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YIAU - Uncharacterized HTH-type transcriptional regulator YiaU
UniProt: P37682 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12289
Length: 324 (299)
Sequences: 36410
Seq/Len: 121.77
YIAU
Paralog alert: 0.88 [within 20: 0.50] - ratio of genomes with paralogs
Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
75_D 79_R 3.753 1.00
20_S 29_V 3.418 1.00
165_S 301_L 2.552 1.00
242_A 249_V 2.518 1.00
101_Y 148_C 2.485 1.00
25_H 28_T 2.419 1.00
171_A 253_D 2.351 1.00
72_Y 86_F 2.319 1.00
19_A 74_N 2.305 1.00
180_Y 195_H 2.248 1.00
23_I 41_L 2.238 1.00
188_R 191_E 2.179 1.00
99_T 127_S 2.179 1.00
16_V 29_V 2.158 1.00
76_M 80_N 2.152 1.00
97_R 125_T 2.15 1.00
97_R 127_S 2.129 1.00
18_A 62_L 2.123 1.00
166_F 169_Q 2.097 1.00
239_L 259_D 2.075 1.00
169_Q 278_D 2.058 1.00
72_Y 79_R 2.056 1.00
15_S 70_L 2.032 1.00
116_D 303_E 1.974 1.00
13_I 40_Y 1.971 1.00
70_L 74_N 1.93 1.00
16_V 20_S 1.912 1.00
50_L 65_F 1.886 1.00
16_V 19_A 1.877 1.00
15_S 19_A 1.864 1.00
69_L 83_L 1.851 1.00
15_S 74_N 1.85 1.00
13_I 37_V 1.847 1.00
54_D 61_M 1.83 1.00
166_F 278_D 1.829 1.00
198_I 247_G 1.817 1.00
196_S 229_N 1.776 1.00
243_R 259_D 1.776 1.00
18_A 70_L 1.757 1.00
173_T 253_D 1.755 1.00
64_P 67_T 1.748 1.00
116_D 299_E 1.739 1.00
19_A 29_V 1.724 1.00
14_I 70_L 1.714 1.00
117_K 124_I 1.694 1.00
138_F 151_L 1.693 1.00
15_S 73_I 1.672 1.00
68_A 86_F 1.671 1.00
140_E 145_P 1.654 1.00
33_A 36_N 1.649 1.00
243_R 264_T 1.647 1.00
13_I 32_I 1.642 1.00
24_S 34_Q 1.642 1.00
117_K 296_V 1.638 1.00
15_S 77_L 1.63 1.00
20_S 25_H 1.613 1.00
22_N 25_H 1.603 1.00
93_E 123_D 1.595 1.00
141_G 147_D 1.547 1.00
198_I 238_A 1.52 1.00
164_A 280_V 1.509 1.00
72_Y 82_Q 1.499 1.00
16_V 30_L 1.467 1.00
76_M 83_L 1.467 1.00
176_A 268_C 1.46 1.00
51_K 54_D 1.444 1.00
150_V 293_V 1.443 1.00
10_E 43_D 1.428 1.00
10_E 40_Y 1.422 1.00
8_Y 80_N 1.416 1.00
69_L 84_N 1.409 1.00
184_H 191_E 1.404 0.99
42_A 46_S 1.403 0.99
17_I 41_L 1.403 0.99
67_T 71_P 1.402 0.99
195_H 248_I 1.391 0.99
10_E 47_K 1.388 0.99
173_T 267_P 1.387 0.99
169_Q 276_W 1.377 0.99
116_D 120_D 1.375 0.99
176_A 180_Y 1.364 0.99
116_D 119_K 1.363 0.99
163_V 285_K 1.357 0.99
176_A 248_I 1.346 0.99
281_A 297_L 1.345 0.99
95_R 123_D 1.342 0.99
98_V 296_V 1.34 0.99
163_V 283_F 1.336 0.99
141_G 148_C 1.324 0.99
289_Q 293_V 1.309 0.99
295_Y 298_D 1.308 0.99
7_K 10_E 1.308 0.99
238_A 249_V 1.305 0.99
257_Q 261_Q 1.298 0.99
72_Y 75_D 1.298 0.99
118_I 196_S 1.265 0.99
232_C 238_A 1.258 0.99
39_K 42_A 1.255 0.99
165_S 283_F 1.249 0.99
47_K 84_N 1.249 0.99
297_L 301_L 1.239 0.98
14_I 53_F 1.236 0.98
131_C 135_R 1.236 0.98
18_A 53_F 1.233 0.98
14_I 18_A 1.231 0.98
240_E 243_R 1.215 0.98
253_D 257_Q 1.214 0.98
115_I 119_K 1.207 0.98
118_I 229_N 1.205 0.98
14_I 52_V 1.202 0.98
107_I 130_T 1.201 0.98
153_S 282_I 1.2 0.98
259_D 264_T 1.197 0.98
72_Y 83_L 1.197 0.98
62_L 66_G 1.196 0.98
144_F 161_S 1.196 0.98
32_I 36_N 1.195 0.98
99_T 129_K 1.19 0.98
71_P 75_D 1.187 0.98
17_I 26_A 1.186 0.98
150_V 281_A 1.185 0.98
68_A 71_P 1.183 0.98
12_K 81_E 1.177 0.98
38_S 42_A 1.177 0.98
120_D 299_E 1.172 0.98
56_T 61_M 1.167 0.97
23_I 60_L 1.164 0.97
79_R 82_Q 1.164 0.97
209_N 213_F 1.153 0.97
16_V 26_A 1.132 0.97
180_Y 196_S 1.131 0.97
108_T 236_Q 1.129 0.97
117_K 299_E 1.124 0.97
267_P 270_Q 1.123 0.97
175_Y 256_V 1.12 0.96
294_Q 298_D 1.111 0.96
170_Y 254_K 1.108 0.96
9_R 12_K 1.106 0.96
177_S 245_H 1.1 0.96
40_Y 43_D 1.096 0.96
155_A 280_V 1.091 0.96
174_A 248_I 1.089 0.96
298_D 301_L 1.085 0.96
53_F 60_L 1.076 0.95
11_L 73_I 1.076 0.95
164_A 282_I 1.076 0.95
120_D 302_R 1.073 0.95
142_V 151_L 1.072 0.95
81_E 85_N 1.069 0.95
240_E 244_N 1.066 0.95
121_I 295_Y 1.061 0.95
239_L 243_R 1.06 0.95
32_I 37_V 1.059 0.95
283_F 297_L 1.054 0.95
196_S 227_K 1.054 0.95
101_Y 153_S 1.05 0.94
68_A 72_Y 1.05 0.94
76_M 79_R 1.05 0.94
166_F 280_V 1.048 0.94
39_K 43_D 1.047 0.94
18_A 66_G 1.043 0.94
127_S 231_V 1.039 0.94
258_S 262_D 1.035 0.94
232_C 241_L 1.033 0.94
100_I 150_V 1.03 0.94
253_D 267_P 1.025 0.93
176_A 181_L 1.024 0.93
75_D 82_Q 1.023 0.93
178_Q 264_T 1.016 0.93
187_S 191_E 1.012 0.93
284_R 287_E 1.007 0.93
117_K 121_I 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3fzvA40.9291000.206Contact Map0.704
1uthA10.93831000.209Contact Map0.742
2esnA40.92591000.21Contact Map0.76
3hhgA80.93521000.211Contact Map0.925
1ixcA20.89811000.214Contact Map0.757
1al3A10.95061000.215Contact Map0.743
3fxqA20.91981000.217Contact Map0.783
3szpA20.8921000.218Contact Map0.767
2h98A20.93831000.228Contact Map0.734
3mz1A40.91671000.231Contact Map0.762
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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