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OPENSEQ.org
YEIE - Uncharacterized HTH-type transcriptional regulator YeiE
UniProt: P0ACR4 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12105
Length: 293 (287)
Sequences: 37405
Seq/Len: 130.33
YEIE
Paralog alert: 0.88 [within 20: 0.50] - ratio of genomes with paralogs
Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
72_A 76_Q 3.649 1.00
17_S 26_M 3.353 1.00
156_E 287_D 2.523 1.00
228_V 235_S 2.473 1.00
94_Y 139_V 2.441 1.00
22_Q 25_V 2.348 1.00
69_R 83_L 2.295 1.00
162_E 239_R 2.248 1.00
16_K 71_L 2.211 1.00
179_T 182_Q 2.143 1.00
92_R 121_E 2.136 1.00
13_E 26_M 2.135 1.00
90_A 119_P 2.126 1.00
73_L 77_A 2.098 1.00
90_A 121_E 2.092 1.00
15_L 59_V 2.07 1.00
157_P 160_E 2.045 1.00
171_S 186_A 2.035 1.00
225_K 245_Q 2.02 1.00
69_R 76_Q 2.009 1.00
20_T 38_L 2.008 1.00
160_E 264_T 1.999 1.00
12_A 67_Y 1.957 1.00
10_V 37_A 1.95 1.00
47_V 62_H 1.935 1.00
67_Y 71_L 1.902 1.00
13_E 17_S 1.867 1.00
12_A 16_K 1.841 1.00
13_E 16_K 1.829 1.00
12_A 71_L 1.826 1.00
157_P 264_T 1.824 1.00
10_V 34_V 1.824 1.00
66_L 80_I 1.822 1.00
110_R 285_Y 1.821 1.00
111_Y 118_L 1.791 1.00
51_D 58_V 1.787 1.00
189_I 233_G 1.772 1.00
229_R 245_Q 1.75 1.00
130_V 142_G 1.73 1.00
164_V 239_R 1.716 1.00
15_L 67_Y 1.708 1.00
229_R 250_T 1.696 1.00
167_A 254_V 1.694 1.00
16_K 26_M 1.68 1.00
11_F 67_Y 1.673 1.00
187_P 215_A 1.666 1.00
132_Q 136_D 1.664 1.00
111_Y 282_F 1.649 1.00
61_E 64_R 1.644 1.00
21_T 31_Q 1.636 1.00
12_A 70_A 1.635 1.00
65_L 83_L 1.633 1.00
30_S 33_A 1.606 1.00
10_V 29_L 1.591 1.00
19_S 22_Q 1.561 1.00
17_S 22_Q 1.554 1.00
12_A 74_L 1.547 1.00
164_V 253_E 1.529 1.00
160_E 262_M 1.51 1.00
155_S 266_W 1.477 1.00
69_R 79_E 1.467 1.00
189_I 224_I 1.462 1.00
7_Q 37_A 1.445 1.00
13_E 27_L 1.441 1.00
73_L 80_I 1.432 1.00
133_A 138_R 1.426 1.00
101_N 222_E 1.419 1.00
7_Q 40_D 1.419 1.00
48_Q 51_D 1.408 1.00
141_I 279_L 1.407 0.99
172_P 186_A 1.398 0.99
5_L 77_A 1.388 0.99
110_R 289_A 1.384 0.99
7_Q 44_Q 1.383 0.99
64_R 68_P 1.368 0.99
110_R 114_D 1.349 0.99
66_L 81_E 1.344 0.99
4_T 7_Q 1.341 0.99
198_R 202_D 1.329 0.99
39_T 43_G 1.318 0.99
186_A 234_I 1.317 0.99
154_I 271_R 1.306 0.99
167_A 234_I 1.306 0.99
154_I 269_H 1.306 0.99
69_R 72_A 1.301 0.99
88_N 117_Q 1.3 0.99
243_E 247_Q 1.299 0.99
275_L 279_L 1.297 0.99
110_R 113_H 1.294 0.99
125_G 129_D 1.291 0.99
224_I 235_S 1.284 0.99
245_Q 250_T 1.279 0.99
281_R 284_D 1.279 0.99
267_R 283_L 1.271 0.99
109_A 113_H 1.251 0.99
133_A 139_V 1.247 0.99
36_A 39_T 1.247 0.99
91_I 282_F 1.24 0.98
11_F 15_L 1.236 0.98
14_V 38_L 1.223 0.98
44_Q 81_E 1.223 0.98
218_L 224_I 1.221 0.98
283_L 287_D 1.218 0.98
112_R 215_A 1.215 0.98
111_Y 285_Y 1.21 0.98
11_F 49_L 1.2 0.98
59_V 63_G 1.199 0.98
156_E 269_H 1.192 0.98
68_P 72_A 1.192 0.98
92_R 123_S 1.191 0.98
239_R 243_E 1.19 0.98
29_L 33_A 1.19 0.98
11_F 50_F 1.188 0.98
14_V 23_A 1.182 0.98
205_L 210_P 1.179 0.98
112_R 187_P 1.174 0.98
135_L 152_E 1.172 0.98
69_R 80_I 1.171 0.98
114_D 285_Y 1.169 0.97
169_P 250_T 1.169 0.97
100_G 124_V 1.164 0.97
226_H 229_R 1.164 0.97
53_V 58_V 1.156 0.97
15_L 50_F 1.156 0.97
65_L 68_P 1.155 0.97
35_S 39_T 1.152 0.97
9_E 78_V 1.146 0.97
141_I 267_R 1.145 0.97
20_T 57_L 1.142 0.97
76_Q 79_E 1.139 0.97
94_Y 144_I 1.119 0.96
37_A 40_D 1.112 0.96
144_I 268_I 1.112 0.96
13_E 23_A 1.107 0.96
176_G 252_S 1.096 0.96
178_V 182_Q 1.095 0.96
161_D 240_R 1.074 0.95
165_V 234_I 1.073 0.95
284_D 287_D 1.072 0.95
111_Y 115_Y 1.07 0.95
36_A 40_D 1.066 0.95
280_R 284_D 1.065 0.95
167_A 171_S 1.059 0.95
8_L 70_A 1.057 0.95
6_R 9_E 1.057 0.95
168_A 231_G 1.057 0.95
226_H 230_H 1.054 0.95
269_H 283_L 1.053 0.95
244_D 248_A 1.053 0.95
114_D 288_P 1.051 0.94
115_Y 281_R 1.048 0.94
65_L 69_R 1.046 0.94
109_A 230_H 1.044 0.94
239_R 253_E 1.043 0.94
166_F 242_I 1.043 0.94
225_K 229_R 1.041 0.94
29_L 34_V 1.036 0.94
157_P 266_W 1.034 0.94
50_F 57_L 1.027 0.94
155_S 268_I 1.026 0.94
72_A 79_E 1.023 0.93
73_L 76_Q 1.02 0.93
15_L 63_G 1.016 0.93
253_E 257_P 1.012 0.93
169_P 252_S 1.012 0.93
146_G 266_W 1.012 0.93
134_V 142_G 1.011 0.93
10_V 27_L 1.007 0.93
78_V 82_Q 1.003 0.93
66_L 70_A 1.001 0.92
167_A 173_L 1.001 0.92
121_E 217_E 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2esnA411000.088Contact Map0.756
1uthA111000.097Contact Map0.733
3fzvA40.99661000.097Contact Map0.725
3fxqA20.99321000.098Contact Map0.777
1ixcA20.97951000.109Contact Map0.759
1al3A10.98981000.11Contact Map0.772
2h98A20.97951000.114Contact Map0.763
3hhgA80.98631000.121Contact Map0.918
2h9bA20.98291000.123Contact Map0.748
3szpA20.97611000.133Contact Map0.766
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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