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OPENSEQ.org
RSPB - Starvation-sensing protein RspB
UniProt: P38105 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12452
Length: 339 (337)
Sequences: 22749
Seq/Len: 67.50
RSPB
Paralog alert: 0.83 [within 20: 0.37] - ratio of genomes with paralogs
Cluster includes: ACUI ADHP CURA FRMA GATD IDND QOR1 RSPB TDH YAHK YBDR YCJQ YDJJ YDJL YGGP YJGB YJJN YPHC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
315_H 318_D 3.522 1.00
30_K 66_D 3.203 1.00
32_K 137_D 3.18 1.00
27_V 128_A 3.047 1.00
32_K 64_V 3.021 1.00
28_R 66_D 2.912 1.00
181_K 208_D 2.809 1.00
79_E 130_K 2.761 1.00
163_T 188_N 2.695 1.00
7_E 15_V 2.688 1.00
200_E 204_E 2.619 1.00
311_F 322_L 2.618 1.00
199_L 203_K 2.577 1.00
136_A 139_Y 2.568 1.00
76_R 79_E 2.562 1.00
25_G 71_G 2.491 1.00
80_R 131_I 2.466 1.00
24_A 70_E 2.457 1.00
30_K 64_V 2.452 1.00
164_V 180_L 2.374 1.00
30_K 120_Y 2.368 1.00
188_N 209_W 2.363 1.00
294_D 298_K 2.335 1.00
74_S 125_A 2.276 1.00
138_Q 310_T 2.271 1.00
312_D 315_H 2.27 1.00
5_L 15_V 2.244 1.00
24_A 71_G 2.224 1.00
221_I 224_E 2.217 1.00
134_A 297_S 2.194 1.00
19_I 120_Y 2.155 1.00
165_L 229_P 2.141 1.00
159_T 162_D 2.139 1.00
309_H 322_L 2.108 1.00
7_E 13_A 2.106 1.00
196_D 200_E 2.106 1.00
21_T 67_A 2.076 1.00
177_V 207_A 2.075 1.00
61_F 116_G 2.065 1.00
162_D 254_R 2.056 1.00
80_R 137_D 2.032 1.00
23_S 26_E 2.031 1.00
318_D 321_S 1.987 1.00
249_A 255_I 1.986 1.00
165_L 192_A 1.983 1.00
200_E 203_K 1.981 1.00
28_R 122_V 1.971 1.00
196_D 212_N 1.965 1.00
311_F 319_A 1.961 1.00
321_S 325_Q 1.952 1.00
66_D 120_Y 1.899 1.00
310_T 336_T 1.89 1.00
62_F 137_D 1.851 1.00
193_D 199_L 1.838 1.00
69_G 72_V 1.812 1.00
199_L 210_A 1.794 1.00
80_R 133_E 1.785 1.00
67_A 77_V 1.766 1.00
68_V 77_V 1.742 1.00
61_F 83_V 1.741 1.00
230_T 250_S 1.735 1.00
249_A 253_A 1.721 1.00
75_A 130_K 1.709 1.00
201_K 204_E 1.691 1.00
216_T 221_I 1.686 1.00
167_Y 245_A 1.67 1.00
131_I 137_D 1.659 1.00
26_E 124_P 1.657 1.00
318_D 322_L 1.654 1.00
45_R 324_E 1.651 1.00
22_P 122_V 1.644 1.00
156_G 231_L 1.641 1.00
190_I 229_P 1.638 1.00
212_N 215_Q 1.626 1.00
2_K 16_E 1.626 1.00
177_V 191_V 1.588 1.00
64_V 80_R 1.583 1.00
196_D 215_Q 1.573 1.00
92_C 95_C 1.557 1.00
254_R 278_S 1.546 1.00
26_E 122_V 1.544 1.00
232_I 245_A 1.542 1.00
169_A 191_V 1.534 1.00
4_I 316_V 1.534 1.00
65_I 75_A 1.53 1.00
25_G 124_P 1.525 1.00
188_N 208_D 1.521 1.00
31_V 61_F 1.519 1.00
117_F 320_I 1.518 1.00
217_P 220_E 1.51 1.00
28_R 120_Y 1.49 1.00
75_A 79_E 1.488 1.00
27_V 75_A 1.473 1.00
249_A 277_L 1.466 1.00
28_R 67_A 1.453 1.00
2_K 119_E 1.426 1.00
22_P 26_E 1.409 1.00
232_I 249_A 1.395 0.99
163_T 190_I 1.393 0.99
33_L 336_T 1.393 0.99
294_D 297_S 1.387 0.99
2_K 314_Q 1.383 0.99
317_A 321_S 1.377 0.99
75_A 128_A 1.366 0.99
64_V 137_D 1.354 0.99
145_P 148_I 1.352 0.99
22_P 28_R 1.348 0.99
44_Y 320_I 1.342 0.99
89_C 92_C 1.339 0.99
131_I 140_A 1.337 0.99
194_R 213_N 1.331 0.99
95_C 103_C 1.33 0.99
32_K 80_R 1.33 0.99
176_I 233_I 1.323 0.99
29_V 63_G 1.311 0.99
3_S 17_R 1.311 0.99
33_L 138_Q 1.307 0.99
308_T 322_L 1.304 0.99
322_L 327_Q 1.301 0.99
92_C 103_C 1.296 0.99
167_Y 192_A 1.286 0.99
254_R 280_F 1.284 0.99
4_I 14_I 1.268 0.99
36_I 319_A 1.262 0.99
295_W 300_L 1.254 0.99
191_V 207_A 1.252 0.99
204_E 305_K 1.247 0.99
203_K 210_A 1.218 0.98
123_V 128_A 1.211 0.98
156_G 256_V 1.202 0.98
163_T 230_T 1.189 0.98
25_G 125_A 1.183 0.98
302_K 305_K 1.175 0.98
196_D 199_L 1.167 0.97
89_C 95_C 1.166 0.97
19_I 28_R 1.159 0.97
166_V 176_I 1.147 0.97
33_L 137_D 1.139 0.97
31_V 121_A 1.125 0.97
182_G 300_L 1.124 0.97
37_C 59_H 1.119 0.96
217_P 221_I 1.118 0.96
35_G 60_E 1.114 0.96
14_I 314_Q 1.111 0.96
234_D 237_C 1.106 0.96
203_K 209_W 1.091 0.96
220_E 224_E 1.088 0.96
68_V 72_V 1.085 0.96
8_K 11_Q 1.082 0.96
158_P 186_V 1.073 0.95
37_C 60_E 1.072 0.95
190_I 209_W 1.069 0.95
194_R 214_S 1.059 0.95
32_K 62_F 1.056 0.95
144_E 148_I 1.056 0.95
139_Y 304_E 1.055 0.95
138_Q 336_T 1.055 0.95
162_D 230_T 1.053 0.95
29_V 81_V 1.047 0.94
313_F 337_F 1.045 0.94
76_R 130_K 1.039 0.94
197_E 200_E 1.036 0.94
178_Q 302_K 1.032 0.94
30_K 119_E 1.017 0.93
4_I 313_F 1.014 0.93
66_D 77_V 1.009 0.93
316_V 335_L 1.002 0.92
91_H 96_S 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4ilkA211000.003Contact Map0.803
4a2cA20.98231000.043Contact Map0.761
4ej6A10.98821000.044Contact Map0.796
2dq4A20.98531000.061Contact Map0.803
1h2bA20.97351000.067Contact Map0.796
3ukoA20.98821000.067Contact Map0.768
1rjwA40.97941000.069Contact Map0.834
3m6iA20.99121000.069Contact Map0.825
4gkvA40.97941000.069Contact Map0.782
1e3iA20.97941000.072Contact Map0.829
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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