May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
YFCH - Epimerase family protein YfcH
UniProt: P77775 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14111
Length: 297 (295)
Sequences: 26397
Seq/Len: 89.48
YFCH
Paralog alert: 0.91 [within 20: 0.61] - ratio of genomes with paralogs
Cluster includes: FCL GALE GM4D HLDD QOR2 RMLB1 RMLB2 RMLD YBJS YEEZ YFCH YRAR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
8_G 29_V 3.257 1.00
236_A 289_E 3.096 1.00
207_G 222_M 2.922 1.00
19_R 206_N 2.852 1.00
239_H 289_E 2.701 1.00
2_N 26_Q 2.695 1.00
287_D 290_E 2.653 1.00
274_K 278_E 2.584 1.00
86_Q 90_N 2.456 1.00
277_E 282_A 2.426 1.00
206_N 284_R 2.41 1.00
54_Q 101_A 2.371 1.00
62_A 212_L 2.361 1.00
5_I 17_I 2.227 1.00
30_V 43_P 2.114 1.00
231_E 235_H 2.102 1.00
108_V 157_R 2.078 1.00
47_L 51_L 2.07 1.00
167_L 291_A 2.034 1.00
240_A 293_A 2.028 1.00
112_G 208_I 2.028 1.00
19_R 209_L 2.022 1.00
43_P 51_L 2.018 1.00
23_L 213_D 2.009 1.00
236_A 239_H 1.981 1.00
19_R 23_L 1.98 1.00
80_Q 83_R 1.978 1.00
65_N 111_S 1.972 1.00
134_N 138_H 1.971 1.00
229_R 232_Q 1.95 1.00
161_L 211_L 1.927 1.00
4_V 60_V 1.924 1.00
127_T 130_E 1.92 1.00
6_T 65_N 1.842 1.00
28_T 60_V 1.83 1.00
202_D 294_D 1.822 1.00
64_I 212_L 1.818 1.00
206_N 210_W 1.811 1.00
232_Q 235_H 1.811 1.00
2_N 28_T 1.806 1.00
16_L 64_I 1.805 1.00
142_A 145_E 1.798 1.00
16_L 66_L 1.73 1.00
200_H 294_D 1.711 1.00
93_Q 97_D 1.701 1.00
16_L 205_V 1.701 1.00
46_T 86_Q 1.7 1.00
163_T 208_I 1.671 1.00
113_S 117_Y 1.67 1.00
61_D 107_S 1.655 1.00
3_I 25_H 1.645 1.00
28_T 41_L 1.644 1.00
236_A 240_A 1.643 1.00
19_R 22_E 1.642 1.00
12_I 166_V 1.62 1.00
118_Y 221_N 1.612 1.00
161_L 208_I 1.611 1.00
225_P 277_E 1.591 1.00
138_H 142_A 1.561 1.00
63_V 99_I 1.528 1.00
209_L 213_D 1.52 1.00
139_K 143_R 1.507 1.00
17_I 29_V 1.502 1.00
49_Q 97_D 1.493 1.00
64_I 208_I 1.458 1.00
276_L 279_A 1.454 1.00
82_E 86_Q 1.454 1.00
273_P 277_E 1.434 1.00
218_G 275_R 1.429 1.00
90_N 93_Q 1.422 1.00
163_T 204_M 1.401 0.99
290_E 293_A 1.399 0.99
210_W 214_N 1.377 0.99
95_L 109_L 1.375 0.99
128_E 275_R 1.367 0.99
19_R 205_V 1.359 0.99
200_H 291_A 1.355 0.99
97_D 100_N 1.342 0.99
20_L 209_L 1.339 0.99
65_N 92_T 1.338 0.99
57_L 63_V 1.331 0.99
108_V 159_C 1.325 0.99
201_I 205_V 1.32 0.99
199_I 204_M 1.312 0.99
127_T 272_L 1.309 0.99
197_A 225_P 1.297 0.99
26_Q 39_S 1.293 0.99
195_Y 227_P 1.29 0.99
23_L 209_L 1.289 0.99
33_N 40_V 1.288 0.99
99_I 109_L 1.282 0.99
11_L 168_A 1.277 0.99
273_P 283_F 1.25 0.99
49_Q 94_K 1.246 0.98
8_G 17_I 1.245 0.98
98_L 102_S 1.244 0.98
179_P 183_L 1.234 0.98
206_N 281_F 1.23 0.98
112_G 163_T 1.229 0.98
47_L 50_G 1.224 0.98
66_L 112_G 1.218 0.98
141_C 145_E 1.217 0.98
193_R 229_R 1.217 0.98
207_G 276_L 1.215 0.98
143_R 146_E 1.211 0.98
164_G 271_A 1.209 0.98
25_H 213_D 1.207 0.98
3_I 62_A 1.206 0.98
193_R 231_E 1.205 0.98
53_D 101_A 1.204 0.98
162_R 219_P 1.204 0.98
54_Q 98_L 1.188 0.98
228_V 288_L 1.186 0.98
2_N 61_D 1.18 0.98
285_W 294_D 1.178 0.98
19_R 202_D 1.171 0.98
18_P 170_D 1.169 0.97
51_L 55_S 1.167 0.97
97_D 101_A 1.165 0.97
14_R 170_D 1.157 0.97
289_E 293_A 1.149 0.97
200_H 285_W 1.144 0.97
126_V 130_E 1.141 0.97
45_V 67_A 1.121 0.97
45_V 91_I 1.121 0.97
137_T 141_C 1.113 0.96
235_H 238_G 1.095 0.96
4_V 30_V 1.094 0.96
18_P 22_E 1.091 0.96
87_S 91_I 1.083 0.96
96_V 109_L 1.08 0.95
290_E 294_D 1.078 0.95
9_T 31_T 1.075 0.95
210_W 279_A 1.074 0.95
238_G 244_P 1.073 0.95
135_E 138_H 1.071 0.95
15_H 202_D 1.068 0.95
28_T 39_S 1.06 0.95
220_F 275_R 1.059 0.95
136_F 140_L 1.055 0.95
123_E 130_E 1.053 0.95
111_S 160_L 1.051 0.94
123_E 127_T 1.042 0.94
240_A 292_L 1.04 0.94
129_E 275_R 1.038 0.94
100_N 154_D 1.036 0.94
162_R 221_N 1.035 0.94
145_E 148_A 1.035 0.94
3_I 20_L 1.033 0.94
100_N 156_T 1.021 0.93
173_I 177_M 1.019 0.93
11_L 201_I 1.018 0.93
15_H 201_I 1.009 0.93
115_T 164_G 1.007 0.93
50_G 55_S 1.007 0.93
250_P 253_A 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1sb8A10.95291000.142Contact Map0.727
3rufA40.95291000.146Contact Map0.793
1rkxA40.95291000.158Contact Map0.784
1rpnA40.94611000.159Contact Map0.799
4id9A20.91921000.16Contact Map0.727
2c20A60.93941000.163Contact Map0.85
2c5aA20.9361000.165Contact Map0.825
1i24A10.94281000.165Contact Map0.684
3m2pA60.92261000.166Contact Map0.805
3ko8A10.94611000.166Contact Map0.782
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.083 seconds.