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OPENSEQ.org
IDND - L-idonate 5-dehydrogenase
UniProt: P39346 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12541
Length: 343 (333)
Sequences: 22403
Seq/Len: 67.28
IDND
Paralog alert: 0.83 [within 20: 0.37] - ratio of genomes with paralogs
Cluster includes: ACUI ADHP CURA FRMA GATD IDND QOR1 RSPB TDH YAHK YBDR YCJQ YDJJ YDJL YGGP YJGB YJJN YPHC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
322_D 325_E 3.526 1.00
35_T 146_E 3.295 1.00
30_T 137_C 3.05 1.00
35_T 70_K 3.029 1.00
11_A 19_T 2.979 1.00
190_K 216_D 2.842 1.00
145_D 148_V 2.798 1.00
83_Q 139_P 2.771 1.00
172_R 196_E 2.61 1.00
207_L 211_K 2.594 1.00
318_Y 329_F 2.584 1.00
208_S 212_E 2.531 1.00
147_K 317_E 2.528 1.00
80_H 83_Q 2.527 1.00
27_N 74_S 2.478 1.00
84_T 140_Y 2.442 1.00
33_Q 129_Y 2.437 1.00
196_E 217_V 2.432 1.00
33_Q 70_K 2.414 1.00
28_N 75_D 2.399 1.00
9_V 19_T 2.317 1.00
27_N 75_D 2.288 1.00
173_V 189_V 2.286 1.00
23_I 129_Y 2.284 1.00
301_S 305_N 2.277 1.00
11_A 17_A 2.256 1.00
319_P 322_D 2.253 1.00
78_E 134_T 2.233 1.00
143_K 304_A 2.161 1.00
168_L 171_K 2.117 1.00
316_A 329_F 2.114 1.00
84_T 146_E 2.114 1.00
171_K 261_V 2.091 1.00
67_V 125_G 2.087 1.00
204_P 208_S 2.08 1.00
186_V 215_A 2.05 1.00
317_E 342_V 2.049 1.00
208_S 211_K 2.04 1.00
31_L 131_M 2.037 1.00
256_T 262_M 2.024 1.00
26_N 29_G 2.011 1.00
68_I 146_E 1.997 1.00
328_R 332_D 1.995 1.00
204_P 220_N 1.978 1.00
325_E 328_R 1.973 1.00
178_V 199_C 1.957 1.00
174_F 200_A 1.938 1.00
174_F 235_Y 1.925 1.00
318_Y 326_A 1.915 1.00
155_L 184_L 1.913 1.00
73_H 76_S 1.906 1.00
140_Y 149_M 1.834 1.00
207_L 218_L 1.808 1.00
6_Q 20_E 1.806 1.00
201_D 207_L 1.795 1.00
84_T 142_A 1.763 1.00
237_D 257_R 1.749 1.00
329_F 334_T 1.736 1.00
79_L 139_P 1.734 1.00
67_V 87_I 1.723 1.00
8_C 323_L 1.7 1.00
220_N 223_N 1.682 1.00
325_E 329_F 1.679 1.00
25_W 131_M 1.676 1.00
96_C 99_C 1.673 1.00
261_V 285_S 1.671 1.00
165_A 238_V 1.67 1.00
176_S 252_C 1.67 1.00
209_L 212_E 1.668 1.00
148_V 311_L 1.663 1.00
140_Y 146_E 1.661 1.00
256_T 260_G 1.656 1.00
29_G 133_E 1.653 1.00
72_I 81_E 1.639 1.00
163_H 298_T 1.637 1.00
191_T 307_V 1.635 1.00
256_T 284_I 1.619 1.00
261_V 287_R 1.616 1.00
71_V 79_L 1.593 1.00
6_Q 128_R 1.573 1.00
204_P 223_N 1.556 1.00
239_S 252_C 1.554 1.00
70_K 84_T 1.548 1.00
31_L 129_Y 1.534 1.00
126_F 327_L 1.526 1.00
6_Q 321_T 1.517 1.00
34_I 67_V 1.515 1.00
186_V 199_C 1.509 1.00
28_N 133_E 1.505 1.00
29_G 131_M 1.502 1.00
36_R 342_V 1.5 1.00
30_T 79_L 1.479 1.00
70_K 146_E 1.476 1.00
198_V 235_Y 1.475 1.00
79_L 83_Q 1.468 1.00
49_E 331_G 1.458 1.00
147_K 342_V 1.446 1.00
25_W 29_G 1.421 1.00
217_V 229_W 1.415 1.00
25_W 31_L 1.414 1.00
7_S 21_Q 1.414 1.00
36_R 147_K 1.407 0.99
93_C 96_C 1.398 0.99
301_S 304_A 1.396 0.99
8_C 18_V 1.384 0.99
239_S 256_T 1.373 0.99
172_R 198_V 1.369 0.99
79_L 137_C 1.368 0.99
47_Y 327_L 1.359 0.99
196_E 216_D 1.357 0.99
324_E 328_R 1.341 0.99
185_I 240_F 1.333 0.99
163_H 192_L 1.324 0.99
35_T 84_T 1.309 0.99
176_S 200_A 1.291 0.99
99_C 107_C 1.284 0.99
96_C 107_C 1.283 0.99
202_V 221_P 1.262 0.99
132_V 137_C 1.249 0.99
199_C 215_A 1.245 0.98
32_V 69_G 1.238 0.98
152_A 303_L 1.233 0.98
167_E 194_A 1.231 0.98
315_S 329_F 1.23 0.98
39_I 326_A 1.224 0.98
93_C 99_C 1.221 0.98
36_R 146_E 1.215 0.98
28_N 134_T 1.204 0.98
204_P 207_L 1.2 0.98
172_R 237_D 1.197 0.98
211_K 218_L 1.192 0.98
302_W 307_V 1.188 0.98
23_I 31_L 1.187 0.98
40_C 65_H 1.174 0.98
212_E 312_P 1.15 0.97
38_G 66_E 1.132 0.97
8_C 320_F 1.125 0.97
191_T 302_W 1.125 0.97
40_C 66_E 1.114 0.96
34_I 130_K 1.113 0.96
241_E 244_G 1.108 0.96
165_A 263_V 1.104 0.96
175_I 185_I 1.1 0.96
309_N 312_P 1.096 0.96
298_T 301_S 1.095 0.96
323_L 341_L 1.089 0.96
153_E 157_V 1.085 0.96
12_G 15_T 1.078 0.95
18_V 321_T 1.068 0.95
205_R 208_S 1.068 0.95
202_V 222_Q 1.062 0.95
211_K 217_V 1.059 0.95
72_I 76_S 1.052 0.95
209_L 336_A 1.051 0.94
328_R 331_G 1.048 0.94
207_L 220_N 1.044 0.94
33_Q 128_R 1.043 0.94
297_N 301_S 1.04 0.94
171_K 237_D 1.037 0.94
32_V 85_V 1.033 0.94
198_V 217_V 1.023 0.93
202_V 207_L 1.02 0.93
158_A 188_A 1.019 0.93
35_T 68_I 1.018 0.93
227_D 230_K 1.018 0.93
167_E 171_K 1.016 0.93
37_G 125_G 1.009 0.93
144_A 149_M 1.007 0.93
189_V 194_A 1.005 0.93
319_P 342_V 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4ej6A10.9651000.067Contact Map0.799
4ilkA20.97381000.078Contact Map0.796
1e3iA20.97671000.091Contact Map0.821
4a2cA20.95631000.091Contact Map0.75
1f8fA10.97381000.094Contact Map0.833
3m6iA20.97671000.096Contact Map0.824
1h2bA20.96791000.096Contact Map0.821
1cdoA20.97961000.097Contact Map0.811
3ukoA20.97961000.099Contact Map0.764
2d8aA10.97381000.1Contact Map0.814
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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