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OPENSEQ.org
GALE - UDP-glucose 4-epimerase
UniProt: P09147 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10362
Length: 338 (326)
Sequences: 24875
Seq/Len: 76.30
GALE
Paralog alert: 0.90 [within 20: 0.58] - ratio of genomes with paralogs
Cluster includes: FCL GALE GM4D HLDD QOR2 RMLB1 RMLB2 RMLD YBJS YEEZ YFCH YRAR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
275_A 319_D 3.251 1.00
8_G 29_I 3.096 1.00
259_Y 309_E 2.919 1.00
317_T 320_E 2.903 1.00
242_G 261_L 2.879 1.00
19_Q 241_D 2.857 1.00
66_T 113_A 2.848 1.00
278_K 319_D 2.759 1.00
2_R 26_D 2.751 1.00
304_S 308_R 2.658 1.00
307_D 313_R 2.588 1.00
257_H 305_K 2.539 1.00
98_D 102_N 2.472 1.00
57_G 64_L 2.372 1.00
61_N 64_L 2.349 1.00
5_V 17_C 2.26 1.00
241_D 315_T 2.232 1.00
23_N 248_E 2.175 1.00
92_K 95_E 2.148 1.00
279_A 323_Q 2.095 1.00
270_L 274_N 2.084 1.00
76_T 247_M 2.082 1.00
30_L 57_G 2.04 1.00
275_A 278_K 2.017 1.00
118_N 171_S 2.017 1.00
19_Q 23_N 2.012 1.00
268_S 271_D 1.986 1.00
137_V 140_F 1.985 1.00
241_D 245_V 1.93 1.00
79_H 121_F 1.912 1.00
19_Q 244_V 1.906 1.00
67_E 71_D 1.904 1.00
122_S 243_H 1.903 1.00
4_L 74_I 1.902 1.00
6_T 79_H 1.9 1.00
237_M 324_D 1.894 1.00
271_D 274_N 1.86 1.00
181_V 321_M 1.857 1.00
16_T 78_I 1.846 1.00
214_S 287_H 1.844 1.00
78_I 247_M 1.828 1.00
60_R 98_D 1.81 1.00
235_H 324_D 1.762 1.00
28_I 74_I 1.755 1.00
2_R 28_I 1.741 1.00
323_Q 327_H 1.68 1.00
327_H 331_R 1.674 1.00
16_T 80_F 1.671 1.00
16_T 240_A 1.665 1.00
264_G 307_D 1.66 1.00
275_A 279_A 1.66 1.00
28_I 55_V 1.656 1.00
177_Y 243_H 1.654 1.00
28_I 53_T 1.653 1.00
66_T 110_A 1.652 1.00
62_E 109_S 1.643 1.00
75_D 117_K 1.63 1.00
105_L 109_S 1.623 1.00
19_Q 22_Q 1.614 1.00
3_V 25_H 1.594 1.00
123_S 127_V 1.589 1.00
175_L 246_A 1.589 1.00
128_Y 260_N 1.588 1.00
26_D 53_T 1.586 1.00
160_L 172_I 1.552 1.00
33_L 54_F 1.552 1.00
28_I 72_H 1.544 1.00
306_A 310_L 1.534 1.00
175_L 243_H 1.515 1.00
102_N 105_L 1.508 1.00
216_A 287_H 1.506 1.00
17_C 29_I 1.501 1.00
105_L 159_I 1.496 1.00
142_T 154_L 1.492 1.00
320_E 323_Q 1.477 1.00
77_V 111_M 1.472 1.00
138_E 305_K 1.454 1.00
154_L 158_Q 1.451 1.00
316_R 324_D 1.424 1.00
94_L 98_D 1.406 0.99
109_S 112_R 1.384 0.99
104_T 156_V 1.38 0.99
206_Q 211_R 1.379 0.99
257_H 309_E 1.373 0.99
235_H 321_M 1.369 0.99
303_A 307_D 1.369 0.99
69_L 77_V 1.364 0.99
137_V 302_D 1.362 0.99
19_Q 240_A 1.355 0.99
62_E 106_R 1.353 0.99
118_N 173_A 1.35 0.99
79_H 104_T 1.35 0.99
62_E 66_T 1.344 0.99
12_I 180_P 1.341 0.99
270_L 288_F 1.338 0.99
107_L 119_F 1.319 0.99
111_M 119_F 1.306 0.99
66_T 114_A 1.306 0.99
241_D 312_W 1.29 0.99
20_L 244_V 1.275 0.99
97_Y 155_M 1.274 0.99
78_I 243_H 1.27 0.99
64_L 67_E 1.268 0.99
177_Y 239_L 1.265 0.99
234_I 239_L 1.265 0.99
67_E 70_H 1.259 0.99
23_N 244_V 1.256 0.99
236_V 240_A 1.254 0.99
8_G 17_C 1.251 0.99
158_Q 161_T 1.249 0.99
244_V 248_E 1.247 0.99
230_V 266_G 1.242 0.98
242_G 306_A 1.22 0.98
235_H 316_R 1.22 0.98
228_T 268_S 1.217 0.98
109_S 113_A 1.215 0.98
151_K 155_M 1.213 0.98
25_H 248_E 1.209 0.98
267_N 318_L 1.204 0.98
53_T 72_H 1.201 0.98
319_D 323_Q 1.197 0.98
122_S 177_Y 1.194 0.98
3_V 76_T 1.193 0.98
303_A 314_V 1.187 0.98
205_A 209_V 1.185 0.98
232_D 264_G 1.174 0.98
136_Y 140_F 1.168 0.97
100_N 152_S 1.167 0.97
19_Q 237_M 1.162 0.97
59_I 81_A 1.156 0.97
274_N 277_S 1.152 0.97
305_K 309_E 1.15 0.97
178_F 301_A 1.148 0.97
110_A 114_A 1.146 0.97
320_E 324_D 1.142 0.97
59_I 103_G 1.14 0.97
2_R 75_D 1.135 0.97
216_A 289_A 1.131 0.97
228_T 270_L 1.13 0.97
121_F 156_V 1.127 0.97
4_L 30_L 1.116 0.96
111_M 116_V 1.115 0.96
70_H 114_A 1.113 0.96
18_V 22_Q 1.106 0.96
133_K 137_V 1.104 0.96
80_F 122_S 1.096 0.96
108_I 163_L 1.094 0.96
245_V 249_K 1.094 0.96
249_K 253_K 1.093 0.96
63_A 67_E 1.091 0.96
29_I 52_P 1.078 0.95
139_S 305_K 1.075 0.95
259_Y 305_K 1.073 0.95
149_Y 153_K 1.073 0.95
99_N 103_G 1.072 0.95
66_T 70_H 1.069 0.95
161_T 174_L 1.067 0.95
133_K 140_F 1.065 0.95
11_Y 182_G 1.06 0.95
119_F 160_L 1.054 0.95
277_S 283_P 1.053 0.95
15_H 237_M 1.051 0.94
161_T 258_I 1.048 0.94
164_Q 172_I 1.048 0.94
245_V 310_L 1.043 0.94
159_I 162_D 1.043 0.94
108_I 119_F 1.037 0.94
305_K 308_R 1.036 0.94
279_A 322_A 1.032 0.94
65_M 110_A 1.014 0.93
174_L 258_I 1.011 0.93
3_V 20_L 1.009 0.93
121_F 160_L 1.008 0.93
214_S 285_N 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1udbA10.9971000.149Contact Map0.829
1ek6A211000.167Contact Map0.82
3enkA20.99411000.167Contact Map0.8
4lisA30.99411000.169Contact Map0.815
1z45A10.9971000.176Contact Map0.845
2c20A60.96751000.186Contact Map0.856
3rufA40.93491000.195Contact Map0.78
1gy8A40.98521000.199Contact Map0.78
1sb8A10.9321000.2Contact Map0.711
3ko8A10.90241000.211Contact Map0.766
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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