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OPENSEQ.org
YCAN - Uncharacterized HTH-type transcriptional regulator YcaN
UniProt: P75836 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13698
Length: 302 (289)
Sequences: 37017
Seq/Len: 128.09
YCAN
Paralog alert: 0.88 [within 20: 0.50] - ratio of genomes with paralogs
Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
72_P 76_E 3.739 1.00
17_N 26_E 3.41 1.00
157_V 289_K 2.629 1.00
98_N 140_F 2.483 1.00
230_V 237_G 2.472 1.00
22_A 25_D 2.392 1.00
69_R 83_E 2.348 1.00
164_K 241_Y 2.297 1.00
16_R 71_R 2.258 1.00
182_H 185_D 2.214 1.00
13_A 26_E 2.178 1.00
96_K 125_E 2.175 1.00
94_T 123_K 2.147 1.00
73_A 77_I 2.146 1.00
158_A 161_P 2.119 1.00
94_T 125_E 2.114 1.00
173_Y 189_H 2.088 1.00
15_A 59_L 2.08 1.00
69_R 76_E 2.047 1.00
227_L 247_Y 2.031 1.00
10_T 37_S 1.99 1.00
12_F 67_Y 1.989 1.00
161_P 266_G 1.989 1.00
20_F 38_I 1.968 1.00
47_I 62_A 1.963 1.00
67_Y 71_R 1.962 1.00
13_A 17_N 1.915 1.00
12_F 71_R 1.878 1.00
158_A 266_G 1.871 1.00
114_G 287_Y 1.87 1.00
13_A 16_R 1.841 1.00
12_F 16_R 1.838 1.00
51_N 58_S 1.828 1.00
10_T 34_I 1.817 1.00
66_L 80_M 1.811 1.00
115_F 122_I 1.811 1.00
231_L 247_Y 1.794 1.00
192_V 235_G 1.77 1.00
15_A 67_Y 1.758 1.00
166_C 241_Y 1.739 1.00
61_E 64_S 1.71 1.00
11_F 67_Y 1.69 1.00
16_R 26_E 1.675 1.00
190_Q 217_N 1.668 1.00
65_N 83_E 1.663 1.00
12_F 70_L 1.647 1.00
115_F 284_F 1.641 1.00
21_R 31_S 1.624 1.00
231_L 252_R 1.611 1.00
19_S 22_A 1.597 1.00
17_N 22_A 1.595 1.00
10_T 29_L 1.592 1.00
12_F 74_F 1.583 1.00
161_P 264_R 1.575 1.00
90_T 121_D 1.566 1.00
30_S 33_A 1.56 1.00
69_R 79_I 1.492 1.00
156_S 268_Q 1.486 1.00
13_A 27_L 1.459 1.00
73_A 80_M 1.459 1.00
192_V 226_E 1.452 1.00
105_R 224_D 1.438 1.00
48_R 51_N 1.438 1.00
7_D 40_T 1.436 1.00
7_D 44_R 1.42 1.00
5_M 77_I 1.413 1.00
7_D 37_S 1.409 1.00
166_C 255_C 1.408 1.00
142_A 281_L 1.406 0.99
114_G 118_E 1.397 0.99
64_S 68_E 1.391 0.99
39_K 43_Q 1.364 0.99
189_H 236_I 1.362 0.99
155_I 273_N 1.344 0.99
66_L 81_L 1.34 0.99
92_T 121_D 1.339 0.99
169_A 256_V 1.338 0.99
114_G 117_R 1.334 0.99
155_I 271_Y 1.331 0.99
69_R 72_P 1.328 0.99
283_A 286_D 1.313 0.99
269_I 285_L 1.312 0.99
285_L 289_K 1.311 0.99
4_N 7_D 1.311 0.99
113_V 117_R 1.295 0.99
277_M 281_L 1.295 0.99
179_K 254_E 1.294 0.99
203_H 207_A 1.292 0.99
169_A 236_I 1.288 0.99
134_D 139_G 1.287 0.99
226_E 237_G 1.282 0.99
245_K 249_D 1.274 0.99
169_A 173_Y 1.272 0.99
247_Y 252_R 1.264 0.99
36_H 39_K 1.257 0.99
220_L 226_E 1.246 0.98
11_F 15_A 1.244 0.98
14_V 38_I 1.241 0.98
95_L 284_F 1.233 0.98
115_F 287_Y 1.229 0.98
44_R 81_L 1.224 0.98
178_G 185_D 1.22 0.98
116_T 190_Q 1.219 0.98
228_E 231_L 1.218 0.98
118_E 287_Y 1.217 0.98
157_V 271_Y 1.21 0.98
68_E 72_P 1.21 0.98
96_K 127_T 1.208 0.98
255_C 258_E 1.201 0.98
241_Y 245_K 1.2 0.98
29_L 33_A 1.194 0.98
69_R 80_M 1.19 0.98
65_N 68_E 1.19 0.98
104_A 128_T 1.187 0.98
35_S 39_K 1.187 0.98
11_F 50_F 1.186 0.98
76_E 79_I 1.184 0.98
116_T 217_N 1.181 0.98
9_A 78_Q 1.181 0.98
53_T 58_S 1.18 0.98
15_A 50_F 1.168 0.97
142_A 269_I 1.165 0.97
135_I 143_G 1.164 0.97
59_L 63_G 1.16 0.97
20_F 57_V 1.148 0.97
134_D 137_Q 1.148 0.97
14_V 23_A 1.146 0.97
11_F 49_L 1.141 0.97
286_D 289_K 1.127 0.97
13_A 23_A 1.122 0.97
282_R 286_D 1.119 0.96
6_S 9_A 1.101 0.96
271_Y 285_L 1.099 0.96
145_R 270_Y 1.096 0.96
168_A 244_I 1.091 0.96
37_S 40_T 1.089 0.96
167_V 236_I 1.089 0.96
241_Y 255_C 1.088 0.96
113_V 232_M 1.087 0.96
118_E 290_T 1.082 0.96
65_N 69_R 1.078 0.95
181_R 185_D 1.076 0.95
8_F 70_L 1.074 0.95
228_E 232_M 1.073 0.95
170_T 233_G 1.072 0.95
147_S 268_Q 1.069 0.95
158_A 268_Q 1.067 0.95
119_Y 283_A 1.064 0.95
156_S 270_Y 1.064 0.95
136_V 153_D 1.055 0.95
115_F 119_Y 1.054 0.95
29_L 34_I 1.053 0.95
246_E 250_T 1.048 0.94
173_Y 190_Q 1.047 0.94
72_P 79_I 1.045 0.94
36_H 40_T 1.044 0.94
50_F 57_V 1.041 0.94
125_E 219_I 1.04 0.94
78_Q 82_D 1.04 0.94
227_L 231_L 1.036 0.94
73_A 76_E 1.036 0.94
190_Q 215_A 1.026 0.94
272_P 275_Q 1.017 0.93
15_A 63_G 1.008 0.93
66_L 70_L 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3hhgA80.99011000.136Contact Map0.922
3fzvA40.98681000.141Contact Map0.721
3szpA20.9571000.143Contact Map0.773
2esnA40.97351000.148Contact Map0.766
1ixcA20.95031000.149Contact Map0.766
3fxqA20.98011000.152Contact Map0.789
2h98A20.96691000.158Contact Map0.72
1uthA10.98341000.158Contact Map0.751
1al3A10.98341000.159Contact Map0.75
3mz1A40.97681000.16Contact Map0.758
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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