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YJGB - Uncharacterized zinc-type alcohol dehydrogenase-like protein YjgB
UniProt: P27250 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11436
Length: 339 (332)
Sequences: 22578
Seq/Len: 68.01
YJGB
Paralog alert: 0.83 [within 20: 0.37] - ratio of genomes with paralogs
Cluster includes: ACUI ADHP CURA FRMA GATD IDND QOR1 RSPB TDH YAHK YBDR YCJQ YDJJ YDJL YGGP YJGB YJJN YPHC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
316_K 319_D 3.474 1.00
36_D 144_I 3.307 1.00
34_Q 70_V 3.174 1.00
31_V 135_V 3.005 1.00
36_D 68_R 2.992 1.00
32_E 70_V 2.899 1.00
143_D 146_S 2.832 1.00
189_H 214_D 2.815 1.00
85_Q 137_P 2.763 1.00
206_Q 210_A 2.718 1.00
171_R 194_E 2.694 1.00
312_F 323_H 2.609 1.00
205_E 209_L 2.605 1.00
82_Q 85_Q 2.559 1.00
29_Q 75_A 2.49 1.00
145_E 311_L 2.474 1.00
34_Q 68_R 2.466 1.00
28_P 74_S 2.466 1.00
86_R 138_L 2.454 1.00
34_Q 127_K 2.377 1.00
172_V 188_L 2.304 1.00
313_P 316_K 2.27 1.00
80_G 132_W 2.266 1.00
194_E 215_K 2.24 1.00
298_R 302_R 2.233 1.00
23_P 127_K 2.232 1.00
28_P 75_A 2.232 1.00
167_T 170_S 2.184 1.00
202_P 206_Q 2.154 1.00
173_G 232_F 2.132 1.00
86_R 144_I 2.131 1.00
25_E 71_A 2.118 1.00
65_V 123_G 2.101 1.00
170_S 257_N 2.083 1.00
185_I 213_A 2.067 1.00
141_N 301_A 2.064 1.00
310_E 323_H 2.045 1.00
27_R 30_D 2.024 1.00
322_Q 326_D 2.008 1.00
66_I 144_I 2.002 1.00
173_G 198_F 1.988 1.00
206_Q 209_L 1.973 1.00
319_D 322_Q 1.966 1.00
252_L 258_F 1.964 1.00
32_E 129_R 1.938 1.00
138_L 147_A 1.934 1.00
311_L 336_K 1.928 1.00
312_F 320_A 1.925 1.00
202_P 218_N 1.91 1.00
70_V 127_K 1.871 1.00
199_S 205_E 1.852 1.00
154_G 183_I 1.822 1.00
73_G 76_A 1.818 1.00
323_H 328_K 1.803 1.00
10_K 19_Y 1.797 1.00
205_E 216_V 1.793 1.00
86_R 140_E 1.771 1.00
49_D 325_R 1.762 1.00
71_A 83_V 1.759 1.00
233_D 253_T 1.758 1.00
257_N 281_S 1.745 1.00
72_L 83_V 1.735 1.00
81_L 137_P 1.714 1.00
196_T 232_F 1.711 1.00
175_I 248_Y 1.695 1.00
26_L 129_R 1.694 1.00
164_H 234_L 1.691 1.00
319_D 323_H 1.689 1.00
207_E 210_A 1.675 1.00
218_N 221_D 1.667 1.00
252_L 256_G 1.665 1.00
252_L 280_R 1.642 1.00
30_D 131_D 1.635 1.00
138_L 144_I 1.627 1.00
185_I 197_A 1.605 1.00
257_N 283_S 1.605 1.00
65_V 89_I 1.598 1.00
235_I 248_Y 1.576 1.00
69_V 81_L 1.565 1.00
68_R 86_R 1.543 1.00
99_C 102_C 1.54 1.00
190_A 304_K 1.537 1.00
8_A 19_Y 1.519 1.00
124_F 321_I 1.518 1.00
35_V 65_V 1.506 1.00
30_D 129_R 1.505 1.00
202_P 221_D 1.505 1.00
162_L 295_K 1.498 1.00
32_E 127_K 1.498 1.00
29_Q 131_D 1.496 1.00
81_L 85_Q 1.488 1.00
32_E 71_A 1.476 1.00
177_I 197_A 1.469 1.00
37_Y 336_K 1.461 1.00
31_V 81_L 1.457 1.00
37_Y 145_E 1.429 1.00
68_R 144_I 1.419 1.00
145_E 336_K 1.415 1.00
26_L 32_E 1.403 0.99
26_L 30_D 1.399 0.99
194_E 214_D 1.398 0.99
146_S 306_A 1.378 0.99
318_N 322_Q 1.372 0.99
235_I 252_L 1.372 0.99
77_Q 80_G 1.369 0.99
171_R 196_T 1.369 0.99
81_L 135_V 1.332 0.99
298_R 301_A 1.331 0.99
184_A 236_I 1.317 0.99
36_D 86_R 1.308 0.99
200_S 219_S 1.301 0.99
33_V 67_G 1.285 0.99
96_C 99_C 1.28 0.99
166_I 193_C 1.277 0.99
175_I 198_F 1.277 0.99
11_E 14_G 1.252 0.99
48_I 321_I 1.246 0.98
197_A 213_A 1.243 0.98
5_K 20_E 1.241 0.98
40_I 320_A 1.238 0.98
102_C 110_C 1.23 0.98
10_K 17_E 1.227 0.98
130_A 135_V 1.221 0.98
209_L 216_V 1.219 0.98
150_L 300_A 1.208 0.98
215_K 228_L 1.201 0.98
37_Y 144_I 1.196 0.98
29_Q 132_W 1.188 0.98
171_R 233_D 1.182 0.98
23_P 32_E 1.177 0.98
202_P 205_E 1.173 0.98
142_I 147_A 1.162 0.97
299_F 304_K 1.15 0.97
99_C 110_C 1.146 0.97
224_A 227_A 1.144 0.97
190_A 299_F 1.142 0.97
295_K 298_R 1.131 0.97
200_S 220_R 1.127 0.97
18_V 315_S 1.125 0.97
209_L 215_K 1.115 0.96
35_V 128_L 1.111 0.96
314_M 337_A 1.108 0.96
174_V 184_A 1.107 0.96
164_H 259_H 1.099 0.96
237_N 240_N 1.098 0.96
226_K 229_A 1.09 0.96
96_C 102_C 1.076 0.95
41_C 64_E 1.075 0.95
203_A 206_Q 1.075 0.95
72_L 76_A 1.073 0.95
41_C 63_H 1.071 0.95
33_V 87_V 1.071 0.95
170_S 233_D 1.07 0.95
39_G 64_E 1.069 0.95
162_L 292_E 1.065 0.95
317_I 335_L 1.062 0.95
70_V 83_V 1.057 0.95
322_Q 325_R 1.047 0.94
294_R 298_R 1.04 0.94
82_Q 137_P 1.037 0.94
36_D 66_I 1.023 0.93
5_K 126_E 1.022 0.93
196_T 215_K 1.021 0.93
205_E 218_N 1.021 0.93
124_F 317_I 1.016 0.93
34_Q 126_E 1.01 0.93
207_E 330_R 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3twoA20.97641000.079Contact Map0.794
1rjwA40.98231000.088Contact Map0.833
4eezA20.98231000.092Contact Map0.824
1uufA10.99411000.092Contact Map0.805
1h2bA20.97941000.094Contact Map0.822
4gkvA40.97641000.094Contact Map0.783
1f8fA10.97941000.096Contact Map0.837
2cf5A10.99411000.1Contact Map0.799
1yqdA20.99411000.103Contact Map0.78
2h6eA10.97941000.103Contact Map0.801
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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