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OPENSEQ.org
FCL - GDP-L-fucose synthase
UniProt: P32055 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11788
Length: 321 (303)
Sequences: 23661
Seq/Len: 78.09
FCL
Paralog alert: 0.91 [within 20: 0.59] - ratio of genomes with paralogs
Cluster includes: FCL GALE GM4D HLDD QOR2 RMLB1 RMLB2 RMLD YBJS YEEZ YFCH YRAR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
259_T 302_E 3.239 1.00
220_A 245_V 2.916 1.00
300_S 303_A 2.828 1.00
22_Q 219_A 2.791 1.00
48_H 96_Q 2.76 1.00
262_K 302_E 2.691 1.00
241_S 289_R 2.573 1.00
81_Y 85_M 2.458 1.00
11_H 33_L 2.436 1.00
219_A 298_E 2.403 1.00
5_R 30_E 2.36 1.00
43_D 46_A 2.351 1.00
58_Q 225_M 2.349 1.00
288_T 292_Q 2.278 1.00
75_Y 78_D 2.262 1.00
8_I 20_R 2.163 1.00
291_H 296_Y 2.156 1.00
263_V 306_A 2.133 1.00
39_L 46_A 2.102 1.00
198_D 271_V 2.086 1.00
101_K 157_D 2.053 1.00
22_Q 222_I 2.021 1.00
26_R 226_E 2.004 1.00
22_Q 26_R 1.987 1.00
259_T 262_K 1.985 1.00
254_R 258_Q 1.968 1.00
167_Y 304_G 1.951 1.00
105_L 221_S 1.94 1.00
120_A 123_E 1.912 1.00
161_V 224_V 1.903 1.00
215_D 307_S 1.898 1.00
49_D 53_S 1.881 1.00
219_A 223_H 1.864 1.00
9_A 61_L 1.851 1.00
252_T 255_E 1.845 1.00
61_L 104_F 1.841 1.00
60_Y 225_M 1.818 1.00
255_E 258_Q 1.811 1.00
42_L 81_Y 1.805 1.00
19_I 60_Y 1.798 1.00
213_H 307_S 1.784 1.00
7_F 56_I 1.783 1.00
19_I 218_A 1.691 1.00
163_P 221_S 1.672 1.00
310_Q 314_E 1.668 1.00
306_A 310_Q 1.663 1.00
48_H 93_A 1.654 1.00
259_T 263_V 1.615 1.00
44_S 92_H 1.613 1.00
34_R 39_L 1.608 1.00
19_I 62_A 1.592 1.00
22_Q 25_Q 1.579 1.00
248_G 291_H 1.568 1.00
57_D 100_N 1.558 1.00
147_C 158_Y 1.557 1.00
222_I 226_E 1.548 1.00
59_V 94_A 1.539 1.00
15_V 166_L 1.537 1.00
200_V 271_V 1.513 1.00
161_V 221_S 1.511 1.00
6_V 28_D 1.501 1.00
111_Y 244_N 1.495 1.00
303_A 306_A 1.477 1.00
299_I 307_S 1.477 1.00
106_G 110_I 1.468 1.00
121_E 289_R 1.461 1.00
85_M 88_S 1.455 1.00
60_Y 221_S 1.432 1.00
88_S 92_H 1.431 1.00
88_S 146_L 1.42 1.00
129_L 141_I 1.413 1.00
141_I 145_K 1.412 1.00
87_E 143_G 1.409 1.00
5_R 32_V 1.402 0.99
61_L 87_E 1.401 0.99
21_R 170_H 1.396 0.99
163_P 217_M 1.374 0.99
23_L 222_I 1.369 0.99
120_A 286_D 1.356 0.99
213_H 304_G 1.347 0.99
17_S 170_H 1.346 0.99
44_S 48_H 1.344 0.99
94_A 102_L 1.341 0.99
22_Q 218_A 1.334 0.99
223_H 227_L 1.324 0.99
90_I 102_L 1.323 0.99
194_Q 197_P 1.309 0.99
290_L 293_L 1.309 0.99
92_H 95_H 1.306 0.99
26_R 222_I 1.304 0.99
254_R 272_F 1.304 0.99
51_F 59_V 1.3 0.99
77_A 81_Y 1.295 0.99
287_V 291_H 1.294 0.99
49_D 52_A 1.288 0.99
219_A 295_W 1.284 0.99
213_H 299_I 1.283 0.99
32_V 54_E 1.281 0.99
251_C 301_L 1.277 0.99
80_I 142_A 1.276 0.99
32_V 56_I 1.269 0.99
198_D 269_R 1.265 0.99
44_S 89_N 1.264 0.99
214_V 218_A 1.263 0.99
46_A 49_D 1.261 0.99
101_K 159_R 1.252 0.99
220_A 290_L 1.242 0.98
28_D 226_E 1.242 0.98
208_M 250_D 1.24 0.98
48_H 97_N 1.234 0.98
5_R 57_D 1.231 0.98
164_T 285_L 1.217 0.98
11_H 20_R 1.205 0.98
83_N 139_A 1.204 0.98
92_H 96_Q 1.202 0.98
151_N 158_Y 1.194 0.98
138_I 142_A 1.191 0.98
145_K 148_E 1.187 0.98
22_Q 215_D 1.185 0.98
212_L 217_M 1.18 0.98
116_K 120_A 1.178 0.98
206_T 254_R 1.175 0.98
261_A 267_K 1.174 0.98
210_E 248_G 1.167 0.97
136_Y 140_K 1.167 0.97
258_Q 261_A 1.161 0.97
302_E 306_A 1.157 0.97
119_M 123_E 1.156 0.97
6_V 58_Q 1.155 0.97
287_V 297_H 1.149 0.97
52_A 97_N 1.136 0.97
148_E 160_S 1.133 0.97
243_I 289_R 1.133 0.97
105_L 163_P 1.13 0.97
104_F 143_G 1.128 0.97
94_A 99_V 1.127 0.97
45_R 49_D 1.124 0.97
32_V 37_D 1.121 0.97
93_A 97_N 1.109 0.96
116_K 123_E 1.108 0.96
14_M 168_G 1.108 0.96
206_T 252_T 1.105 0.96
303_A 307_S 1.104 0.96
122_S 289_R 1.104 0.96
41_L 86_I 1.099 0.96
95_H 154_Y 1.098 0.96
102_L 147_C 1.086 0.96
200_V 273_D 1.082 0.96
30_E 34_R 1.082 0.96
148_E 242_H 1.075 0.95
20_R 33_L 1.073 0.95
21_R 25_Q 1.071 0.95
41_L 63_A 1.068 0.95
62_A 105_L 1.067 0.95
82_Q 86_I 1.064 0.95
148_E 158_Y 1.036 0.94
48_H 52_A 1.034 0.94
46_A 50_F 1.025 0.93
91_I 150_Y 1.022 0.93
47_V 93_A 1.02 0.93
80_I 139_A 1.017 0.93
18_A 215_D 1.014 0.93
187_R 197_P 1.008 0.93
6_V 23_L 1.007 0.93
9_A 63_A 1.004 0.93
104_F 160_S 1.003 0.93
250_D 282_R 1.002 0.92
223_H 293_L 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1e6uA10.99691000.13Contact Map0.797
1sb8A10.92211000.159Contact Map0.696
3rufA40.92521000.168Contact Map0.774
4egbA80.92211000.176Contact Map0.859
2hunA20.91591000.18Contact Map0.861
4e5yA40.97511000.182Contact Map0.705
2c20A60.94081000.189Contact Map0.848
2c5aA20.93461000.189Contact Map0.82
1orrA40.92831000.19Contact Map0.801
1rkxA40.93771000.19Contact Map0.786
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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