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OPENSEQ.org
GATD - Galactitol-1-phosphate 5-dehydrogenase
UniProt: P0A9S3 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12417
Length: 346 (345)
Sequences: 22281
Seq/Len: 64.58
GATD
Paralog alert: 0.83 [within 20: 0.37] - ratio of genomes with paralogs
Cluster includes: ACUI ADHP CURA FRMA GATD IDND QOR1 RSPB TDH YAHK YBDR YCJQ YDJJ YDJL YGGP YJGB YJJN YPHC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
325_S 328_Q 3.548 1.00
33_A 137_I 3.391 1.00
31_K 66_D 3.279 1.00
28_V 128_V 3.089 1.00
33_A 64_Y 3.036 1.00
29_R 66_D 3.01 1.00
136_P 139_D 2.867 1.00
181_V 207_M 2.866 1.00
79_D 130_A 2.855 1.00
199_A 203_S 2.748 1.00
76_H 79_D 2.603 1.00
198_L 202_K 2.568 1.00
321_G 332_D 2.566 1.00
80_A 131_L 2.557 1.00
31_K 64_Y 2.501 1.00
26_D 71_G 2.471 1.00
138_E 320_R 2.454 1.00
31_K 120_Y 2.435 1.00
164_V 180_A 2.395 1.00
7_D 15_A 2.323 1.00
19_I 120_Y 2.318 1.00
74_D 125_R 2.28 1.00
304_R 308_E 2.274 1.00
25_Q 70_S 2.266 1.00
163_N 186_K 2.251 1.00
322_S 325_S 2.24 1.00
195_S 199_A 2.228 1.00
134_D 307_T 2.191 1.00
80_A 137_I 2.149 1.00
159_C 162_K 2.132 1.00
21_E 67_A 2.121 1.00
177_I 206_A 2.113 1.00
61_F 116_G 2.11 1.00
162_K 255_Q 2.072 1.00
250_A 256_L 2.072 1.00
328_Q 331_R 2.066 1.00
62_S 137_I 2.064 1.00
25_Q 71_G 2.062 1.00
319_H 332_D 2.04 1.00
29_R 122_V 2.039 1.00
165_I 191_I 2.017 1.00
199_A 202_K 2.009 1.00
195_S 211_N 2 1.00
66_D 120_Y 1.921 1.00
321_G 329_A 1.909 1.00
192_D 198_L 1.907 1.00
5_V 15_A 1.891 1.00
131_L 140_G 1.886 1.00
7_D 13_R 1.866 1.00
69_G 72_V 1.851 1.00
61_F 83_C 1.814 1.00
331_R 335_R 1.806 1.00
198_L 209_T 1.805 1.00
80_A 133_T 1.793 1.00
67_A 77_P 1.784 1.00
75_L 130_A 1.762 1.00
255_Q 282_T 1.754 1.00
139_D 314_E 1.751 1.00
68_V 77_P 1.746 1.00
211_N 214_E 1.728 1.00
200_L 203_S 1.72 1.00
27_E 124_K 1.719 1.00
167_I 246_A 1.711 1.00
182_A 310_K 1.696 1.00
131_L 137_I 1.692 1.00
250_A 254_A 1.692 1.00
328_Q 332_D 1.687 1.00
219_Q 222_S 1.661 1.00
195_S 214_E 1.659 1.00
177_I 190_A 1.659 1.00
250_A 281_L 1.641 1.00
255_Q 284_I 1.633 1.00
233_I 246_A 1.619 1.00
156_A 232_L 1.597 1.00
117_F 330_V 1.59 1.00
332_D 337_A 1.576 1.00
64_Y 80_A 1.572 1.00
165_I 229_F 1.572 1.00
22_I 122_V 1.565 1.00
27_E 122_V 1.564 1.00
32_I 61_F 1.562 1.00
29_R 120_Y 1.561 1.00
26_D 124_K 1.543 1.00
65_I 75_L 1.539 1.00
92_C 95_C 1.53 1.00
75_L 79_D 1.528 1.00
186_K 208_Q 1.517 1.00
23_K 27_E 1.508 1.00
187_S 208_Q 1.507 1.00
28_V 75_L 1.505 1.00
163_N 187_S 1.49 1.00
29_R 67_A 1.477 1.00
169_A 190_A 1.469 1.00
34_S 138_E 1.465 1.00
163_N 189_T 1.454 1.00
304_R 307_T 1.447 1.00
2_K 16_E 1.439 1.00
64_Y 137_I 1.438 1.00
89_C 92_C 1.427 1.00
4_V 326_F 1.414 1.00
189_T 229_F 1.414 1.00
320_R 345_I 1.404 0.99
167_I 191_I 1.402 0.99
327_A 331_R 1.381 0.99
146_I 175_L 1.369 0.99
33_A 80_A 1.36 0.99
176_A 234_L 1.357 0.99
233_I 250_A 1.35 0.99
231_Q 251_G 1.35 0.99
22_I 29_R 1.344 0.99
95_C 103_C 1.343 0.99
223_V 226_E 1.343 0.99
75_L 128_V 1.343 0.99
193_I 212_S 1.327 0.99
30_V 63_G 1.322 0.99
318_A 332_D 1.313 0.99
190_A 206_A 1.293 0.99
92_C 103_C 1.289 0.99
216_S 219_Q 1.259 0.99
123_V 128_V 1.253 0.99
158_G 185_A 1.246 0.98
202_K 209_T 1.246 0.98
37_L 329_A 1.236 0.98
235_E 238_G 1.23 0.98
305_L 310_K 1.226 0.98
2_K 119_E 1.217 0.98
34_S 137_I 1.213 0.98
22_I 27_E 1.211 0.98
154_H 301_T 1.194 0.98
138_E 345_I 1.193 0.98
26_D 125_R 1.187 0.98
2_K 324_E 1.183 0.98
19_I 29_R 1.176 0.98
182_A 305_L 1.173 0.98
143_I 306_L 1.161 0.97
186_K 207_M 1.156 0.97
89_C 95_C 1.155 0.97
312_S 315_P 1.151 0.97
166_I 176_A 1.149 0.97
36_G 60_E 1.143 0.97
220_M 223_V 1.141 0.97
156_A 257_A 1.132 0.97
195_S 198_L 1.13 0.97
32_I 121_I 1.129 0.97
202_K 208_Q 1.128 0.97
38_C 59_H 1.115 0.96
14_V 324_E 1.114 0.96
38_C 60_E 1.113 0.96
301_T 304_R 1.112 0.96
165_I 230_N 1.111 0.96
203_S 315_P 1.11 0.96
68_V 72_V 1.101 0.96
154_H 298_E 1.098 0.96
200_L 339_P 1.096 0.96
198_L 211_N 1.091 0.96
3_S 17_S 1.09 0.96
196_E 199_A 1.09 0.96
4_V 14_V 1.089 0.96
193_I 213_S 1.086 0.96
34_S 345_I 1.085 0.96
33_A 62_S 1.083 0.96
189_T 208_Q 1.067 0.95
30_V 81_V 1.066 0.95
135_M 140_G 1.063 0.95
66_D 77_P 1.052 0.95
180_A 185_A 1.046 0.94
76_H 130_A 1.045 0.94
31_K 119_E 1.043 0.94
300_E 304_R 1.042 0.94
166_I 180_A 1.032 0.94
149_G 179_C 1.025 0.93
8_T 11_I 1.025 0.93
193_I 198_L 1.019 0.93
219_Q 223_V 1.019 0.93
179_C 305_L 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4a2cA20.99131000.061Contact Map0.753
4ej6A10.96531000.096Contact Map0.792
2dq4A20.96241000.105Contact Map0.78
4ilkA20.95661000.107Contact Map0.783
1h2bA20.95381000.111Contact Map0.799
1e3iA20.96531000.115Contact Map0.812
4eezA20.95381000.116Contact Map0.832
1f8fA10.96821000.118Contact Map0.819
3m6iA20.95951000.122Contact Map0.82
4gkvA40.9481000.123Contact Map0.778
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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