 0.77 0.00
70_N 124_C 0.77 0.00
194_V 325_N 0.77 0.00
181_L 95_F 0.77 0.00
130_P 116_S 0.77 0.00
178_Y 262_I 0.77 0.00
160_A 256_A 0.77 0.00
203_Q 166_Q 0.76 0.00
7_R 337_T 0.76 0.00
174_S 57_E 0.76 0.00
57_T 91_L 0.76 0.00
46_L 351_L 0.76 0.00
49_G 351_L 0.76 0.00
188_G 313_S 0.76 0.00
42_L 78_V 0.76 0.00
193_T 343_E 0.75 0.00
128_A 248_P 0.75 0.00
47_E 195_S 0.75 0.00
131_E 300_I 0.75 0.00
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions
(includes both intra and inter preds)

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