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OPENSEQ.org
GM4D - GDP-mannose 4,6-dehydratase
UniProt: P0AC88 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11787
Length: 373 (331)
Sequences: 18891
Seq/Len: 57.07
GM4D
Paralog alert: 0.89 [within 20: 0.47] - ratio of genomes with paralogs
Cluster includes: FCL GALE GM4D HLDD QOR2 RMLB1 RMLB2 RMLD YBJS YEEZ YFCH YRAR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
265_M 340_R 3.355 1.00
249_F 330_K 3.277 1.00
10_V 31_G 3.182 1.00
338_T 341_E 3.136 1.00
268_A 340_R 3.094 1.00
236_M 251_I 2.979 1.00
72_T 119_F 2.939 1.00
21_F 235_K 2.913 1.00
328_H 334_K 2.874 1.00
4_V 28_E 2.866 1.00
235_K 336_E 2.81 1.00
247_E 326_K 2.69 1.00
63_G 70_N 2.681 1.00
325_T 329_E 2.677 1.00
7_I 19_A 2.531 1.00
67_D 70_N 2.475 1.00
82_E 241_L 2.469 1.00
104_D 108_M 2.411 1.00
269_Q 344_S 2.166 1.00
25_K 242_Q 2.143 1.00
127_R 178_Y 2.126 1.00
235_K 239_M 2.118 1.00
21_F 25_K 2.104 1.00
260_R 264_E 2.079 1.00
32_I 63_G 2.046 1.00
98_S 101_Y 2.033 1.00
66_S 104_D 2.028 1.00
231_K 345_E 2.019 1.00
73_R 77_E 1.988 1.00
188_E 342_M 1.977 1.00
229_H 345_E 1.952 1.00
182_G 240_M 1.928 1.00
21_F 238_W 1.92 1.00
261_Q 264_E 1.92 1.00
18_L 84_Y 1.909 1.00
258_S 261_Q 1.898 1.00
344_S 348_A 1.885 1.00
18_L 234_V 1.872 1.00
8_T 85_N 1.868 1.00
84_Y 241_L 1.856 1.00
6_L 80_P 1.786 1.00
30_H 80_P 1.757 1.00
72_T 116_A 1.75 1.00
265_M 268_A 1.735 1.00
184_L 237_Q 1.733 1.00
30_H 61_H 1.732 1.00
18_L 86_L 1.727 1.00
21_F 24_E 1.672 1.00
146_K 149_T 1.671 1.00
68_T 115_E 1.655 1.00
85_N 130_Q 1.644 1.00
20_E 191_R 1.643 1.00
131_A 237_Q 1.629 1.00
4_V 30_H 1.625 1.00
341_E 344_S 1.617 1.00
30_H 59_H 1.605 1.00
5_A 27_Y 1.603 1.00
30_H 78_V 1.599 1.00
327_A 331_L 1.557 1.00
110_T 164_A 1.545 1.00
168_T 179_A 1.541 1.00
265_M 269_Q 1.54 1.00
81_D 126_T 1.534 1.00
83_V 117_I 1.533 1.00
35_R 60_L 1.504 1.00
117_I 128_F 1.503 1.00
132_S 136_L 1.493 1.00
137_Y 250_V 1.49 1.00
28_E 59_H 1.486 1.00
111_L 167_I 1.485 1.00
337_I 345_E 1.485 1.00
14_D 187_H 1.484 1.00
75_L 83_V 1.48 1.00
238_W 242_Q 1.476 1.00
100_E 104_D 1.468 1.00
19_A 31_G 1.467 1.00
229_H 337_I 1.46 1.00
207_N 212_L 1.428 1.00
59_H 78_V 1.421 1.00
324_P 328_H 1.405 0.99
229_H 342_M 1.393 0.99
85_N 110_T 1.393 0.99
113_L 128_F 1.392 0.99
254_G 328_H 1.389 0.99
72_T 120_L 1.367 0.99
224_L 256_Q 1.356 0.99
247_E 330_K 1.355 0.99
115_E 118_R 1.35 0.99
257_Y 339_L 1.349 0.99
70_N 73_R 1.344 0.99
73_R 76_R 1.336 0.99
182_G 237_Q 1.322 0.99
84_Y 237_Q 1.315 0.99
68_T 112_R 1.313 0.99
147_E 326_K 1.311 0.99
146_K 323_D 1.299 0.99
10_V 19_A 1.294 0.99
16_S 191_R 1.293 0.99
106_D 160_A 1.287 0.99
21_F 231_K 1.276 0.99
341_E 345_E 1.275 0.99
142_E 146_K 1.272 0.99
162_L 166_W 1.271 0.99
267_A 273_K 1.268 0.99
340_R 344_S 1.266 0.99
68_T 72_T 1.265 0.99
324_P 335_P 1.263 0.99
111_L 115_E 1.263 0.99
115_E 119_F 1.254 0.99
108_M 111_L 1.253 0.99
151_F 162_L 1.248 0.99
172_R 179_A 1.245 0.98
239_M 243_Q 1.244 0.98
222_D 258_S 1.243 0.98
65_L 109_G 1.241 0.98
128_F 168_T 1.239 0.98
25_K 238_W 1.232 0.98
21_F 234_V 1.227 0.98
31_G 58_F 1.215 0.98
27_Y 242_Q 1.212 0.98
118_R 175_Y 1.208 0.98
222_D 260_R 1.208 0.98
130_Q 164_A 1.205 0.98
230_A 234_V 1.198 0.98
236_M 327_A 1.19 0.98
228_G 233_Y 1.188 0.98
169_V 181_N 1.183 0.98
326_K 330_K 1.169 0.97
264_E 267_A 1.169 0.97
185_F 322_G 1.156 0.97
252_A 322_G 1.144 0.97
240_M 327_A 1.142 0.97
5_A 82_E 1.141 0.97
22_L 238_W 1.139 0.97
235_K 337_I 1.138 0.97
145_Q 149_T 1.138 0.97
131_A 184_L 1.135 0.97
269_Q 343_V 1.131 0.97
142_E 149_T 1.13 0.97
215_C 306_A 1.129 0.97
20_E 24_E 1.126 0.97
127_R 180_C 1.123 0.97
32_I 71_L 1.122 0.97
76_R 120_L 1.119 0.96
269_Q 347_V 1.119 0.96
159_V 163_Y 1.116 0.96
256_Q 319_T 1.116 0.96
118_R 177_M 1.111 0.96
184_L 233_Y 1.11 0.96
70_N 74_I 1.107 0.96
249_F 326_K 1.105 0.96
103_A 163_Y 1.105 0.96
348_A 352_E 1.1 0.96
13_Q 189_S 1.095 0.96
4_V 81_D 1.081 0.95
23_L 58_F 1.079 0.95
166_W 169_V 1.076 0.95
239_M 331_L 1.074 0.95
231_K 337_I 1.074 0.95
226_D 254_G 1.074 0.95
116_A 120_L 1.071 0.95
42_E 45_D 1.067 0.95
69_S 73_R 1.067 0.95
200_K 204_A 1.066 0.95
32_I 70_N 1.061 0.95
122_L 126_T 1.051 0.94
105_V 109_G 1.05 0.94
61_H 74_I 1.045 0.94
206_A 210_Q 1.039 0.94
86_L 237_Q 1.029 0.94
148_T 326_K 1.028 0.94
68_T 119_F 1.027 0.94
114_L 171_Y 1.027 0.94
235_K 333_W 1.023 0.93
6_L 32_I 1.023 0.93
69_S 72_T 1.023 0.93
130_Q 168_T 1.02 0.93
5_A 22_L 1.019 0.93
257_Y 262_F 1.019 0.93
86_L 131_A 1.015 0.93
74_I 78_V 1.015 0.93
71_L 116_A 1.014 0.93
72_T 76_R 1.013 0.93
270_L 347_V 1.012 0.93
130_Q 181_N 1.002 0.92
199_R 202_T 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1db3A10.96511000.241Contact Map0.798
1rpnA40.8661000.276Contact Map0.775
2z1mA40.91421000.282Contact Map0.853
1t2aA40.9331000.291Contact Map0.81
1n7hA20.91421000.294Contact Map0.742
1sb8A10.86331000.296Contact Map0.713
3rufA40.8661000.301Contact Map0.776
1orrA40.85791000.302Contact Map0.803
1rkxA40.88471000.307Contact Map0.777
2pk3A20.81231000.31Contact Map0.833
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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