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OPENSEQ.org
RMLB2 - dTDP-glucose 4,6-dehydratase 2
UniProt: P27830 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11453
Length: 355 (325)
Sequences: 22544
Seq/Len: 69.37
RMLB2
Paralog alert: 0.90 [within 20: 0.57] - ratio of genomes with paralogs
Cluster includes: FCL GALE GM4D HLDD QOR2 RMLB1 RMLB2 RMLD YBJS YEEZ YFCH YRAR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
265_T 321_E 3.191 1.00
9_G 31_V 3.15 1.00
249_Y 311_E 2.985 1.00
319_T 322_S 2.908 1.00
235_A 251_I 2.888 1.00
3_K 28_A 2.815 1.00
67_A 114_A 2.815 1.00
20_Y 234_R 2.812 1.00
268_E 321_E 2.739 1.00
309_A 315_L 2.62 1.00
247_E 307_K 2.598 1.00
234_R 317_Q 2.497 1.00
58_V 65_E 2.414 1.00
99_E 103_V 2.396 1.00
62_D 65_E 2.362 1.00
306_S 310_R 2.356 1.00
77_C 240_A 2.317 1.00
6_I 18_V 2.276 1.00
93_G 96_A 2.215 1.00
269_L 325_R 2.137 1.00
128_R 181_P 2.074 1.00
260_L 264_E 2.037 1.00
20_Y 237_Y 1.989 1.00
191_Y 323_G 1.981 1.00
24_E 241_T 1.975 1.00
149_T 152_T 1.948 1.00
68_R 72_E 1.942 1.00
234_R 238_C 1.918 1.00
7_T 80_H 1.916 1.00
230_E 326_K 1.909 1.00
80_H 131_H 1.908 1.00
185_T 239_V 1.894 1.00
32_V 58_V 1.888 1.00
61_C 99_E 1.876 1.00
17_L 79_M 1.868 1.00
265_T 268_E 1.868 1.00
258_K 261_D 1.856 1.00
132_I 236_L 1.845 1.00
261_D 264_E 1.838 1.00
20_Y 24_E 1.808 1.00
79_M 240_A 1.794 1.00
5_L 75_P 1.781 1.00
30_V 75_P 1.778 1.00
329_Q 333_A 1.755 1.00
228_Y 326_K 1.745 1.00
213_S 289_T 1.742 1.00
63_R 110_E 1.696 1.00
325_R 329_Q 1.688 1.00
17_L 233_A 1.687 1.00
17_L 81_L 1.661 1.00
67_A 111_A 1.642 1.00
187_C 236_L 1.63 1.00
20_Y 23_N 1.612 1.00
265_T 269_L 1.609 1.00
30_V 56_E 1.595 1.00
30_V 73_H 1.592 1.00
13_I 190_N 1.582 1.00
133_S 137_V 1.576 1.00
138_Y 250_N 1.574 1.00
3_K 30_V 1.561 1.00
254_H 309_A 1.554 1.00
171_V 182_T 1.544 1.00
308_I 312_L 1.528 1.00
35_L 55_F 1.525 1.00
30_V 54_A 1.522 1.00
78_V 112_A 1.518 1.00
322_S 325_R 1.508 1.00
4_I 27_D 1.503 1.00
28_A 54_A 1.488 1.00
206_L 210_A 1.477 1.00
106_Y 110_E 1.473 1.00
150_E 307_K 1.466 1.00
18_V 31_V 1.455 1.00
237_Y 241_T 1.454 1.00
106_Y 170_L 1.447 1.00
185_T 236_L 1.445 1.00
80_H 105_T 1.426 1.00
95_A 99_E 1.418 1.00
318_E 326_K 1.417 1.00
79_M 236_L 1.414 1.00
154_Y 165_A 1.412 1.00
70_F 78_V 1.408 1.00
19_R 194_Y 1.402 0.99
103_V 106_Y 1.399 0.99
105_T 167_S 1.398 0.99
24_E 27_D 1.396 0.99
207_N 212_K 1.383 0.99
15_S 194_Y 1.378 0.99
112_A 129_F 1.378 0.99
108_L 129_F 1.349 0.99
63_R 67_A 1.339 0.99
228_Y 323_G 1.339 0.99
21_I 237_Y 1.326 0.99
228_Y 318_E 1.313 0.99
68_R 71_T 1.311 0.99
149_T 304_D 1.31 0.99
54_A 73_H 1.308 0.99
215_P 289_T 1.3 0.99
223_I 256_E 1.296 0.99
225_D 254_H 1.293 0.99
247_E 311_E 1.29 0.99
238_C 242_T 1.289 0.99
165_A 169_H 1.288 0.99
63_R 107_T 1.284 0.99
65_E 68_R 1.279 0.99
187_C 232_H 1.278 0.99
20_Y 233_A 1.273 0.99
305_A 309_A 1.273 0.99
27_D 241_T 1.271 0.99
229_V 233_A 1.263 0.99
67_A 115_Y 1.261 0.99
110_E 113_R 1.25 0.99
12_F 192_G 1.239 0.98
20_Y 230_E 1.237 0.98
188_S 303_I 1.23 0.98
110_E 114_A 1.229 0.98
148_F 152_T 1.223 0.98
235_A 308_I 1.22 0.98
101_N 163_S 1.219 0.98
227_L 232_H 1.214 0.98
60_I 104_G 1.208 0.98
98_I 166_S 1.207 0.98
42_M 45_A 1.206 0.98
9_G 18_V 1.202 0.98
305_A 316_P 1.201 0.98
169_H 172_R 1.197 0.98
129_F 171_V 1.189 0.98
162_A 166_S 1.185 0.98
234_R 314_W 1.18 0.98
111_A 115_Y 1.179 0.98
71_T 115_Y 1.179 0.98
257_R 320_F 1.178 0.98
128_R 183_L 1.173 0.98
321_E 325_R 1.172 0.98
4_I 77_C 1.151 0.97
131_H 167_S 1.149 0.97
221_Q 260_L 1.146 0.97
221_Q 258_K 1.142 0.97
132_I 187_C 1.141 0.97
264_E 267_C 1.141 0.97
81_L 132_I 1.137 0.97
60_I 82_A 1.133 0.97
307_K 311_E 1.128 0.97
172_R 184_I 1.124 0.97
76_D 124_K 1.123 0.97
31_V 53_F 1.121 0.97
322_S 326_K 1.12 0.96
238_C 312_L 1.099 0.96
113_R 178_Y 1.098 0.96
160_Y 164_K 1.095 0.96
3_K 76_D 1.092 0.96
249_Y 307_K 1.09 0.96
24_E 237_Y 1.086 0.96
64_A 68_R 1.077 0.95
100_T 104_G 1.072 0.95
175_L 182_T 1.072 0.95
172_R 182_T 1.063 0.95
260_L 290_F 1.06 0.95
5_L 32_V 1.052 0.95
151_T 307_K 1.04 0.94
98_I 163_S 1.04 0.94
66_L 111_A 1.034 0.94
65_E 69_V 1.033 0.94
109_L 174_W 1.031 0.94
19_R 23_N 1.031 0.94
131_H 171_V 1.028 0.94
172_R 248_T 1.018 0.93
4_I 79_M 1.012 0.93
64_A 67_A 1.008 0.93
307_K 310_R 1.008 0.93
184_I 248_T 1.007 0.93
186_N 248_T 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4egbA80.90421000.263Contact Map0.869
1sb8A10.88451000.275Contact Map0.724
2hunA20.92391000.278Contact Map0.878
1r6dA10.92681000.279Contact Map0.712
3rufA40.88731000.28Contact Map0.794
1kewA20.96341000.28Contact Map0.797
1orrA40.89581000.287Contact Map0.814
1oc2A20.92681000.288Contact Map0.77
2c20A60.87321000.29Contact Map0.862
2q1sA10.91551000.292Contact Map0.684
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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