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OPENSEQ.org
LEUO - HTH-type transcriptional regulator LeuO
UniProt: P10151 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10531
Length: 314 (291)
Sequences: 36801
Seq/Len: 126.46
LEUO
Paralog alert: 0.88 [within 20: 0.50] - ratio of genomes with paralogs
Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
91_Q 95_L 3.681 1.00
36_E 45_V 3.364 1.00
250_V 257_A 2.457 1.00
117_C 162_T 2.356 1.00
41_R 44_H 2.348 1.00
185_E 261_R 2.27 1.00
179_V 309_V 2.267 1.00
88_S 102_G 2.228 1.00
202_L 205_D 2.212 1.00
35_Q 90_R 2.209 1.00
194_H 209_E 2.171 1.00
32_A 45_V 2.169 1.00
113_V 142_H 2.139 1.00
115_H 144_M 2.12 1.00
113_V 144_M 2.096 1.00
92_A 96_V 2.095 1.00
180_P 183_K 2.089 1.00
34_M 78_P 2.056 1.00
183_K 286_T 2.053 1.00
247_L 267_F 2.035 1.00
88_S 95_L 2.028 1.00
31_D 86_F 1.976 1.00
29_V 56_A 1.957 1.00
39_I 57_V 1.944 1.00
66_D 81_R 1.938 1.00
86_F 90_R 1.919 1.00
180_P 286_T 1.897 1.00
32_A 36_E 1.895 1.00
31_D 35_Q 1.871 1.00
31_D 90_R 1.85 1.00
29_V 53_V 1.822 1.00
32_A 35_Q 1.815 1.00
70_V 77_Q 1.809 1.00
134_I 141_I 1.803 1.00
251_S 272_E 1.8 1.00
133_H 307_Q 1.799 1.00
251_S 267_F 1.778 1.00
85_L 99_E 1.757 1.00
187_V 261_R 1.748 1.00
190_A 276_L 1.726 1.00
34_M 86_F 1.723 1.00
210_Q 237_A 1.691 1.00
80_A 83_F 1.675 1.00
30_F 86_F 1.675 1.00
212_A 255_L 1.666 1.00
40_T 50_Q 1.66 1.00
35_Q 45_V 1.652 1.00
153_T 165_V 1.651 1.00
31_D 89_V 1.649 1.00
183_K 284_S 1.615 1.00
187_V 275_V 1.603 1.00
29_V 48_M 1.594 1.00
84_Q 102_G 1.592 1.00
36_E 41_R 1.584 1.00
38_N 41_R 1.58 1.00
155_H 159_Y 1.577 1.00
49_S 52_A 1.564 1.00
31_D 93_L 1.564 1.00
109_S 140_N 1.556 1.00
156_Q 161_E 1.483 1.00
178_S 288_Y 1.473 1.00
88_S 98_N 1.453 1.00
32_A 46_L 1.435 1.00
26_L 56_A 1.432 1.00
67_E 70_V 1.426 1.00
26_L 59_R 1.419 1.00
212_A 246_V 1.413 1.00
92_A 99_E 1.391 0.99
124_S 244_M 1.39 0.99
83_F 87_G 1.387 0.99
26_L 63_M 1.385 0.99
24_L 96_V 1.379 0.99
133_H 137_I 1.367 0.99
177_T 293_E 1.357 0.99
23_D 26_L 1.351 0.99
209_E 256_V 1.341 0.99
133_H 136_Q 1.341 0.99
177_T 291_W 1.338 0.99
58_A 62_V 1.337 0.99
267_F 272_E 1.335 0.99
190_A 256_V 1.327 0.99
111_E 140_N 1.326 0.99
134_I 304_M 1.321 0.99
303_W 307_Q 1.3 0.99
88_S 91_Q 1.292 0.99
192_K 272_E 1.288 0.99
148_S 152_N 1.288 0.99
85_L 100_L 1.284 0.99
246_V 257_A 1.277 0.99
265_E 269_E 1.276 0.99
240_G 246_V 1.271 0.99
132_N 136_Q 1.27 0.99
164_F 301_H 1.262 0.99
157_L 165_V 1.24 0.98
133_H 311_I 1.237 0.98
135_E 237_A 1.227 0.98
55_N 58_A 1.221 0.98
261_R 265_E 1.22 0.98
30_F 34_M 1.22 0.98
179_V 291_W 1.215 0.98
156_Q 162_T 1.206 0.98
158_R 175_E 1.204 0.98
220_A 224_Q 1.202 0.98
164_F 289_L 1.2 0.98
195_P 209_E 1.195 0.98
87_G 91_Q 1.195 0.98
33_V 57_V 1.19 0.98
30_F 69_F 1.187 0.98
135_E 210_Q 1.185 0.98
39_I 76_I 1.184 0.98
34_M 69_F 1.181 0.98
123_D 147_S 1.181 0.98
248_S 251_S 1.175 0.98
84_Q 87_G 1.175 0.98
78_P 82_A 1.172 0.98
297_R 301_H 1.171 0.98
30_F 68_L 1.168 0.97
48_M 52_A 1.166 0.97
63_M 100_L 1.16 0.97
88_S 99_E 1.16 0.97
33_V 42_A 1.158 0.97
72_Y 77_Q 1.155 0.97
54_S 58_A 1.153 0.97
28_T 97_Q 1.151 0.97
289_L 305_E 1.15 0.97
115_H 146_K 1.149 0.97
95_L 98_N 1.146 0.97
169_E 288_Y 1.124 0.97
134_I 138_A 1.119 0.96
303_W 306_E 1.119 0.96
227_Y 232_K 1.113 0.96
167_S 290_S 1.113 0.96
201_L 205_D 1.111 0.96
191_S 253_T 1.099 0.96
261_R 275_V 1.098 0.96
32_A 42_A 1.098 0.96
184_D 262_W 1.097 0.96
190_A 194_H 1.093 0.96
56_A 59_R 1.078 0.95
194_H 210_Q 1.076 0.95
84_Q 88_S 1.073 0.95
132_N 252_Q 1.073 0.95
302_Q 306_E 1.073 0.95
55_N 59_R 1.072 0.95
275_V 278_L 1.072 0.95
192_K 274_Q 1.072 0.95
189_V 264_A 1.07 0.95
180_P 288_Y 1.069 0.95
25_N 28_T 1.063 0.95
27_L 89_V 1.062 0.95
248_S 252_Q 1.055 0.95
134_I 307_Q 1.055 0.95
188_L 256_V 1.052 0.95
178_S 290_S 1.051 0.94
292_H 295_A 1.042 0.94
48_M 53_V 1.035 0.94
247_L 251_S 1.035 0.94
91_Q 98_N 1.035 0.94
92_A 95_L 1.034 0.94
117_C 167_S 1.023 0.93
69_F 76_I 1.021 0.93
266_E 270_S 1.013 0.93
85_L 89_V 1.012 0.93
34_M 82_A 1.012 0.93
114_F 304_M 1.011 0.93
305_E 309_V 1.009 0.93
210_Q 235_S 1.008 0.93
264_A 267_F 1.006 0.93
137_I 307_Q 1.003 0.93
116_L 164_F 1.002 0.92
144_M 239_Q 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1uthA10.95861000.189Contact Map0.725
2esnA40.96181000.192Contact Map0.755
3fxqA20.93311000.203Contact Map0.768
3fzvA40.94271000.205Contact Map0.711
1ixcA20.92361000.221Contact Map0.749
1al3A10.92991000.222Contact Map0.758
2h98A20.92041000.225Contact Map0.736
2h9bA20.92041000.232Contact Map0.738
3szpA20.92041000.239Contact Map0.768
3hhgA80.92681000.244Contact Map0.919
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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