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OPENSEQ.org
YIDZ - HTH-type transcriptional regulator YidZ
UniProt: P31463 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11721
Length: 319 (293)
Sequences: 36866
Seq/Len: 125.82
YIDZ
Paralog alert: 0.88 [within 20: 0.49] - ratio of genomes with paralogs
Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
77_E 81_M 3.768 1.00
22_E 31_R 3.449 1.00
102_A 146_V 2.453 1.00
27_K 30_K 2.421 1.00
74_N 88_K 2.352 1.00
173_E 312_K 2.335 1.00
188_H 203_Y 2.282 1.00
196_N 199_T 2.274 1.00
21_Q 76_A 2.269 1.00
179_V 257_P 2.258 1.00
18_L 31_R 2.228 1.00
100_E 129_K 2.203 1.00
98_K 127_T 2.191 1.00
174_V 177_S 2.152 1.00
98_K 129_K 2.14 1.00
78_W 82_S 2.133 1.00
177_S 289_P 2.109 1.00
74_N 81_M 2.104 1.00
20_M 64_P 2.09 1.00
25_V 43_L 2.04 1.00
15_C 42_S 2.039 1.00
17_Q 72_E 2.014 1.00
52_D 67_L 1.987 1.00
118_Q 310_T 1.977 1.00
72_E 76_A 1.971 1.00
18_L 22_E 1.961 1.00
17_Q 21_Q 1.923 1.00
174_V 289_P 1.915 1.00
119_I 126_A 1.909 1.00
242_L 263_Y 1.887 1.00
17_Q 76_A 1.887 1.00
18_L 21_Q 1.882 1.00
56_V 63_S 1.881 1.00
71_M 85_L 1.86 1.00
15_C 39_V 1.855 1.00
137_S 149_G 1.775 1.00
20_M 72_E 1.759 1.00
66_P 69_V 1.737 1.00
245_A 253_L 1.728 1.00
21_Q 31_R 1.727 1.00
16_L 72_E 1.708 1.00
17_Q 75_L 1.701 1.00
26_T 36_P 1.68 1.00
70_S 88_K 1.662 1.00
35_T 38_A 1.655 1.00
181_C 257_P 1.655 1.00
22_E 27_K 1.644 1.00
15_C 34_V 1.641 1.00
24_S 27_K 1.633 1.00
17_Q 79_M 1.619 1.00
204_P 232_A 1.619 1.00
184_L 272_V 1.564 1.00
139_D 143_R 1.531 1.00
74_N 84_L 1.499 1.00
78_W 85_L 1.496 1.00
12_L 42_S 1.478 1.00
140_A 145_E 1.473 1.00
12_L 45_K 1.469 1.00
109_M 239_E 1.467 1.00
18_L 32_I 1.461 1.00
53_P 56_V 1.457 1.00
172_Y 291_T 1.447 1.00
215_T 219_D 1.446 1.00
71_M 86_L 1.446 1.00
69_V 73_Q 1.433 1.00
12_L 49_W 1.427 1.00
118_Q 314_L 1.424 1.00
206_I 241_S 1.414 1.00
118_Q 122_R 1.41 1.00
9_D 12_L 1.402 0.99
10_L 82_S 1.4 0.99
246_A 268_Q 1.389 0.99
177_S 280_E 1.362 0.99
44_A 48_A 1.358 0.99
118_Q 121_Q 1.345 0.99
181_C 271_L 1.342 0.99
306_W 310_T 1.341 0.99
74_N 77_E 1.333 0.99
171_D 296_K 1.329 0.99
171_D 294_W 1.326 0.99
148_I 304_I 1.32 0.99
141_I 149_G 1.316 0.99
248_P 251_L 1.314 0.99
235_L 241_S 1.298 0.99
261_Q 265_Q 1.296 0.99
206_I 251_L 1.287 0.99
184_L 252_L 1.285 0.99
16_L 20_M 1.282 0.99
203_Y 252_L 1.278 0.99
117_K 121_Q 1.278 0.99
19_L 43_L 1.271 0.99
189_P 203_Y 1.259 0.99
120_Y 204_P 1.248 0.99
119_I 307_L 1.247 0.99
41_K 44_A 1.242 0.98
173_E 294_W 1.242 0.98
186_K 268_Q 1.237 0.98
263_Y 268_Q 1.237 0.98
74_N 85_L 1.235 0.98
148_I 292_L 1.232 0.98
108_M 132_N 1.228 0.98
140_A 146_V 1.225 0.98
16_L 55_F 1.223 0.98
300_H 304_I 1.219 0.98
49_W 86_L 1.217 0.98
70_S 73_Q 1.217 0.98
19_L 28_A 1.216 0.98
34_V 38_A 1.215 0.98
20_M 55_F 1.213 0.98
25_V 62_L 1.213 0.98
100_E 131_R 1.205 0.98
73_Q 77_E 1.204 0.98
16_L 54_L 1.201 0.98
119_I 123_Y 1.198 0.98
151_S 293_L 1.198 0.98
96_G 125_Q 1.198 0.98
40_S 44_A 1.192 0.98
58_S 63_S 1.189 0.98
195_W 199_T 1.189 0.98
64_P 68_M 1.187 0.98
81_M 84_L 1.184 0.98
142_T 169_A 1.172 0.98
120_Y 232_A 1.172 0.98
306_W 309_E 1.156 0.97
222_L 227_R 1.15 0.97
42_S 45_K 1.146 0.97
271_L 274_L 1.143 0.97
188_H 204_P 1.131 0.97
186_K 270_P 1.131 0.97
243_F 246_A 1.13 0.97
14_L 83_N 1.13 0.97
174_V 291_T 1.121 0.97
41_K 45_K 1.12 0.96
178_D 258_R 1.118 0.96
18_L 28_A 1.109 0.96
257_P 261_Q 1.108 0.96
184_L 188_H 1.105 0.96
11_N 14_L 1.103 0.96
70_S 74_N 1.093 0.96
295_H 298_N 1.088 0.96
102_A 151_S 1.084 0.96
55_F 62_L 1.081 0.95
292_L 308_R 1.079 0.95
13_L 75_L 1.079 0.95
122_R 310_T 1.076 0.95
241_S 253_L 1.075 0.95
153_R 291_T 1.067 0.95
193_Q 270_P 1.066 0.95
305_V 309_E 1.063 0.95
78_W 81_M 1.058 0.95
183_W 260_C 1.057 0.95
34_V 39_V 1.057 0.95
172_Y 293_L 1.054 0.95
308_R 312_K 1.053 0.95
83_N 87_D 1.051 0.94
71_M 75_L 1.045 0.94
182_V 252_L 1.043 0.94
20_M 68_M 1.042 0.94
119_I 310_T 1.041 0.94
129_K 234_S 1.041 0.94
102_A 137_S 1.033 0.94
77_E 84_L 1.031 0.94
101_L 148_I 1.029 0.94
262_Y 266_L 1.026 0.94
140_A 143_R 1.02 0.93
184_L 189_P 1.02 0.93
99_F 307_L 1.01 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2esnA40.9531000.109Contact Map0.767
1uthA10.94361000.126Contact Map0.771
3fzvA40.92791000.135Contact Map0.719
3fxqA20.92791000.144Contact Map0.786
1ixcA20.9061000.146Contact Map0.761
1al3A10.92161000.148Contact Map0.757
2h98A20.90911000.152Contact Map0.76
2h9bA20.91221000.158Contact Map0.749
3szpA20.9061000.165Contact Map0.761
3hhgA80.91851000.185Contact Map0.912
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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