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YPHC - Uncharacterized zinc-type alcohol dehydrogenase-like protein YphC
UniProt: P77360 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13464
Length: 353 (348)
Sequences: 22591
Seq/Len: 64.92
YPHC
Paralog alert: 0.83 [within 20: 0.37] - ratio of genomes with paralogs
Cluster includes: ACUI ADHP CURA FRMA GATD IDND QOR1 RSPB TDH YAHK YBDR YCJQ YDJJ YDJL YGGP YJGB YJJN YPHC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
331_Q 334_D 3.51 1.00
35_K 150_Y 3.286 1.00
33_K 77_V 3.156 1.00
30_V 141_L 2.976 1.00
35_K 75_Q 2.946 1.00
31_L 77_V 2.907 1.00
195_K 221_M 2.873 1.00
149_S 152_D 2.809 1.00
90_D 143_L 2.779 1.00
213_A 217_Q 2.608 1.00
327_F 338_L 2.607 1.00
212_L 216_K 2.589 1.00
235_I 238_E 2.55 1.00
87_K 90_D 2.529 1.00
151_E 326_R 2.515 1.00
28_N 82_G 2.511 1.00
91_R 144_L 2.465 1.00
27_I 81_Q 2.453 1.00
33_K 75_Q 2.441 1.00
33_K 133_Y 2.385 1.00
310_H 314_D 2.325 1.00
85_H 138_E 2.278 1.00
178_V 194_A 2.274 1.00
328_S 331_Q 2.27 1.00
177_N 200_K 2.222 1.00
173_S 176_D 2.175 1.00
147_A 313_T 2.174 1.00
22_V 133_Y 2.168 1.00
179_L 244_A 2.147 1.00
209_P 213_A 2.141 1.00
91_R 150_Y 2.122 1.00
27_I 82_G 2.12 1.00
326_R 350_N 2.118 1.00
72_P 129_G 2.106 1.00
10_P 18_R 2.105 1.00
24_T 78_A 2.092 1.00
325_H 338_L 2.088 1.00
176_D 269_R 2.071 1.00
264_T 270_V 2.052 1.00
191_M 220_V 2.025 1.00
26_G 29_Q 2.017 1.00
73_C 150_Y 1.989 1.00
334_D 337_A 1.984 1.00
213_A 216_K 1.977 1.00
327_F 335_A 1.952 1.00
179_L 205_V 1.944 1.00
160_V 189_M 1.919 1.00
31_L 135_L 1.915 1.00
209_P 225_Y 1.897 1.00
77_V 133_Y 1.874 1.00
144_L 153_G 1.863 1.00
206_D 212_L 1.858 1.00
337_A 341_S 1.85 1.00
168_L 197_R 1.841 1.00
91_R 146_D 1.82 1.00
338_L 343_K 1.787 1.00
80_G 83_C 1.773 1.00
78_A 88_E 1.759 1.00
245_D 265_A 1.749 1.00
212_L 223_H 1.742 1.00
264_T 268_G 1.727 1.00
79_M 88_E 1.725 1.00
72_P 94_V 1.723 1.00
86_F 143_L 1.719 1.00
269_R 293_R 1.715 1.00
170_G 246_V 1.713 1.00
214_M 217_Q 1.681 1.00
334_D 338_L 1.66 1.00
144_L 150_Y 1.659 1.00
8_Y 18_R 1.655 1.00
203_I 244_A 1.648 1.00
181_V 260_A 1.647 1.00
10_P 16_D 1.641 1.00
29_Q 137_E 1.638 1.00
231_G 234_Q 1.633 1.00
168_L 307_K 1.61 1.00
196_G 316_K 1.604 1.00
191_M 204_G 1.591 1.00
264_T 292_R 1.588 1.00
76_I 86_F 1.58 1.00
247_A 260_A 1.572 1.00
200_K 222_D 1.565 1.00
269_R 295_I 1.564 1.00
25_P 135_L 1.559 1.00
36_S 350_N 1.555 1.00
130_H 336_Y 1.54 1.00
103_C 106_C 1.533 1.00
75_Q 91_R 1.524 1.00
151_E 350_N 1.518 1.00
29_Q 135_L 1.511 1.00
222_D 239_L 1.505 1.00
28_N 137_E 1.5 1.00
31_L 133_Y 1.496 1.00
86_F 90_D 1.489 1.00
183_L 204_G 1.489 1.00
34_M 72_P 1.475 1.00
31_L 78_A 1.468 1.00
30_V 86_F 1.456 1.00
310_H 313_T 1.427 1.00
230_E 235_I 1.417 1.00
75_Q 150_Y 1.416 1.00
36_S 151_E 1.415 1.00
177_N 203_I 1.403 0.99
201_R 222_D 1.394 0.99
247_A 264_T 1.388 0.99
86_F 141_L 1.374 0.99
25_P 29_Q 1.372 0.99
48_Y 340_A 1.371 0.99
333_G 337_A 1.361 0.99
25_P 31_L 1.35 0.99
234_Q 238_E 1.328 0.99
190_A 248_L 1.315 0.99
5_L 19_E 1.299 0.99
106_C 114_C 1.296 0.99
172_V 199_A 1.294 0.99
177_N 201_R 1.291 0.99
35_K 91_R 1.29 0.99
32_I 74_G 1.286 0.99
204_G 220_V 1.277 0.99
324_T 338_L 1.267 0.99
181_V 205_V 1.264 0.99
100_C 103_C 1.262 0.99
156_I 312_L 1.256 0.99
152_D 320_R 1.246 0.98
136_A 141_L 1.237 0.98
39_I 335_A 1.237 0.98
329_L 351_F 1.236 0.98
207_M 226_L 1.234 0.98
36_S 150_Y 1.233 0.98
200_K 221_M 1.204 0.98
216_K 223_H 1.201 0.98
217_Q 321_N 1.178 0.98
22_V 31_L 1.177 0.98
100_C 106_C 1.174 0.98
5_L 132_E 1.173 0.98
311_D 316_K 1.169 0.97
177_N 245_D 1.162 0.97
196_G 311_D 1.16 0.97
40_C 70_H 1.16 0.97
28_N 138_E 1.158 0.97
47_I 336_Y 1.155 0.97
7_A 332_A 1.153 0.97
235_I 239_L 1.152 0.97
103_C 114_C 1.15 0.97
148_L 153_G 1.15 0.97
209_P 212_L 1.147 0.97
164_Y 168_L 1.146 0.97
180_V 190_A 1.144 0.97
5_L 330_E 1.141 0.97
225_Y 228_T 1.14 0.97
152_D 318_W 1.124 0.97
332_A 349_I 1.118 0.96
34_M 134_L 1.116 0.96
318_W 321_N 1.11 0.96
38_G 71_E 1.11 0.96
249_D 252_G 1.108 0.96
209_P 228_T 1.105 0.96
170_G 271_V 1.103 0.96
79_M 83_C 1.098 0.96
17_L 330_E 1.097 0.96
40_C 71_E 1.086 0.96
307_K 310_H 1.077 0.95
328_S 350_N 1.075 0.95
216_K 222_D 1.071 0.95
32_I 92_V 1.058 0.95
28_N 81_Q 1.054 0.95
77_V 88_E 1.052 0.95
176_D 245_D 1.049 0.94
163_A 193_L 1.041 0.94
337_A 340_A 1.039 0.94
87_K 143_L 1.036 0.94
180_V 194_A 1.034 0.94
210_E 213_A 1.029 0.94
33_K 132_E 1.019 0.93
35_K 73_C 1.019 0.93
306_E 310_H 1.018 0.93
212_L 225_Y 1.014 0.93
172_V 176_D 1.007 0.93
203_I 222_D 1.005 0.93
194_A 199_A 1.003 0.93
102_F 107_R 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3ukoA20.97731000.119Contact Map0.744
4ej6A10.96031000.121Contact Map0.773
1f8fA10.96321000.123Contact Map0.822
1cdoA20.97171000.125Contact Map0.789
1e3iA20.9661000.125Contact Map0.813
2jhfA20.96881000.128Contact Map0.783
1h2bA20.95471000.131Contact Map0.813
1p0fA20.9661000.133Contact Map0.783
4ilkA20.95471000.133Contact Map0.788
4a2cA20.94621000.139Contact Map0.742
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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