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OPENSEQ.org
HLDD - ADP-L-glycero-D-manno-heptose-6-epimerase
UniProt: P67910 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10838
Length: 310 (304)
Sequences: 25098
Seq/Len: 82.56
HLDD
Paralog alert: 0.91 [within 20: 0.60] - ratio of genomes with paralogs
Cluster includes: FCL GALE GM4D HLDD QOR2 RMLB1 RMLB2 RMLD YBJS YEEZ YFCH YRAR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
249_A 296_A 3.288 1.00
7_G 29_V 3.154 1.00
220_V 235_L 3.032 1.00
294_T 297_E 2.966 1.00
18_A 219_D 2.958 1.00
252_A 296_A 2.782 1.00
231_G 282_N 2.646 1.00
91_D 95_Q 2.578 1.00
57_L 106_E 2.515 1.00
71_A 225_L 2.484 1.00
281_T 285_A 2.351 1.00
4_V 16_V 2.299 1.00
85_D 88_Y 2.204 1.00
219_D 291_P 2.163 1.00
22_K 226_E 2.137 1.00
253_Y 300_T 2.132 1.00
244_Q 248_D 2.122 1.00
52_D 55_D 2.115 1.00
18_A 222_L 2.103 1.00
1_M 26_D 2.066 1.00
18_A 22_K 2.064 1.00
197_S 260_E 2.06 1.00
114_A 221_N 2.036 1.00
249_A 252_A 2.015 1.00
171_Y 298_G 2.01 1.00
242_S 245_A 2.006 1.00
30_V 48_A 1.974 1.00
284_R 289_D 1.971 1.00
165_F 224_F 1.96 1.00
48_A 55_D 1.954 1.00
74_H 113_Y 1.942 1.00
5_T 74_H 1.931 1.00
73_F 225_L 1.923 1.00
215_G 301_E 1.922 1.00
219_D 223_W 1.919 1.00
15_I 73_F 1.916 1.00
213_Y 301_E 1.848 1.00
3_I 69_V 1.831 1.00
245_A 248_D 1.829 1.00
28_L 69_V 1.814 1.00
15_I 218_A 1.738 1.00
167_Y 221_N 1.73 1.00
300_T 304_A 1.725 1.00
151_V 162_I 1.698 1.00
58_I 62_A 1.696 1.00
53_K 102_H 1.683 1.00
190_T 194_N 1.681 1.00
11_I 170_V 1.681 1.00
51_M 91_D 1.677 1.00
15_I 75_E 1.674 1.00
98_K 102_H 1.668 1.00
18_A 21_D 1.666 1.00
249_A 253_Y 1.627 1.00
222_L 226_E 1.609 1.00
304_A 308_R 1.599 1.00
203_G 206_N 1.598 1.00
120_Y 234_N 1.597 1.00
72_I 104_C 1.595 1.00
199_K 260_E 1.591 1.00
110_P 161_Q 1.59 1.00
238_G 284_R 1.578 1.00
115_S 119_T 1.564 1.00
129_E 132_E 1.555 1.00
16_V 29_V 1.548 1.00
2_I 24_I 1.542 1.00
95_Q 98_K 1.542 1.00
165_F 221_N 1.537 1.00
57_L 103_Y 1.514 1.00
297_E 300_T 1.511 1.00
98_K 150_Y 1.499 1.00
97_S 147_F 1.498 1.00
145_F 149_E 1.488 1.00
73_F 221_N 1.45 1.00
167_Y 217_V 1.447 1.00
19_L 222_L 1.442 1.00
134_E 145_F 1.436 1.00
28_L 67_G 1.432 1.00
18_A 218_A 1.409 1.00
100_L 111_F 1.397 0.99
104_C 111_F 1.372 0.99
7_G 16_V 1.37 0.99
74_H 97_S 1.359 0.99
102_H 105_L 1.355 0.99
87_K 91_D 1.346 0.99
244_Q 261_Y 1.343 0.99
213_Y 298_G 1.342 0.99
22_K 222_L 1.342 0.99
191_Q 196_E 1.332 0.99
280_L 284_R 1.329 0.99
214_V 218_A 1.327 0.99
17_K 174_R 1.322 0.99
90_M 146_L 1.317 0.99
223_W 227_N 1.306 0.99
53_K 99_E 1.303 0.99
241_E 295_V 1.288 0.99
130_S 282_N 1.285 0.99
149_E 152_R 1.284 0.99
28_L 46_N 1.276 0.99
168_F 278_A 1.265 0.99
13_S 174_R 1.265 0.99
208_K 240_A 1.263 0.99
93_N 143_S 1.255 0.99
219_D 288_Y 1.253 0.99
220_V 283_L 1.248 0.99
155_L 162_I 1.227 0.98
212_V 217_V 1.223 0.98
142_Y 146_L 1.221 0.98
1_M 28_L 1.218 0.98
53_K 57_L 1.218 0.98
114_A 167_Y 1.215 0.98
283_L 286_A 1.215 0.98
18_A 215_G 1.211 0.98
210_D 238_G 1.211 0.98
197_S 258_Q 1.206 0.98
102_H 106_E 1.2 0.98
152_R 164_G 1.194 0.98
140_Y 144_K 1.188 0.98
296_A 300_T 1.181 0.98
2_I 71_A 1.173 0.98
233_F 282_N 1.17 0.97
248_D 251_L 1.169 0.97
75_E 114_A 1.167 0.97
113_Y 147_F 1.163 0.97
60_I 72_I 1.161 0.97
55_D 58_I 1.16 0.97
103_Y 107_R 1.151 0.97
3_I 30_V 1.141 0.97
24_I 226_E 1.137 0.97
50_Y 96_Y 1.135 0.97
105_L 158_A 1.135 0.97
152_R 232_I 1.133 0.97
111_F 151_V 1.132 0.97
17_K 21_D 1.123 0.97
297_E 301_E 1.122 0.97
152_R 162_I 1.114 0.96
101_L 154_I 1.107 0.96
2_I 19_L 1.101 0.96
166_R 232_I 1.09 0.96
10_F 172_G 1.076 0.95
293_K 301_E 1.064 0.95
101_L 111_F 1.06 0.95
14_N 215_G 1.058 0.95
92_N 96_Y 1.053 0.95
50_Y 76_G 1.053 0.95
57_L 61_M 1.044 0.94
129_E 279_D 1.043 0.94
57_L 107_R 1.042 0.94
223_W 286_A 1.042 0.94
113_Y 164_G 1.036 0.94
14_N 214_V 1.032 0.94
281_T 284_R 1.03 0.94
213_Y 293_K 1.027 0.94
5_T 76_G 1.022 0.93
241_E 245_A 1.02 0.93
183_S 186_F 1.014 0.93
253_Y 303_M 1.012 0.93
224_F 283_L 1.011 0.93
165_F 235_L 1.007 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1sb8A10.95811000.132Contact Map0.722
3rufA40.9711000.14Contact Map0.785
2x6tA100.99351000.145Contact Map0.72
4ej0A100.99031000.145Contact Map0.728
1eq2A100.99351000.149Contact Map0.744
3m2pA60.93231000.156Contact Map0.801
1rkxA40.95481000.157Contact Map0.811
1orrA40.96131000.158Contact Map0.819
4egbA80.95161000.158Contact Map0.875
2c5aA20.95481000.16Contact Map0.823
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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