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OPENSEQ.org
ALLS - HTH-type transcriptional activator AllS
UniProt: P0ACR0 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13267
Length: 308 (290)
Sequences: 37402
Seq/Len: 128.97
ALLS
Paralog alert: 0.88 [within 20: 0.50] - ratio of genomes with paralogs
Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
71_D 75_W 3.735 1.00
16_T 25_R 3.395 1.00
232_H 239_G 2.491 1.00
97_V 143_F 2.395 1.00
21_K 24_E 2.389 1.00
68_Q 82_E 2.355 1.00
168_Q 243_K 2.28 1.00
187_T 190_Q 2.224 1.00
15_E 70_R 2.216 1.00
12_A 25_R 2.196 1.00
162_D 290_T 2.179 1.00
93_Q 123_Q 2.176 1.00
95_N 125_H 2.158 1.00
72_W 76_L 2.135 1.00
93_Q 125_H 2.133 1.00
177_H 194_F 2.125 1.00
163_P 166_S 2.091 1.00
14_A 58_L 2.045 1.00
166_S 268_P 2.04 1.00
68_Q 75_W 2.04 1.00
229_I 249_M 2.038 1.00
11_I 66_L 1.994 1.00
114_W 288_L 1.993 1.00
9_T 36_R 1.98 1.00
66_L 70_R 1.964 1.00
46_V 61_A 1.945 1.00
12_A 16_T 1.908 1.00
19_F 37_I 1.904 1.00
11_I 70_R 1.866 1.00
11_I 15_E 1.866 1.00
50_F 57_T 1.84 1.00
163_P 268_P 1.839 1.00
115_L 122_T 1.838 1.00
12_A 15_E 1.833 1.00
233_L 249_M 1.816 1.00
65_L 79_M 1.798 1.00
9_T 33_I 1.793 1.00
170_R 243_K 1.75 1.00
233_L 254_Q 1.749 1.00
14_A 66_L 1.73 1.00
60_A 63_E 1.711 1.00
64_H 82_E 1.702 1.00
10_F 66_L 1.67 1.00
173_M 258_R 1.669 1.00
197_V 237_G 1.664 1.00
136_D 140_Y 1.661 1.00
11_I 69_A 1.651 1.00
15_E 25_R 1.647 1.00
20_S 30_T 1.616 1.00
134_V 146_A 1.609 1.00
18_S 21_K 1.601 1.00
89_G 121_F 1.599 1.00
11_I 73_L 1.597 1.00
166_S 266_P 1.592 1.00
16_T 21_K 1.589 1.00
9_T 28_K 1.583 1.00
170_R 257_S 1.581 1.00
29_T 32_T 1.574 1.00
68_Q 78_S 1.525 1.00
137_S 142_G 1.491 1.00
12_A 26_L 1.475 1.00
105_P 226_E 1.465 1.00
161_L 270_S 1.45 1.00
72_W 79_M 1.445 1.00
47_A 50_F 1.438 1.00
284_D 287_T 1.427 1.00
197_V 228_K 1.422 1.00
6_T 39_L 1.421 1.00
114_W 118_R 1.413 1.00
6_T 43_N 1.409 1.00
63_E 67_S 1.395 0.99
6_T 36_R 1.392 0.99
65_L 80_P 1.373 0.99
129_Q 133_G 1.363 0.99
91_E 121_F 1.36 0.99
173_M 238_I 1.354 0.99
283_E 287_T 1.346 0.99
114_W 117_E 1.346 0.99
194_F 238_I 1.344 0.99
38_K 42_E 1.331 0.99
247_Q 251_D 1.331 0.99
68_Q 71_D 1.319 0.99
160_S 273_W 1.315 0.99
160_S 275_K 1.311 0.99
113_A 117_E 1.297 0.99
228_K 239_G 1.293 0.99
138_L 146_A 1.289 0.99
249_M 254_Q 1.283 0.99
206_L 210_V 1.281 0.99
284_D 288_L 1.279 0.99
184_E 256_V 1.276 0.99
43_N 80_P 1.261 0.99
4_P 76_L 1.255 0.99
286_V 290_T 1.254 0.99
137_S 143_F 1.249 0.99
115_L 285_I 1.245 0.98
175_A 254_Q 1.242 0.98
145_L 271_L 1.236 0.98
162_D 273_W 1.236 0.98
222_V 228_K 1.223 0.98
145_L 282_V 1.219 0.98
95_N 127_S 1.215 0.98
10_F 14_A 1.213 0.98
67_S 71_D 1.213 0.98
35_Y 38_K 1.205 0.98
13_V 37_I 1.204 0.98
178_P 194_F 1.201 0.98
230_A 233_L 1.2 0.98
195_P 219_E 1.196 0.98
182_V 190_Q 1.195 0.98
75_W 78_S 1.191 0.98
162_D 286_V 1.19 0.98
68_Q 79_M 1.186 0.98
34_S 38_K 1.186 0.98
116_N 195_P 1.183 0.98
243_K 247_Q 1.183 0.98
64_H 67_S 1.182 0.98
10_F 49_F 1.18 0.98
139_L 158_T 1.179 0.98
52_T 57_T 1.179 0.98
28_K 32_T 1.174 0.98
14_A 49_F 1.155 0.97
13_V 22_A 1.148 0.97
10_F 48_L 1.148 0.97
19_F 56_V 1.143 0.97
8_R 77_E 1.141 0.97
3_D 6_T 1.137 0.97
58_L 62_G 1.133 0.97
118_R 288_L 1.13 0.97
186_L 190_Q 1.124 0.97
163_P 270_S 1.122 0.97
148_G 272_A 1.119 0.96
12_A 22_A 1.115 0.96
243_K 257_S 1.111 0.96
173_M 177_H 1.107 0.96
206_L 209_R 1.1 0.96
113_A 234_A 1.098 0.96
175_A 256_V 1.098 0.96
115_L 119_Y 1.091 0.96
104_N 128_R 1.091 0.96
64_H 68_Q 1.091 0.96
248_S 252_N 1.087 0.96
171_F 238_I 1.087 0.96
36_R 39_L 1.083 0.96
230_A 234_A 1.082 0.96
7_L 69_A 1.081 0.95
172_V 246_C 1.079 0.95
174_A 235_G 1.078 0.95
35_Y 39_L 1.076 0.95
161_L 272_A 1.075 0.95
5_E 8_R 1.073 0.95
207_T 211_A 1.058 0.95
229_I 233_L 1.058 0.95
167_V 244_S 1.058 0.95
49_F 56_V 1.054 0.95
71_D 78_S 1.047 0.94
273_W 286_V 1.044 0.94
72_W 75_W 1.043 0.94
28_K 33_I 1.04 0.94
77_E 81_S 1.035 0.94
177_H 195_P 1.031 0.94
96_I 145_L 1.001 0.92
65_L 69_A 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2esnA40.95131000.154Contact Map0.764
3fxqA20.97081000.154Contact Map0.779
3fzvA40.9611000.17Contact Map0.719
1uthA10.96431000.173Contact Map0.749
1ixcA20.93511000.176Contact Map0.761
1al3A10.98381000.179Contact Map0.79
2h98A20.97731000.182Contact Map0.761
2h9bA20.9741000.184Contact Map0.765
3szpA20.92861000.192Contact Map0.759
3hhgA80.95781000.194Contact Map0.926
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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