| UniProt: | P26646 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG11315 | ||
| Length: | 324 (321) | ||
| Sequences: | 22691 | ||
| Seq/Len: | 70.69 |
| ACUI
Paralog alert: 0.83 [within 20: 0.38] - ratio of genomes with paralogs Cluster includes: ACUI ADHP CURA FRMA GATD IDND QOR1 RSPB TDH YAHK YBDR YCJQ YDJJ YDJL YGGP YJGB YJJN YPHC |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 302_E | 305_N | 3.481 | 1.00 | |
| 35_H | 118_A | 3.297 | 1.00 | |
| 33_D | 70_R | 3.205 | 1.00 | |
| 35_H | 68_T | 2.993 | 1.00 | |
| 30_V | 109_L | 2.914 | 1.00 | |
| 7_E | 18_Q | 2.91 | 1.00 | |
| 31_T | 70_R | 2.905 | 1.00 | |
| 117_D | 120_K | 2.813 | 1.00 | |
| 168_H | 193_S | 2.777 | 1.00 | |
| 81_Q | 111_A | 2.762 | 1.00 | |
| 149_E | 173_Q | 2.759 | 1.00 | |
| 185_E | 189_S | 2.735 | 1.00 | |
| 184_H | 188_K | 2.606 | 1.00 | |
| 298_I | 309_A | 2.571 | 1.00 | |
| 78_H | 81_Q | 2.568 | 1.00 | |
| 119_R | 297_E | 2.533 | 1.00 | |
| 33_D | 68_T | 2.439 | 1.00 | |
| 82_E | 112_M | 2.392 | 1.00 | |
| 33_D | 101_Q | 2.353 | 1.00 | |
| 173_Q | 194_R | 2.304 | 1.00 | |
| 150_I | 167_L | 2.285 | 1.00 | |
| 5_L | 18_Q | 2.274 | 1.00 | |
| 284_A | 288_E | 2.272 | 1.00 | |
| 299_S | 302_E | 2.241 | 1.00 | |
| 7_E | 16_S | 2.222 | 1.00 | |
| 296_K | 309_A | 2.215 | 1.00 | |
| 22_E | 101_Q | 2.204 | 1.00 | |
| 181_E | 185_E | 2.181 | 1.00 | |
| 76_R | 106_G | 2.166 | 1.00 | |
| 297_E | 322_K | 2.135 | 1.00 | |
| 24_R | 71_T | 2.107 | 1.00 | |
| 65_F | 97_G | 2.081 | 1.00 | |
| 155_A | 176_A | 2.07 | 1.00 | |
| 151_V | 212_W | 2.059 | 1.00 | |
| 26_P | 29_D | 2.056 | 1.00 | |
| 144_R | 147_D | 2.053 | 1.00 | |
| 115_G | 287_P | 2.045 | 1.00 | |
| 164_V | 192_A | 2.039 | 1.00 | |
| 82_E | 118_A | 2.027 | 1.00 | |
| 305_N | 308_E | 1.99 | 1.00 | |
| 308_E | 312_N | 1.981 | 1.00 | |
| 31_T | 103_R | 1.973 | 1.00 | |
| 185_E | 188_K | 1.943 | 1.00 | |
| 66_A | 118_A | 1.928 | 1.00 | |
| 231_M | 237_V | 1.916 | 1.00 | |
| 128_G | 162_T | 1.908 | 1.00 | |
| 70_R | 101_Q | 1.895 | 1.00 | |
| 151_V | 177_V | 1.888 | 1.00 | |
| 298_I | 306_F | 1.888 | 1.00 | |
| 147_D | 236_C | 1.86 | 1.00 | |
| 48_T | 311_I | 1.832 | 1.00 | |
| 71_T | 79_A | 1.819 | 1.00 | |
| 309_A | 314_Q | 1.818 | 1.00 | |
| 65_F | 85_L | 1.81 | 1.00 | |
| 112_M | 121_A | 1.798 | 1.00 | |
| 184_H | 195_V | 1.787 | 1.00 | |
| 136_M | 170_L | 1.783 | 1.00 | |
| 181_E | 197_P | 1.772 | 1.00 | |
| 213_A | 232_N | 1.753 | 1.00 | |
| 236_C | 261_R | 1.738 | 1.00 | |
| 2_Q | 19_T | 1.726 | 1.00 | |
| 178_S | 184_H | 1.713 | 1.00 | |
| 77_F | 111_A | 1.705 | 1.00 | |
| 305_N | 309_A | 1.696 | 1.00 | |
| 72_S | 79_A | 1.687 | 1.00 | |
| 4_L | 303_A | 1.683 | 1.00 | |
| 231_M | 235_G | 1.682 | 1.00 | |
| 236_C | 263_Q | 1.679 | 1.00 | |
| 25_L | 103_R | 1.676 | 1.00 | |
| 82_E | 114_Q | 1.671 | 1.00 | |
| 186_Y | 189_S | 1.634 | 1.00 | |
| 231_M | 260_V | 1.622 | 1.00 | |
| 112_M | 118_A | 1.614 | 1.00 | |
| 69_V | 77_F | 1.614 | 1.00 | |
| 153_T | 227_V | 1.603 | 1.00 | |
| 29_D | 105_K | 1.597 | 1.00 | |
| 169_K | 290_F | 1.585 | 1.00 | |
| 175_V | 212_W | 1.582 | 1.00 | |
| 68_T | 82_E | 1.556 | 1.00 | |
| 215_A | 227_V | 1.554 | 1.00 | |
| 200_E | 203_E | 1.548 | 1.00 | |
| 28_G | 105_K | 1.539 | 1.00 | |
| 2_Q | 100_E | 1.515 | 1.00 | |
| 31_T | 101_Q | 1.503 | 1.00 | |
| 119_R | 322_K | 1.498 | 1.00 | |
| 29_D | 103_R | 1.495 | 1.00 | |
| 77_F | 81_Q | 1.488 | 1.00 | |
| 34_V | 65_F | 1.486 | 1.00 | |
| 36_W | 322_K | 1.486 | 1.00 | |
| 2_Q | 301_S | 1.481 | 1.00 | |
| 30_V | 77_F | 1.476 | 1.00 | |
| 31_T | 71_T | 1.474 | 1.00 | |
| 3_A | 20_L | 1.456 | 1.00 | |
| 141_A | 214_G | 1.447 | 1.00 | |
| 173_Q | 193_S | 1.443 | 1.00 | |
| 25_L | 31_T | 1.442 | 1.00 | |
| 36_W | 119_R | 1.437 | 1.00 | |
| 164_V | 176_A | 1.426 | 1.00 | |
| 68_T | 118_A | 1.406 | 0.99 | |
| 98_L | 307_A | 1.406 | 0.99 | |
| 25_L | 29_D | 1.406 | 0.99 | |
| 136_M | 281_R | 1.401 | 0.99 | |
| 304_P | 308_E | 1.389 | 0.99 | |
| 149_E | 175_V | 1.37 | 0.99 | |
| 77_F | 109_L | 1.368 | 0.99 | |
| 215_A | 231_M | 1.36 | 0.99 | |
| 163_A | 216_I | 1.33 | 0.99 | |
| 194_R | 207_L | 1.317 | 0.99 | |
| 284_A | 287_P | 1.316 | 0.99 | |
| 32_V | 67_G | 1.313 | 0.99 | |
| 35_H | 82_E | 1.309 | 0.99 | |
| 4_L | 17_V | 1.307 | 0.99 | |
| 179_G | 198_R | 1.306 | 0.99 | |
| 28_G | 106_G | 1.281 | 0.99 | |
| 104_V | 109_L | 1.275 | 0.99 | |
| 153_T | 177_V | 1.252 | 0.99 | |
| 143_V | 172_Y | 1.24 | 0.98 | |
| 203_E | 206_P | 1.232 | 0.98 | |
| 188_K | 195_V | 1.221 | 0.98 | |
| 47_I | 307_A | 1.2 | 0.98 | |
| 149_E | 213_A | 1.195 | 0.98 | |
| 39_L | 306_F | 1.179 | 0.98 | |
| 176_A | 192_A | 1.178 | 0.98 | |
| 152_V | 163_A | 1.176 | 0.98 | |
| 181_E | 184_H | 1.174 | 0.98 | |
| 116_L | 121_A | 1.172 | 0.98 | |
| 285_D | 290_F | 1.168 | 0.97 | |
| 22_E | 31_T | 1.167 | 0.97 | |
| 300_L | 323_V | 1.152 | 0.97 | |
| 36_W | 118_A | 1.151 | 0.97 | |
| 169_K | 285_D | 1.13 | 0.97 | |
| 120_K | 292_T | 1.125 | 0.97 | |
| 132_M | 136_M | 1.116 | 0.96 | |
| 34_V | 102_A | 1.113 | 0.96 | |
| 280_Q | 284_A | 1.108 | 0.96 | |
| 17_V | 301_S | 1.093 | 0.96 | |
| 188_K | 194_R | 1.088 | 0.96 | |
| 141_A | 238_A | 1.069 | 0.95 | |
| 32_V | 83_V | 1.069 | 0.95 | |
| 303_A | 321_V | 1.051 | 0.94 | |
| 131_A | 166_L | 1.05 | 0.94 | |
| 217_D | 220_G | 1.048 | 0.94 | |
| 308_E | 311_I | 1.045 | 0.94 | |
| 229_A | 254_P | 1.035 | 0.94 | |
| 152_V | 167_L | 1.031 | 0.94 | |
| 2_Q | 17_V | 1.025 | 0.93 | |
| 281_R | 284_A | 1.023 | 0.93 | |
| 70_R | 79_A | 1.022 | 0.93 | |
| 4_L | 300_L | 1.02 | 0.93 | |
| 78_H | 111_A | 1.02 | 0.93 | |
| 47_I | 311_I | 1.016 | 0.93 | |
| 299_S | 322_K | 1.006 | 0.93 | |
| 33_D | 100_E | 1.004 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3nx4A | 2 | 1 | 100 | 0.024 | Contact Map | 0.743 |
| 4j6fA | 2 | 0.966 | 100 | 0.064 | Contact Map | 0.797 |
| 4a27A | 2 | 0.966 | 100 | 0.064 | Contact Map | 0.836 |
| 4dupA | 2 | 0.9691 | 100 | 0.065 | Contact Map | 0.812 |
| 3uogA | 2 | 0.9599 | 100 | 0.068 | Contact Map | 0.806 |
| 1tt7A | 6 | 0.9938 | 100 | 0.068 | Contact Map | 0.789 |
| 4jxkA | 2 | 0.9938 | 100 | 0.07 | Contact Map | 0.725 |
| 1zsyA | 1 | 0.9722 | 100 | 0.073 | Contact Map | 0.745 |
| 4eyeA | 2 | 0.963 | 100 | 0.078 | Contact Map | 0.807 |
| 4gi2A | 2 | 0.9784 | 100 | 0.081 | Contact Map | 0.818 |
Sequence Conservation (Image Generated using WebLogo v3)