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OPENSEQ.org
DSDC - HTH-type transcriptional regulator DsdC
UniProt: P46068 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13161
Length: 311 (294)
Sequences: 36409
Seq/Len: 123.84
DSDC
Paralog alert: 0.88 [within 20: 0.49] - ratio of genomes with paralogs
Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
84_S 88_T 3.587 1.00
29_H 38_E 3.566 1.00
167_H 304_R 2.703 1.00
108_Y 150_I 2.579 1.00
34_L 37_E 2.505 1.00
245_A 252_A 2.459 1.00
173_E 256_K 2.4 1.00
28_R 83_K 2.314 1.00
25_V 38_E 2.282 1.00
104_T 133_S 2.271 1.00
106_T 135_T 2.262 1.00
191_T 194_N 2.197 1.00
104_T 135_T 2.196 1.00
27_A 71_L 2.172 1.00
168_F 171_D 2.168 1.00
24_E 79_Y 2.122 1.00
124_D 306_Q 2.114 1.00
32_F 50_I 2.092 1.00
22_T 49_R 2.049 1.00
242_V 262_R 2.042 1.00
81_A 88_T 2.022 1.00
25_V 29_H 2.011 1.00
59_I 74_E 2.001 1.00
79_Y 83_K 1.983 1.00
171_D 282_H 1.956 1.00
85_S 89_L 1.951 1.00
24_E 83_K 1.95 1.00
24_E 28_R 1.948 1.00
124_D 302_W 1.941 1.00
22_T 46_V 1.928 1.00
25_V 28_R 1.915 1.00
125_F 132_I 1.911 1.00
182_Y 198_C 1.902 1.00
63_V 70_E 1.887 1.00
246_M 262_R 1.859 1.00
175_L 256_K 1.85 1.00
27_A 79_Y 1.819 1.00
73_H 76_K 1.798 1.00
168_F 282_H 1.795 1.00
23_F 79_Y 1.786 1.00
28_R 38_E 1.779 1.00
33_A 43_P 1.717 1.00
125_F 299_F 1.716 1.00
24_E 82_L 1.693 1.00
81_A 95_D 1.685 1.00
29_H 34_L 1.676 1.00
246_M 267_E 1.674 1.00
22_T 41_L 1.67 1.00
31_S 34_L 1.667 1.00
42_S 45_A 1.662 1.00
201_L 250_G 1.611 1.00
100_E 131_S 1.602 1.00
152_L 296_I 1.59 1.00
60_Q 63_V 1.5 1.00
76_K 80_W 1.49 1.00
25_V 39_L 1.488 1.00
19_K 56_E 1.485 1.00
124_D 128_R 1.482 1.00
171_D 280_H 1.477 1.00
19_K 49_R 1.474 1.00
19_K 52_Q 1.471 1.00
115_Q 239_D 1.45 1.00
102_S 131_S 1.436 1.00
24_E 86_L 1.436 1.00
78_V 92_E 1.43 1.00
51_N 55_E 1.421 1.00
124_D 127_R 1.416 1.00
166_H 284_Y 1.405 0.99
178_C 251_V 1.393 0.99
300_I 304_R 1.378 0.99
165_T 289_P 1.372 0.99
178_C 270_A 1.351 0.99
298_A 301_I 1.349 0.99
260_Q 264_A 1.34 0.99
81_A 84_S 1.337 0.99
123_G 127_R 1.33 0.99
105_L 299_F 1.326 0.99
188_L 269_V 1.32 0.99
78_V 93_I 1.311 0.99
23_F 27_A 1.3 0.99
262_R 267_E 1.298 0.99
85_S 92_E 1.295 0.99
220_A 225_V 1.293 0.99
114_A 138_T 1.292 0.99
125_F 302_W 1.286 0.99
48_H 51_N 1.283 0.99
16_Q 19_K 1.282 0.99
26_A 50_I 1.281 0.99
144_N 149_G 1.276 0.99
165_T 287_T 1.275 0.99
81_A 92_E 1.272 0.99
88_T 91_Q 1.266 0.99
81_A 91_Q 1.264 0.99
41_L 45_A 1.259 0.99
198_C 251_V 1.259 0.99
106_T 137_L 1.251 0.99
128_R 302_W 1.251 0.99
77_R 80_W 1.247 0.99
23_F 61_L 1.245 0.98
145_L 153_A 1.243 0.98
27_A 62_F 1.238 0.98
80_W 84_S 1.227 0.98
285_I 300_I 1.222 0.98
32_F 69_V 1.221 0.98
23_F 62_F 1.221 0.98
235_F 241_A 1.213 0.98
241_A 252_A 1.211 0.98
77_R 95_D 1.21 0.98
256_K 260_Q 1.208 0.98
47_S 51_N 1.208 0.98
270_A 273_G 1.207 0.98
301_I 304_R 1.201 0.98
65_S 70_E 1.198 0.98
71_L 75_G 1.198 0.98
26_A 35_A 1.196 0.98
167_H 287_T 1.192 0.98
201_L 241_A 1.183 0.98
17_L 89_L 1.182 0.98
243_I 246_M 1.175 0.98
297_E 301_I 1.175 0.98
18_S 21_H 1.175 0.98
179_S 248_H 1.174 0.98
190_N 194_N 1.164 0.97
187_A 194_N 1.164 0.97
25_V 35_A 1.157 0.97
49_R 52_Q 1.156 0.97
176_P 251_V 1.153 0.97
129_Y 298_A 1.152 0.97
177_V 259_V 1.144 0.97
128_R 305_E 1.143 0.97
146_Q 163_Q 1.136 0.97
123_G 247_N 1.133 0.97
56_E 93_I 1.12 0.96
172_E 257_R 1.116 0.96
178_C 182_Y 1.115 0.96
178_C 183_A 1.113 0.96
41_L 46_V 1.109 0.96
261_K 265_S 1.106 0.96
125_F 129_Y 1.102 0.96
48_H 52_Q 1.102 0.96
287_T 300_I 1.1 0.96
62_F 69_V 1.099 0.96
155_Y 286_T 1.098 0.96
20_M 82_L 1.097 0.96
152_L 285_I 1.087 0.96
21_H 90_N 1.085 0.96
175_L 270_A 1.084 0.96
77_R 81_A 1.072 0.95
235_F 244_A 1.064 0.95
144_N 147_R 1.05 0.94
288_L 291_R 1.048 0.94
126_T 199_T 1.04 0.94
27_A 75_G 1.04 0.94
108_Y 155_Y 1.039 0.94
85_S 88_T 1.038 0.94
243_I 247_N 1.036 0.94
78_V 82_L 1.035 0.94
183_A 188_L 1.034 0.94
183_A 198_C 1.033 0.94
26_A 32_F 1.03 0.94
22_T 39_L 1.026 0.94
166_H 286_T 1.02 0.93
15_W 56_E 1.017 0.93
157_D 284_Y 1.016 0.93
120_P 247_N 1.01 0.93
167_H 300_I 1.007 0.93
107_L 152_L 1.004 0.93
26_A 62_F 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2esnA40.95821000.173Contact Map0.777
3fxqA20.9261000.176Contact Map0.783
3fzvA40.93891000.18Contact Map0.721
1uthA10.95181000.181Contact Map0.754
3hhgA80.94211000.188Contact Map0.938
1ixcA20.9261000.188Contact Map0.773
2h98A20.9261000.189Contact Map0.753
3szpA20.9261000.19Contact Map0.782
1al3A10.9261000.195Contact Map0.69
2h9bA20.9261000.198Contact Map0.75
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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