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OPENSEQ.org
RMLB1 - dTDP-glucose 4,6-dehydratase 1
UniProt: P37759 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12412
Length: 361 (321)
Sequences: 21849
Seq/Len: 68.07
RMLB1
Paralog alert: 0.90 [within 20: 0.56] - ratio of genomes with paralogs
Cluster includes: FCL GALE GM4D HLDD QOR2 RMLB1 RMLB2 RMLD YBJS YEEZ YFCH YRAR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
8_G 30_N 3.159 1.00
272_T 324_E 3.134 1.00
256_Y 314_A 2.917 1.00
242_A 258_I 2.895 1.00
322_T 325_S 2.844 1.00
66_A 113_N 2.822 1.00
275_D 324_E 2.786 1.00
19_H 241_R 2.773 1.00
2_K 27_S 2.771 1.00
312_G 318_K 2.664 1.00
254_E 310_K 2.637 1.00
241_R 320_Q 2.556 1.00
57_A 64_A 2.416 1.00
98_E 102_V 2.364 1.00
61_D 64_A 2.353 1.00
76_A 247_V 2.333 1.00
309_E 313_R 2.322 1.00
5_V 17_V 2.263 1.00
92_G 95_A 2.211 1.00
23_N 248_T 2.11 1.00
276_L 328_R 2.1 1.00
127_R 188_P 2.032 1.00
198_Y 326_G 2.029 1.00
19_H 23_N 2.015 1.00
267_I 271_L 2.005 1.00
19_H 244_Y 1.969 1.00
241_R 245_T 1.942 1.00
6_T 79_H 1.924 1.00
156_T 159_T 1.901 1.00
60_C 98_E 1.891 1.00
237_E 329_K 1.886 1.00
67_R 71_Q 1.874 1.00
268_D 271_L 1.87 1.00
192_T 246_V 1.87 1.00
265_K 268_D 1.861 1.00
272_T 275_D 1.844 1.00
16_V 78_M 1.837 1.00
79_H 130_H 1.829 1.00
31_V 57_A 1.824 1.00
78_M 247_V 1.804 1.00
131_I 243_L 1.798 1.00
332_E 336_S 1.776 1.00
235_Y 329_K 1.764 1.00
16_V 240_A 1.724 1.00
4_L 74_P 1.719 1.00
328_R 332_E 1.711 1.00
220_A 292_T 1.698 1.00
66_A 110_A 1.694 1.00
29_V 74_P 1.681 1.00
62_A 109_E 1.672 1.00
19_H 22_N 1.658 1.00
16_V 80_L 1.655 1.00
194_C 243_L 1.63 1.00
272_T 276_L 1.604 1.00
12_I 197_N 1.602 1.00
29_V 55_E 1.586 1.00
77_V 111_A 1.568 1.00
34_L 54_F 1.567 1.00
23_N 26_D 1.563 1.00
29_V 72_H 1.562 1.00
132_S 136_V 1.552 1.00
178_V 189_T 1.551 1.00
2_K 29_V 1.515 1.00
137_Y 257_N 1.515 1.00
261_H 312_G 1.514 1.00
213_L 217_E 1.508 1.00
311_I 315_L 1.505 1.00
29_V 53_V 1.501 1.00
325_S 328_R 1.484 1.00
3_I 26_D 1.48 1.00
105_Y 177_L 1.48 1.00
244_Y 248_T 1.474 1.00
69_F 77_V 1.46 1.00
27_S 53_V 1.449 1.00
105_Y 109_E 1.433 1.00
321_E 329_K 1.422 1.00
17_V 30_N 1.413 1.00
79_H 104_T 1.41 1.00
111_A 128_F 1.408 1.00
192_T 243_L 1.407 0.99
161_Y 172_A 1.407 0.99
18_R 201_Y 1.404 0.99
78_M 243_L 1.4 0.99
94_A 98_E 1.382 0.99
107_L 128_F 1.381 0.99
104_T 174_S 1.381 0.99
157_E 310_K 1.379 0.99
222_P 292_T 1.376 0.99
214_N 219_K 1.365 0.99
67_R 70_A 1.338 0.99
102_V 105_Y 1.336 0.99
62_A 66_A 1.329 0.99
14_S 201_Y 1.323 0.99
235_Y 326_G 1.313 0.99
235_Y 321_E 1.308 0.99
20_I 244_Y 1.307 0.99
156_T 307_D 1.299 0.99
53_V 72_H 1.296 0.99
66_A 114_Y 1.295 0.99
26_D 248_T 1.284 0.99
62_A 106_V 1.281 0.99
245_T 249_E 1.278 0.99
254_E 314_A 1.274 0.99
75_D 123_K 1.27 0.99
19_H 240_A 1.269 0.99
23_N 244_Y 1.268 0.99
109_E 112_R 1.264 0.99
230_I 263_E 1.255 0.99
308_A 312_G 1.244 0.98
64_A 67_R 1.231 0.98
194_C 239_H 1.22 0.98
172_A 176_H 1.219 0.98
19_H 237_E 1.215 0.98
41_E 44_A 1.215 0.98
234_L 239_H 1.215 0.98
8_G 17_V 1.208 0.98
195_S 306_I 1.208 0.98
109_E 113_N 1.208 0.98
70_A 114_Y 1.207 0.98
155_F 159_T 1.204 0.98
59_I 103_G 1.202 0.98
11_F 199_G 1.201 0.98
308_A 319_P 1.199 0.98
236_V 240_A 1.194 0.98
242_A 311_I 1.181 0.98
169_A 173_S 1.179 0.98
100_N 170_S 1.176 0.98
267_I 293_Y 1.176 0.98
179_R 191_V 1.175 0.98
264_K 323_F 1.174 0.98
324_E 328_R 1.164 0.97
228_D 265_K 1.158 0.97
310_K 314_A 1.157 0.97
97_I 173_S 1.148 0.97
325_S 329_K 1.148 0.97
128_F 178_V 1.143 0.97
182_K 189_T 1.142 0.97
228_D 267_I 1.141 0.97
3_I 76_A 1.14 0.97
232_D 261_H 1.138 0.97
131_I 194_C 1.136 0.97
30_N 52_Y 1.126 0.97
127_R 190_I 1.125 0.97
271_L 274_C 1.106 0.96
176_H 179_R 1.104 0.96
110_A 114_Y 1.096 0.96
112_R 185_Y 1.093 0.96
241_R 317_W 1.092 0.96
130_H 174_S 1.082 0.96
80_L 131_I 1.076 0.95
59_I 81_A 1.072 0.95
63_P 67_R 1.066 0.95
256_Y 310_K 1.064 0.95
245_T 315_L 1.061 0.95
64_A 68_I 1.053 0.95
99_T 103_G 1.045 0.94
207_L 211_V 1.039 0.94
2_K 75_D 1.037 0.94
18_R 22_N 1.036 0.94
177_L 180_A 1.033 0.94
108_L 181_W 1.032 0.94
167_Y 171_K 1.031 0.94
179_R 189_T 1.028 0.94
55_E 68_I 1.028 0.94
193_N 255_T 1.021 0.93
65_M 110_A 1.02 0.93
112_R 187_L 1.019 0.93
97_I 170_S 1.018 0.93
111_A 120_S 1.008 0.93
191_V 255_T 1.008 0.93
31_V 65_M 1.007 0.93
259_G 306_I 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1kewA20.98341000.257Contact Map0.795
2hunA20.90861000.297Contact Map0.863
4egbA80.88641000.3Contact Map0.864
1sb8A10.8671000.31Contact Map0.726
3rufA40.86981000.315Contact Map0.791
1r6dA10.89471000.315Contact Map0.709
1oc2A20.9281000.327Contact Map0.763
1orrA40.90581000.328Contact Map0.811
2c20A60.8561000.329Contact Map0.866
2q1sA10.9031000.331Contact Map0.675
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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