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YCJZ - Uncharacterized HTH-type transcriptional regulator YcjZ
UniProt: P77333 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13923
Length: 299 (293)
Sequences: 37343
Seq/Len: 127.45
YCJZ
Paralog alert: 0.88 [within 20: 0.50] - ratio of genomes with paralogs
Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
73_P 77_D 3.787 1.00
18_E 27_R 3.45 1.00
158_I 294_K 2.589 1.00
235_A 242_A 2.485 1.00
99_T 141_F 2.467 1.00
23_R 26_A 2.377 1.00
70_V 84_S 2.354 1.00
165_P 246_Y 2.271 1.00
17_E 72_G 2.239 1.00
14_V 27_R 2.217 1.00
183_S 186_Q 2.201 1.00
95_T 124_D 2.176 1.00
97_R 126_Q 2.176 1.00
95_T 126_Q 2.147 1.00
74_M 78_I 2.136 1.00
159_R 162_P 2.119 1.00
16_A 60_P 2.077 1.00
70_V 77_D 2.066 1.00
11_A 38_I 2.029 1.00
13_V 68_L 2.013 1.00
232_I 252_A 2.006 1.00
48_L 63_A 2.005 1.00
162_P 271_G 1.998 1.00
21_F 39_V 1.989 1.00
68_L 72_G 1.984 1.00
174_Y 190_H 1.955 1.00
13_V 72_G 1.924 1.00
14_V 18_E 1.923 1.00
115_T 292_R 1.897 1.00
13_V 17_E 1.896 1.00
159_R 271_G 1.882 1.00
14_V 17_E 1.869 1.00
52_T 59_V 1.861 1.00
67_L 81_A 1.83 1.00
11_A 35_L 1.821 1.00
236_I 252_A 1.799 1.00
116_F 123_I 1.797 1.00
16_A 68_L 1.768 1.00
115_T 296_K 1.755 1.00
167_A 246_Y 1.737 1.00
66_H 84_S 1.702 1.00
193_I 240_G 1.699 1.00
62_E 65_E 1.692 1.00
12_F 68_L 1.679 1.00
13_V 71_L 1.678 1.00
17_E 27_R 1.668 1.00
191_Q 222_Q 1.649 1.00
236_I 257_K 1.637 1.00
116_F 289_F 1.624 1.00
22_T 32_Q 1.62 1.00
11_A 30_M 1.614 1.00
20_S 23_R 1.61 1.00
18_E 23_R 1.606 1.00
31_A 34_A 1.58 1.00
13_V 75_L 1.566 1.00
91_R 122_E 1.556 1.00
162_P 269_L 1.545 1.00
70_V 80_S 1.527 1.00
157_A 273_H 1.526 1.00
74_M 81_A 1.49 1.00
14_V 28_L 1.485 1.00
106_K 229_D 1.479 1.00
8_D 45_R 1.467 1.00
8_D 41_R 1.457 1.00
49_R 52_T 1.456 1.00
115_T 119_S 1.428 1.00
190_H 241_L 1.425 1.00
8_D 38_I 1.413 1.00
6_I 78_I 1.405 0.99
65_E 69_S 1.4 0.99
193_I 231_I 1.386 0.99
70_V 73_P 1.378 0.99
40_R 44_E 1.377 0.99
143_A 286_F 1.368 0.99
93_S 122_E 1.366 0.99
167_A 260_R 1.364 0.99
67_L 82_M 1.355 0.99
156_I 278_H 1.344 0.99
156_I 276_Y 1.342 0.99
115_T 118_K 1.337 0.99
135_D 140_R 1.319 0.99
288_L 291_D 1.318 0.99
114_R 118_K 1.314 0.99
180_V 259_I 1.313 0.99
5_E 8_D 1.305 0.99
282_A 286_F 1.304 0.99
290_I 294_K 1.303 0.99
231_I 242_A 1.302 0.99
274_L 290_I 1.299 0.99
170_G 174_Y 1.299 0.99
170_G 241_L 1.27 0.99
250_E 254_K 1.27 0.99
37_Q 40_R 1.267 0.99
225_L 231_I 1.25 0.99
45_R 82_M 1.246 0.98
69_S 73_P 1.237 0.98
12_F 16_A 1.237 0.98
158_I 276_Y 1.237 0.98
15_V 39_V 1.236 0.98
233_D 236_I 1.228 0.98
30_M 34_A 1.225 0.98
70_V 81_A 1.222 0.98
119_S 292_R 1.222 0.98
252_A 257_K 1.22 0.98
246_Y 250_E 1.219 0.98
97_R 128_T 1.211 0.98
96_I 289_F 1.209 0.98
77_D 80_S 1.208 0.98
54_T 59_V 1.207 0.98
12_F 51_L 1.203 0.98
116_F 292_R 1.201 0.98
66_H 69_S 1.197 0.98
117_L 191_Q 1.19 0.98
16_A 51_L 1.189 0.98
143_A 274_L 1.187 0.98
36_S 40_R 1.184 0.98
170_G 261_V 1.176 0.98
105_A 129_I 1.167 0.97
21_F 58_V 1.16 0.97
10_M 79_D 1.159 0.97
60_P 64_G 1.146 0.97
15_V 24_A 1.145 0.97
12_F 50_L 1.135 0.97
135_D 138_S 1.134 0.97
14_V 24_A 1.13 0.97
117_L 222_Q 1.121 0.97
287_S 291_D 1.121 0.97
114_R 237_D 1.12 0.96
276_Y 290_I 1.12 0.96
291_D 294_K 1.119 0.96
182_T 186_Q 1.105 0.96
179_S 186_Q 1.104 0.96
66_H 70_V 1.1 0.96
9_L 71_L 1.099 0.96
260_R 263_D 1.096 0.96
169_V 249_V 1.096 0.96
38_I 41_R 1.095 0.96
233_D 237_D 1.094 0.96
136_V 144_G 1.085 0.96
168_I 241_L 1.083 0.96
7_A 10_M 1.082 0.96
159_R 273_H 1.082 0.96
119_S 295_Y 1.08 0.95
116_F 120_H 1.078 0.95
146_R 275_Y 1.076 0.95
232_I 236_I 1.069 0.95
137_V 154_D 1.068 0.95
30_M 35_L 1.067 0.95
37_Q 41_R 1.067 0.95
171_S 238_G 1.064 0.95
79_D 83_A 1.062 0.95
73_P 80_S 1.06 0.95
120_H 288_L 1.057 0.95
157_A 275_Y 1.056 0.95
51_L 58_V 1.056 0.95
74_M 77_D 1.056 0.95
251_R 255_E 1.045 0.94
205_R 209_I 1.019 0.93
246_Y 260_R 1.018 0.93
67_L 71_L 1.016 0.93
15_V 21_F 1.015 0.93
111_P 237_D 1.015 0.93
277_P 280_R 1.014 0.93
174_Y 191_Q 1.011 0.93
11_A 28_L 1.009 0.93
158_I 290_I 1.005 0.93
15_V 51_L 1.004 0.93
82_M 86_S 1.001 0.92
163_D 247_D 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3fzvA40.98331000.091Contact Map0.726
2esnA40.97991000.1Contact Map0.765
3hhgA80.98331000.101Contact Map0.931
1uthA10.98331000.106Contact Map0.749
3szpA20.97321000.107Contact Map0.771
3fxqA20.96991000.108Contact Map0.794
3mz1A40.97661000.11Contact Map0.772
1ixcA20.97321000.112Contact Map0.769
2h98A20.96991000.112Contact Map0.733
1al3A10.97321000.12Contact Map0.743
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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