May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
YDJL - Uncharacterized zinc-type alcohol dehydrogenase-like protein YdjL
UniProt: P77539 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13488
Length: 358 (349)
Sequences: 22287
Seq/Len: 63.86
YDJL
Paralog alert: 0.83 [within 20: 0.37] - ratio of genomes with paralogs
Cluster includes: ACUI ADHP CURA FRMA GATD IDND QOR1 RSPB TDH YAHK YBDR YCJQ YDJJ YDJL YGGP YJGB YJJN YPHC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
334_Q 337_E 3.676 1.00
34_K 150_Y 3.456 1.00
32_E 68_A 3.342 1.00
34_K 66_C 3.113 1.00
29_V 141_L 3.091 1.00
30_V 68_A 3.023 1.00
195_R 224_T 3.004 1.00
149_D 152_D 2.952 1.00
81_Q 143_E 2.902 1.00
330_I 341_A 2.72 1.00
78_K 81_Q 2.677 1.00
237_R 240_Q 2.673 1.00
216_P 220_E 2.652 1.00
215_F 219_K 2.617 1.00
27_E 73_K 2.614 1.00
26_P 72_E 2.606 1.00
151_E 329_R 2.586 1.00
32_E 66_C 2.563 1.00
82_R 144_I 2.543 1.00
178_V 194_A 2.534 1.00
32_E 126_Y 2.477 1.00
177_D 200_V 2.433 1.00
331_G 334_Q 2.394 1.00
313_R 317_S 2.35 1.00
26_P 73_K 2.324 1.00
21_Q 126_Y 2.293 1.00
173_L 176_Q 2.253 1.00
147_G 316_A 2.248 1.00
179_V 247_L 2.223 1.00
82_R 150_Y 2.205 1.00
63_F 122_G 2.153 1.00
176_Q 272_E 2.145 1.00
191_V 223_A 2.134 1.00
25_G 28_D 2.128 1.00
23_M 69_Q 2.12 1.00
267_L 273_V 2.114 1.00
337_E 340_D 2.1 1.00
64_A 150_Y 2.089 1.00
328_H 341_A 2.082 1.00
340_D 344_D 2.078 1.00
76_D 131_G 2.025 1.00
330_I 338_G 2.014 1.00
30_V 128_L 2.01 1.00
216_P 219_K 1.978 1.00
68_A 126_Y 1.959 1.00
152_D 323_K 1.95 1.00
144_I 153_A 1.9 1.00
82_R 146_D 1.863 1.00
159_I 189_F 1.85 1.00
69_Q 79_V 1.832 1.00
329_R 353_T 1.831 1.00
77_W 143_E 1.823 1.00
71_G 74_V 1.822 1.00
233_D 236_A 1.818 1.00
232_E 237_R 1.816 1.00
70_V 79_V 1.811 1.00
248_G 268_R 1.793 1.00
167_A 197_M 1.79 1.00
63_F 85_S 1.78 1.00
272_E 296_S 1.772 1.00
217_V 220_E 1.75 1.00
267_L 271_G 1.739 1.00
337_E 341_A 1.735 1.00
28_D 130_P 1.729 1.00
200_V 225_A 1.718 1.00
144_I 150_Y 1.711 1.00
228_N 231_T 1.711 1.00
215_F 226_V 1.681 1.00
181_I 263_A 1.675 1.00
267_L 295_K 1.663 1.00
24_C 128_L 1.661 1.00
272_E 298_I 1.661 1.00
196_I 319_A 1.657 1.00
225_A 241_I 1.654 1.00
67_I 77_W 1.643 1.00
250_V 263_A 1.613 1.00
66_C 82_R 1.6 1.00
33_I 63_F 1.593 1.00
47_N 343_V 1.592 1.00
28_D 128_L 1.586 1.00
170_S 249_L 1.585 1.00
30_V 126_Y 1.576 1.00
77_W 81_Q 1.568 1.00
123_F 339_F 1.553 1.00
7_F 17_I 1.541 1.00
30_V 69_Q 1.502 1.00
35_A 151_E 1.492 1.00
95_C 98_C 1.487 1.00
66_C 150_Y 1.484 1.00
29_V 77_W 1.48 1.00
5_A 17_I 1.472 1.00
341_A 346_T 1.469 1.00
35_A 353_T 1.467 1.00
27_E 130_P 1.452 1.00
250_V 267_L 1.437 1.00
212_A 216_P 1.433 1.00
24_C 30_V 1.43 1.00
313_R 316_A 1.43 1.00
24_C 28_D 1.42 1.00
336_R 340_D 1.411 1.00
236_A 240_Q 1.376 0.99
34_K 82_R 1.367 0.99
31_I 65_G 1.358 0.99
172_F 199_A 1.342 0.99
190_S 251_I 1.338 0.99
77_W 141_L 1.33 0.99
327_T 341_A 1.321 0.99
92_C 95_C 1.307 0.99
183_T 204_V 1.28 0.99
212_A 228_N 1.272 0.99
35_A 150_Y 1.266 0.99
200_V 224_T 1.264 0.99
219_K 226_V 1.262 0.99
98_C 106_C 1.256 0.99
38_I 338_G 1.253 0.99
151_E 353_T 1.252 0.99
170_S 274_V 1.227 0.98
129_V 141_L 1.225 0.98
167_A 310_N 1.221 0.98
177_D 248_G 1.209 0.98
46_Y 339_F 1.192 0.98
21_Q 30_V 1.189 0.98
237_R 241_I 1.188 0.98
180_V 190_S 1.184 0.98
92_C 98_C 1.179 0.98
314_L 319_A 1.173 0.98
196_I 314_L 1.162 0.97
37_A 62_E 1.16 0.97
2_K 18_D 1.155 0.97
191_V 203_V 1.153 0.97
220_E 324_P 1.153 0.97
156_L 315_L 1.152 0.97
39_C 61_H 1.146 0.97
7_F 15_K 1.144 0.97
33_I 127_C 1.139 0.97
16_M 333_S 1.139 0.97
39_C 62_E 1.135 0.97
219_K 225_A 1.135 0.97
321_K 324_P 1.131 0.97
177_D 201_N 1.131 0.97
201_N 225_A 1.119 0.96
206_G 229_G 1.119 0.96
163_Y 167_A 1.116 0.96
252_E 255_G 1.115 0.96
332_L 354_Y 1.113 0.96
70_V 74_V 1.112 0.96
233_D 237_R 1.101 0.96
310_N 313_R 1.096 0.96
340_D 343_V 1.096 0.96
31_I 83_V 1.093 0.96
68_A 79_V 1.092 0.96
148_V 153_A 1.09 0.96
208_Q 228_N 1.078 0.95
95_C 106_C 1.071 0.95
32_E 125_K 1.068 0.95
177_D 202_I 1.067 0.95
180_V 194_A 1.066 0.95
34_K 64_A 1.061 0.95
27_E 72_E 1.057 0.95
176_Q 248_G 1.054 0.95
179_V 205_V 1.047 0.94
78_K 143_E 1.038 0.94
36_A 122_G 1.033 0.94
21_Q 69_Q 1.03 0.94
27_E 131_G 1.026 0.94
123_F 335_W 1.026 0.94
309_R 313_R 1.02 0.93
94_V 99_E 1.02 0.93
254_S 259_A 1.019 0.93
179_V 266_M 1.018 0.93
194_A 199_A 1.015 0.93
247_L 250_V 1.008 0.93
207_L 228_N 1.006 0.93
181_I 250_V 1.004 0.93
335_W 352_M 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4ej6A10.94131000.13Contact Map0.776
4a2cA20.9331000.138Contact Map0.758
2dq4A20.93851000.141Contact Map0.785
4eezA20.94691000.142Contact Map0.806
1rjwA40.93581000.148Contact Map0.817
1f8fA10.94411000.148Contact Map0.812
1e3iA20.94411000.148Contact Map0.81
4ilkA20.93581000.148Contact Map0.78
4gi2A20.95251000.148Contact Map0.799
3ukoA20.94971000.148Contact Map0.757
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0147 seconds.