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OPENSEQ.org

QOR1 - Quinone oxidoreductase 1
UniProt: P28304 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11492
Length: 327 (325)
Sequences: 22787
Seq/Len: 70.11

QOR1
Paralog alert: 0.83 [within 20: 0.38] - ratio of genomes with paralogs
Cluster includes: ACUI ADHP CURA FRMA GATD IDND QOR1 RSPB TDH YAHK YBDR YCJQ YDJJ YDJL YGGP YJGB YJJN YPHC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
306_D 309_R 3.366 1.00
36_K 115_F 3.225 1.00
34_E 70_S 3.092 1.00
36_K 68_I 2.919 1.00
31_I 106_A 2.848 1.00
32_Q 70_S 2.809 1.00
8_H 19_V 2.779 1.00
114_S 117_Q 2.723 1.00
83_D 108_I 2.704 1.00
162_K 187_W 2.691 1.00
179_Q 183_K 2.616 1.00
143_Q 167_K 2.596 1.00
302_Y 313_I 2.564 1.00
80_K 83_D 2.471 1.00
178_A 182_L 2.47 1.00
116_E 301_K 2.452 1.00
200_R 203_E 2.439 1.00
28_E 74_S 2.384 1.00
34_E 68_I 2.365 1.00
84_R 109_L 2.362 1.00
29_N 75_G 2.327 1.00
34_E 98_V 2.277 1.00
285_S 289_S 2.217 1.00
6_E 19_V 2.204 1.00
144_F 161_A 2.199 1.00
78_H 103_A 2.195 1.00
28_E 75_G 2.186 1.00
167_K 188_Q 2.181 1.00
303_P 306_D 2.179 1.00
23_P 98_V 2.142 1.00
65_A 94_A 2.118 1.00
300_Q 313_I 2.101 1.00
112_A 288_A 2.097 1.00
139_K 142_E 2.083 1.00
8_H 17_Q 2.065 1.00
175_A 179_Q 2.039 1.00
84_R 115_F 2.031 1.00
145_L 210_V 2.021 1.00
25_D 71_K 2.006 1.00
27_A 30_E 2.004 1.00
158_C 186_A 1.986 1.00
309_R 312_E 1.932 1.00
302_Y 310_A 1.929 1.00
142_E 234_L 1.929 1.00
312_E 316_S 1.924 1.00
66_A 115_F 1.903 1.00
32_Q 100_N 1.9 1.00
125_G 156_I 1.887 1.00
229_L 235_M 1.873 1.00
70_S 98_V 1.856 1.00
179_Q 182_L 1.855 1.00
145_L 171_T 1.851 1.00
301_K 326_I 1.843 1.00
149_A 170_G 1.839 1.00
175_A 191_N 1.822 1.00
313_I 318_A 1.76 1.00
109_L 118_A 1.737 1.00
133_R 164_L 1.721 1.00
178_A 189_V 1.719 1.00
3_T 20_E 1.711 1.00
49_S 315_E 1.709 1.00
71_K 81_A 1.709 1.00
172_V 178_A 1.694 1.00
73_G 76_V 1.69 1.00
211_R 230_Q 1.686 1.00
84_R 111_A 1.665 1.00
195_E 200_R 1.659 1.00
79_I 108_I 1.652 1.00
72_V 81_A 1.638 1.00
26_P 100_N 1.613 1.00
229_L 233_G 1.604 1.00
109_L 115_F 1.594 1.00
309_R 313_I 1.59 1.00
169_I 210_V 1.584 1.00
163_A 291_V 1.578 1.00
180_S 183_K 1.563 1.00
147_H 225_S 1.56 1.00
5_I 307_A 1.559 1.00
191_N 194_E 1.554 1.00
196_D 199_E 1.553 1.00
234_L 260_Y 1.551 1.00
175_A 194_E 1.548 1.00
30_E 102_I 1.541 1.00
65_A 87_Y 1.534 1.00
68_I 84_R 1.516 1.00
188_Q 204_I 1.511 1.00
213_V 225_S 1.508 1.00
29_N 102_I 1.5 1.00
69_V 79_I 1.484 1.00
35_N 65_A 1.48 1.00
79_I 83_D 1.477 1.00
32_Q 98_V 1.476 1.00
3_T 305_K 1.468 1.00
95_Y 311_H 1.456 1.00
3_T 97_S 1.453 1.00
32_Q 71_K 1.45 1.00
30_E 100_N 1.45 1.00
136_Y 212_V 1.427 1.00
167_K 187_W 1.399 0.99
31_I 79_I 1.392 0.99
37_A 116_E 1.382 0.99
68_I 115_F 1.382 0.99
158_C 170_G 1.37 0.99
4_R 21_F 1.37 0.99
26_P 32_Q 1.349 0.99
229_L 259_L 1.348 0.99
26_P 30_E 1.342 0.99
308_Q 312_E 1.34 0.99
213_V 229_L 1.322 0.99
157_A 214_Y 1.318 0.99
199_E 203_E 1.311 0.99
285_S 288_A 1.307 0.99
173_G 192_Y 1.303 0.99
143_Q 169_I 1.3 0.99
79_I 106_A 1.293 0.99
256_K 259_L 1.291 0.99
37_A 326_I 1.282 0.99
299_Q 313_I 1.281 0.99
5_I 18_A 1.272 0.99
33_V 67_G 1.265 0.99
117_Q 293_K 1.263 0.99
116_E 326_I 1.257 0.99
147_H 171_T 1.255 0.99
234_L 262_T 1.237 0.98
36_K 84_R 1.233 0.98
101_I 106_A 1.216 0.98
286_L 291_V 1.204 0.98
138_I 166_A 1.186 0.98
175_A 178_A 1.182 0.98
40_I 310_A 1.179 0.98
129_Y 133_R 1.173 0.98
48_R 311_H 1.171 0.98
182_L 189_V 1.165 0.97
29_N 103_A 1.162 0.97
41_N 63_T 1.162 0.97
133_R 282_E 1.161 0.97
37_A 115_F 1.141 0.97
146_F 157_A 1.135 0.97
23_P 32_Q 1.134 0.97
163_A 286_L 1.127 0.97
170_G 186_A 1.124 0.97
143_Q 211_R 1.124 0.97
136_Y 236_V 1.119 0.96
113_I 118_A 1.108 0.96
35_N 99_H 1.084 0.96
200_R 204_I 1.074 0.95
173_G 193_R 1.069 0.95
215_D 218_G 1.052 0.95
18_A 305_K 1.043 0.94
134_K 275_E 1.042 0.94
182_L 188_Q 1.038 0.94
146_F 161_A 1.037 0.94
282_E 285_S 1.035 0.94
312_E 315_E 1.03 0.94
128_V 160_W 1.023 0.93
33_V 85_V 1.022 0.93
142_E 211_R 1.021 0.93
41_N 64_E 1.015 0.93
34_E 97_S 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1qorA211000.019Contact Map0.795
3jynA10.99391000.025Contact Map0.766
1wlyA10.99081000.046Contact Map0.747
4dupA20.98471000.048Contact Map0.803
4eyeA20.97861000.05Contact Map0.785
3qwbA40.98171000.051Contact Map0.802
1yb5A20.97861000.059Contact Map0.84
4j6fA20.96021000.061Contact Map0.761
3uogA20.95721000.065Contact Map0.829
4a27A20.97551000.066Contact Map0.841

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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