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OPENSEQ.org
CYSB - HTH-type transcriptional regulator CysB
UniProt: P0A9F3 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10184
Length: 324 (295)
Sequences: 36109
Seq/Len: 122.40
CYSB
Paralog alert: 0.88 [within 20: 0.49] - ratio of genomes with paralogs
Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
72_E 76_K 3.739 1.00
15_H 25_G 3.375 1.00
234_V 241_G 2.484 1.00
98_A 143_A 2.453 1.00
21_S 24_E 2.42 1.00
69_I 83_V 2.348 1.00
161_L 292_A 2.302 1.00
14_N 71_R 2.276 1.00
167_N 245_S 2.25 1.00
185_T 188_E 2.242 1.00
176_H 192_Y 2.219 1.00
96_Y 125_H 2.207 1.00
11_E 25_G 2.206 1.00
94_S 123_S 2.177 1.00
73_V 77_V 2.17 1.00
94_S 125_H 2.14 1.00
19_V 37_V 2.12 1.00
162_P 165_H 2.111 1.00
13_V 59_V 2.11 1.00
69_I 76_K 2.075 1.00
10_V 67_I 2.027 1.00
67_I 71_R 1.98 1.00
114_G 294_H 1.971 1.00
165_H 269_T 1.962 1.00
8_Y 36_Q 1.961 1.00
46_I 62_A 1.947 1.00
11_E 15_H 1.914 1.00
115_F 122_V 1.884 1.00
11_E 14_N 1.863 1.00
136_D 140_K 1.86 1.00
10_V 14_N 1.858 1.00
195_V 239_G 1.854 1.00
8_Y 33_I 1.852 1.00
10_V 71_R 1.851 1.00
66_I 80_I 1.827 1.00
235_R 255_D 1.787 1.00
50_S 58_Q 1.784 1.00
172_V 259_V 1.746 1.00
162_P 269_T 1.741 1.00
114_G 290_R 1.737 1.00
13_V 67_I 1.729 1.00
231_K 251_V 1.709 1.00
61_P 64_Q 1.708 1.00
193_P 221_V 1.702 1.00
14_N 25_G 1.692 1.00
10_V 70_A 1.692 1.00
9_I 67_I 1.691 1.00
169_A 245_S 1.669 1.00
134_I 146_A 1.669 1.00
20_S 30_Q 1.655 1.00
18_N 21_S 1.619 1.00
29_S 32_G 1.607 1.00
10_V 74_L 1.605 1.00
90_P 121_R 1.6 1.00
65_E 83_V 1.599 1.00
169_A 258_R 1.58 1.00
181_K 188_E 1.577 1.00
8_Y 28_T 1.569 1.00
115_F 287_F 1.56 1.00
15_H 21_S 1.553 1.00
195_V 230_I 1.516 1.00
137_A 142_N 1.502 1.00
105_R 228_D 1.481 1.00
160_M 271_K 1.474 1.00
73_V 80_I 1.473 1.00
235_R 251_V 1.471 1.00
69_I 79_A 1.469 1.00
11_E 26_L 1.465 1.00
47_Q 50_S 1.456 1.00
204_R 208_D 1.441 1.00
64_Q 68_R 1.433 1.00
5_Q 39_M 1.417 1.00
5_Q 36_Q 1.416 1.00
114_G 118_R 1.415 1.00
165_H 267_H 1.405 0.99
5_Q 43_E 1.401 0.99
66_I 81_K 1.401 0.99
3_L 77_V 1.397 0.99
38_R 42_D 1.369 0.99
114_G 117_E 1.365 0.99
192_Y 240_V 1.363 0.99
129_G 133_Q 1.359 0.99
172_V 240_V 1.35 0.99
92_K 121_R 1.346 0.99
145_F 284_M 1.346 0.99
159_V 274_F 1.326 0.99
12_V 37_V 1.323 0.99
69_I 72_E 1.322 0.99
272_I 288_I 1.309 0.99
113_K 117_E 1.307 0.99
230_I 241_G 1.293 0.99
159_V 276_R 1.29 0.99
137_A 143_A 1.288 0.99
2_K 5_Q 1.283 0.99
174_P 255_D 1.265 0.99
224_A 230_I 1.263 0.99
248_V 251_V 1.258 0.99
116_I 193_P 1.245 0.98
9_I 13_V 1.244 0.98
43_E 81_K 1.243 0.98
177_P 192_Y 1.242 0.98
35_K 38_R 1.235 0.98
116_I 221_V 1.209 0.98
65_E 68_R 1.199 0.98
95_L 287_F 1.199 0.98
96_Y 127_H 1.197 0.98
232_T 235_R 1.194 0.98
68_R 72_E 1.192 0.98
9_I 48_I 1.191 0.98
184_I 188_E 1.184 0.98
286_D 289_Q 1.183 0.98
9_I 49_F 1.183 0.98
211_F 216_L 1.182 0.98
12_V 22_T 1.177 0.98
59_V 63_G 1.177 0.98
28_T 32_G 1.175 0.98
115_F 290_R 1.174 0.98
7_R 78_D 1.173 0.98
13_V 49_F 1.173 0.98
69_I 80_I 1.172 0.98
104_A 128_Q 1.168 0.97
139_S 157_D 1.167 0.97
34_S 38_R 1.164 0.97
145_F 272_I 1.163 0.97
280_L 284_M 1.16 0.97
161_L 274_F 1.158 0.97
182_K 257_V 1.157 0.97
76_K 79_A 1.135 0.97
249_D 252_A 1.133 0.97
258_R 261_A 1.124 0.97
173_T 237_G 1.114 0.96
115_F 119_Y 1.107 0.96
176_H 193_P 1.107 0.96
245_S 249_D 1.106 0.96
285_Y 289_Q 1.104 0.96
4_Q 7_R 1.1 0.96
28_T 33_I 1.098 0.96
11_E 22_T 1.098 0.96
36_Q 39_M 1.096 0.96
170_I 240_V 1.089 0.96
6_L 70_A 1.086 0.96
232_T 236_L 1.086 0.96
138_V 146_A 1.086 0.96
65_E 69_I 1.085 0.96
288_I 292_A 1.083 0.96
174_P 257_V 1.083 0.96
19_V 56_L 1.083 0.96
245_S 258_R 1.079 0.95
113_K 236_L 1.077 0.95
193_P 219_R 1.075 0.95
172_V 176_H 1.068 0.95
35_K 39_M 1.067 0.95
275_R 278_T 1.061 0.95
73_V 76_K 1.061 0.95
118_R 290_R 1.044 0.94
66_I 70_A 1.042 0.94
289_Q 292_A 1.042 0.94
162_P 271_K 1.042 0.94
78_D 82_S 1.038 0.94
118_R 293_P 1.038 0.94
97_I 145_F 1.034 0.94
251_V 255_D 1.031 0.94
160_M 273_G 1.026 0.94
52_S 58_Q 1.024 0.93
274_F 288_I 1.023 0.93
148_A 273_G 1.022 0.93
72_E 79_A 1.018 0.93
231_K 235_R 1.017 0.93
125_H 223_T 1.016 0.93
13_V 63_G 1.014 0.93
224_A 233_Y 1.011 0.93
98_A 148_A 1.007 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1al3A111000.155Contact Map0.738
1ixcA20.90121000.229Contact Map0.749
2esnA40.91361000.231Contact Map0.753
1uthA10.92591000.233Contact Map0.731
3fzvA40.92281000.236Contact Map0.709
2h98A20.94441000.237Contact Map0.739
3fxqA20.9291000.239Contact Map0.774
2h9bA20.94441000.244Contact Map0.726
3szpA20.89511000.255Contact Map0.752
3hhgA80.9291000.27Contact Map0.918
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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