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YAHK - Uncharacterized zinc-type alcohol dehydrogenase-like protein YahK
UniProt: P75691 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13595
Length: 349 (338)
Sequences: 22427
Seq/Len: 66.35
YAHK
Paralog alert: 0.83 [within 20: 0.37] - ratio of genomes with paralogs
Cluster includes: ACUI ADHP CURA FRMA GATD IDND QOR1 RSPB TDH YAHK YBDR YCJQ YDJJ YDJL YGGP YJGB YJJN YPHC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
323_Q 326_E 3.54 1.00
35_A 150_L 3.376 1.00
33_E 69_V 3.217 1.00
30_V 140_V 3.083 1.00
35_A 67_R 3.012 1.00
31_K 69_V 2.935 1.00
148_E 152_A 2.868 1.00
195_H 220_D 2.856 1.00
82_D 142_R 2.807 1.00
177_K 200_H 2.71 1.00
212_E 216_A 2.671 1.00
319_I 330_R 2.641 1.00
211_R 215_K 2.599 1.00
79_A 82_D 2.598 1.00
27_P 73_D 2.502 1.00
28_N 74_Q 2.498 1.00
151_A 318_M 2.495 1.00
83_L 143_I 2.476 1.00
33_E 67_R 2.472 1.00
33_E 132_Q 2.412 1.00
178_V 194_A 2.348 1.00
77_K 137_E 2.327 1.00
320_R 323_Q 2.303 1.00
148_E 151_A 2.288 1.00
27_P 74_Q 2.264 1.00
22_R 132_Q 2.26 1.00
305_D 309_E 2.26 1.00
200_H 221_E 2.25 1.00
173_G 176_K 2.194 1.00
208_E 212_E 2.186 1.00
179_G 238_F 2.168 1.00
24_E 70_A 2.162 1.00
83_L 150_L 2.157 1.00
146_P 308_A 2.14 1.00
191_I 219_A 2.111 1.00
64_I 128_G 2.107 1.00
176_K 263_T 2.087 1.00
317_E 330_R 2.078 1.00
318_M 343_D 2.072 1.00
329_E 333_R 2.069 1.00
26_G 29_D 2.063 1.00
258_L 264_M 2.025 1.00
179_G 204_F 1.999 1.00
65_V 150_L 1.996 1.00
326_E 329_E 1.988 1.00
31_K 134_V 1.982 1.00
212_E 215_K 1.981 1.00
208_E 224_N 1.948 1.00
319_I 327_A 1.942 1.00
143_I 153_V 1.93 1.00
69_V 132_Q 1.893 1.00
160_G 189_M 1.852 1.00
205_T 211_R 1.845 1.00
211_R 222_V 1.8 1.00
72_G 75_V 1.799 1.00
330_R 335_D 1.794 1.00
83_L 145_H 1.792 1.00
9_Y 18_M 1.788 1.00
239_D 259_K 1.787 1.00
70_A 80_P 1.782 1.00
48_R 332_L 1.775 1.00
263_T 288_A 1.768 1.00
78_Y 142_R 1.741 1.00
71_V 80_P 1.738 1.00
202_V 238_F 1.726 1.00
25_P 134_V 1.725 1.00
258_L 262_G 1.716 1.00
326_E 330_R 1.695 1.00
213_A 216_A 1.693 1.00
181_V 254_F 1.693 1.00
224_N 227_N 1.679 1.00
258_L 287_R 1.679 1.00
29_D 136_H 1.674 1.00
170_W 240_F 1.667 1.00
143_I 150_L 1.663 1.00
263_T 290_A 1.628 1.00
191_I 203_A 1.612 1.00
241_I 254_F 1.606 1.00
67_R 83_L 1.564 1.00
208_E 227_N 1.559 1.00
196_A 311_G 1.558 1.00
34_I 64_I 1.547 1.00
129_Y 328_Y 1.537 1.00
168_R 302_E 1.536 1.00
28_N 136_H 1.528 1.00
29_D 134_V 1.526 1.00
78_Y 82_D 1.523 1.00
31_K 132_Q 1.519 1.00
64_I 86_V 1.507 1.00
36_Y 343_D 1.502 1.00
68_V 78_Y 1.501 1.00
31_K 70_A 1.492 1.00
183_I 203_A 1.487 1.00
30_V 78_Y 1.477 1.00
151_A 343_D 1.458 1.00
67_R 150_L 1.457 1.00
36_Y 151_A 1.436 1.00
96_C 99_C 1.431 1.00
25_P 29_D 1.416 1.00
25_P 31_K 1.412 1.00
200_H 220_D 1.409 1.00
152_A 313_V 1.399 0.99
325_N 329_E 1.395 0.99
241_I 258_L 1.393 0.99
177_K 202_V 1.386 0.99
305_D 308_A 1.361 0.99
78_Y 140_V 1.355 0.99
93_C 96_C 1.342 0.99
7_G 18_M 1.338 0.99
190_G 242_L 1.334 0.99
206_T 225_S 1.326 0.99
35_A 83_L 1.322 0.99
32_I 66_G 1.305 0.99
321_A 344_N 1.299 0.99
10_S 13_Q 1.29 0.99
172_A 199_A 1.289 0.99
203_A 219_A 1.273 0.99
181_V 204_F 1.272 0.99
47_V 328_Y 1.262 0.99
39_V 327_A 1.246 0.98
135_V 140_V 1.232 0.98
215_K 222_V 1.231 0.98
156_L 307_C 1.212 0.98
36_Y 150_L 1.21 0.98
22_R 31_K 1.207 0.98
28_N 137_E 1.203 0.98
177_K 239_D 1.196 0.98
208_E 211_R 1.186 0.98
96_C 107_C 1.173 0.98
147_Q 153_V 1.168 0.97
180_V 190_G 1.167 0.97
232_A 235_L 1.167 0.97
168_R 197_M 1.165 0.97
306_F 311_G 1.161 0.97
230_E 233_A 1.148 0.97
196_A 306_F 1.146 0.97
17_P 322_D 1.14 0.97
34_I 133_I 1.136 0.97
215_K 221_E 1.135 0.97
99_C 107_C 1.132 0.97
206_T 226_R 1.131 0.97
302_E 305_D 1.129 0.97
9_Y 16_E 1.12 0.96
243_N 246_A 1.11 0.96
4_K 19_D 1.11 0.96
40_C 62_H 1.108 0.96
170_W 265_T 1.09 0.96
71_V 75_V 1.084 0.96
324_I 342_I 1.084 0.96
209_A 212_E 1.077 0.95
221_E 234_H 1.075 0.95
40_C 63_E 1.068 0.95
176_K 239_D 1.066 0.95
69_V 80_P 1.065 0.95
38_G 63_E 1.059 0.95
79_A 142_R 1.058 0.95
180_V 194_A 1.055 0.95
211_R 224_N 1.05 0.94
213_A 337_K 1.049 0.94
33_E 131_Q 1.049 0.94
329_E 332_L 1.045 0.94
32_I 84_V 1.041 0.94
35_A 65_V 1.038 0.94
202_V 221_E 1.037 0.94
301_Q 305_D 1.026 0.94
129_Y 324_I 1.025 0.93
93_C 99_C 1.017 0.93
256_T 281_N 1.009 0.93
37_C 128_G 1.004 0.93
172_A 176_K 1.004 0.93
47_V 332_L 1.002 0.92
179_G 257_L 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1uufA10.99711000.097Contact Map0.791
3twoA20.98281000.101Contact Map0.783
2cf5A10.99141000.118Contact Map0.787
1rjwA40.95421000.121Contact Map0.825
4eezA20.95991000.121Contact Map0.821
1yqdA20.99141000.122Contact Map0.779
4gkvA40.94561000.127Contact Map0.782
1f8fA10.97131000.127Contact Map0.828
1h2bA20.94841000.128Contact Map0.812
3ukoA20.97991000.133Contact Map0.748
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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