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YAHB - Uncharacterized HTH-type transcriptional regulator YahB
UniProt: P77700 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13586
Length: 310 (290)
Sequences: 36748
Seq/Len: 126.72
YAHB
Paralog alert: 0.88 [within 20: 0.50] - ratio of genomes with paralogs
Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
74_D 78_D 3.707 1.00
19_F 28_E 3.371 1.00
235_Q 242_G 2.505 1.00
100_C 146_A 2.444 1.00
165_T 293_A 2.382 1.00
24_K 27_E 2.362 1.00
71_K 85_R 2.307 1.00
171_R 246_D 2.272 1.00
18_R 73_T 2.211 1.00
190_A 193_Q 2.195 1.00
15_T 28_E 2.177 1.00
98_R 128_T 2.15 1.00
96_R 126_Q 2.14 1.00
180_H 197_Y 2.136 1.00
75_L 79_F 2.121 1.00
96_R 128_T 2.098 1.00
166_E 169_A 2.085 1.00
169_A 271_R 2.062 1.00
17_A 61_L 2.049 1.00
71_K 78_D 2.036 1.00
232_C 252_A 2.011 1.00
22_F 40_I 1.997 1.00
14_T 69_F 1.984 1.00
12_A 39_T 1.966 1.00
69_F 73_T 1.937 1.00
49_V 64_S 1.904 1.00
117_V 291_Q 1.892 1.00
166_E 271_R 1.889 1.00
15_T 19_F 1.885 1.00
14_T 18_R 1.86 1.00
15_T 18_R 1.851 1.00
14_T 73_T 1.846 1.00
118_L 125_C 1.838 1.00
12_A 36_I 1.818 1.00
53_T 60_E 1.805 1.00
68_F 82_I 1.796 1.00
200_I 240_G 1.776 1.00
236_I 252_A 1.775 1.00
173_A 246_D 1.756 1.00
236_I 257_L 1.733 1.00
17_A 69_F 1.717 1.00
13_F 69_F 1.688 1.00
63_E 66_R 1.688 1.00
176_I 261_R 1.68 1.00
14_T 72_A 1.661 1.00
67_Y 85_R 1.656 1.00
18_R 28_E 1.651 1.00
139_D 143_N 1.649 1.00
23_S 33_T 1.633 1.00
137_V 149_A 1.625 1.00
169_A 269_D 1.624 1.00
12_A 31_L 1.596 1.00
32_T 35_A 1.594 1.00
21_S 24_K 1.581 1.00
14_T 76_L 1.576 1.00
19_F 24_K 1.572 1.00
173_A 260_T 1.567 1.00
92_G 124_T 1.558 1.00
164_Y 273_L 1.492 1.00
71_K 81_A 1.484 1.00
140_A 145_Q 1.475 1.00
108_P 229_N 1.454 1.00
75_L 82_I 1.45 1.00
15_T 29_L 1.443 1.00
50_V 53_T 1.429 1.00
200_I 231_K 1.427 1.00
9_N 42_R 1.426 1.00
9_N 39_T 1.4 0.99
118_L 288_I 1.398 0.99
117_V 121_Q 1.398 0.99
9_N 46_G 1.385 0.99
66_R 70_R 1.385 0.99
198_P 222_S 1.371 0.99
197_Y 241_I 1.366 0.99
68_F 83_K 1.365 0.99
7_E 79_F 1.362 0.99
287_W 290_K 1.351 0.99
176_I 241_I 1.35 0.99
148_I 285_T 1.346 0.99
41_K 45_T 1.342 0.99
94_E 124_T 1.339 0.99
163_D 276_T 1.321 0.99
250_R 254_T 1.32 0.99
117_V 120_K 1.318 0.99
71_K 74_D 1.312 0.99
6_T 9_N 1.308 0.99
132_E 136_G 1.304 0.99
163_D 278_H 1.301 0.99
141_I 149_A 1.279 0.99
252_A 257_L 1.277 0.99
286_Q 290_K 1.273 0.99
116_Q 120_K 1.268 0.99
231_K 242_G 1.266 0.99
178_P 257_L 1.251 0.99
165_T 276_T 1.238 0.98
289_K 293_A 1.228 0.98
16_A 40_I 1.222 0.98
13_F 17_A 1.221 0.98
140_A 146_A 1.22 0.98
38_Y 41_K 1.22 0.98
148_I 274_L 1.212 0.98
187_E 259_V 1.211 0.98
46_G 83_K 1.209 0.98
119_K 198_P 1.203 0.98
185_V 193_Q 1.202 0.98
209_I 213_V 1.202 0.98
233_Q 236_I 1.202 0.98
31_L 35_A 1.195 0.98
225_V 231_K 1.19 0.98
70_R 74_D 1.186 0.98
181_P 197_Y 1.18 0.98
98_R 130_T 1.18 0.98
37_S 41_K 1.179 0.98
67_Y 70_R 1.179 0.98
13_F 52_F 1.177 0.98
71_K 82_I 1.173 0.98
246_D 250_R 1.173 0.98
13_F 51_L 1.172 0.98
142_I 161_G 1.171 0.98
55_S 60_E 1.17 0.97
78_D 81_A 1.163 0.97
16_A 25_A 1.157 0.97
61_L 65_G 1.146 0.97
17_A 52_F 1.146 0.97
11_L 80_Y 1.144 0.97
22_F 59_I 1.143 0.97
246_D 260_T 1.138 0.97
107_T 131_T 1.126 0.97
151_G 275_A 1.126 0.97
121_Q 291_Q 1.123 0.97
189_I 193_Q 1.116 0.96
15_T 25_A 1.116 0.96
274_L 289_K 1.113 0.96
39_T 42_R 1.1 0.96
178_P 259_V 1.099 0.96
176_I 180_H 1.096 0.96
116_Q 237_L 1.093 0.96
281_T 285_T 1.093 0.96
251_E 255_Q 1.093 0.96
118_L 122_F 1.092 0.96
170_I 247_Y 1.091 0.96
290_K 293_A 1.09 0.96
166_E 273_L 1.085 0.96
117_V 295_N 1.084 0.96
174_F 241_I 1.083 0.96
97_V 288_I 1.081 0.95
8_E 11_L 1.08 0.95
38_Y 42_R 1.078 0.95
276_T 289_K 1.075 0.95
177_A 238_G 1.072 0.95
180_H 198_P 1.07 0.95
10_L 72_A 1.067 0.95
67_Y 71_K 1.063 0.95
175_A 249_V 1.06 0.95
233_Q 237_L 1.057 0.95
232_C 236_I 1.053 0.95
164_Y 275_A 1.052 0.95
153_P 273_L 1.045 0.94
31_L 36_I 1.039 0.94
80_Y 84_R 1.036 0.94
75_L 78_D 1.035 0.94
52_F 59_I 1.033 0.94
100_C 151_G 1.03 0.94
165_T 289_K 1.028 0.94
74_D 81_A 1.027 0.94
17_A 65_G 1.014 0.93
176_I 182_L 1.013 0.93
68_F 72_A 1.013 0.93
118_L 291_Q 1.002 0.92
128_T 224_L 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2esnA40.95161000.155Contact Map0.757
3fxqA20.96451000.162Contact Map0.775
1uthA10.96451000.163Contact Map0.728
3fzvA40.96131000.169Contact Map0.718
1al3A10.97421000.178Contact Map0.773
1ixcA20.9291000.179Contact Map0.749
2h9bA20.96771000.185Contact Map0.76
2h98A20.96771000.185Contact Map0.759
3hhgA80.96451000.194Contact Map0.923
3szpA20.92261000.194Contact Map0.764
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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